Cited by 138Adipose Tissue and MetabolismGenetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

The DOI matches its Crossref record; 73 of the 74 references it cites were found in a registry or an index.

Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats

Perrone, Carmen E., Mattocks, Dwight A.L., Jarvis-Morar, Maureen, Plummer, Jason D., Orentreich, Norman·2010·Metabolism

DOI 10.1016/j.metabol.2009.10.023

Open this paper in CoChat — free account

Abstract

Methionine restriction increases life span in rats and mice and reduces age-related accretion of adipose tissue in Fischer 344 rats. Recent reports have shown that adipose tissue mitochondrial content and function are associated with adiposity; therefore, the expression of genes involved in mitochondrial biogenesis and oxidative capacity was examined in white adipose tissue, liver, and skeletal muscle from Fischer 344 rats fed control (0.86% methionine) or methionine-restricted (0.17% methionine) diets for 3 months. Methionine restriction induced transcriptional changes of peroxisome proliferator-activated receptors, peroxisome proliferator-activated receptor coactivators 1alpha and 1beta, and some of their known target genes in all of these tissues. In addition, tissue-specific responses were elicited at the protein level. In inguinal adipose tissue, methionine restriction increased protein levels of peroxisome proliferator-activated receptor and peroxisome proliferator-activated receptor coactivator target genes. It also induced mitochondrial DNA copy number, suggesting mitochondrial biogenesis and corresponding with the up-regulation of citrate synthase activity. In contrast, methionine restriction induced changes in mitochondrial glycerol-3-phosphate dehydrogenase activity and stearoyl-coenzyme A desaturase 1 protein levels only in liver and uncoupling protein 3 and cytochrome c oxidase subunit IV protein levels only in skeletal muscle. No increase in mitochondrial DNA copy number was observed in liver and skeletal muscle despite an increase in mitochondrial citrate synthase activity. The results indicate that adiposity resistance in methionine-restricted rats is associated with mitochondrial biogenesis in inguinal adipose tissue and increased mitochondrial aerobic capacity in liver and skeletal muscle.

Integrity signals

Registry

Crossref · 10.1016/j.metabol.2009.10.023

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · cited 1×
“Nuclear respiratory factors 1 and 2 control the expression of mitochondrial transcription factor A (Tfam), which is essential for the replication, maintenance, and transcription of mitochondrial DNA (mtDNA) [26,27] as well as the expression of nuclear genes encoding mitochondrial respiratory chain subunits [28].”
Background
Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (PGC-1α): Transcriptional Coactivator and Metabolic Regulator
Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076
Transcriptional regulation of adipogenesisPreprint
Rosen, E. D., Walkey, C. J., Puigserver, P., & Spiegelman, B. M. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 1,908
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
Finck, B. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27794 · Cited by 1,461
Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity
Wang, Y.-X., Lee, C.-H., Tiep, S., Yu, R. T., Ham, J., Kang, H., & Evans, R. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00269-1 · Cited by 1,296
The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes
Vega, R. B., Huss, J. M., & Kelly, D. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1868-1876.2000 · Cited by 1,195
Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
Cao, H., Gerhold, K. A., Mayers, J. R., Wiest, M. M., Watkins, S. M., & Hotamışlıgil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.07.048 · Cited by 1,174
Peroxisome Proliferator-Activated Receptor γ Coactivator 1 Coactivators, Energy Homeostasis, and Metabolism
Handschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0037 · Cited by 1,090

Show all 74 references

Sorted by citations

Extending life span by increasing oxidative stress
Ristow, M., & Schmeisser, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.010 · Cited by 737
Methionine metabolism in health and cancer: a nexus of diet and precision medicine
Sanderson, S. M., Gao, X., Dai, Z., & Locasale, J. W. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0187-8 · Cited by 601
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534
Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density
Ables, G. P., Perrone, C. E., Orentreich, D. S., & Orentreich∥, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051357 · Cited by 241
Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21
Lees, E. K., Król, E., Grant, L., Shearer, K., Wyse, C. A., Moncur, E. M., Bykowska, A. S., Mody, N., Gettys, T. W., & Delibegović, M. (2014) · Aging Cell · doi:10.1111/acel.12238 · Cited by 203
Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice
Stone, K. P., Wanders, D., Orgeron, M., Cortez, C. C., & Gettys, T. W. (2014) · Diabetes · doi:10.2337/db14-0464 · Cited by 201
Cysteine supplementation reverses methionine restriction effects on rat adiposity: Significance of stearoyl-coenzyme A desaturase
Elshorbagy, A. K., Valdivia-Garcia, M., Mattocks, D. A. L., Plummer, J. D., Smith, A. D., Drevon, C. A., Refsum, H., & Perrone, C. E. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m010215 · Cited by 177
Self-citation
Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction
Sánchez-Román, I., & Barja, G. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.021 · Cited by 146
Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction
Wanders, D., Stone, K. P., Forney, L. A., Cortez, C. C., Dille, K. N., Simon, J., Xu, M., Hotard, E. C., Nikonorova, I. A., Pettit, A. P., et al. (2016) · Diabetes · doi:10.2337/db15-1324 · Cited by 138
Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats
Hasek, B. E., Boudreau, A., Shin, J., Feng, D., Hulver, M. W., Van, N. T., Laque, A., Stewart, L. K., Stone, K. P., Wanders, D., et al. (2013) · Diabetes · doi:10.2337/db13-0501 · Cited by 136
Bone Marrow Adiposity: Basic and Clinical Implications
Sebo, Z. L., Rendina-Ruedy, E., Ables, G. P., Lindskog, D. M., Rodeheffer, M. S., Fazeli, P. K., & Horowitz, M. C. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00138 · Cited by 143
Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice
Malloy, V. L., Perrone, C. E., Mattocks, D. A. L., Ables, G. P., Caliendo, N. S., Orentreich, D. S., & Orentreich∥, N. (2013) · Metabolism · doi:10.1016/j.metabol.2013.06.012 · Cited by 118
Cysteine and obesity
Elshorbagy, A. K., Kožich, V., Smith, A. D., & Refsum, H. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834d199f · Cited by 116
The Impact of Dietary Methionine Restriction on Biomarkers of Metabolic Health
Orgeron, M., Stone, K. P., Wanders, D., Cortez, C. C., Van, N. T., & Gettys, T. W. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00011-9 · Cited by 110
Genomic and Metabolic Responses to Methionine-Restricted and Methionine-Restricted, Cysteine-Supplemented Diets in Fischer 344 Rat Inguinal Adipose Tissue, Liver and Quadriceps Muscle
Perrone, C. E., Mattocks, D. A. L., Plummer, J. D., Chittur, S. V., Mohney, R. P., Vignola, K. S., Orentreich, D. S., & Orentreich∥, N. (2012) · Lifestyle Genomics · doi:10.1159/000339347 · Cited by 100
Methionine restriction on lipid metabolism and its possible mechanisms
Zhou, X., He, L., Wan, D., HuanSheng, Y., Yao, K., Wu, G., Wu, X., & Yin, Y. (2016) · Amino Acids · doi:10.1007/s00726-016-2247-7 · Cited by 102
High‐protein diet more effectively reduces hepatic fat than low‐protein diet despite lower autophagy and FGF21 levels
Xu, C., Markova, M., Seebeck, N., Loft, A., Hornemann, S., Gantert, T., Kabisch, S., Herz, K., Loske, J., Ost, M., et al. (2020) · Liver International · doi:10.1111/liv.14596 · Cited by 88
Effect of Dietary Methionine Level on Muscle Growth Mechanisms in Juvenile Rainbow Trout (Oncorhynchus Mykiss)
Alami-Durante, H., Bazin, D., Cluzeaud, M., Fontagné-Dicharry, S., Kaushik, S., & Geurden, I. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2017.10.030 · Cited by 83
Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study
Olsén, T., Øvrebø, B., Haj‐Yasein, N. N., Lee-Ødegård, S., Svendsen, K., Hjorth, M., Bastani, N. E., Norheim, F., Drevon, C. A., Refsum, H., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02288-x · Cited by 83
Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice
Sinha, R., Cooper, T. K., Rogers, C. J., Sinha, I., Turbitt, W. J., Calcagnotto, A., Perrone, C. E., & Richie, J. P. (2014) · The Prostate · doi:10.1002/pros.22884 · Cited by 80
Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat
Maddineni, S. R., Nichenametla, S. N., Sinha, R., Wilson, R. P., & Richie, J. P. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213477988 · Cited by 79
Methionine restriction on oxidative stress and immune response in dss-induced colitis mice
Liu, G., Yu, L., Fang, J. Q., Hu, C. A., Yin, J., Ni, H., Ren, W., Duraipandiyan, V., Chen, S., Al-Dhabi, N. A., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17812 · Cited by 81
Dietary methionine restriction reduces hepatic steatosis and oxidative stress in high-fat-fed mice by promoting H 2 S production
Yang, Y., Wang, Y., Sun, J., Zhang, J., Guo, H., Shi, Y., Cheng, X., Tang, X., & Le, G. (2018) · Food & Function · doi:10.1039/c8fo01629a · Cited by 78
Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents
Perrone, C. E., Malloy, V. L., Orentreich, D. S., & Orentreich∥, N. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.07.005 · Cited by 76
Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice
Hens, J. R., Sinha, I., Perodin, F., Cooper, T. K., Sinha, R., Plummer, J. D., Perrone, C. E., & Orentreich, D. S. (2016) · BMC Cancer · doi:10.1186/s12885-016-2367-1 · Cited by 75
Dietary Methionine Restriction Ameliorated Fat Accumulation, Systemic Inflammation, and Increased Energy Metabolism by Altering Gut Microbiota in Middle-Aged Mice Administered Different Fat Diets
Wu, G., Shi, Y., Han, L., Feng, C., Ge, Y., Yu, Y., Xue Ming, T. A. N. G., Cheng, X., Sun, J., & Le, G. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c02965 · Cited by 74
Dietary cystine level affects metabolic rate and glycaemic control in adult mice
Elshorbagy, A. K., Church, C., Valdivia‐Garcia, M., Smith, A. D., Refsum, H., & Cox, R. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.12.009 · Cited by 69
Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice
Lees, E. K., Banks, R., Cook, C., Hill, S., Morrice, N., Grant, L., Mody, N., & Delibegović, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-10381-3 · Cited by 68
β-Catenin Links Hepatic Metabolic Zonation with Lipid Metabolism and Diet-Induced Obesity in Mice
Behari, J., Li, H., Liu, S., Stefanovic-Racic, M., Alonso, L., O'Donnell, C. P., Shiva, S., Singamsetty, S., Watanabe, Y., Singh, V. P., et al. (2014) · The American Journal of Pathology · doi:10.1016/j.ajpath.2014.08.022 · Cited by 65
Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism
Wei, W., & Ruvkun, G. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008021117 · Cited by 56
Methionine restriction slows down senescence in human diploid fibroblasts
Kozieł, R., Ruckenstuhl, C., Albertini, E., Neuhaus, M., Netzberger, C., Bust, M., Madeo, F., Wiesner, R. J., & Jansen‐Dürr, P. (2014) · Aging Cell · doi:10.1111/acel.12266 · Cited by 62
Glutathionyl systems and metabolic dysfunction in obesity
Picklo, M. J., Long, E. K., & Vomhof‐DeKrey, E. E. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv042 · Cited by 64
Methionine and choline regulate the metabolic phenotype of a ketogenic diet
Pissios, P., Hong, S., Kennedy, A. R., Prasad, D., Liu, F., & Maratos–Flier, E. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.07.003 · Cited by 62
Transcriptional impact of dietary methionine restriction on systemic inflammation: Relevance to biomarkers of metabolic disease during aging
Wanders, D., Ghosh, S., Stone, K. P., Van, N. T., & Gettys, T. W. (2013) · BioFactors · doi:10.1002/biof.1111 · Cited by 61
Combining Dietary Sulfur Amino Acid Restriction with Polyunsaturated Fatty Acid Intake in Humans: A Randomized Controlled Pilot Trial
Olsén, T., Øvrebø, B., Turner, C., Bastani, N. E., Refsum, H., & Vinknes, K. J. (2018) · Nutrients · doi:10.3390/nu10121822 · Cited by 60
Effects of methionine intake on cognitive function in mild cognitive impairment patients and APP/PS1 Alzheimer's Disease model mice: Role of the cystathionine-β-synthase/H2S pathway
Xi, Y., Zhang, Y., Zhou, Y., Liu, Q., Chen, X., Liu, X., Grune, T., Shi, L. S., Hou, M., & Liu, Z. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102595 · Cited by 62
Metabolic responses to dietary leucine restriction involve remodeling of adipose tissue and enhanced hepatic insulin signaling
Wanders, D., Stone, K. P., Dille, K., Simon, J., Pierse, A., & Gettys, T. W. (2015) · BioFactors · doi:10.1002/biof.1240 · Cited by 57
Remodeling of lipid metabolism by dietary restriction of essential amino acids
Anthony, T. G., Morrison, C. D., & Gettys, T. W. (2013) · Diabetes · doi:10.2337/db12-1613 · Cited by 52
Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights
Jonsson, W. O., Margolies, N., & Anthony, T. G. (2019) · Nutrients · doi:10.3390/nu11061349 · Cited by 51
Extension of Cellular Lifespan by Methionine Restriction Involves Alterations in Central Carbon Metabolism and Is Mitophagy-Dependent
Plummer, J. D., & Johnson, J. E. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00301 · Cited by 48
Methionine restriction beyond life‐span extension
Ables, G. P., Hens, J. R., & Nichenametla, S. N. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13014 · Cited by 51
The Origins, Evolution, and Future of Dietary Methionine Restriction
Fang, H., Stone, K. P., Wanders, D., Forney, L. A., & Gettys, T. W. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062320-111849 · Cited by 47
Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults
Richie, J. P., Sinha, R., Dong, Z., Nichenametla, S. N., Ables, G. P., Ciccarella, A., Sinha, I., Calcagnotto, A., Chinchilli, V. M., Reinhart, L., et al. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-1883-3 · Cited by 47
Dietary l-methionine restriction decreases oxidative stress in porcine liver mitochondria
Yang, Y., Yun, J., Wu, G., Sun, K., Zhaolai, D., & Wu, Z. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.03.004 · Cited by 46
An integrative analysis of tissue-specific transcriptomic and metabolomic responses to short-term dietary methionine restriction in mice
Ghosh, S., Forney, L. A., Wanders, D., Stone, K. P., & Gettys, T. W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177513 · Cited by 44
Dietary Methionine Restriction Signals to the Brain Through Fibroblast Growth Factor 21 to Regulate Energy Balance and Remodeling of Adipose Tissue
Forney, L. A., Fang, H., Sims, L. C., Stone, K. P., Vincik, L. Y., Vick, A. M., Gibson, A. N., Burk, D. H., & Gettys, T. W. (2020) · Obesity · doi:10.1002/oby.22919 · Cited by 43
The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective
Bresgen, N., Kovacs, M., Lahnsteiner, A., Felder, T. K., & Rinnerthaler, M. (2023) · Biomolecules · doi:10.3390/biom13060912 · Cited by 41
Methionine restriction alters bone morphology and affects osteoblast differentiation
Ouattara, A., Cooke, D., Gopalakrishnan, R., Huang, T., & Ables, G. P. (2016) · Bone Reports · doi:10.1016/j.bonr.2016.02.002 · Cited by 40
Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial
Olsén, T., Stolt, E. T. K., Øvrebø, B., Elshorbagy, A. K., Tore, E. C., Lee-Ødegård, S., Troensegaard, H., Johannessen, H., Doeland, B., Vo, A. A. D., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04833-w · Cited by 39
Dietary methionine restriction improves glucose metabolism in the skeletal muscle of obese mice
Luo, T., Yang, Y., Xu, Y., Gao, Q., Wu, G., Jiang, Y., Sun, J., Shi, Y., & Le, G. (2019) · Food & Function · doi:10.1039/c8fo02571a · Cited by 42
Sexually Dimorphic Effects of Dietary Methionine Restriction are Dependent on Age when the Diet is Introduced
Forney, L. A., Stone, K. P., Gibson, A. N., Vick, A. M., Sims, L. C., Fang, H., & Gettys, T. W. (2020) · Obesity · doi:10.1002/oby.22721 · Cited by 39
Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle
Rajabian, N., Ikhapoh, I. A., Shahini, S., Choudhury, D., Thiyagarajan, R., Shahini, A., Kulczyk, J., Breed, K., Saha, S., Mohamed, M. A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36483-3 · Cited by 41
Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations
Vinknes, K. J., Dekker, J. M., Drevon, C. A., Refsum, H., Nurk, E., Nijpels, G., Stehouwer, C. D. A., Teerlink, T., Tell, G. S., Nygard, O. K., et al. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.09.007 · Cited by 37
Mitochondrial complex I inhibition triggers NAD+-independent glucose oxidation via successive NADPH formation, “futile” fatty acid cycling, and FADH2 oxidation
Abrosimov, R., Baeken, M. W., Hauf, S., Wittig, I., Hajieva, P., Perrone, C. E., & Moosmann, B. (2024) · GeroScience · doi:10.1007/s11357-023-01059-y · Cited by 37
Myocardial metabolic alterations in mice with diet-induced atherosclerosis: linking sulfur amino acid and lipid metabolism
Lee, J., Jung, S., Kim, N., Shin, M., Ryu, D. H., & Hwang, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-13991-z · Cited by 37
Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance
Elshorbagy, A. K., Valdivia‐Garcia, M., Mattocks, D. A. L., Plummer, J. D., Orentreich, D. S., Orentreich∥, N., Refsum, H., & Perrone, C. E. (2012) · Metabolism · doi:10.1016/j.metabol.2012.10.005 · Cited by 35
Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction
Patil, Y. N., Dille, K. N., Burk, D. H., Cortez, C. C., & Gettys, T. W. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.05.016 · Cited by 32
Cystathionine β‐synthase‐deficient mice thrive on a low‐methionine diet
Gupta, S., Melnyk, S. B., & Kruger, W. D. (2013) · The FASEB Journal · doi:10.1096/fj.13-240770 · Cited by 33
Compromised responses to dietary methionine restriction in adipose tissue but not liver of ob/ob mice
Stone, K. P., Wanders, D., Calderon, L. F., Spurgin, S. B., Scherer, P. E., & Gettys, T. W. (2015) · Obesity · doi:10.1002/oby.21177 · Cited by 32
Cold tolerance, cold-induced hyperphagia, and nonshivering thermogenesis are normal in α1-AMPK−/−mice
Bauwens, J. D., Schmuck, E. G., Lindholm, C. R., Ertel, R. L., Mulligan, J. D., Hovis, I. W., Viollet, B., & Saupe, K. W. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00444.2010 · Cited by 32
The effects of dietary methionine restriction on the function and metabolic reprogramming in the liver and brain – implications for longevity
Mladenović, D. R., Radosavljević, T. S., Hrnčić, D., Rašić-Marković, A., & Stanojlović, O. P. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0073 · Cited by 30
The acute transcriptional responses to dietary methionine restriction are triggered by inhibition of ternary complex formation and linked to Erk1/2, mTOR, and ATF4
Stone, K. P., Ghosh, S., Kovalik, J. P., Orgeron, M., Wanders, D., Sims, L. C., & Gettys, T. W. (2021) · Scientific Reports · doi:10.1038/s41598-021-83380-0 · Cited by 29
Interactive effects of water salinity and dietary methionine levels on growth performance, whole-body composition, plasma parameters, and expression of major nutrient metabolism genes in juvenile genetically improved farmed Tilapia (Oreochromis niloticus)
Xu, H., Ren, M., Liang, H., Ge, X., Ji, K., Huang, D., Yu, H., & Wu, L. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737381 · Cited by 29
Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response
Forney, L. A., Stone, K. P., Wanders, D., & Gettys, T. W. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.12.002 · Cited by 28
Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice
Arao, Y., Kawai, H., Kamimura, K., Kobayashi, T., Nakano, O., Hayatsu, M., Ushiki, T., & Terai, S. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.180 · Cited by 27
Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice
Lees, E. K., Król, E., Shearer, K., Mody, N., Gettys, T. W., & Delibegović, M. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.038 · Cited by 26
The Antisteatotic and Hypolipidemic Effect of Insect Meal in Obese Zucker Rats is Accompanied by Profound Changes in Hepatic Phospholipid and 1-Carbon Metabolism
Meyer, S., Gessner, D. K., Wen, G., Most, E., Liebisch, G., Zorn, H., Ringseis, R., & Eder, K. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801305 · Cited by 23
Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects
Guerra, B. A., Brandão, B. B., Pinto, S., Salgueiro, W. G., De‐Souza, E. A., Reis, F. C. G., Batista, T. M., Cavalcante‐Silva, V., D’Almeida, V., Castilho, B. A., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.017 · Cited by 23
Dietary methionine deficiency stunts growth and increases fat deposition via suppression of fatty acids transportation and hepatic catabolism in Pekin ducks
Wu, Y., Tang, J., Wen, Z., Zhang, B., Cao, J., Zhao, L., Guo, Z., Xie, M., Zhou, Z., & Hou, S. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00709-z · Cited by 22
Skeletal muscles respond differently when piglets are offered a diet 30 % deficient in total sulfur amino acid for 10 days
Conde-Aguilera, J. A., Lefaucheur, L., Tesseraud, S., Mercier, Y., Floc'H, N. L., & van Milgen, J. J. (2015) · European Journal of Nutrition · doi:10.1007/s00394-014-0830-9 · Cited by 21
Methionine concentration in the diet has a tissue-specific effect on chromosomal stability in female mice
Aissa, A. F., Gomes, T. D. U. H., Almeida, M. R., Hernandes, L. C., Darin, J. D. C., Bianchi, M. L. P., & Antunes, L. M. G. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.09.004 · Cited by 20
Nutrient Sensing and Redox Balance: GCN2 as a New Integrator in Aging
Falcón, P., Escandón, M., Brito, Á., & Matus, S. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5730532 · Cited by 21
Effects of Aging and Methionine Restriction on Rat Kidney Metabolome
Pradas, I., Jové, M., Cabré, R., Ayala, V., Mota‐Martorell, N., & Pamplona, R. (2019) · Metabolites · doi:10.3390/metabo9110280 · Cited by 18
Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice
Niewiadomski, J., Zhou, J. Q., Roman, H. B., Liu, X., Hirschberger, L. L., Locasale, J. W., & Stipanuk, M. H. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13021 · Cited by 18
Methionine-Restricted Diet: A Feasible Strategy Against Chronic or Aging-Related Diseases
Wu, G., Xu, J., Wang, Q., Fang, Z., Fang, Y., Jiang, Y., Zhang, X., Cheng, X., Sun, J., & Le, G. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c05829 · Cited by 17
One-Carbon Metabolism
Suh, E., Choi, S., & Friso, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00036-4 · Cited by 19
Understanding glucose uptake during methionine deprivation in incubated rainbow trout (Oncorhynchus mykiss) hepatocytes using a non-radioactive method
Craig, P. M., Massarsky, A., & Moon, T. W. (2013) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2013.06.005 · Cited by 15
Effect of different levels of dietary methionine restriction on relieving oxidative stress and behavioral deficits in middle-aged mice fed low-, medium-, or high-fat diet
Wu, G., Han, L., Shi, Y., Feng, C., Yan, B., Sun, J., Xue Ming, T. A. N. G., & Le, G. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103782 · Cited by 14
Mitochondrial metabolism in aging: Effect of dietary interventions
Cerqueira, F. M., & Kowaltowski, A. J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.009 · Cited by 14
Effects of nutrients and diet on mitochondrial dysfunction: An opportunity for therapeutic approaches in human disease
Do, L. H., da Costa, R. T., & Solesio, M. E. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118493 · Cited by 13
Implementation of dietary methionine restriction using casein after selective, oxidative deletion of methionine
Fang, H., Stone, K. P., Forney, L. A., Sims, L. C., Gutierrez, G. C., Ghosh, S., & Gettys, T. W. (2021) · iScience · doi:10.1016/j.isci.2021.102470 · Cited by 13
Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats
Komninou, D., Malloy, V. L., Zimmerman, J. A., Sinha, R., & Richie, J. P. (2019) · GeroScience · doi:10.1007/s11357-019-00129-4 · Cited by 13
Mitochondria, Autophagy and Inflammation: Interconnected in Aging
Silva, R. C. M. C. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01231-x · Cited by 13
Reactive oxygen species, health and longevity
Bianchi, V. E., & Falcioni, G. (2016) · AIMS molecular science · doi:10.3934/molsci.2016.4.479 · Cited by 11
Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study
Olsén, T., Øvrebø, B., Turner, C., Bastani, N. E., Refsum, H., & Vinknes, K. J. (2021) · BMC Research Notes · doi:10.1186/s13104-021-05463-5 · Cited by 11
Optimized Nutrition in Mitochondrial Disease Correlates to Improved Muscle Fatigue, Strength, and Quality of Life
DiVito, D., Wellik, A., Burfield, J., Peterson, J. T., Flickinger, J., Tindall, A. M., Albanowski, K., Vishnubhatt, S., MacMullen, L. E., Martin, I., et al. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01418-9 · Cited by 10
The role of suppression of hepatic SCD1 expression in the metabolic effects of dietary methionine restriction
Forney, L. A., Stone, K. P., Wanders, D., Ntambi, J. M., & Gettys, T. W. (2017) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2017-0404 · Cited by 10
Elucidating the Pharmacological Properties of Zingiber officinale Roscoe (Ginger) on Muscle Ageing by Untargeted Metabolomic Profiling of Human Myoblasts
Sahardi, N. F. N. M., Jaafar, F., Tan, J. K., Nordin, M. F. M., & Makpol, S. (2023) · Nutrients · doi:10.3390/nu15214520 · Cited by 8
Feeding of Hermetia illucens Larvae Meal Attenuates Hepatic Lipid Synthesis and Fatty Liver Development in Obese Zucker Rats
Marschall, M. J. M., Grundmann, S. M., Geßner, D. K., Wen, G., Most, E., Eder, K., & Ringseis, R. (2023) · Nutrients · doi:10.3390/nu15020287 · Cited by 9
Can we alter dietary macronutrient compositions and alleviate mitochondrial disease?
Ballard, J. W. O. (2016) · Journal of Rare Diseases Research & Treatment · doi:10.29245/2572-9411/2016/3.1043 · Cited by 8
A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function
Degens, H., Swaminathan, A., & Tallis, J. A. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000261 · Cited by 7
Supplementation of Sulfur-Containing Amino Acids or Essential Amino Acids Does Not Reverse the Hepatic Lipid-Lowering Effect of a Protein-Rich Insect Meal in Obese Zucker Rats
Meyer, S., Schäfer, L., Röhrig, J., Maheshwari, G., Most, E., Zorn, H., Ringseis, R., Eder, K., & Gessner, D. K. (2020) · Nutrients · doi:10.3390/nu12040987 · Cited by 5
Physical activity of mice on dietary sulfur amino acid restriction is influenced by age of diet initiation and biological sex
Cooke, D., & Ables, G. P. (2023) · Scientific Reports · doi:10.1038/s41598-023-47676-7 · Cited by 5
The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression
Elshorbagy, A. K., Bastani, N. E., Lee-Ødegård, S., Øvrebø, B., Haj‐Yasein, N. N., Svendsen, K., Turner, C., Refsum, H., Vinknes, K. J., & Olsén, T. (2022) · Amino Acids · doi:10.1007/s00726-022-03229-2 · Cited by 5
Nutritional Regulation of Mitochondrial Function
Vasam, G., Reid, K., Burelle, Y., & Menzies, K. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00004-3 · Cited by 6
Short‐term dietary methionine restriction with high fat diet counteracts metabolic dysfunction in male mice
McGilvrey, M. I., Fortier, B., Cooke, D., Mahdi, M. A., Tero, B. W., Potts, C. M., Kaija, A., Ryzhova, L., Cora, C., Richardson, A. D., et al. (2025) · Physiological Reports · doi:10.14814/phy2.70405 · Cited by 4
The hallmarks of protein and amino acid restriction in aging and longevity
Knopf, B. A., & Lamming, D. W. (2026) · Cell Press Blue · doi:10.1016/j.cpblue.2026.100079 · Cited by 4
Angiogenesis-independent VEGF signaling enhances exercise capacity by increasing fat oxidation in mice fed sulfur amino acid-restricted diets
Mann, C. G., MacArthur, M. R., Zhang, J., Gong, S., AbuSalim, J. E., Hunter, C. J., Lu, W., Agius, T., Longchamp, A., Allagnat, F., et al. (2025) · iScience · doi:10.1016/j.isci.2025.114148 · Cited by 3
The effect of short-term methionine restriction on hydrogen peroxide metabolism in Fischer-344 rat skeletal muscle mitochondria
Tamanna, N., Munro, D., Kroeker, K., Banh, S., & Treberg, J. R. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.08.006 · Cited by 3
Impact of methionine restriction on muscle aerobic metabolism and hypertrophy in young and old mice on an obesogenic diet
Swaminathan, A., Cesanelli, L., Venckūnas, T., & Degens, H. (2022) · Growth Factors · doi:10.1080/08977194.2022.2083963 · Cited by 3

Authors: Perrone, C. E., Mattocks, D. A. L., Jarvis-Morar, M., Plummer, J. D., & Orentreich, N.
Affiliations: Orentreich Foundation for the Advancement of Science (US)
ORCID: Mattocks, Dwight A.L.
Venue: Metabolism
Publisher: Elsevier BV
Published: 2010-07
Volume: 59
Issue: 7
Pages: 1000-1011
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2009.10.023
OpenAlex: W1981999383
Cited by: 136
References: 74
Citations by year: 2026: 6 · 2025: 4 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 24 · 2019: 12 · 2018: 2 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 11 · 2012: 5
FWCI: 4.54
Type: journal article
Language: en
Update notices: erratum (2010-11-01)
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: methionine restriction, mitochondrial biogenesis, cardiorespiratory fitness, white adipose tissue, liver, skeletal muscle, peroxisome proliferator-activated receptors, mitochondrial DNA copy number, citrate synthase, UCP3, stearoyl-CoA desaturase 1, glycerol-3-phosphate dehydrogenase, cytochrome c oxidase, adiposity, aging, F344 rats
MeSH terms: Aerobiosis, Animals, Body Weight, Citrate (si)-Synthase, DNA, Mitochondrial, Liver, Male, Methionine, Mitochondria, Mitochondria, Liver, Mitochondria, Muscle, Organ Size, Rats, Inbred F344, Stearoyl-CoA Desaturase, Blotting, Western, Gene Expression, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Adiposity, Glycerol-3-Phosphate Dehydrogenase (NAD+), Rats, Adipose Tissue, White

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks