Cited by 151Renin-Angiotensin System StudiesVitamin D Research StudiesParathyroid Disorders and Treatments

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The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes

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Vaidya, Anand, Williams, Jonathan S.·2012·Metabolism

DOI 10.1016/j.metabol.2011.09.007PMC PMC3290690

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Abstract

Vitamin D has been implicated in the pathophysiology of extraskeletal conditions such as hypertension, kidney disease, and diabetes via its ability to negatively regulate the renin-angiotensin system (RAS). This article reviews the evidence supporting a link between vitamin D and the RAS in these conditions, with specific emphasis on translational observations and their limitations. A literature review of animal and human studies evaluating the role of vitamin D in hypertension, kidney disease, and diabetes was performed. Excess activity of the RAS has been implicated in the pathogenesis of hypertension, chronic kidney disease, decreased insulin secretion, and insulin resistance. Animal studies provide strong support for 1,25-dihydroxyvitamin D(3)-mediated downregulation of renin expression and RAS activity via its interaction with the vitamin D receptor. Furthermore, the activity of vitamin D metabolites in animals is associated with reductions in blood pressure, proteinuria and renal injury, and with improved β-cell function. Many observational, and a few interventional, studies in humans have supported these findings; however, there is a lack of well-designed prospective human interventional studies to definitively assess clinical outcomes. There is a need for more well-designed prospective interventional studies to validate this hypothesis in human clinical outcomes.

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Vitamin D Deficiency
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F., Remme, W. J., Cody, R., Castaigne, A., Perez, A., Palensky, J., & Wittes, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411001 · Cited by 9,214
Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663
Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol
Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Julius, S., Beevers, G., de Faire, U., Fyhrquist, F., Ibsen, H., Kristiansson, K., Lederballe-Pedersen, O., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08089-3 · Cited by 5,407
Vitamin D
Norman, A. W. (1979) · Cited by 3,769
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F. M., Remme, W. J., Cody, R. J., Castaigne, A., Pérez, A. J. P., Palensky, J., & Wittes, J. T. (2000) · Survey of Anesthesiology · doi:10.1097/00132586-200006000-00059 · Cited by 2,927
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
Hyppönen, E., Läärä, E., Reunanen, A., Järvelin, M., & Virtanen, S. M. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06580-1 · Cited by 1,948
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., & Demay, M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0004 · Cited by 1,783
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Li, Y. C., Kong, J., Wei, M., Chen, Z.-F., Liu, S. Q., & Cao, L.-P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215219 · Cited by 1,625
Textbook of Endocrinology
Williams, R. M., Wilson, J. D., & Foster, D. W. (1952) · Diabetes · doi:10.2337/diab.1.2.159 · Cited by 1,450
Vitamin D: modulator of the immune system
Baeke, F., Takiishi, T., Korf, H., Gysemans, C. A., & Mathieu, C. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.04.001 · Cited by 1,333
Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis
Elliott, W. J., & Meyer, P. M. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60108-1 · Cited by 1,016
Serum 25-Hydroxyvitamin D, Diabetes, and Ethnicity in the Third National Health and Nutrition Examination Survey
Scragg, R. K. R., Sowers, M. R., & Bell, C. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2813 · Cited by 964
Survival of Patients Undergoing Hemodialysis with Paricalcitol or Calcitriol Therapy
Teng, M. F., Wolf, M. S., Lowrie, E. G., Ofsthun, N. J., Lazarus, J. M., & Thadhani, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022536 · Cited by 922
Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension
Forman, J. P., Giovannucci, E. L., Holmes, M. D., Bischoff-Ferrari, H. A., Tworoger, S. S., Willett, W. C., & Curhan, G. C. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.087288 · Cited by 903
A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolutionPreprint
Ramagopalan, S. V., Heger, A., Berlanga‐Taylor, A. J., Maugeri, N., Lincoln, M. R., Burrell, A., Handunnetthi, L., Handel, A. E., Disanto, G., Orton, S. M., et al. (2010) · Genome Research · doi:10.1101/gr.107920.110 · Cited by 881
1,25-Dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line
Wood, R. J., Tchack, L., & Taparia, S. (2001) · BMC Physiology · doi:10.1186/1472-6793-1-11 · Cited by 847
Activated Injectable Vitamin D and Hemodialysis Survival
Teng, M. F., Wolf, M. S., Ofsthun, M. N., Lazarus, J. M., Hernán, M. Á., Camargo, C. A., & Thadhani, R. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004070573 · Cited by 775
Systematic Review: Vitamin D and Cardiometabolic Outcomes
Pittas, A. G., Chung, M., Trikalinos, T., Mitri, J., Brendel, M., Patel, K., Lichtenstein, A. H., Lau, J., & Balk, E. M. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-5-201003020-00009 · Cited by 761
Effect of ramipril on the incidence of diabetes
(2006) · New England Journal of Medicine · doi:10.1056/nejmoa065061 · Cited by 737
Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2vitamin D3: Genomic and non-genomic mechanisms
Haussler, M. R., Jurutka, P. W., Mizwicki, M. T., & Norman, A. W. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.05.010 · Cited by 713
Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial
de Zeeuw, D., Agarwal, R., Amdahl, M., Audhya, P., Coyne, D. W., Garimella, T. S., Parving, H., Pritchett, Y., Remuzzi, G., Ritz, E., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61032-x · Cited by 696
Effect of valsartan on the incidence of diabetes and cardiovascular events
(2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001121 · Cited by 660
Effects of a Short-Term Vitamin D3 and Calcium Supplementation on Blood Pressure and Parathyroid Hormone Levels in Elderly Women
Pfeifer, M., Begerow, B., Minne, H. W., Nachtigall, D., & Hansen, C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7393 · Cited by 645
Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient – a randomised, placebo-controlled trial
von Hurst, P. R., Stonehouse, W., & Coad, J. (2010) · British Journal of Nutrition · doi:10.1017/s0007114509992017 · Cited by 624
Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance
Forouhi, N. G., Luan, J., Cooper, A., Boucher, B. J., & Wareham, N. J. (2008) · Diabetes · doi:10.2337/db08-0593 · Cited by 618
Vitamin D and type 2 diabetes: a systematic review
Mitri, J., Muraru, M., & Pittas, A. G. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.118 · Cited by 585
Serum 25-hydroxyvitamin D, Ethnicity, and Blood Pressure in the Third National Health and Nutrition Examination Survey
Scragg, R. K. R., Sowers, M., & BELL, C. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2007.01.017 · Cited by 579
Serum Aldosterone and the Incidence of Hypertension in Nonhypertensive Persons
Vasan, R. S., Evans, J. C., Larson, M. G., Wilson, P. W. F., Meigs, J. B., Rifai, N., Benjamin, E. J., & Levy, D. A. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033263 · Cited by 573
Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems
Xiang, W., Kong, J., Chen, S., Cao, L., Qiao, G., Zheng, W., Liu, W., Li, X., Gardner, D. G., & Li, Y. C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00224.2004 · Cited by 573
Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers
Zittermann, A., Frisch, S., Berthold, H. K., Götting, C., Kühn, J., Kleesiek, K., Stehle, P., Koertke, H., & Köerfer, R. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27004 · Cited by 563
Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels
Sugden, J., Davies, J. I., Witham, M. D., Morris, A. D., & Struthers, A. D. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02360.x · Cited by 549
Ultraviolet B and blood pressure
Krause, R., Bühring, M., Hopfenmüller, W., Holick, M. F., & Sharma, A. M. (1998) · The Lancet · doi:10.1016/s0140-6736(05)60827-6 · Cited by 514
1,25-Dihydroxyvitamin D3 Suppresses Renin Gene Transcription by Blocking the Activity of the Cyclic AMP Response Element in the Renin Gene Promoter
Yuan, W., Pan, W., Kong, J., Zheng, W., Szeto, F. L., Wong, K. E., Cohen, R., Kłopot, A., Zhang, Z., & Li, Y. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705495200 · Cited by 496
Ultraviolet Light May Contribute to Geographic and Racial Blood Pressure Differences
Rostand, S. G. (1997) · Hypertension · doi:10.1161/01.hyp.30.2.150 · Cited by 472
Vitamin D Insufficiency and Deficiency in Chronic Kidney Disease
González, E. A., Sachdeva, A., Oliver, D. A., & Martin, K. J. (2004) · American Journal of Nephrology · doi:10.1159/000081023 · Cited by 439
Vitamin D levels and patient outcome in chronic kidney disease
Ravani, P., Malberti, F., Tripepi, G. L., Pecchini, P., Cutrupi, S., Pizzini, P., Mallamaci, F., & Zoccali, C. (2008) · Kidney International · doi:10.1038/ki.2008.501 · Cited by 439
Vitamin D and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Elamin, M. B., Elnour, N. O. A., Elamin, K. B., Fatourechi, M. M., Alkatib, A. A., Almandoz, J. P., Liu, H., Lane, M. A., Mullan, R. J., Hazem, A., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0398 · Cited by 421
Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus
Available, N. A. N. (1999) · Diabetologia · doi:10.1007/s001250051112 · Cited by 420
Effect of Vitamin D Deficiency and Replacement on Endothelial Function in Asymptomatic Subjects
Tarçın, Ö., Yavuz, D. G., Özben, B., Telli, A., Öğünç, A. V., Yüksel, M., Toprak, A. C., Yazıcı, D., Sancak, S., Deyneli, O., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1212 · Cited by 418
Vitamin D status and arterial hypertension: a systematic review
Pilz, S., Tomaschitz, A., Ritz, E., & Pieber, T. R. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.135 · Cited by 403
Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1α-hydroxylase knockout mice
Zhou, C., Lu, F., Cao, K., Xu, D., Goltzman, D., & Miao, D. (2008) · Kidney International · doi:10.1038/ki.2008.101 · Cited by 402
Effect of vitamin D on blood pressure: a systematic review and meta-analysis
Witham, M. D., Nadir, M. A., & Struthers, A. D. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832f075b · Cited by 396
25-Hydroxyvitamin D, IGF-1, and Metabolic Syndrome at 45 Years of Age
Hyppönen, E., Boucher, B. J., Berry, D. J., & Power, C. (2007) · Diabetes · doi:10.2337/db07-1122 · Cited by 390
Antiproteinuric effect of oral paricalcitol in chronic kidney disease
Agarwal, R., Acharya, M., Tian, J., Hippensteel, R., Melnick, J. Z., Qiu, P., Williams, L. A., & BATLLE, D. C. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00755.x · Cited by 373
Calcium-Regulating Hormones in Essential Hypertension
Resnick, L. M., MÜLLER, F. B., & LARAGH, J. H. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-5-649 · Cited by 371
Vitamin D Status Is Associated With Arterial Stiffness and Vascular Dysfunction in Healthy Humans
Mheid, I. A., Patel, R. S., Murrow, J. R., Morris, A. A., Rahman, A. M., Fike, L. V., Kavtaradze, N., Uphoff, I., Hooper, C. W., Tangpricha, V., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.02.051 · Cited by 371
Calcium Plus Vitamin D Supplementation and the Risk of Incident Diabetes in the Women's Health Initiative
de Boer, I. H., Tinker, L. F., Connelly, S., Curb, J. D., Howard, B. V., Kestenbaum, B. R., Larson, J. C., Manson, J. E., Margolis, K. L., Siscovick, D. S., et al. (2008) · Diabetes Care · doi:10.2337/dc07-1829 · Cited by 368
25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial Dysfunction in Middle-Aged and Older Adults
Jablonski, K., Chonchol, M., Pierce, G. L., Walker, A. E., & Seals, D. R. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.160929 · Cited by 364
Vitamin D status and health correlates among German adults
Hintzpeter, B., Mensink, G., Thierfelder, W., Müller, M., & Scheidt‐Nave, C. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602825 · Cited by 358
Vitamin D regulation of the renin–angiotensin system
Li, Y. C. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10343 · Cited by 358
Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy
Bäder, M. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105610 · Cited by 352
Lower risk for cardiovascular mortality in oral 1 -hydroxy vitamin D3 users in a haemodialysis population
Shoji, T., Shinohara, K., Kimoto, E., Emoto, M., Tahara, H., Koyama, H., Inaba, M., Fukumoto, S., Ishimura, E., Miki, T., et al. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg513 · Cited by 350
Serum 25-Hydroxyvitamin D Concentration and Subsequent Risk of Type 2 Diabetes
Sarkkola, C., Knekt, P., Männistö, S., Rissanen, H. A., Laaksonen, M. A., Montonen, J., & Reunanen, A. (2007) · Diabetes Care · doi:10.2337/dc07-0292 · Cited by 336
Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension Among Young Women
Forman, J. P., Curhan, G. C., & Taylor, E. N. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.117630 · Cited by 335
Effects of a Short-Term Vitamin D3 and Calcium Supplementation on Blood Pressure and Parathyroid Hormone Levels in Elderly Women
Pfeifer, M. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.4.1633 · Cited by 334
Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans
Forman, J. P., Williams, J. S., & Fisher, N. D. L. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.148619 · Cited by 331
Self-citation
Paricalcitol Reduces Albuminuria and Inflammation in Chronic Kidney Disease
Alborzi, P., Patel, N. K., Peterson, C., Bills, J. E., Bekele, D. M., Bunaye, Z., Light, R. P., & Agarwal, R. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.113159 · Cited by 331
Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes
Knekt, P., Laaksonen, M. A., Sarkkola, C., Härkänen, T., Marniemi, J., Heliövaara, M., Rissanen, H. A., Montonen, J., & Reunanen, A. (2008) · Epidemiology · doi:10.1097/ede.0b013e318176b8ad · Cited by 329
A double‐blind, randomized, placebo‐controlled trial of the short‐term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle‐aged, centrally obese men
Nagpal, J., Pande, J. N., & Bhartia, A. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02636.x · Cited by 317
Plasma 25-Hydroxyvitamin D Is Associated with Markers of the Insulin Resistant Phenotype in Nondiabetic Adults
Liu, E., Meigs, J. B., Pittas, A. G., McKeown, N. M., Economos, C. D., Booth, S. L., & Jacques, P. F. (2008) · Journal of Nutrition · doi:10.3945/jn.108.093831 · Cited by 313
Vitamin D Supplementation in Chronic Kidney Disease
Kandula, P., Dobre, M. A., Schold, J. D., Schreiber, M. J., Mehrotra, R., & Navaneethan, S. D. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03940510 · Cited by 306
The EURODIAB Substudy 2 Study Group Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus
de Beaufort, C. E. (1999) · Open Repository and Bibliography (University of Luxembourg) · Cited by 305
25-Hydroxyvitamin D Levels and Albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III)
de Boer, I. H., Ioannou, G. N., Kestenbaum, B. R., Brunzell, J. D., & Weiss, N. S. (2007) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.04.015 · Cited by 296
Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase
Zhang, Z., Zhang, Y., Ning, G., Deb, D. K., Kong, J., & Li, Y. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803751105 · Cited by 288
Improved Islet Morphology after Blockade of the Renin- Angiotensin System in the ZDF Rat
Tikellis, C., Wookey, P. J., Candido, R., Andrikopoulos, S., Thomas, M. C., & Cooper, M. E. (2004) · Diabetes · doi:10.2337/diabetes.53.4.989 · Cited by 285
Vitamin D, Parathyroid Hormone Levels, and the Prevalence of Metabolic Syndrome in Community-Dwelling Older Adults
Reis, J. P., von Mühlen, D. G., Kritz‐Silverstein, D. C., Wingard, D. L., & Barrett-Connor, E. L. (2007) · Diabetes Care · doi:10.2337/dc06-2438 · Cited by 281
Daily consumption of vitamin D– or vitamin D + calcium–fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial
Nikooyeh, B., Neyestani, T. R., Farvid, M., Alavi-Majd, H., Houshiarrad, A., Kalayi, A., Shariatzadeh, N., Gharavi, A., Heravifard, S., Tayebinejad, N., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.007336 · Cited by 277
Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome
Li, R., Brereton, R. E., Anderson, R. A., Wallace, A. M., & Ho, C. K. M. (2011) · Metabolism · doi:10.1016/j.metabol.2011.03.002 · Cited by 266
Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysis
Burgaz, A., Orsini, N., Larsson, S. C., & Wolk, A. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834320f9 · Cited by 254
Association of Oral Calcitriol with Improved Survival in Nondialyzed CKD
Shoben, A. B., Rudser, K. D., de Boer, I. H., Young, B. A., & Kestenbaum, B. R. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007111164 · Cited by 253
Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations.
Major, G. C., Alarie, F. P., Doré, J., Phouttama, S., & Tremblay, A. (2007) · PubMed · doi:10.1093/ajcn/85.1.54 · Cited by 251
Effect of Calcium and Vitamin D Supplementation on Blood Pressure
Margolis, K. L., Ray, R. M., Horn, L. V., Manson, J. E., Allison, M., Black, H. R., Beresford, S. A. A., Connelly, S. A., Curb, J. D., Grimm, R. H., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114991 · Cited by 251
Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin–angiotensin system
Tomaschitz, A., Pilz, S., Ritz, E., Grammer, T., Drechsler, C., Boehm, B. O., & März, W. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.05.037 · Cited by 246
Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels
Jorde, R., & Figenschau, Y. (2009) · European Journal of Nutrition · doi:10.1007/s00394-009-0020-3 · Cited by 244
Vitamin D Receptor Attenuates Renal Fibrosis by Suppressing the Renin-Angiotensin System
Zhang, Y., Kong, J., Deb, D. K., Chang, A., & Li, Y. C. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009080872 · Cited by 243
Serum 25-Hydroxyvitamin D, Calcium Intake, and Risk of Type 2 Diabetes After 5 Years
Gagnon, C., Lu, Z. X., Magliano, D. J., Dunstan, D. W., Shaw, J. E., Zimmet, P., Sikaris, K. A., Grantham, N., Ebeling, P. R., & Daly, R. M. (2011) · Diabetes Care · doi:10.2337/dc10-2167 · Cited by 241
Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population‐based study in older men and women
Snijder, M. B., Lips, P. T. A. M., Seidell, J. C., Visser, M., Deeg, D. J. H., Dekker, J. M., & van Dam, R. M. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01778.x · Cited by 230
No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year
Jorde, R., Sneve, M., Torjesen, P. A., & Figenschau, Y. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02181.x · Cited by 230
Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets
Lau, T., Carlsson, P., & Leung, P. S. (2004) · Diabetologia · doi:10.1007/s00125-003-1295-1 · Cited by 228
Plasma 25-Hydroxyvitamin D Concentration and Risk of Incident Type 2 Diabetes in Women
Pittas, A. G., Sun, Q., Manson, J. E., Dawson-Hughes, B. F., & Hu, F. B. (2010) · Diabetes Care · doi:10.2337/dc10-0790 · Cited by 218
Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey
Judd, S. E., Nanes, M. S., Ziegler, T. R., Wilson, P. W. F., & Tangpricha, V. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.136 · Cited by 214
Adiponectin: A Key Player in Obesity Related Disorders
Matsuzawa, Y. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791208893 · Cited by 203
Oral active vitamin D is associated with improved survival in hemodialysis patients
Naves‐Díaz, M., Álvarez-Hernández, D., Passlick‐Deetjen, J., Guinsburg, A. M., Marelli, C., Rodrı́guez-Puyol, D., & Cannata-Andía, J. B. (2008) · Kidney International · doi:10.1038/ki.2008.343 · Cited by 194
Oral Paricalcitol in the Treatment of Patients With CKD and Proteinuria: A Randomized Trial
Fishbane, S. N., Chittineni, H., Packman, M., Dutka, P., Ali, N. M., & Durie, N. M. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.04.036 · Cited by 191
Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population
Gannagé‐Yared, M., Chédid, R., Khalifé, S., Azzi, E., Zoghbi, F., & Halaby, G. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-0952 · Cited by 183
Angiotensin II Type 1 Receptor Blockade Improves β-Cell Function and Glucose Tolerance in a Mouse Model of Type 2 Diabetes
Chu, K. Y., Lau, T., Carlsson, P., & Leung, P. S. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1022 · Cited by 179
Vitamin D Levels and Mortality in Type 2 Diabetes
Joergensen, C., Gall, M.-A., Schmedes, A., Tarnow, L., Parving, H., & Rossing, P. R. (2010) · Diabetes Care · doi:10.2337/dc10-0582 · Cited by 173
Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study
Liu, E., Meigs, J. B., Pittas, A. G., Economos, C. D., McKeown, N. M., Booth, S. L., & Jacques, P. F. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28441 · Cited by 172
Vitamin D Affects Survival Independently of Vascular Calcification in Chronic Kidney Disease
Barreto, D. V., Barreto, F. C., Liabeuf, S., Temmar, M., Boitte, F., Choukroun, G. J., Fournier, A. E., & Massy, Z. A. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00260109 · Cited by 168
Impact of Activated Vitamin D and Race on Survival among Hemodialysis Patients
Wolf, M. S., Betancourt, J. R., Chang, Y., Shah, A., Teng, M. F., Tamez, H. E., Gutiérrez, O. M., Camargo, C. A., Melamed, M. L., Norris, K. C., et al. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007091002 · Cited by 161
No association of vitamin D intake or 25-hydroxyvitamin D levels in childhood with risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY)
Simpson, M. D., Brady, H., Yin, X., Seifert, J. A., Barriga, K. J., Hoffman, M., Bugawan, T. L., Barón, A. E., Sokol, R. J., Eisenbarth, G. S., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2278-2 · Cited by 160
Vitamin D3 Supplementation for 16 Weeks Improves Flow-Mediated Dilation in Overweight African-American Adults
Harris, R. A., Pedersen-White, J., Guo, D.-H., Stallmann-Jorgensen, I. S., Keeton, D., Huang, Y., Shah, Y., Zhu, H., & Dong, Y. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.12 · Cited by 159
25‐Hydroxyvitamin D Concentration Correlates With Insulin‐Sensitivity and BMI in Obesity
Muscogiuri, G., Sorice, G. P., Prioletta, A., Policola, C., Casa, S. D., Pontecorvi, A., & Giaccari, A. (2010) · Obesity · doi:10.1038/oby.2010.11 · Cited by 151
Vitamin D and Hypertension
Vaidya, A., & Forman, J. P. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.140160 · Cited by 148
Self-citation
Association of A1C Levels With Vitamin D Status in U.S. Adults
Kositsawat, J., Freeman, V. L., Gerber, B. S., & Geraci, S. A. (2010) · Diabetes Care · doi:10.2337/dc09-2150 · Cited by 141
Serum 25-Hydroxyvitamin D Levels Are Strongly Related to Systolic Blood Pressure But Do Not Predict Future Hypertension
Jorde, R., Figenschau, Y., Emaus, N., Hutchinson, M. S., & Grimnes, G. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.143990 · Cited by 138
The impact of vitamin D deficiency on diabetes and cardiovascular risk
Baz-Hecht, M., & Goldfine, A. B. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283372859 · Cited by 137
Oral cholecalciferol decreases albuminuria and urinary TGF-β1 in patients with type 2 diabetic nephropathy on established renin–angiotensin–aldosterone system inhibition
Kim, M.-J., Frankel, A., Donaldson, M., Darch, S. J., Pusey, C. D., Hill, P. D., Mayr, M., & Tam, F. W. K. (2011) · Kidney International · doi:10.1038/ki.2011.224 · Cited by 133
Vitamin D Deficiency Is Associated with Depletion of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Patients with Type 2 Diabetes
Yiu, Y.-F., Chan, Y., Yiu, K., Siu, C., Li, S.-W., Wong, L.-Y., Lee, S. W. L., Tam, S., Wong, E. W. K., Cheung, B. M. Y., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2212 · Cited by 133
Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes
Deb, D. K., Sun, T., Wong, K. E., Zhang, Z., Ning, G., Zhang, Y., Kong, J., Shi, H., Chang, A., & Li, Y. C. (2010) · Kidney International · doi:10.1038/ki.2010.22 · Cited by 128
Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults.
Scragg, R. K. R., Khaw, K., & Murphy, S. W. (1995) · PubMed · Cited by 126
Serum 25-Hydroxyvitamin D and Change in Estimated Glomerular Filtration Rate
de Boer, I. H., Katz, R., Chonchol, M., Ix, J. H., Sarnak, M. J., Shlipak, M. G., Siscovick, D. S., & Kestenbaum, B. R. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02640311 · Cited by 122
Association of Kidney Function, Vitamin D Deficiency, and Circulating Markers of Mineral and Bone Disorders in CKD
Ureña, P., Metzger, M., Haymann, J., Karras, A., Boffa, J., Flamant, M., Vrtovsnik, F., Gauci, C., Froissart, M., Houillier, P., et al. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.04.029 · Cited by 118
Vitamin D Levels, Microvascular Complications, and Mortality in Type 1 Diabetes
Joergensen, C., Hovind, P. H., Schmedes, A., Parving, H., & Rossing, P. R. (2011) · Diabetes Care · doi:10.2337/dc10-2459 · Cited by 117
Low-salt diet increases insulin resistance in healthy subjects
Garg, R., Williams, G. H., Hurwitz, S., Brown, N. J., Hopkins, P. N., & Adler, G. K. (2010) · Metabolism · doi:10.1016/j.metabol.2010.09.005 · Cited by 108
Oral Calcitriol for the Treatment of Persistent Proteinuria in Immunoglobulin A Nephropathy: An Uncontrolled Trial
Szeto, C., Chow, K., Kwan, B. C., Chung, K.-Y., Leung, C., & Li, P. K. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.12.038 · Cited by 100
Aldosterone Production and Insulin Resistance in Healthy Adults
Garg, R., Hurwitz, S., Williams, G. H., Hopkins, P. N., & Adler, G. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2521 · Cited by 99
The Independent Association Between 25‐Hydroxyvitamin D and Adiponectin and Its Relation With BMI in Two Large Cohorts: The NHS and the HPFS
Vaidya, A., Williams, J. S., & Forman, J. P. (2011) · Obesity · doi:10.1038/oby.2011.210 · Cited by 95
Self-citation
Subacute infusion of physiological doses of parathyroid hormone raises blood pressure in humans
Fliser, D., Franek, E., FODE, P., Stefański, A., Schmitt, C. P., Lyons, M., & Ritz, E. (1997) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/12.5.933 · Cited by 94
25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians
Vaidya, A., Forman, J. P., Hopkins, P. N., Seely, E. W., & Williams, J. S. (2011) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320310391922 · Cited by 93
Self-citation
Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism
Wang, X. X., Jiang, T., Shen, Y., Santamaria, H., Solis, N., ARBEENY, C. M., & Levi, M. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00338.2010 · Cited by 90
Vitamin D, the renin-angiotensin system, and insulin resistance
Rammos, G., Tseke, P., & Ziakka, S. (2008) · International Urology and Nephrology · doi:10.1007/s11255-007-9244-4 · Cited by 87
Ramipril treatment suppresses islet fibrosis in Otsuka Long–Evans Tokushima fatty rats
Ko, S., Kwon, H., Kim, S., Moon, S. D., Ahn, Y., Song, K., Son, H.-S., Cha, B., Lee, K., Son, H., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.023 · Cited by 87
The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets
Lupi, R., Guerra, S. D., Bugliani, M., Boggi, U., Mosca, F., Torri, S., Prato, S. D., & Marchetti, P. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02086 · Cited by 87
High glucose increases extracellular matrix production in pancreatic stellate cells by activating the renin–angiotensin system
Ko, S., Hong, O., Kim, J., Ahn, Y.-B., Song, K., Cha, B., Son, H., Kim, M., Jeong, I., & Yoon, K. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20797 · Cited by 86
A novel role for vitamin D: modulation of expression and function of the local renin–angiotensin system in mouse pancreatic islets
Cheng, Q., Li, Y. C., Boucher, B. J., & Leung, P. S. (2011) · Diabetologia · doi:10.1007/s00125-011-2100-1 · Cited by 86
The association between vitamin D status and circulating adiponectin independent of adiposity in subjects with abnormal glucose tolerance
Nimitphong, H., Chanprasertyothin, S., Jongjaroenprasert, W., & Ongphiphadhanakul, B. (2009) · Endocrine · doi:10.1007/s12020-009-9216-9 · Cited by 84
Vitamin D and Cardiometabolic Outcomes: A Systematic Review
Pittas, A. G., Chung, M. C., Trikalinos, T. A., Mitri, J., Brendel, M., Patel, K., Lichtenstein, A. H., Lau, J., & Balk, E. M. (2010) · Annals of Internal Medicine · doi:10.1059/0003-4819-152-5-201003020-00009 · Cited by 82
Influence of obesity on vitamin D–binding protein and 25-hydroxy vitamin D levels in African American and white women
Winters, S. J., Chennubhatla, R., Wang, C., & Miller, J. J. (2009) · Metabolism · doi:10.1016/j.metabol.2008.10.017 · Cited by 80
The renin-angiotensin system and insulin resistance
Liu, Z. (2007) · Current Diabetes Reports · doi:10.1007/s11892-007-0007-5 · Cited by 76
Salt intake and insulin sensitivity in healthy human volunteers
Townsend, R. R., Kapoor, S. C., & McFadden, C. B. (2007) · Clinical Science · doi:10.1042/cs20060361 · Cited by 66
Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome
Stiefel, P., Vallejo‐Vaz, A. J., Morillo, J. S. G., & Villar, J. (2011) · International Journal of Hypertension · doi:10.4061/2011/685238 · Cited by 56
Vitamin D and Subsequent Systolic Hypertension Among Women
Griffin, F. C., Gadegbeku, C. A., & Sowers, M. R. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.226 · Cited by 56
No effect of ultraviolet radiation on blood pressure and other cardiovascular risk factors
Scragg, R. K. R., Wishart, J., Stewart, A. W., Ofanoa, M., Kerse, N. M., Dyall, L., & Lawes, C. M. M. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328349666d · Cited by 54
The influence of body mass index and renin–angiotensin–aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men
Vaidya, A., Forman, J. P., UNDERWOOD, P. C., Hopkins, P. N., Williams, G. H., Pojoga, L. H., & Williams, J. S. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0025 · Cited by 54
Self-citation
1,25-Dihydroxyvitamin D as a Cardiovascular Hormone Effects on Calcium Current and Cytosolic Free Calcium in Vascular Smooth Muscle Cells
Shan, J. J., Resnick, L. M., Lewanczuk, R. Z., Karpinski, E., Li, B., & Pang, P. K. T. (1993) · American Journal of Hypertension · doi:10.1093/ajh/6.12.983 · Cited by 54
Relationship between serum parathyroid hormone levels in the elderly and 24 h ambulatory blood pressures
Morfis, L., Smerdely, P., & Howes, L. G. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715110-00011 · Cited by 53
Long-term effect of calcium-vitamin D3 fortified milk on blood pressure and serum lipid concentrations in healthy older men
Daly, R. M., & Nowson, C. A. (2009) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2008.79 · Cited by 52
Vitamin D and the vascular sensitivity to angiotensin II in obese Caucasians with hypertension
Vaidya, A., Forman, J. P., & Williams, J. S. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2010.110 · Cited by 52
Self-citation
Effects of hyperglycemia on angiotensin II receptor type 1 expression and insulin secretion in an INS-1E pancreatic beta-cell line.
Leung, K. K., & Leung, P. S. (2008) · PubMed · Cited by 47
No significant effect of calcium and vitamin D supplementation on blood pressure and calcium metabolism in elderly Chinese.
Pan, W., Wang, C.-Y., La, L., Kao, L. S., & Yeh, S. ‐. (1993) · PubMed · Cited by 46
Role of Vitamin D in Chronic Kidney Disease
Patel, T. V., & Singh, A. (2009) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2009.01.004 · Cited by 43
Relationship of mineral metabolism and long-term calcium and cholecalciferol supplementation to blood pressure in normotensive men
ORWOLL, E. S., & Oviatt, S. K. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.4.717 · Cited by 43
Confirmed hypertension and plasma 25(OH)D concentrations amongst elderly men
Burgaz, A., Byberg, L., Rautiainen, S., Orsini, N., Håkansson, N., Ärnlöv, J., Sundström, J., Lind, L., Melhus, H., Michaëlsson, K., et al. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02309.x · Cited by 39
Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Brock, K. E., Huang, W., Fraser, D. R., Ke, L., Tseng, M., Mason, R. S., Stolzenberg‐Solomon, R. Z., Freedman, D. M., Ahn, J., Peters, U., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001590 · Cited by 37
Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action
Perry, C. G., Palmer, T., CLELAND, S. J., Morton, I., Salt, I. P., Petrie, J. R., Gould, G. W., & Connell, J. (2003) · Clinical Science · doi:10.1042/cs20020320 · Cited by 35
Effect of Combination Therapy with Angiotensin Receptor Blocker and 1,25-Dihydroxyvitamin D3 in Type 2 Diabetic Nephropathy in KK-Ay/Ta Mice
Ohara, I., Tanimoto, M., Gohda, T., Yamazaki, T., Hagiwara, S., Murakoshi, M., Aoki, T., Toyoda, H., Ishikawa, Y., Funabiki, K., et al. (2010) · Nephron Experimental Nephrology · doi:10.1159/000320284 · Cited by 33
Inhibition of renin: an updated review of the development of renin inhibitors.
Li, Y. C. (2007) · PubMed · Cited by 30
Regulation of parathyroid hormone and vitamin D in essential hypertension*
Young, E. W., Morris, C. D., Holcomb, S., McMillan, G., & McCarron, D. A. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00214-6 · Cited by 23
Which antihypertensive drugs are the most nephroprotective and why?
Cravedi, P., Ruggenenti, P. L., & Remuzzi, G. (2010) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2010.521742 · Cited by 23
Calciotropic hormones in salt-sensitive essential hypertension: 1,25-dihydroxyvitamin D and parathyroid hypertensive factor.
Lm, R. (1994) · PubMed · Cited by 17
Current Research of the RAS in Diabetes Mellitus
Leung, P. S. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-9060-7_8 · Cited by 10

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Authors: Vaidya, A., & Williams, J. S.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Vaidya, Anand
Williams, Jonathan S.
Venue: Metabolism
Publisher: Elsevier BV
Published: 2012-04
Volume: 61
Issue: 4
Pages: 450-458
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2011.09.007
PMC: PMC3290690
OpenAlex: W1978517521
Cited by: 151
References: 149
Citations by year: 2026: 4 · 2024: 7 · 2023: 11 · 2022: 6 · 2021: 20 · 2020: 17 · 2019: 9 · 2018: 9 · 2017: 14 · 2016: 8 · 2015: 12 · 2014: 13 · 2013: 12 · 2012: 9
FWCI: 1.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (K23HL084236, K23HL08236-03, F32HL104776, K23HL111771)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Keywords: vitamin D, renin-angiotensin system, hypertension, chronic kidney disease, diabetes mellitus, insulin resistance, 1,25-dihydroxyvitamin D3, vitamin D receptor, renin expression, proteinuria, beta-cell function, blood pressure
MeSH terms: Animals, Diabetes Mellitus, Female, Humans, Hypertension, Kidney Diseases, Male, Renin-Angiotensin System, Vitamin D, Receptors, Calcitriol, Models, Animal

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The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes

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