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Radiology report generation with a learned knowledge base and multi-modal alignment
Open accessAbstract
In clinics, a radiology report is crucial for guiding a patient's treatment. However, writing radiology reports is a heavy burden for radiologists. To this end, we present an automatic, multi-modal approach for report generation from a chest x-ray. Our approach, motivated by the observation that the descriptions in radiology reports are highly correlated with specific information of the x-ray images, features two distinct modules: (i) Learned knowledge base: To absorb the knowledge embedded in the radiology reports, we build a knowledge base that can automatically distill and restore medical knowledge from textual embedding without manual labor; (ii) Multi-modal alignment: to promote the semantic alignment among reports, disease labels, and images, we explicitly utilize textual embedding to guide the learning of the visual feature space. We evaluate the performance of the proposed model using metrics from both natural language generation and clinic efficacy on the public IU-Xray and MIMIC-CXR datasets. Our ablation study shows that each module contributes to improving the quality of generated reports. Furthermore, the assistance of both modules, our approach outperforms state-of-the-art methods over almost all the metrics. Code is available at https://github.com/LX-doctorAI1/M2KT.
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“the uncategorized keyword list in CheXpert may not be transferable from one image modality to different modalities”
From Towards a holistic framework for multimodal LLM in 3D brain CT radiology report generation (2025) · cites this paper as [12]
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“the 14-feature retrieval rates cannot reflect the multi-semantic context (inclusive or exclusive; progression or resolution; relative location and size) of the disease nature over an extended clinical course.”
From Towards a holistic framework for multimodal LLM in 3D brain CT radiology report generation (2025) · cites this paper as [12]
Citations
Cites
Deep Residual Learning for Image Recognition
He, K., Zhang, X., Ren, S., & Sun, J. (2016) · 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr.2016.90 · Cited by 235,474
Vaswani, A., Shazeer, N., Parmar, N., Uszkoreit, J., Jones, L., Gomez, A. N., Kaiser, L., & Polosukhin, I. (2017) · arXiv · doi:10.48550/arxiv.1706.03762 · Cited by 120,404
BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding
Devlin, J., Chang, M.-W., Lee, K., & Toutanova, K. (2019) · Proceedings of the 2019 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 1 (Long and Short Papers) · doi:10.18653/v1/n19-1423 · Cited by 54,325
BLEU: a method for automatic evaluation of machine translation
Papineni, K., Roukos, S., Ward, T., & Zhu, W.-J. (2001) · Proceedings of the 40th Annual Meeting on Association for Computational Linguistics - ACL '02 · doi:10.3115/1073083.1073135 · Cited by 21,344
(2004) · Cited by 9,718
Show, Attend and Tell: Neural Image Caption Generation with Visual Attention
Xu, K., Ba, J., Kiros, R., Cho, K., Courville, A., Salakhutdinov, R., Zemel, R., & Bengio, Y. (2015) · arXiv · doi:10.48550/arxiv.1502.03044 · Cited by 8,248
Show and tell: A neural image caption generator
Vinyals, O., Toshev, A., Bengio, S., & Erhan, D. (2015) · 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr.2015.7298935 · Cited by 6,318
CIDEr: Consensus-based image description evaluation
Vedantam, R., Zitnick, C. L., & Parikh, D. (2015) · 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr.2015.7299087 · Cited by 4,845
Unsupervised Feature Learning via Non-parametric Instance Discrimination
Wu, Z., Xiong, Y., Yu, S. X., & Lin, D. (2018) · 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition · doi:10.1109/cvpr.2018.00393 · Cited by 3,664
Improved Baselines with Momentum Contrastive LearningPreprint
Chen, X., Fan, H., Girshick, R., & He, K. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2003.04297 · Cited by 3,497
MIMIC-CXR, a de-identified publicly available database of chest radiographs with free-text reports
Johnson, A. E. W., Pollard, T. J., Berkowitz, S. J., Greenbaum, N. R., Lungren, M. P., Deng, C.-Y., Mark, R. G., & Horng, S. (2019) · Scientific Data · doi:10.1038/s41597-019-0322-0 · Cited by 1,816
Knowing When to Look: Adaptive Attention via a Visual Sentinel for Image Captioning
Lu, J., Xiong, C., Parikh, D., & Socher, R. (2017) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr.2017.345 · Cited by 1,724
Hybrid computing using a neural network with dynamic external memory
Graves, A., Wayne, G., Reynolds, M., Harley, T., Danihelka, I., Grabska-Barwińska, A., Colmenarejo, S. G., Grefenstette, E., Ramalho, T., Agapiou, J., et al. (2016) · Nature · doi:10.1038/nature20101 · Cited by 1,412
Zhou, S. K., Greenspan, H. K., Davatzikos, C. A., Duncan, J. S., van Ginneken, B., Madabhushi, A., Prince, J. L., Rueckert, D., & Summers, R. M. (2021) · Proceedings of the IEEE · doi:10.1109/jproc.2021.3054390 · Cited by 1,373
Self-citationPreparing a collection of radiology examinations for distribution and retrieval
Demner-Fushman, D., Kohli, M. D., Rosenman, M. B., Shooshan, S. E., Rodriguez, L., Antani, S., Thoma, G. R., & McDonald, C. J. (2016) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocv080 · Cited by 1,164
Attention on Attention for Image Captioning
Huang, L., Wang, W., Chen, J., & Wei, X.-Y. (2019) · 2019 IEEE/CVF International Conference on Computer Vision (ICCV) · doi:10.1109/iccv.2019.00473 · Cited by 1,092
(2016) · doi:10.18653/v1/d16-1147 · Cited by 1,035
Generating Radiology Reports via Memory-driven Transformer
Chen, Z., Song, Y., Chang, T.-H., & Wan, X. (2020) · Proceedings of the 2020 Conference on Empirical Methods in Natural Language Processing (EMNLP) · doi:10.18653/v1/2020.emnlp-main.112 · Cited by 693
On the Automatic Generation of Medical Imaging Reports
Jing, B., Xie, P., & Xing, E. (2018) · Proceedings of the 56th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · doi:10.18653/v1/p18-1240 · Cited by 657
Wang, X., Peng, Y., Lü, L., Lu, Z., & Summers, R. M. (2018) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr.2018.00943 · Cited by 594
Bruno, M. A., Walker, E. A., & Abujudeh, H. H. (2015) · Radiographics · doi:10.1148/rg.2015150023 · Cited by 577
Learning local feature descriptors with triplets and shallow convolutional neural networks
Balntas, V., Riba, E., Ponsa, D., & Mikolajczyk, K. (2016) · British Machine Vision Conference (BMVC) · doi:10.5244/c.30.119 · Cited by 555
Exploring and Distilling Posterior and Prior Knowledge for Radiology Report Generation
Liu, F., Wu, X., Ge, S., Fan, W., & Zou, Y. (2021) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr46437.2021.01354 · Cited by 422
Self-citationLearning to Read Chest X-Rays: Recurrent Neural Cascade Model for Automated Image Annotation
Shin, H.-C., Roberts, K. E., Lü, L., Demner‐Fushman, D., Yao, J., & Summers, R. M. (2016) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr.2016.274 · Cited by 401
CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison
Irvin, J., Rajpurkar, P., Ko, M., Yu, Y., Ciurea-Ilcus, S., Chute, C., Marklund, H., Haghgoo, B., Ball, R., Shpanskaya, K., et al. (2019) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v33i01.3301590 · Cited by 392
When Radiology Report Generation Meets Knowledge Graph
Zhang, Y., Wang, X., Xu, Z., Yu, Q., Yuille, A., & Xu, D. (2020) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v34i07.6989 · Cited by 348
Knowledge-Driven Encode, Retrieve, Paraphrase for Medical Image Report Generation
Li, C. Y., Liang, X., Hu, Z., & Xing, E. P. (2019) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v33i01.33016666 · Cited by 316
Hybrid Retrieval-Generation Reinforced Agent for Medical Image Report Generation
Li, C. Y., Liang, X., Hu, Z., & Xing, E. P. (2018) · arXiv · doi:10.48550/arxiv.1805.08298 · Cited by 271
Barzilay, R., & Kan, M.-Y. (2017) · Annual Meeting of the Association for Computational Linguistics · doi:10.18653/v1/p17-1 · Cited by 269
Bottom-Up and Top-Down Attention for Image Captioning and VQA.Preprint
Anderson, P., He, X., Buehler, C., Teney, D., Johnson, M., Gould, S. J., & Zhang, L. (2017) · arXiv (Cornell University) · Cited by 252
Multimodal Recurrent Model with Attention for Automated Radiology Report Generation
Xue, Y., Xu, T., Long, L. R., Xue, Z., Antani, S., Thoma, G. R., & Huang, X. (2018) · Lecture notes in computer science · doi:10.1007/978-3-030-00928-1_52 · Cited by 245
Knowledge matters: Chest radiology report generation with general and specific knowledge
Yang, S., Wu, X., Ge, S., Zhou, S. K., & Xiao, L. (2022) · Medical Image Analysis · doi:10.1016/j.media.2022.102510 · Cited by 225
Self-citationShow, Describe and Conclude: On Exploiting the Structure Information of Chest X-ray Reports
Jing, B., Wang, Z., & Xing, E. (2019) · Proceedings of the conference - Association for Computational Linguistics. Meeting · doi:10.18653/v1/p19-1657 · Cited by 223
Yuan, J., Liao, H., Luo, R., & Luo, J. (2019) · Lecture notes in computer science · doi:10.1007/978-3-030-32226-7_80 · Cited by 215
Handbook of Medical Image Computing and Computer Assisted Intervention
(2019) · Elsevier eBooks · doi:10.1016/c2017-0-04608-6 · Cited by 203
Contrastive Attention for Automatic Chest X-ray Report Generation
Liu, F., Yin, C., Wu, X., Ge, S., Zhang, P., & Sun, X. (2021) · Findings of the Association for Computational Linguistics: ACL (Findings of ACL) · doi:10.18653/v1/2021.findings-acl.23 · Cited by 180
Self-citationYou, D., Liu, F., Ge, S., Xie, X., Zhang, J., & Wu, X. (2021) · Lecture notes in computer science · doi:10.1007/978-3-030-87199-4_7 · Cited by 176
Self-citationCompetence-based Multimodal Curriculum Learning for Medical Report Generation
Liu, F., Ge, S., & Wu, X. (2021) · doi:10.18653/v1/2021.acl-long.234 · Cited by 153
Self-citationProgressive Transformer-Based Generation of Radiology Reports
Nooralahzadeh, F., Gonzalez, N. A. P., Frauenfelder, T., Fujimoto, K., & Krauthammer, M. O. (2021) · Findings of the Association for Computational Linguistics: EMNLP (Findings of EMNLP) · doi:10.18653/v1/2021.findings-emnlp.241 · Cited by 121
Joint Modeling of Chest Radiographs and Radiology Reports for Pulmonary Edema Assessment
Chauhan, G., Liao, R., Wells, W. M., Andreas, J., Wang, X., Berkowitz, S. J., Horng, S., Szolovits, P., & Golland, P. (2020) · Lecture notes in computer science · doi:10.1007/978-3-030-59713-9_51 · Cited by 59
Chest X-Ray Report Generation Through Fine-Grained Label Learning
Syeda-Mahmood, T. F., Wong, K. C. L., Gur, Y., Wu, J. T.-Y., Jadhav, A., Kashyap, S., Karargyris, A., Pillai, A., Sharma, A., Syed, A., et al. (2020) · Lecture notes in computer science · doi:10.1007/978-3-030-59713-9_54 · Cited by 57
Cited by
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METransformer: Radiology Report Generation by Transformer with Multiple Learnable Expert Tokens
Wang, Z., Liu, L., Wang, L., & Zhou, L. (2023) · 2023 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr52729.2023.01112 · Cited by 184
“Most recently, many works [16, 21, 22, 40, 41, 47] attempt to integrate knowledge graphs into medical report generation pipeline to improve the quality of the generated reports.”
BackgroundExplainable Deep Learning Methods in Medical Image Classification: A Survey
Patrício, C., Neves, J. C., & Teixeira, L. F. (2023) · ACM Computing Surveys · doi:10.1145/3625287 · Cited by 207
PromptMRG: Diagnosis-Driven Prompts for Medical Report Generation
Jin, H., Che, H., Lin, Y., & Chen, H. (2024) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v38i3.28038 · Cited by 181
Multimodal generative AI for medical image interpretation
Rao, V. M., Hla, M., Moor, M., Adithan, S., Kwak, S., Topol, E. J., & Rajpurkar, P. (2025) · Nature · doi:10.1038/s41586-025-08675-y · Cited by 134
Automated Radiology Report Generation: A Review of Recent Advances
Sloan, P., Clatworthy, P. L., Simpson, E., & Mirmehdi, M. (2024) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2024.3408456 · Cited by 106
Metadata
- Authors
- Yang, S., Wu, X., Ge, S., Zheng, Z., Zhou, S. K., & Xiao, L.
- Affiliations
- Chinese Academy of Sciences (CN)
- Tencent (China) (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- University of Science and Technology of China (CN)
- Beijing University of Posts and Telecommunications (CN)
- Corresponding author
- Xiao, Li
- Venue
- Medical Image Analysis
- Publisher
- Elsevier BV
- Published
- 2023-05
- Volume
- 86
- Pages
- 102798
- ISSN
- 1361-8415 (ISSN-L)
- OpenAlex
- W4360604432
- Cited by
- 199
- References
- 47
- Citations by year
- 2026: 58 · 2025: 89 · 2024: 41 · 2023: 11
- FWCI
- 18.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Medical Image Analysis (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University) (cc-by)
- Funders
- Tencent
- National Natural Science Foundation of China (31900979)
- Topics
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Multimodal Machine Learning Applications
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Keywords
- radiology report generation, chest radiography, knowledge distillation, multimodal alignment, text embeddings, semantic alignment, natural language generation
- MeSH terms
- Humans, Learning, Radiography, Radiology, Benchmarking, Knowledge Bases
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