Cited by 321Hypothalamic control of reproductive hormonesOvarian function and disordersAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 268 of the 272 references it cites were found in a registry or an index.

The complex interaction between obesity, metabolic syndrome and reproductive axis: A narrative review

Michalakis, Konstantinos, Mintziori, Gesthimani, Kaprara, Athina, Tarlatzis, Basil C., Goulis, Dimitrios G.·2013·Metabolism

DOI 10.1016/j.metabol.2012.08.012

Open this paper in CoChat — free account

Abstract

The aim of this narrative review is to provide current evidence for the interaction between obesity, metabolic syndrome (MS) and reproductive axis. Gonadotropin-releasing hormone (GnRH) pulses and, consequently, normal function of reproductive (hypothalamus-pituitary-gonadal) axis depend on normal energy balance, which presupposes sufficient food intake, reasonable energy consumption and average thermoregulatory costs. In case of an energy imbalance, reproductive dysfunction may occur. In young women, excessive leanness is accompanied by puberty delay, whereas premature puberty might be a manifestation of obesity. In a similar way, obesity in men affects fertility. Excess adipose tissue results in increased conversion of testosterone to estradiol, which may lead to secondary hypogonadism through reproductive axis suppression. Moreover, oxidative stress at the level of the testicular micro-environment may result in decreased spermatogenesis and sperm damage. Products of the adipocyte, such as leptin, adiponectin and resistin, and gut peptides, such as ghrelin, are considered to be crucial in the interaction between energy balance and reproduction. Finally, an indirect evidence for the interplay between MS and reproductive axis is the fact that when treating components of one, parameters of the other can be improved as well. These therapeutic interventions include lifestyle modifications, pharmacological agents, such as sex hormone replacement therapy, and surgical procedures. Although many issues remain unclear, the elucidation of the complex interaction between MS and reproductive axis will have obvious clinical implications in the therapeutic approach of both entities.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.metabol.2012.08.012

Cites

268 of 268 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Effect of Obesity on Parameters of Ovarian Reserve in Premenopausal Women
El-Halawaty, S., ElKattan, E. A., Azab, H., ElGhamry, N., & Al-Inany, H. G. (2010) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)34573-x · Cited by 73
Retracted
Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443 · cited 2×
“[191] Nakazato M, Murakami N, Date Y, et al.”
Background
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940 · cited 2×
“[196] Cummings DE, Purnell JQ, Frayo RS, et al.”
Background
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351

Flagged first, then by citations

Show all 272 references

4 of the 272 references couldn’t be matched to a known paper.

Sorted by citations

Items 201–300 of 321

Assessing puberty in female cheetahs (Acinonyx jubatus) via faecal hormone metabolites and body weight
Maly, M. A., Edwards, K. L., Koester, D. C., Farin, C. E., & Crosier, A. E. (2021) · Reproduction Fertility and Development · doi:10.1071/rd21169 · Cited by 7
Assessing puberty in ex situ male cheetahs (Acinonyx jubatus) via fecal hormone metabolites and body weights
Maly, M. A., Edwards, K. L., Farin, C. E., Koester, D. C., & Crosier, A. E. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.07.011 · Cited by 7
Detecting benign uterine tumors by autofluorescence lifetime imaging microscopy through adjacent healthy cervical tissues
Huang, M., Zhang, Z., Wang, X., Xie, Y., Fei, Y., Ma, J., Wang, J., Chen, L., Mi, L., & Wang, Y. (2019) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545819400066 · Cited by 7
Stomach - Key Player in the Regulation of Metabolism
Štimac, D., Majanović, S. K., & Franjić, N. (2014) · Digestive Diseases · doi:10.1159/000357849 · Cited by 7
Ergothioneine rescues obesity-induced testicular dysfunction via dual restoration of steroidogenesis and mitochondrial redox homeostasis
Li, X., Lin, J., Wu, M., Han, F., Chen, S., HongFei, K., Huang, Z., Peng, T., Lan, Y., Fu, X., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104090 · Cited by 6
Modeling the contribution of the obesity epidemic to the temporal decline in sperm counts
Kasman, A. M., Giudice, F. D., Shkolyar, E., Porreca, A., Busetto, G. M., Lü, Y., & Eisenberg, M. L. (2020) · Archivio Italiano di Urologia e Andrologia · doi:10.4081/aiua.2020.4.357 · Cited by 6
Hypoparathyroidism and late-onset hypogonadism in an adult male with familial 22q11.2 deletion syndrome: a case report with 3-year follow-up and review of the literature
Chen, X., Yang, L., Li, J., & Tan, H. (2022) · BMC Endocrine Disorders · doi:10.1186/s12902-022-01150-z · Cited by 6
Pre-pubertal diet restriction reduces reactive oxygen species and restores fertility in male WNIN/Obese rat
Dinesh Yadav, D. M., Muralidhar, M. N., Prasad, S. M. V. K., & Kalashikam, R. R. (2017) · Andrologia · doi:10.1111/and.12849 · Cited by 6
Association of serum and follicular fluid leptin and in vitro Fertilization/ ICSI outcome: A systematic review and meta-analysis
Jafarpour, S., Khosravi, S., Janghorbani, M., Mansourian, M., Karimi, R., Ghiasi, M. R., Miraghajani, M. S., Symonds, M. E., Farajzadeghan, Z., & Salehi, R. (2020) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2020.101924 · Cited by 7
Baking of methionine-choline deficient diet aggravates testis injury in mice
Jiang, X., Li, X., Feng, W., Qin, Y., Li, Z., Nie, H., Qin, W., Han, L., & Bai, W. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112245 · Cited by 6
Hypogonadism in men with multiple sclerosis: Prevalence and clinical associations
Diaconu, C. I., Lee, A., Onomichi, K. B., Jager, R. L. D., Riley, C., Levine, L., Vargas, W. S., Shelter, K., Jager, P. L. D., & Farber, R. S. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.103508 · Cited by 6
Associations of eating speed with fat distribution and body shape vary in different age groups and obesity status
Ni, S., Jia, M., Wang, X., Hong, Y. S., Zhao, X., Zhang, L., Ru, Y., Yang, F., & Zhu, S. (2022) · Nutrition & Metabolism · doi:10.1186/s12986-022-00698-w · Cited by 6
Female ponderal index at birth and idiopathic infertility
Dupont, C., Hulot, A., Jaffrézic, F., Faure, C., Czernichow, S., di Clemente, N., Racine, C., Chavatte‐Palmer, P., Lévy, R., & Alifert group (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174419000394 · Cited by 6
Energy balancing by fat Pik3ca
Nelson, V. L., Ballou, L. M., & Lin, R. Z. (2014) · Adipocyte · doi:10.4161/21623945.2014.955397 · Cited by 6
The Insulin/Insulin‐like Growth Factor signalling connects metabolism with sexual differentiation
Weger, B. D., & Gachon, F. (2020) · Acta Physiologica · doi:10.1111/apha.13576 · Cited by 6
Causal relationships between metabolic syndrome, plasma metabolites, and female reproductive diseases: insights from a two-step mendelian randomization approach
Li, L., Ma, J., Sun, N., Hu, P., Lin, Y., & Zhang, Q. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00955-8 · Cited by 5
Next-Generation Dietary Antioxidants in Women’s Reproductive Health: Mechanisms, Reproductive Outcomes, and Therapeutic Potential
Rahman, A., Jalouli, M., Al-Zharani, M. M., & Harrath, A. H. (2026) · Antioxidants · doi:10.3390/antiox15030319 · Cited by 7
Investigation of the potential teratogenic effects of fructose on the embryo using the rat whole embryo culture model
Gür, H. E., Balcıoğlu, E., Patat, D., Uçar, S., Gür, F. M., Yalçın, B., & Nisari, M. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114985 · Cited by 5
Factors associated with infertility among the Lebanese population: a cross-sectional study
Dia, N., Mansour, S., Kharaba, Z. J., Malaeb, B., Dine, A. S. E., Kokash, S., Nasser, S. A., Hallit, S. R., & Malaeb, D. N. (2023) · International Journal of Environmental Health Research · doi:10.1080/09603123.2023.2190084 · Cited by 6
Hypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy
Onanuga, I. O., Jegede, A. I., Offor, U., Ogedengbe, O. O., Naidu, E. C., Peter, A. I., & Azu, O. O. (2018) · Archives of Medical Science · doi:10.5114/aoms.2018.75220 · Cited by 5
Associations of sex hormones with components of insulin-glucose homeostasis
Васильевна, Ц. О., Badin, A. R., Геннадьевна, Б. З., Ложкина, Н. Г., & Platonov, D. Y. (2018) · Obesity and metabolism · doi:10.14341/omet9482 · Cited by 5
Effects of oral contraceptives on serum concentrations of adipokines and adiposity indices of women with polycystic ovary syndrome: a randomized controlled trial
Amiri, M., Rahmati, M., Hedayati, M., Nahidi, F., & Tehrani, F. R. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01349-8 · Cited by 5
Mediterranean diet and female fertility: Cross-talk of an evidence-based approach
Grammatikopoulou, M. G., Lampropoulou, M., & Goulis, D. G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818649-7.00041-2 · Cited by 5
Self-citation
The Connection between MicroRNAs from Visceral Adipose Tissue and Non-Alcoholic Fatty Liver Disease
Zubáňová, V., Červinková, Z., Kučera, O., & Palička, V. (2021) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2021.1 · Cited by 5
Leptin Levels in Serum or Semen and Its Association with Male Infertility: A Meta-Analysis with 1138 Cases
Mo, Y., Liang, F., Mehmood, A., Niu, X., Xie, Y., Shah, S., Lin, Z., Sun, Y. P., Tan, D., Guo, Y., et al. (2022) · International Journal of Endocrinology · doi:10.1155/2022/9462683 · Cited by 4
Female Fertility Outcome Following Bariatric Surgery: Five-Year Follow Up
Shehata, M. A., Abosena, W., Elghazeery, M. A., El-Dorf, A., Khirallah, M. G., & Attar, A. E. (2025) · Obesity Surgery · doi:10.1007/s11695-025-08047-5 · Cited by 4
Melatonin and the Metabolic Syndrome
Nduhirabandi, F., & Lochner, A. (2013) · Springer eBooks · doi:10.1007/978-81-322-0825-9_6 · Cited by 4
Should psoriasis be considered a risk factor for hypogonadism in male patients? A monocentric, prospective, observational pilot study
Hillary, T., & Gutermuth, J. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13944 · Cited by 4
Polycystic ovary syndrome: approach to correction of metabolic disorders
Kaluginа, L. V., & Татарчук, Т. Ф. (2020) · Reproductive Endocrinology · doi:10.18370/2309-4117.2020.52.54-60 · Cited by 4
The therapeutic effects of distinct exercise types on metabolic syndrome‐induced reproductive system impairment in male rats: Potential contribution of mitochondria‐related genes
Karaman, M. E., & Tektemur, A. (2022) · Andrologia · doi:10.1111/and.14391 · Cited by 4
Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term
Zhang, Q., Guo, M., Chen, T., Cheng, H., Yang, Q., Zhao, Z., She, R., Yang, X., Xiao, W., Yang, X., et al. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1024864 · Cited by 4
Metabolic syndrome and female reproductive system (review)
Dyakonov (2016) · Russian Journal of Human Reproduction · doi:10.17116/repro201622237-43 · Cited by 5
The inﬂuence of disordered fat metabolism on male fertility at the reproductive age and the eﬀectiveness of the ECF programs
Vityazeva, I. I., Altashina, M. V., & Troshina, E. A. (2014) · Problems of Endocrinology · doi:10.14341/probl201460534-42 · Cited by 4
Adiponectin and metabolic syndrome: pathway on the relationship
Kawada, T. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.104 · Cited by 4
Alterations in the Morphology of the Testis and Epididymis Caused by the Consumption of Hyperlipidic Diets in Wistar Rats
Castellanos, R. T., Delgado, M. M., Valderrama, L. R., Cruz, I. A., Barberena, E. C., Otal, A. M. M., Rodríguez‐Tobón, E., Tobón, A. R., Ramírez, J. O., & Arenas‐Ríos, E. (2025) · Life · doi:10.3390/life15060959 · Cited by 3
Varicocele‐Induced Male Infertility: A Bibliometric Perspectives of Mechanistic Insights and Clinical Trends
Ma, D., Li, D., Zhang, Y., Ma, S., Du, G., Guo, J., & Wang, F. (2025) · Andrologia · doi:10.1155/and/5003971 · Cited by 3
Beyond body mass index: the role of fat distribution in male sperm quality
Ma, D., Zhang, M., Zhang, X., & Xu, L. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1702791 · Cited by 3
Functional genomics reveals adipose-kidney crosstalk as a contributor to kidney fibrosis via the OSM-OSMR pathway
Zhang, J., Liu, Z., Dong, S., Xu, K., Wang, K., Gong, L., Liu, Q., Guo, Y., Zhu, Y., She, J., et al. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01624-y · Cited by 4
Associations of plasma hypocretin-1 with metabolic and reproductive health: Two systematic reviews of clinical studies
Dunietz, G. L., Vanini, G., Shannon, C., O'Brien, L. M., & Chervin, R. D. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101307 · Cited by 3
Evaluation of the Utility of Seminal Plasma Resistin and Leptin in Predicting Successful Surgical Sperm Retrieval in Men with Non-Obstructive Azoospermia
Amer, M. K., Zohdy, W., Din, S. F. G., Moawad, H. H., Saedy, D. A. H. E., Gamal, E. A. Z., & Ragab, A. (2023) · Journal of Reproduction & Infertility · doi:10.18502/jri.v24i2.12496 · Cited by 3
A systematic review and meta‐analysis of the effects of diabetes on human and murine epididymis
Carvalho, R. P. R., Guimarães‐Ervilha, L. O., Viana, A. G. A., Ribeiro, I. M., Ramírez-López, C. J., & Machado‐Neves, M. (2025) · Andrology · doi:10.1111/andr.70026 · Cited by 4
The clinical and biochemical characteristics associated with insulin resistance in non-obese young women
Wang, C., Chang, C.-J., & Hsu, M.-I. (2016) · Gynecological Endocrinology · doi:10.3109/09513590.2016.1163671 · Cited by 3
Assessing Puberty in Ex Situ Cheetahs (Acinonyx jubatus) via Growth Patterns and Fecal Hormone Metabolites.
Maly, M. A. (2015) · NCSU Libraries Repository (North Carolina State University Libraries) · Cited by 3
Male fertility between biology and the socioeconomic context news from the past (Alghero, 1866–1935)
Breschi, M., Fornasin, A., Gonano, G., Mazzoni, S., & Manfredini, M. (2019) · Economics & Human Biology · doi:10.1016/j.ehb.2019.100833 · Cited by 3
Longitudinal assessment of classic and 11-oxygenated androgen concentrations and their association with type 2 diabetes mellitus development: the Tromsø study
Allaoui, G., Rylander, C., Fuskevåg, O., Grimnes, G., Averina, M., Wilsgaard, T., & Berg, V. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02266-5 · Cited by 2
Effect of lycium barbarum polysaccharide on ameliorating high-fat diet-damaged spermatogenesis via PCSK9 and TLR4 signaling pathways in obese mice
Wang, J., Chen, Y., Ni, R., Su, M., Cao, Y., Zhou, R., Li, X., Li, J., Tang, Y., Tang, J., et al. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10928-y · Cited by 2
Mechanistic insights into cholesterol–bile acid metabolic dysregulation in ovarian aging
Yang, Z., Qi, X., & Qiao, J. (2026) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/csb-2025-5865 · Cited by 2
METABOLIC SYNDROME AND MALE INFERTILITY: A MODERN LOOK AT THE PROBLEM
Kozopas, N. M., Maksymyuk, H. V., Лаповец, Л. Е., & Odnorig, L. O. (2018) · Bulletin of Problems Biology and Medicine · doi:10.29254/2077-4214-2018-2-144-26-30 · Cited by 2
Modern view of the problem: the influence of obesity as a key component of metabolic syndrome on the development and progression of endometrial cancer
Pavlov, A. Y., Dzidzaria, A. G., Kalinchenko, S. Y., & Muravyeva, P. V. (2024) · Malignant tumours · doi:10.18027/2224-5057-2024-010 · Cited by 2
Narrative review on expression of non-coding RNA in biofluids in conditions associated with couple infertility
Kolańska, K., Zerbib, E., Dabi, Y., Chabbert‐Buffet, N., d’Argent, E. M., Favier, A., Ferrier, C., Touboul, C., Hamamah, S., & Daraï, É. (2025) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2025.104957 · Cited by 4
Obesity and the HPO Axis
Polotsky, A. J., & Doblado, M. A. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2611-4_2 · Cited by 2
CURRENT STATE OF THE PROBLEM OF OVERWEIGHT AND OBESITY IN WOMEN
Ткаченко, Л. В., Sviridova, N. I., & Skladanovskaya, T. V. (2017) · Journal of Volgograd State Medical University · doi:10.19163/1994-9480-2017-4(64)-3-7 · Cited by 2
Variation of reproductive hormone profile in male patients with obstructive sleep apnea: a meta-analysis
Zeng, Z., Rao, M., Guoyi, L., Kong, F., & Liu, S. (2015) · Sleep and Biological Rhythms · doi:10.1007/s41105-015-0041-7 · Cited by 2
Adiponectin and the expression of BAX and caspase 3 in high-fructose - induced testicular injury in albino mice
Hameed, A. F., Fatal, G. A., Akkila, S. S., & Ibrahim, M. S. (2022) · Biomedicine · doi:10.51248/.v42i4.1721 · Cited by 1
Особенности влияния синдрома поликистозных яичников на психосоматическое состояние женщин
Амирбекова, Ж. Т., Панькова, А. Н., Мейрамова, Т. Қ., & Мурзашева, Г. К. (2024) · Репродуктивная медицина · doi:10.37800/rm.1.2024.67-73 · Cited by 1
Protective Metabolic Effects of Chickpea Sprout Against Obesity-Induced Insulin Resistance and Hypoestrogenism in Rats
Mailloux‐Salinas, P., Jiménez‐Martínez, C., Arias‐Chávez, D. J., Gordillo-Bernal, A. A., Cid‐Gallegos, M. S., Alamilla‐Beltrán, L., & Bravo, G. (2025) · Molecules · doi:10.3390/molecules30244673 · Cited by 1
Intermittent fasting attenuates ovarian chronic inflammation in obese mice by inhibiting the CXCL12–CXCR4 axis
chen, X. X., Han, Z., Yu, X., & Hao, X. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116603 · Cited by 1
The Connections Between Androgens and Adipose Tissue Function in Polycystic Ovary Syndrome Patients
Albu, A. I., Florea, S., & Fica, S. V. (2014) · International Journal of Sciences: Basic and Applied Research · Cited by 1
Morbid Obesity
Schleu, M. F., & Barbosa, K. F. (2020) · Springer eBooks · doi:10.1007/978-3-030-28803-7_3 · Cited by 1
High estradiol levels during a long agonist IVF protocol are associated with decreased food intake, higher leptin concentrations, and lower levels of high-sensitivity C-reactive protein
Leppänen, J., Nuotio, P., Randell, K. M., Romppanen, J., Keski‐Nisula, L., Laitinen, T. P., Pihlajamäki, J., Schwab, U., & Heinonen, S. T. (2023) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-06950-9 · Cited by 1
Analysis of the role of education and sport in the heavy burden of obesity
Kłosińska, M. J., Domańska, I., Gałuszka, A., Drabik, S., Sulkowska, N., Kaczyńska, A., Chmiel, P., & Osial, N. (2023) · Journal of Education Health and Sport · doi:10.12775/jehs.2023.43.01.015 · Cited by 1
Overweight and Obesity in Children as Predictors of Early Puberty: A Meta-Analysis
Kovtun, O. P., Brodovskaya, T. O., & Ustiuzhanina, M. A. (2024) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn8810 · Cited by 1
Effects of Lifestyle on Female Reproductive Features and Success: Lessons from Animal Models
Gonzalez‐Bulnes, A., & Astiz, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800872-0.00017-2 · Cited by 1
Obesity and Reproductive Dysfunction in Men and Women
Fullston, T., Wu, L., Teede, H. J., & Moran, L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800872-0.00011-1 · Cited by 2
Complications of Pregnancy
Palomba, S., & Fauser, B. C. J. M. (2018) · Springer eBooks · doi:10.1007/978-3-319-45534-1_22 · Cited by 1
Obesity Physical and Mental Health Consequences in Ageing
Chooramani, G., Prasad, B. V., & Akbar, S. (2018) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-5225-3480-8.ch016 · Cited by 1
Nutrition, environnement et fertilité masculine
Dupont, C., & Lévy, R. (2018) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2018.11.005 · Cited by 1
Synergistic anti-obesity effects of red cabbage and chromium administration on obese rats
Tahoon, N. A. (2021) · مجلة الاقتصاد المنزلي · doi:10.21608/jhe.2021.178697 · Cited by 1
An assessment of coping with infertility stress and eating disorders in women undergoing IVF treatment
Erdoğan, K., Şanlıer, N. T., Kocabaş, Ş., & Üstün, Y. E. (2022) · Journal of Public Health · doi:10.1007/s10389-022-01780-6 · Cited by 1
Effects of a Maternal Pre-pregnancy Dietary and Pharmacological Intervention on Maternal Fecundity and Offspring Health in Sprague-Dawley Rats
Dennison, C. A. (2013) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/25816 · Cited by 1
Obesity and Reproduction
Ortiz-Flores, A. E., & Escobar-Morreale, H. F. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.66100-7 · Cited by 1
Adiposity and metabolic syndrome
Sarigianni, M., Papatheodorou, K., & Τσάπας, Α. (2015) · doi:10.4155/fseb2013.14.58 · Cited by 1
Correction of disorders of carbohydrate and lipid metabolism in patients with infertility during the stage of preparation for in vitro fertilization
Krasnopolskaya, K. V., Orazov, M. R., Sokolova, E. A., Isakova, K. M., Shishkina, A. V., & Shostenko, L. V. (2022) · Russian Bulletin of Obstetrician-Gynecologist · doi:10.17116/rosakush202222021113 · Cited by 1
The role of melatonin in cardioprotection : an investigation into the mechanisms involved in glucose homeostasis, microvascular endothelial function and mitochondrial function in normal and insulin resistant states
Nduhirabandi, F. (2014) · SUNScholar (Stellenbosch University)
La leptina nella fisiologia e patologia della funzione riproduttiva femminile
Vezzani, S., Vincentis, S. D., Simoni, M., & Magnani, E. (2015) · L Endocrinologo · doi:10.1007/s40619-015-0148-8
Consequências do consumo materno de dieta de cafeteria sobre o perfil endócrino e a função reprodutiva da prole
Jacobs, S. (2013) · Americanae (AECID Library)
Hypogonadism and Obesity
Maggi, M., Morelli, A., Luconi, M., Lotti, F., Lucchese, M., Facchiano, E., & Corona, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-15356-8_5
New insights in sperm biology: How benchside results in the search for molecular markers may help understand male infertility
Marchiani, S., Tamburrino, L., Muratori, M., & Baldi, E. (2016) · World Journal of Translational Medicine · doi:10.5528/wjtm.v5.i1.26
Cross-Sectional Epidemiology and Intervention Studies of Mediators of the Energy Imbalance-Prostate Cancer Association
Hemelrijck, M. V., & Rohrmann, S. (2017) · Energy balance and cancer · doi:10.1007/978-3-319-64940-5_5
L’effet du poids du père sur la fertilité et sur la santé des descendants
Dupont, C., Sermondade, N., Elfassy, Y., & Lévy, R. (2017) · Obésité · doi:10.1007/s11690-017-0568-7
Dieta hiperlipídica materna: influências sobre o comportamento maternal e o desenvolvimento da prole.
Klein, M. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2016.tde-10112016-163151
Hipogonadismo associado à obesidade: efeitos do tratamento com citrato de clomifeno
Soares, A. H. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-13062018-074535
Análise morfológica de neurônios que expressam o receptor de leptina durante as diferentes fases da maturação sexual de camundongos.
de Moraes, L. C. L. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2019.tde-31072019-074925
Obese and Overweight Males
Kim, K.-B., & Shin, Y.-A. (2020) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/kjo.2020.0.0.0
Pediatric Bariatric Surgery and Sexual Developmental Milestones
Steele, K. E. (2020) · Difficult decisions in surgery: an evidence-based approach · doi:10.1007/978-3-030-55329-6_34
The effect of a high sucrose diet on ovarian morphology : an age-matched generational study
Foiret, J. R. (2019) · SUNScholar (Stellenbosch University)
Obésité et fertilité masculine
Dupont, C., Lévy, R., & Sermondade, N. (2021) · Elsevier eBooks · doi:10.1016/b978-2-294-76753-1.00057-6
Endocrinopathies et excès pondéral
Espiard, S., Bauters, C. C., Cortet, C., Douillard, C., Ladsous, M., & Vantyghem, M. (2021) · Elsevier eBooks · doi:10.1016/b978-2-294-76753-1.00068-0
What Does Fat Do?
Denton, N. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780198865278.003.0003
Different Estradiol Level's Impact on Appetite Regulation, Food Intake, and Concentrations of Leptin, Glucagon-Like Peptide-1, and High-Sensitivity C-Reactive Protein During a Long Agonist IVF ProtocolPreprint
Leppänen, J., Nuotio, P., Randell, K. M., Romppanen, J., Keski‐Nisula, L., Laitinen, T., Pihlajamäki, J., Schwab, U., & Heinonen, S. T. (2021) · Research Square · doi:10.21203/rs.3.rs-1192036/v1
Daño a la integridad del ADN y la membrana del espermatozoide de conejo Nueva Zelanda blanco causados por sobrepeso
Soto-Castruita, A. (2015) · doi:10.24275/uami.6d56zw75n
Faculty Opinions recommendation of The relationship between male BMI and waist circumference on semen quality: data from the LIFE study.
Sandlow, J. I., & Harnisch, B. A. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718199319.793489193
Efecto del sobrepeso y la obesidad en los cambios de la morfología celular del epidídimo y parámetros espermáticos en la rata Wistar
Delgado, M. G. M. (2020) · doi:10.24275/uami.x920fw923
Endocrine Infertility
Piubello, G. (2014) · Springer eBooks · doi:10.1007/978-3-319-08503-6_14
Arterial hypertension and diabetes developed in pregnancy
Zagarskikh, E. Y., Александрович, П. С., Rishchuk, S. V., & Proshchai, G. A. (2022) · HERALD of North-Western State Medical University named after I I Mechnikov · doi:10.17816/mechnikov108134
Lyophilized açai Berry Reverses the Damage in Sperm DNA, Acrosome and Mitochondria in Aged Rat ModelPreprint
Simões-Ferreira, T. C., Silva, Y. C. D., Fortini, S., de Rosa, T. D. Q., de Araújo, M. P., Miraglia, S. M., Gomes, A. C. D. C. N., & Vendramini, V. (2023) · Research Square · doi:10.21203/rs.3.rs-2544156/v1 · Cited by 1
Hormono-metabolic disorders in women with hypothalamic syndrome in the ontogenetic aspect
Жуковец, И. В., & Leshchenko, O. Y. (2023) · Bulletin physiology and pathology of respiration · doi:10.36604/1998-5029-2023-87-99-107
Are Pituitary Functions Different in Obese Patients According to Body Mass Index Classes?
Seyrek, N. Ç. (2023) · Ankara Medical Journal · doi:10.5505/amj.2023.26096
How I Approach Hepatocellular Adenomas in Hormonally Distinct Populations: Time to Think Outside the (Contraceptive Pill) Box
Wang, M., Cedars, M. I., Mehta, N. J., & Sarkar, M. A. (2023) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002456
Analysis of risk factors related to assisted reproduction and assisted pregnancy outcomes in infertile menPreprint
Wang, K., Xu, Y., Qin, N., Zheng, J.-X., Guo, Y., Bai, J., Yang, Y., & Li, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-4175454/v1

Authors: Michalakis, K., Mintziori, G., Kaprara, A., Tarlatzis, B. C., & Goulis, D. G.
Affiliations: Aristotle University of Thessaloniki (GR)
Corresponding author: Goulis, Dimitrios G.
ORCID: Michalakis, Konstantinos
Mintziori, Gesthimani
Kaprara, Athina
Tarlatzis, Basil C.
Goulis, Dimitrios G.
Venue: Metabolism
Publisher: Elsevier BV
Published: 2013-04
Volume: 62
Issue: 4
Pages: 457-478
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2012.08.012
OpenAlex: W2115987699
Cited by: 321
References: 272
Citations by year: 2026: 10 · 2025: 15 · 2024: 19 · 2023: 16 · 2022: 18 · 2021: 21 · 2020: 29 · 2019: 30 · 2018: 23 · 2017: 26 · 2016: 27 · 2015: 35 · 2014: 38 · 2013: 14
FWCI: 3.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: obesity, metabolic syndrome, reproductive axis, hypothalamic-pituitary-gonadal axis, energy balance, puberty, precocious puberty, male infertility, secondary hypogonadism, oxidative stress, spermatogenesis, leptin, adiponectin, resistin, ghrelin, sex hormone replacement therapy, bariatric surgery, lifestyle modification
MeSH terms: Adult, Female, Fertility, Gastrointestinal Hormones, Humans, Infertility, Life Style, Male, Obesity, Pregnancy, Reproduction, Gonadal Steroid Hormones, Metabolic Syndrome, Bariatric Surgery

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The complex interaction between obesity, metabolic syndrome and reproductive axis: A narrative review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks