Cited by 321Hypothalamic control of reproductive hormonesOvarian function and disordersAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 268 of the 272 references it cites were found in a registry or an index.

The complex interaction between obesity, metabolic syndrome and reproductive axis: A narrative review

Michalakis, Konstantinos, Mintziori, Gesthimani, Kaprara, Athina, Tarlatzis, Basil C., Goulis, Dimitrios G.·2013·Metabolism

DOI 10.1016/j.metabol.2012.08.012

Open this paper in CoChat — free account

Abstract

The aim of this narrative review is to provide current evidence for the interaction between obesity, metabolic syndrome (MS) and reproductive axis. Gonadotropin-releasing hormone (GnRH) pulses and, consequently, normal function of reproductive (hypothalamus-pituitary-gonadal) axis depend on normal energy balance, which presupposes sufficient food intake, reasonable energy consumption and average thermoregulatory costs. In case of an energy imbalance, reproductive dysfunction may occur. In young women, excessive leanness is accompanied by puberty delay, whereas premature puberty might be a manifestation of obesity. In a similar way, obesity in men affects fertility. Excess adipose tissue results in increased conversion of testosterone to estradiol, which may lead to secondary hypogonadism through reproductive axis suppression. Moreover, oxidative stress at the level of the testicular micro-environment may result in decreased spermatogenesis and sperm damage. Products of the adipocyte, such as leptin, adiponectin and resistin, and gut peptides, such as ghrelin, are considered to be crucial in the interaction between energy balance and reproduction. Finally, an indirect evidence for the interplay between MS and reproductive axis is the fact that when treating components of one, parameters of the other can be improved as well. These therapeutic interventions include lifestyle modifications, pharmacological agents, such as sex hormone replacement therapy, and surgical procedures. Although many issues remain unclear, the elucidation of the complex interaction between MS and reproductive axis will have obvious clinical implications in the therapeutic approach of both entities.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.metabol.2012.08.012

Cites

268 of 268 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Effect of Obesity on Parameters of Ovarian Reserve in Premenopausal Women
El-Halawaty, S., ElKattan, E. A., Azab, H., ElGhamry, N., & Al-Inany, H. G. (2010) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)34573-x · Cited by 73
Retracted
Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443 · cited 2×
“[191] Nakazato M, Murakami N, Date Y, et al.”
Background
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940 · cited 2×
“[196] Cummings DE, Purnell JQ, Frayo RS, et al.”
Background
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351

Flagged first, then by citations

Show all 272 references

4 of the 272 references couldn’t be matched to a known paper.

Sorted by citations

Items 101–200 of 321

Obesity and Sex Affect the Immune Responses to Tick-Borne Encephalitis Booster Vaccination
Garner‐Spitzer, E., Pöllabauer, E.-M., Wagner, A., Guzek, A., Zwazl, I., Seidl-Friedrich, C., Binder, C. J., Stiasny, K., Kundi, M., & Wiedermann, U. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00860 · Cited by 33
Extensive Assessment of Underlying Etiological Factors in Primary Infertile Men Reduces the Proportion of Men With Idiopathic Infertility
Ventimiglia, E., Pozzi, E., Capogrosso, P., Boeri, L., Alfano, M., Cazzaniga, W., Matloob, R., Abbate, C., Viganò, P., Montorsi, F., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.801125 · Cited by 33
Validation of the American Society for Reproductive Medicine guidelines/recommendations in white European men presenting for couple's infertility
Ventimiglia, E., Capogrosso, P., Boeri, L., Ippolito, S., Scano, R., Moschini, M., Gandaglia, G., Papaleo, E., Montorsi, F., & Salonia, A. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.06.044 · Cited by 32
The effects ofBrassica junceaL. leaf extract on obesity and lipid profiles of rats fed a high-fat/high-cholesterol diet
Lee, J., Kim, H. A., & Lee, J. (2018) · Nutrition Research and Practice · doi:10.4162/nrp.2018.12.4.298 · Cited by 32
Metabolic syndrome and smoking are independent risk factors of male idiopathic infertility
the ALIFERT collaborative group, Dupont, C., Faure, C., Daoud, F., Gautier, B., Czernichow, S., & Lévy, R. (2019) · Basic and Clinical Andrology · doi:10.1186/s12610-019-0090-x · Cited by 34
Serum miR-155 as a potential biomarker of male fertility
Tsatsanis, C., Bobjer, J., Rastkhani, H., Dermitzaki, E., Katrinaki, M., Margioris, A. N., Giwercman, Y. L., & Giwercman, A. (2015) · Human Reproduction · doi:10.1093/humrep/dev031 · Cited by 32
Eruca sativa Mill . seed extract promotes anti‐obesity and hypoglycemic effects in mice fed with a high‐fat diet
Piragine, E., Flori, L., Mannelli, L. D. C., Ghelardini, C., Pagnotta, E., Matteo, R., Lazzeri, L., Martelli, A., Miragliotta, V., Pirone, A., et al. (2020) · Phytotherapy Research · doi:10.1002/ptr.6941 · Cited by 31
Excess Maternal Fructose Consumption Increases Fetal Loss and Impairs Endometrial Decidualization in Mice
Saben, J. L., Shyr, Z. A., Rhee, J. S., Drury, A. M., Scheaffer, S. M., & Moley, K. H. (2015) · Endocrinology · doi:10.1210/en.2015-1618 · Cited by 31
Metabolic syndrome and semen quality in adult population
Chen, Y., Kao, T., Peng, T., Yang, H., Wu, C., & Chen, W. (2019) · Journal of Diabetes · doi:10.1111/1753-0407.12995 · Cited by 34
Self-reported eating speed in relation to non-alcoholic fatty liver disease in adults
Lee, S., Ko, B.-J., Gong, Y.-H., Han, K., Lee, A. S. Y., Han, B., Yoon, Y. J., Park, S.-Y., Kim, J., & Mantzoros, C. S. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0851-z · Cited by 30
Leptin Within the Subphysiological to Physiological Range Dose Dependently Improves Male Reproductive Function in an Obesity Mouse Model
Hoffmann, A., Manjowk, G.-M., Wagner, I. V., Klöting, N., Ebert, T., Jeßnitzer, B., Lössner, U., Stukenborg, J., Blüher, M., Stümvoll, M., et al. (2016) · Endocrinology · doi:10.1210/en.2015-1966 · Cited by 29
Pregnancy complications in spontaneous and assisted conceptions of women with infertility and subfertility factors. A comprehensive review
Palomba, S., Santagni, S., Gibbins, K. J., Sala, G. B. L., & Silver, R. M. (2016) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2016.08.007 · Cited by 32
RNAi Reveals Role of Insulin-Like Androgenic Gland Hormone 2 (IAG2) in Sexual Differentiation and Growth in Hermaphrodite Shrimp
Liu, F., Shi, W., Ye, H., Liu, A., & Zhu, Z. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.666763 · Cited by 28
How Obesity Affects Female Fertility
Al-yasiry, R. Z., Jwad, M. A., Hassan, M. F., & Alsayigh, H. A. (2022) · Medical Journal of Babylon · doi:10.4103/mjbl.mjbl_8_22 · Cited by 31
Precocious puberty under stressful conditions: new understanding and insights from the lessons learnt from international adoptions and the COVID-19 pandemic
Street, M. E., Ponzi, D., Renati, R., Petraroli, M., D’Alvano, T., Lattanzi, C., Ferrari, V. D., Rollo, D., & Stagi, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1149417 · Cited by 32
Comorbidities and male infertility
Ventimiglia, E., Montorsi, F., & Salonia, A. (2016) · Current Opinion in Urology · doi:10.1097/mou.0000000000000259 · Cited by 28
DMC (2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone) improves glucose tolerance as a potent AMPK activator
Choi, J. W., Kim, M., Song, H., Lee, C.-S., Oh, W. K., Mook‐Jung, I., Chung, S. S., & Park, K. S. (2015) · Metabolism · doi:10.1016/j.metabol.2015.12.010 · Cited by 27
The impact of metabolically healthy obesity in primary infertile men: Results from a cross‐sectional study
Cazzaniga, W., Candela, L., Boeri, L., Capogrosso, P., Pozzi, E., Belladelli, F., Baudo, A., Ventimiglia, E., Alfano, M., Abbate, C., et al. (2020) · Andrology · doi:10.1111/andr.12861 · Cited by 29
Obesity: A Doorway to a Molecular Path Leading to Infertility
Ahmad, R., & Haque, M. (2022) · Cureus · doi:10.7759/cureus.30770 · Cited by 30
The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women
Klisic, A. N., Kotur‐Stevuljević, J., Kavarić, N., Martinović, M., & Matic, M. G. (2016) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-016-0325-1 · Cited by 27
Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism
Andreoli, M. F., Stoker, C., Rossetti, M. F., Alzamendi, A., Castrogiovanni, D. C., Luque, E. H., & Ramos, J. G. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.12.002 · Cited by 26
Association Between Body Mass Index and Thyroid Function in Euthyroid Chinese Adults
Fu, J. H., Zhang, L., An, Y., Duan, Y., Liu, J., & Wang, G. (2021) · Medical Science Monitor · doi:10.12659/msm.930865 · Cited by 26
Cannabinoids and PPAR Ligands: The Future in Treatment of Polycystic Ovary Syndrome Women with Obesity and Reduced Fertility
Przybycień, P., Gąsior‐Perczak, D., & Placha, W. (2022) · Cells · doi:10.3390/cells11162569 · Cited by 26
Histologically proven hepatic steatosis associates with lower testosterone levels in men with obesity
de Velde, F. V., Bekaert, M., Hoorens, A., Geerts, A. M., T'Sjoen, G. G., Fiers, T., Kaufman, J., Nieuwenhove, Y. V., & Lapauw, B. (2019) · Asian Journal of Andrology · doi:10.4103/aja.aja_68_19 · Cited by 23
Obesity and common pathways of cancer and cardiovascular disease
Formica, V., Morelli, C., Riondino, S., Renzi, N., Nitti, D., Daniele, N. D., Roselli, M., & Tesauro, M. (2020) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2020.100065 · Cited by 23
Melatonin ameliorates endocrine dysfunction and defective sperm integrity associated with high‐fat diet‐induced obesity in male Wistar rats
Oladele, C. A., Akintayo, C. O., Badejogbin, O. C., Oniyide, A. A., Omoaghe, A. O., Agunbiade, T. B., & Olaniyi, K. S. (2021) · Andrologia · doi:10.1111/and.14242 · Cited by 22
Resistin in Human Seminal Plasma: Relationship with Lipid Peroxidation, CAT Activity, GSH/GSSG Ratio, and Semen Parameters
Moretti, E., Micheli, L., Noto, D., Fiaschi, A. I., Menchiari, A., & Cerretani, D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2192093 · Cited by 22
The impact of obesity on the male reproductive axis.
Mihalca, R., & Fica, S. V. (2014) · Europe PMC (PubMed Central) · Cited by 22
Melatonin and Melatonergic Drugs in Clinical Practice
Srinivasan, V. J., Shillcutt, S. D., Öter, Ş., & Brzezinski, A. (2014) · Springer eBooks · doi:10.1007/978-81-322-0825-9 · Cited by 23
The Association Between Lipid Serum and Semen Parameters: a Systematic Review
Pakpahan, C., Rezano, A., Margiana, R., Amanda, B., Agustinus, A., & Darmadi, D. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-01040-8 · Cited by 21
Association of Obesity-Mediated Insulin Resistance and Hypothalamic Volumes: Possible Sex Differences
Ha, J., Cohen, J. I., Tirsi, A., & Convit, A. J. (2013) · Disease Markers · doi:10.1155/2013/531736 · Cited by 21
Melatonin and diet-induced metabolic syndrome in rats: impact on the hypophysial-testicular axis
Bernasconi, P. A. S., Cardoso, N., Reynoso, R., Scacchi, P. A., & Cardinali, D. P. (2013) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0005 · Cited by 21
Digital palpation of endotracheal tube tip as a method of confirming endotracheal tube position in neonates: an open‐label, three‐armed randomized controlled trial
Saboo, A. R., Dutta, S., & Sodhi, K. S. (2013) · Pediatric Anesthesia · doi:10.1111/pan.12147 · Cited by 21
Pathophysiology of obesity-related infertility and its prevention and treatment by potential phytotherapeutics
Uddandrao, V. V. S., Naidu, P. B., Chandrasekaran, P., & Saravanan, G. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01411-4 · Cited by 26
A short-term arm-crank exercise program improved testosterone deficiency in adults with chronic spinal cord injury
Rosety-Rodríguez, M., Rosety, I., Fornieles, G., Rosety, J. M., Elosegui, S., Rosety, M. Á., & Ordóñez, F. J. (2014) · International braz j urol · doi:10.1590/s1677-5538.ibju.2014.03.10 · Cited by 19
Assessment of follicular fluid leptin levels and insulin resistance as outcome predictors in women undergoing in vitro fertilization–intracytoplasmic sperm injection
Llaneza-Suárez, D., Llaneza, P., González, C., de la Fuente, P. E., García-Ochoa, C., Garrido, P., Castañón, V., & Pérez-López, F. R. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.09.012 · Cited by 19
Contemporary Diagnostic Work-Up for Male Infertility: Emphasizing Comprehensive Baseline Assessment
Pozzi, E., Belladelli, F., Corsini, C., Boeri, L., Capogrosso, P., Fallara, G., Candela, L., Bertini, A., Cattafi, F., Raffo, M., et al. (2024) · The World Journal of Men s Health · doi:10.5534/wjmh.240069 · Cited by 19
Lean Tissue Index and Body Cell Mass Can Be Predictors of Low Free Testosterone Levels in Men on Hemodialysis
Rymarz, A., Matyjek, A., Gomółka, M., & Niemczyk, S. (2019) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2019.03.078 · Cited by 18
Barocrinology: The Endocrinology of Obesity from Bench to Bedside
Kalra, S., Kapoor, N., Bhattacharya, S., Aydin, H., & Coetzee, A. (2020) · Medical Sciences · doi:10.3390/medsci8040051 · Cited by 19
Manchette-acrosome disorders during spermiogenesis and low efficiency of seminiferous tubules in hypercholesterolemic rabbit model
Simón, L., Funes, A. K., Yapur, M. A., Cabrillana, M. E., Monclus, M. A., Boarelli, P. V., Vincenti, A. E., Lancellotti, T. E. S., & Fornés, M. W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172994 · Cited by 18
Maternal age affects the relationship of basal FSH and anti-Müllerian hormone concentrations with post-ICSI/IVF live birth
Junior, J. B., Canto, M. D., Ponti, E. D., Brambillasca, F., Brigante, C., Gippone, S., Renzini, M. M., & Marca, A. L. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.12.005 · Cited by 18
Metabolism of testosterone during weight loss in men with obesity
Van de Velde, F., Deventer, K., Van Gansbeke, W., Van Eenoo, P., Van Renterghem, P., Fiers, T., Reyns, T., Kaufman, J. M., Van Nieuwenhove, Y., & Lapauw, B. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105851 · Cited by 17
Beneficial effects of metformin on mice female fertility after a high-fat diet intake
Velázquez, C., Herrero, Y., Bianchi, M. S., Cohen, D. J., Cuasnicu, P. S., Prost, K., Marinoni, R., Pascuali, N., Parborell, F., & Abramovich, D. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.111995 · Cited by 17
Hypogonadism and nonalcoholic fatty liver disease
Papadimitriou, K., Mousiolis, A. C., Mintziori, G., Tarenidou, C., Pοlyzos, S. A., & Goulis, D. G. (2024) · Endocrine · doi:10.1007/s12020-024-03878-1 · Cited by 18
Self-citation
Testosterone Supplementation Therapy in the Treatment of Patients with Metabolic Syndrome
Kovac, J. R., Pastuszak, A. W., Lamb, D. J., & Lipshultz, L. I. (2014) · Postgraduate Medicine · doi:10.3810/pgm.2014.11.2843 · Cited by 18
Visceral Adipose Tissue and Leptin Hyperproduction Are Associated With Hypogonadism in Men With Chronic Kidney Disease
Cobo, G., Cordeiro, A. C., Amparo, F. C., Amodeo, C., Lindholm, B., & Carrero, J. J. (2017) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2017.01.023 · Cited by 17
Effectiveness of a therapeutic multiple-lifestyle intervention taking into account the periconceptional environment in the management of infertile couples: study design of a randomized controlled trial – the PEPCI study
Dupont, C., Aegerter, P., Foucaut, A.-M., Reyre, A., Lhuissier, F., Bourgain, M., Chabbert‐Buffet, N., Cédrin‐Durnerin, I., Selleret, L., Cosson, E., et al. (2020) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-020-2855-9 · Cited by 17
Proof of concept and development of a couple-based machine learning model to stratify infertile patients with idiopathic infertility
Bachelot, G., Lévy, R., Bachelot, A., Faure, C., Czernichow, S., Dupont, C., Lamazière, A., Alifert Collaborative Group, Aknin, I., Cédrin‐Durnerin, I., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-03165-3 · Cited by 17
Obesity and reproductive health of women
Gorbatenko, N. V., Bezhenar, V. F., & Fishman, M. (2017) · Obesity and metabolism · doi:10.14341/omet201713-8 · Cited by 17
Role of estrogen receptors, P450 aromatase, PCNA and p53 in high-fat-induced impairment of spermatogenesis in rats
Verderame, M., Migliaccio, V., & Scudiero, R. (2018) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2018.07.002 · Cited by 16
Health-promotion interventions enhance and maintain self-efficacy for adults at cardiometabolic risk: A randomized controlled trial
Wu, M., Wu, S. V., Lee, M., Peng, L., Tsao, L., & Lee, W. (2019) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2019.01.009 · Cited by 20
Worldwide prevalence of obesity among firefighters: a systematic review protocol
Soares, E. D. M. K. V. K., Smith, D. L., & Porto, L. G. G. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-031282 · Cited by 16
Increased insulin resistance in men with unexplained infertility
Mansour, R., El-Faissal, Y., Kamel, A., Kamal, O., Aboulserour, G., Aboulghar, M. A., & Fahmy, I. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.08.020 · Cited by 17
Serum chemerin levels are negatively associated with male fertility and reproductive hormones
Bobjer, J., Katrinaki, M., Dermitzaki, E., Margioris, A. N., Giwercman, A., & Tsatsanis, C. (2018) · Human Reproduction · doi:10.1093/humrep/dey310 · Cited by 16
Roles of Crustacean Female Sex Hormone 1a in a Protandric Simultaneous Hermaphrodite Shrimp
Liu, F., Shi, W., Huang, L. J., Wang, G., Zhu, Z., & Ye, H. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.791965 · Cited by 15
Neuropeptidome of the Hypothalamus and Pituitary Gland of Indicine × Taurine Heifers: Evidence of Differential Neuropeptide Processing in the Pituitary Gland before and after Puberty
DeAtley, K. L., Colgrave, M. L., Cánovas, Á., Wijffels, G. L., Ashley, R. L., Silver, G. A., Rincón, G., Medrano, J. F. F., Islas‐Trejo, A., Fortes, M. R. S., et al. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00875 · Cited by 15
Associations of oxytocin with metabolic parameters in obese women of childbearing age
Du, F.-M., Hong-Yu, K., Duan, B., Liu, D., & Yu, X. (2019) · Endokrynologia Polska · doi:10.5603/ep.a2019.0028 · Cited by 15
Primary, secondary, and compensated hypogonadism: A novel risk stratification for infertile men
Ventimiglia, E., Capogrosso, P., Boeri, L., Cazzaniga, W., Pederzoli, F., Frego, N., Oreggia, D., Dehò, F., Gaboardi, F., Mirone, V., et al. (2017) · European Urology Supplements · doi:10.1016/s1569-9056(17)30509-2 · Cited by 15
Relationship of serum 25-Hydroxyvitamin D (25[OH]D) levels and components of metabolic syndrome in prepubertal children
Kwon, J. H., Lee, S. E., Lee, H. A., Kim, Y. J., Lee, H. Y., Gwak, H. S., Park, E. A., Cho, S. J., Oh, S., Ha, E., et al. (2015) · Nutrition · doi:10.1016/j.nut.2015.04.023 · Cited by 14
Multilevel approach to male fertility by machine learning highlights a hidden link between haematological and spermatogenetic cells
Santi, D., Spaggiari, G., Casonati, A., Casarini, L., Grassi, R., Vecchi, B., Roli, L., Santis, M. C. D., Orlando, G., Gravotta, E., et al. (2020) · Andrology · doi:10.1111/andr.12826 · Cited by 14
Effects of Orchidectomy and Testosterone Replacement on Numbers of Kisspeptin‐, Neurokinin B‐, and Dynorphin A‐Immunoreactive Neurones in the Arcuate Nucleus of the Hypothalamus in Obese and Diabetic Rats
Dudek, M., Kolodziejski, P. A., Pruszyńska‐Oszmałek, E., Ziarniak, K., & Sliwowska, J. H. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12453 · Cited by 14
Lifestyle Stress and Its Impact on Male Reproductive Health
Pressman, A., Hernandez, A., & Sikka, S. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801299-4.00005-0 · Cited by 14
Prevalence and Risk Factors of Obesity among Elderly Attending Geriatric Outpatient Clinics in Mansoura City.
Shebl, A. M., Hatata, E.-S. Z., Boughdady, A. M., & El-Sayed, S. M. (2015) · Journals & Books Hosting (International Knowledge Sharing Platform) · Cited by 14
Sex-related differences in the effects of high-fat diets on DHEA-treated rats
Cecconello, A. L., Trapp, M., Hoefel, A. L., Marques, C. V., Arbo, B. D., Osterkamp, G., Kucharski, L. C., & Ribeiro, M. F. M. (2014) · Endocrine · doi:10.1007/s12020-014-0396-6 · Cited by 13
Metabolic disorders in adipocytokine imbalance and gestational complications
Борисовна, Ч. Н., Иванович, М. С., Vasilkova, T. N., & Александровна, Т. И. (2017) · Obesity and metabolism · doi:10.14341/omet201719-16 · Cited by 13
TP53INP2 Promotes Bovine Adipocytes Differentiation Through Autophagy Activation
Zhang, W., Li, P., Wang, S., Cheng, G., Wang, L., Mi, X., Su, X., Wang, Y., & Zan, L. (2019) · Animals · doi:10.3390/ani9121060 · Cited by 13
Progress in Investigating the Impact of Obesity on Male Reproductive Function
Kang, Y., Li, P., Yuan, S., Fu, S., Zhang, X., Zhang, J., Dong, C., Xiong, R., Zhao, H., & Huang, D. (2025) · Biomedicines · doi:10.3390/biomedicines13092054 · Cited by 12
Metabolic syndrome and male fertility disorders: Is there a causal link?
Cohen, D. J., Giaccagli, M. M., Herzfeld, J. D., González, L. N., Cuasnicu, P. S., & Ros, V. G. D. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09659-9 · Cited by 12
Impact of diet-induced obesity in male mouse reproductive system: The role of advanced glycation end product–receptor for advanced glycation end product axis
Moschonas, D. P., Piperi, C., Korkolopoulou, P. A., Levidou, G., Kavantzas, N., Trigka, E., Vlachos, I. S., Arapostathi, C., Perrea, D. N., Mitropoulos, D. N., et al. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214531899 · Cited by 12
Laparoscopic sleeve gastrectomy improves reproductive hormone levels in morbidly obese males -- a series of 28 cases.
Mihalca, R., Copăescu, C., Sîrbu, A. M., Florea, S., Martin, S. C., Barbu, C. G., & Fica, S. V. (2014) · PubMed · Cited by 12
Male reproductive success is correlated with testosterone in the eastern black rhinoceros (Diceros bicornis michaeli)
Edwards, K. L., Shultz, S., Pilgrim, M., & Walker, S. L. (2015) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.12.015 · Cited by 12
Can serum vaspin levels predict clomiphene resistance in infertile women with PCOS?
Doğan, K., Ekin, M., Helvacıoğlu, Ç., & Yaşar, L. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2017.08.006 · Cited by 12
Seminal plasma adipokines: involvement in human reproductive functions
Elfassy, Y., McAvoy, C., Fellahi, S., Dupont, J., Fève, B., Lévy, R., & Bastard, J. (2017) · European Cytokine Network · doi:10.1684/ecn.2018.0403 · Cited by 14
Management of weight loss in obesity-associated male infertility: a spotlight on bariatric surgery
Abiad, F., Awwad, J. T., Abbas, H. A., Zebian, D., & Ghazeeri, G. S. (2017) · Human Fertility · doi:10.1080/14647273.2017.1317369 · Cited by 11
A cross-talk between leptin and 17β-estradiol in vitellogenin synthesis in rainbow trout Oncorhynchus mykiss liver
Paolucci, M., Coccia, E., Imperatore, R., & Varricchio, E. (2019) · Fish Physiology and Biochemistry · doi:10.1007/s10695-019-00720-8 · Cited by 10
Modulatory effects of ghrelin on sperm quality alterations induced by a fructose-enriched diet
Ramírez, N. D., Luque, E. M., Jones, X. M., Torres, P. J., Moreira‐Espinoza, M. J., Cantarelli, V. I., Ponzio, M. F., Arja, A., Rabaglino, M. B., & Martini, A. C. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02886 · Cited by 10
The Prevalence and Components of Metabolic Syndrome in Men from Infertile Couples and Its Relation on Semen Analysis
Lê, M. T., Tran, N. Q. T., Nguyễn, Đ. N., & Nguyễn, V. Q. H. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s302575 · Cited by 11
Putative causal inference for the relationship between obesity and sex hormones in males: a bidirectional Mendelian randomization study
Wan, B., Ma, N., Zhou, Z., & Lv, C. (2023) · PeerJ · doi:10.7717/peerj.15760 · Cited by 10
Nutrition and Reproductive Health: Sperm versus Erythrocyte Lipidomic Profile andω-3 Intake
Mendeluk, G. R., Cohen, M. I., Ferreri, C., & Chatgilialoglu, C. (2015) · Journal of Nutrition and Metabolism · doi:10.1155/2015/670526 · Cited by 12
Sertoli cell function in young males with metabolic syndrome
Saikia, U., Saikia, K., Sarma, D., & Appaiah, S. (2019) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_574_18 · Cited by 10
A Review of Obstetrical Outcomes and Complications in Pregnant Women after Bariatric Surgery
Haseeb, Y. A. (2019) · Sultan Qaboos University medical journal · doi:10.18295/squmj.2019.19.04.003 · Cited by 10
Prenatal programming of obesity in a swine model of leptin resistance: modulatory effects of controlled postnatal nutrition and exercise
Barbero-Fernández, A., Astiz, S., Óvilo, C., López-Bote, C. J., Perez-Solana, M., Ayuso, M., Real, I. G., & Gonzalez‐Bulnes, A. (2014) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174414000208 · Cited by 10
Where do obesity and male infertility collide?
Jahangir, M., Nazari, M., Babakhanzadeh, E., & Manshadi, S. D. (2024) · BMC Medical Genomics · doi:10.1186/s12920-024-01897-5 · Cited by 13
The effects of a low-calorie diet or an isocaloric diet combined with metformin on sex hormones In obese women of child-bearing age
Swora-Cwynar, E., Kujawska-Łuczak, M., Suliburska, J., Reguła, J., Kargulewicz, A., Kręgielska-Narożna, M., Marcinkowska, E., Kanikowska, A., Bielas, M., Grzymislawski, M. B., et al. (2016) · Acta Scientiarum Polonorum Technologia Alimentaria · doi:10.17306/j.afs.2016.2.21 · Cited by 9
Age-related differences in fluctuations in insulin resistance evaluated with HOMA-IR and triglyceride and glucose-based indices during the menstrual cycle, as determined using the NHANES cross-sectional dataset
Porchia, L. M., Ochoa-Précoma, R., Reyes-Albarracín, Y., González-Mejía, M. E., & López‐Bayghen, E. (2024) · Maturitas · doi:10.1016/j.maturitas.2024.108085 · Cited by 9
Asociación entre obesidad abdominal y daño oxidativo seminal en pacientes con síndrome metabólico
Rosety, I., Elosegui, S., Pery, M. T., Fornieles, G., Rosety, J. M., Díaz, A. J., Rodríguez-Pareja, A., Brenes, F., Rosety-Rodríguez, M., Ordóñez, F. J., et al. (2014) · Revista médica de Chile · doi:10.4067/s0034-98872014000600007 · Cited by 9
Gender Obesity Report – Einfluss von Adipositas auf Reproduktion und Schwangerschaft
Harreiter, J., & Kautzky‐Willer, A. (2015) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-015-0410-5 · Cited by 9
Sexual dysfunction and central obesity in patients with first episode psychosis
Theleritis, C. G., Bonaccorso, S., Habib, N., Stahl, D. R., Gaughran, F., Vitoratou, S., Atakan, Z., Kolliakou, A., Gardner-Sood, P., Dazzan, P., et al. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2016.11.008 · Cited by 9
Recategorisation of body mass index to achieve andrological predictive power: a study in more than 20 000 patients
Ramírez, N. D., Molina, R. I., Tissera, A. D., Luque, E. M., Torres, P. J., Bianconi, S., Beltramone, F., Larcher, J. M. S., Estofan, G. M., Mangeaud, A. P., et al. (2020) · Reproduction Fertility and Development · doi:10.1071/rd19429 · Cited by 9
The effects of acupoint catgut embedding therapy on anthropometric parameters and endocrine function in obese women: a systematic review and meta-analysis
Li, S., Zhou, H., Zhou, M., Lou, L., Luo, L., & Ji, S. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1583556 · Cited by 8
Obesity in women: current aspects of reproductive health disorders
Artemenko, Y. S., Khamoshina, M. B., Андреевна, Р. В., & Zyukina, Z. V. (2022) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2022-16-5-32-39 · Cited by 13
A North American study of anthropometric factors and semen quality
Joseph, M. D., Hatch, E. E., Koenig, M. R., Eisenberg, M. L., Wang, T. R., Sommer, G. J., Stuver, S. O., Rothman, K. J., & Wise, L. A. (2023) · Fertility and Sterility · doi:10.1016/j.fertnstert.2023.04.040 · Cited by 8
Metabolic and immune dysfunctions in post-traumatic stress disorder: what can we learn from animal models?
Lushchak, O. V., Orrù, M., Strilbytska, O. M., Berezovskyi, V., Cherkas, A., Storey, K. B., & Bayliak, M. M. (2023) · EXCLI journal · doi:10.17179/excli2023-6391 · Cited by 12
The potential regulatory mechanisms of the gonadotropin-releasing hormone in gonadotropin transcriptions identified with bioinformatics analyses
Xiang, W., Zhang, B., Lv, F., Feng, G., Chen, L., Yang, F., Zhang, K., Cao, C., Wang, P., & Chu, M. (2017) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-017-0264-3 · Cited by 8
Mammography before and after bariatric surgery
Mokhtari, T. E., Rosas, U. S., Downey, J. R., Miyake, K. K., Ikeda, D. M., & Morton, J. M. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.10.021 · Cited by 8
Mutltifaceted biological roles of leptin
Charchour, R., Dufour‐Rainfray, D., Morineau, G., Vatier, C., Fellahi, S., Vigouroux, C., Genoux, A., Capeau, J., Lacorte, J., Collet, C., et al. (2020) · Annales de biologie clinique · doi:10.1684/abc.2020.1560 · Cited by 8
Obesity and polycystic ovary syndrome influence on intestinal permeability at fasting, and modify the effect of diverse macronutrients on the gut barrier
Martínez-García, M. Á., Quintero-Tobar, A., Quiñones, S. D. L., Insenser, M. R., Fernández‐Durán, E., Escobar-Morreale, H. F., & Luque‐Ramírez, M. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114338 · Cited by 8
Lifestyle Related Fertility Disorders in North Jordan: Potential for Improvement
Hamadneh, J., Amarin, Z. O., Hamadneh, S., Obeidat, N. A., Kassab, M. I., & Hani, M. B. (2017) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2017.45 · Cited by 7
Sensitivity of pituitary gonadotropes to hyperglycemia leads to epigenetic aberrations and reduced follicle‐stimulating hormone levels
Feldman, A., Saleh, A., Pnueli, L., Qiao, S., Shlomi, T., Boehm, U., & Melamed, P. (2018) · The FASEB Journal · doi:10.1096/fj.201800943r · Cited by 6
Comparison of Adiponectin Levels During the Menstrual Cycle Between Normal Weight and Overweight/Obese Young Females
Salem, A. M., Latif, R., & Rafique, N. (2019) · Physiological Research · doi:10.33549/physiolres.934197 · Cited by 7

Authors: Michalakis, K., Mintziori, G., Kaprara, A., Tarlatzis, B. C., & Goulis, D. G.
Affiliations: Aristotle University of Thessaloniki (GR)
Corresponding author: Goulis, Dimitrios G.
ORCID: Michalakis, Konstantinos
Mintziori, Gesthimani
Kaprara, Athina
Tarlatzis, Basil C.
Goulis, Dimitrios G.
Venue: Metabolism
Publisher: Elsevier BV
Published: 2013-04
Volume: 62
Issue: 4
Pages: 457-478
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2012.08.012
OpenAlex: W2115987699
Cited by: 321
References: 272
Citations by year: 2026: 10 · 2025: 15 · 2024: 19 · 2023: 16 · 2022: 18 · 2021: 21 · 2020: 29 · 2019: 30 · 2018: 23 · 2017: 26 · 2016: 27 · 2015: 35 · 2014: 38 · 2013: 14
FWCI: 3.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: obesity, metabolic syndrome, reproductive axis, hypothalamic-pituitary-gonadal axis, energy balance, puberty, precocious puberty, male infertility, secondary hypogonadism, oxidative stress, spermatogenesis, leptin, adiponectin, resistin, ghrelin, sex hormone replacement therapy, bariatric surgery, lifestyle modification
MeSH terms: Adult, Female, Fertility, Gastrointestinal Hormones, Humans, Infertility, Life Style, Male, Obesity, Pregnancy, Reproduction, Gonadal Steroid Hormones, Metabolic Syndrome, Bariatric Surgery

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The complex interaction between obesity, metabolic syndrome and reproductive axis: A narrative review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks