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Cited by 109Mangiferin and Mango ExtractsEndoplasmic Reticulum Stress and DiseaseNatural Antidiabetic Agents Studies

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells

Song, Junna, Li, Jia, Hou, Fangjie, Wang, Xiaona, Liu, Baolin·2015·Metabolism
DOI 10.1016/j.metabol.2014.11.008
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Abstract

Background Endothelial dysfunction is tightly associated with cardiovascular complications in diabetic patients. This study aims to investigate the effects of mangiferin on the regulation of endothelial homeostasis under endoplasmic reticulum stress (ER stress) conditions. Results High glucose (25 mmol/L) exposure induced ER stress and promoted ROS production in endothelial cells. Mangiferin effectively inhibited ER stress-associated oxidative stress by attenuating IRE1α phosphorylation and reducing ROS production. In response to ER stress, thioredoxin-interacting protein (TXNIP) expression increased, followed by NLRP3 inflammasome activation and increased IL-1β secretion. Mangiferin treatment attenuated the expressions of TXNIP and NLRP3 and reduced IL-1β and IL-6 production, demonstrating its inhibitory effects on TXNIP/NLRP3 inflammasome activation. NLRP3 inflammasome activation is responsible for mitochondrial cell death. Mangiferin restored the loss of the mitochondrial membrane potential (Δψm) and inhibited caspase-3 activity, and thereby protected cells from high glucose-induced apoptosis. Moreover, mangiferin inhibited ET-1 secretion and restored the loss of NO production when cells were exposed to high glucose. Mangiferin enhanced AMPK phosphorylation and AMPK inhibitor compound C diminished its beneficial effects, indicating the potential role of AMPK in its action. Conclusion Our work showed the beneficial effects of mangiferin on the improvement of endothelial hom…

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Citations

Cites

Research works printed but not linked: 26

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Metadata

Authors
Song, J., Li, J., Hou, F., Wang, X., & Liu, B.
Affiliations
  • Hebei University of Chinese Medicine (CN)
  • Nanjing University of Chinese Medicine (CN)
Corresponding author
Liu, Baolin
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
2015-03
Volume
64
Issue
3
Pages
428-437
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2014.11.008
OpenAlex
W2009497505
Cited by
109
References
0
Citations by year
2026: 4 · 2025: 3 · 2024: 8 · 2023: 10 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 7 · 2018: 13 · 2017: 13 · 2016: 12 · 2015: 6
FWCI
22.22
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Hebei University of Chinese Medicine College (QNZ 4014016)
  • Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
mangiferin, endoplasmic reticulum stress, TXNIP, NLRP3 inflammasome, AMPK, endothelial dysfunction, endothelial cells, high glucose, oxidative stress, IRE1α, IL-1β, interleukin-6, mitochondrial membrane potential, caspase-3, apoptosis, endothelin-1, nitric oxide, cardiovascular complications of diabetes
MeSH terms
NLR Family, Pyrin Domain-Containing 3 Protein, Carrier Proteins, Endoribonucleases, Humans, Hypoglycemic Agents, Inflammation, Nitric Oxide, Cytokines, Apoptosis, Protein Serine-Threonine Kinases, Reactive Oxygen Species, MAP Kinase Signaling System, Endothelial Cells, Xanthones, Membrane Potential, Mitochondrial, Endoplasmic Reticulum Stress, Human Umbilical Vein Endothelial Cells

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