Long-term exercise increases the DNA binding activity of peroxisome proliferator–activated receptor γ in rat adipose tissue
Abstract
The aim of the present study was to examine the effect of 8 weeks of voluntary wheel running on the gene expression, at the protein level, of 2 enzymes involved in lipogenesis (fatty acid synthase [FAS] and diacylglycerol acyl transferase 1), 2 proteins involved in lipolysis (hormone-sensitive lipase [HSL] and perilipin), and 3 transcription factors mediating the induction of genes involved in lipid metabolism (the alpha, gamma, and delta members of the peroxisome proliferator-activated receptor, or PPAR, family) in rat liver, gastrocnemius muscle, epididymal fat, and subcutaneous fat. Proteins were measured through Western blot analysis in the tissues of 11 trained and 14 untrained rats. The trained rats had lower FAS in the liver; higher FAS, HSL, and perilipin in epididymal fat; and higher HSL in subcutaneous fat. In addition, the trained rats had higher total protein concentrations in both fat depots. No significant differences in the liver, muscle, or adipose tissue PPAR contents were found between groups. However, the DNA binding activity of PPARgamma, measured through an enzyme immunoassay-based method, was higher in both fat depots of the trained rats. Our findings suggest that long-term wheel running had significant effects on the concentrations of proteins playing key roles in lipogenesis and lipolysis in rat liver and adipose tissue. These effects may be due to PPAR activation rather than induction, rendering the transcriptional regulation of target genes more economical and flexible. The activation of PPARgamma with exercise may mediate its beneficial effect on insulin sensitivity.
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Aerobic exercise upregulates uncoupling protein-1 and peroxisome proliferator-activated receptor gamma, which further enhance lipolysis in adipose tissues.
“Aerobic exercise also upregulates certain proteins, such as uncoupling protein-1 and peroxisome proliferator-activated receptor gamma (71), which further enhance lipolysis in adipose tissues (72).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [71]
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Mazur, I. I., Drozdovska, S., Валеріївна, А. О., Vinnichuk, Y. D., Polishchuk, A., Andreev, I. O., Досенко, В. Є., Pickering, C., & Ahmetov, I. I. (2020) · Faktori eksperimental noi evolucii organizmiv · doi:10.7124/feeo.v27.1326
- Authors
- Petridou, A., Tsalouhidou, S., Tsalis, G., Schulz, T., Michna, H., & Mougios, V.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- Technical University of Munich (DE)
- Corresponding author
- Mougios, Vassilis
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 56
- Issue
- 8
- Pages
- 1029-1036
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2106239358
- Cited by
- 61
- References
- 36
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 3 · 2012: 7
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of National Education and Religious Affairs
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- PPARγ, voluntary wheel running, exercise training, adipose tissue, lipogenesis, lipolysis, fatty acid synthase, hormone-sensitive lipase, perilipin, diacylglycerol acyltransferase 1, lipid metabolism, transcriptional regulation, insulin sensitivity, liver, skeletal muscle
- MeSH terms
- Adipose Tissue, Animals, DNA, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Epididymis, Lipolysis, Liver, Male, Muscle Proteins, Physical Conditioning, Animal, Proteins, Blotting, Western, Rats, Wistar, Muscle, Skeletal, Leptin, PPAR gamma, Subcutaneous Fat, Lipogenesis, Rats
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