Cited by 109Mangiferin and Mango ExtractsEndoplasmic Reticulum Stress and DiseaseNatural Antidiabetic Agents Studies

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells

Song, Junna, Li, Jia, Hou, Fangjie, Wang, Xiaona, Liu, Baolin·2015·Metabolism

DOI 10.1016/j.metabol.2014.11.008

Open this paper in CoChat — free account

Abstract

Background Endothelial dysfunction is tightly associated with cardiovascular complications in diabetic patients. This study aims to investigate the effects of mangiferin on the regulation of endothelial homeostasis under endoplasmic reticulum stress (ER stress) conditions. Results High glucose (25 mmol/L) exposure induced ER stress and promoted ROS production in endothelial cells. Mangiferin effectively inhibited ER stress-associated oxidative stress by attenuating IRE1α phosphorylation and reducing ROS production. In response to ER stress, thioredoxin-interacting protein (TXNIP) expression increased, followed by NLRP3 inflammasome activation and increased IL-1β secretion. Mangiferin treatment attenuated the expressions of TXNIP and NLRP3 and reduced IL-1β and IL-6 production, demonstrating its inhibitory effects on TXNIP/NLRP3 inflammasome activation. NLRP3 inflammasome activation is responsible for mitochondrial cell death. Mangiferin restored the loss of the mitochondrial membrane potential (Δψm) and inhibited caspase-3 activity, and thereby protected cells from high glucose-induced apoptosis. Moreover, mangiferin inhibited ET-1 secretion and restored the loss of NO production when cells were exposed to high glucose. Mangiferin enhanced AMPK phosphorylation and AMPK inhibitor compound C diminished its beneficial effects, indicating the potential role of AMPK in its action. Conclusion Our work showed the beneficial effects of mangiferin on the improvement of endothelial hom…

Integrity signals

Registry

Crossref · 10.1016/j.metabol.2014.11.008

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708
Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6
Li, Y., Schwabe, R. F., DeVries-Seimon, T., Yao, P. M., Gerbod-Giannone, M.-C., Tall, A. R., Davis, R. J., Flavell, R., Brenner, D. A., & Tabas, I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501759200 · Cited by 421
Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK
Niu, Y., Li, S., Na, L., Feng, R., Liu, L., Li, Y., & Sun, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030782 · Cited by 116
Mangiferin facilitates islet regeneration and β-cell proliferation through upregulation of cell cycle and β-cell regeneration regulators
Wang, H.-L., Li, C.-Y., Zhang, B., Liu, Y.-D., Lu, B.-M., Shi, Z., An, N., Zhao, L.-K., Zhang, J.-J., Bao, J.-K., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15059016 · Cited by 51

Show all 0 references

Research works printed but not linked: 26

Ruderman, 1992, Glucose and diabetic vascular disease, FASEB J, 6, 2905, 10.1096/fasebj.6.11.1644256 · DOI
Calles-Escandon, 2001, Diabetes and endothelial dysfunction: a clinical perspective, Endocr Rev, 22, 36, 10.1210/edrv.22.1.0417 · DOI
Zhang, 2008, From endoplasmic-reticulum stress to the inflammatory response, Nature, 454, 455, 10.1038/nature07203 · DOI · Paper page
Hetz, 2012, The unfolded protein response: controlling cell fate decisions under ER stress and beyond, Nat Rev Mol Cell Biol, 13, 89, 10.1038/nrm3270 · DOI
Oslowski, 2012, Thioredoxin-interacting protein mediates ER stress-induced beta cell death through initiation of the inflammasome, Cell Metab, 16, 265, 10.1016/j.cmet.2012.07.005 · DOI
Dutta, 2005, Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis, Lab Invest, 85, 798, 10.1038/labinvest.3700280 · DOI
Wen, 2011, Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling, Nat Immunol, 12, 408, 10.1038/ni.2022 · DOI · Paper page
Qi, 2007, deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart, J Mol Cell Cardiol, 43, 420, 10.1016/j.yjmcc.2007.07.061 · DOI
Yoshioka, 2012, Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia–reperfusion injury, J Clin Invest, 122, 267, 10.1172/JCI44927 · DOI
Dong, 2010, Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo, Diabetes, 59, 1386, 10.2337/db09-1637 · DOI
Galan, 1843, Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction, Biochim Biophys Acta, 2014, 1063
Mohamed, 2014, Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet, Diabetologia, 57, 413, 10.1007/s00125-013-3101-z · DOI
Marquez, 2012, Mangiferin decreases inflammation and oxidative damage in rat brain after stress, Eur J Nutr, 51, 729, 10.1007/s00394-011-0252-x · DOI · Paper page
Gong, 2013, Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1, J Nutr Biochem, 24, 1173, 10.1016/j.jnutbio.2012.09.003 · DOI
Muruganandan, 2005, Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats, J Ethnopharmacol, 97, 497, 10.1016/j.jep.2004.12.010 · DOI · Paper page
Wang, 2014, Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase, Pharm Biol, 52, 68, 10.3109/13880209.2013.814691 · DOI
Zhao, 2014, The total phenolic fraction of Anemarrhena asphodeloides inhibits inflammation and reduces insulin resistance in adipocytes via regulation of AMP-kinase activity, Planta Med, 80, 146, 10.1055/s-0033-1360197 · DOI
Zhao, 2014, Total polyphenol of Anemarrhena asphodeloides ameliorates advanced glycation end products-induced endothelial dysfunction by regulation of AMP-kinase, J Diabetes, 6, 304, 10.1111/1753-0407.12111 · DOI
Wu, 2013, AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1, Mol Cell, 49, 1167, 10.1016/j.molcel.2013.01.035 · DOI
Giaccari, 2009, Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes — mechanisms and potentials for treatment, Nutr Metab Cardiovasc Dis, 19, 365, 10.1016/j.numecd.2009.03.018 · DOI
Du, 2000, Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation, Proc Natl Acad Sci U S A, 97, 12222, 10.1073/pnas.97.22.12222 · DOI
Han, 2009, IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates, Cell, 138, 562, 10.1016/j.cell.2009.07.017 · DOI
Lerner, 2012, IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress, Cell Metab, 16, 250, 10.1016/j.cmet.2012.07.007 · DOI
Fang, 2011, High glucose condition upregulated Txnip expression level in rat mesangial cells through ROS/MEK/MAPK pathway, Mol Cell Biochem, 347, 175, 10.1007/s11010-010-0626-z · DOI
Choi, 2014, Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases, Mol Cells, 6, 441, 10.14348/molcells.2014.0104 · DOI
Rosati, 2010, Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL, Blood, 116, 2713, 10.1182/blood-2010-03-275628 · DOI

Sorted by citations

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases
Abderrazak, A., Syrovets, T., Couchie, D., Hadri, K. E., Friguet, B., Simmet, T., & Rouis, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.008 · Cited by 749
Mangiferin: A natural miracle bioactive compound against lifestyle related disorders
Imran, M., Arshad, M. S., Butt, M. S., Kwon, J.-H., Arshad, M. U., & Sultan, M. T. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0449-y · Cited by 366
Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects
Xia, C., Zeng, Z.-Y., Fang, B., Tao, M., Gu, C., Zheng, L., Wang, Y., Shi, Y., Fang, C., Mei, S., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.07.026 · Cited by 294
Regulation of AMP-activated protein kinase by natural and synthetic activators
Hardie, D. G. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.06.002 · Cited by 180
Pyroptosis is a critical immune-inflammatory response involved in atherosclerosis
He, X., Fan, X., Bai, B., Lu, N., Zhang, S., & Zhang, L. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105447 · Cited by 174
Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication
Nasoohi, S., Ismael, S., & Ishrat, T. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0917-z · Cited by 162
Innovative Technologies for Extraction and Microencapsulation of Bioactives from Plant-Based Food Waste and Their Applications in Functional Food Development
Pattnaik, M., Pandey, P., Martin, G. J. O., Mishra, H. N., & Ashokkumar, M. (2021) · Foods · doi:10.3390/foods10020279 · Cited by 146
Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139
“…as the phosphorylation of AMP-activated protein kinase (AMPK), was attenuated in endothelial cells cultured with mangiferin at concentrations of 0.1, 1 and 10 µM, demonstrating its inhibitory effects on TXNIP/NLRP3 inflammasome activation and it ameliorative effects on endothelial dysfunction (45).”
Influential
Role and mechanism of ROS scavengers in alleviating NLRP3‐mediated inflammation
Takami, S., & Xu, J.-X. (2018) · Biotechnology and applied biochemistry · doi:10.1002/bab.1700 · Cited by 139
Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury
Yang, K., Zhang, P., Li, J., Zhang, G., & Chang, X. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101034 · Cited by 136
“Besides, mangiferin also protects the myocardium from ERS-induced injury by decreasing the activation of the PERK/eIF2 a /ATF4/CHOP pathway while increasing SIRT1-mediated eIF2 a deacetylation [105] (Fig.”
Self-citation
Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1 β Production
Tőzsér, J., & Benkő, S. (2016) · Mediators of Inflammation · doi:10.1155/2016/5460302 · Cited by 129
ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of Atherosclerosis
Chen, X., Guo, X.-C., Ge, Q., Zhao, Y., Mu, H., & Zhang, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3462530 · Cited by 135
“ROS play a significant role in oxidative stress, inflammation, apoptosis, cell growth, alteration in vascular tone, and oxidation of low-density lipoprotein cholesterol (LDL-C) [158, 159].”
Background
Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke
Xu, Q., Zhao, B., Ye, Y., Li, Y., Zhang, Y., Xiong, X., & Gu, L. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02137-8 · Cited by 119
“ROS play important roles in inflammation, oxidative stress, changes in blood vessel tension, and oxidation of low-density lipoprotein cholesterol (LDL-C) [64, 65].”
Background
Endoplasmic reticulum stress and the development of endothelial dysfunction
Battson, M. L., Lee, D. M., & Gentile, C. L. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00437.2016 · Cited by 105
“For example, in cultured endothelial cells, glucose-induced increases in inflammatory cytokines and endothelin-1, as well as reductions in NO, are accompanied by UPR activation and mitigated by chemical chaperones (35, 124).”
Background
Reversibility of endothelial dysfunction in diabetes: role of polyphenols
Suganya, N., Bhakkiyalakshmi, E., Sarada, D. V. L., & Ramkumar, K. M. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001884 · Cited by 116
Natural products targeting ER stress pathway for the treatment of cardiovascular diseases
Choy, K., Murugan, D., & Mustafa, M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.04.013 · Cited by 95
Exercise-stimulated FGF23 promotes exercise performance via controlling the excess reactive oxygen species production and enhancing mitochondrial function in skeletal muscle
Li, D.-J., Fu, H., Zhao, T., Ni, M., & Shen, F.-M. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.009 · Cited by 92
“9 ROS production 2’,7’-Dichlorofluorescin (DCFH) was used as a fluorescent probe to measure the ROS according to the method described previously with some modification[26].”
Method
Anticancer and anti-inflammatory properties of mangiferin: A review of its molecular mechanisms
Mei, S., Ma, H., & Chen, X. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.111997 · Cited by 103
NLRP3 Inflammasome Expression and Signaling in Human Diabetic Wounds and in High Glucose Induced Macrophages
Zhang, X., Dai, J.-Z., Li, L., Chen, H., & Chai, Y. (2017) · Journal of Diabetes Research · doi:10.1155/2017/5281358 · Cited by 91
“[21] reported Mangiferin treatment attenuated the expressions of NLRP3 and reduced IL-1β production in the presence of high glucose.”
Background
Curcumin and its analogues protect from endoplasmic reticulum stress: mechanisms and pathways.
Shakeri, A., Zirak, M., Hayes, A., Reiter, R., & Karimi, G. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104335 · Cited by 85
Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome
Bulugonda, R. K., kumar, K. A., Gangappa, D., Beeda, H., Philip, G. H., Muralidhara Rao, D., & Faisal, S. M. (2017) · Scientific Reports · doi:10.1038/srep42683 · Cited by 74
“Recent studies have shown that Mangiferin inhibits NLRP3 inflammasome in liver and endothelial cells to protect against liver injury and endothelial dysfunction 32,33 .”
Endoplasmic Reticulum Stress and Cancer: Could Unfolded Protein Response Be a Druggable Target for Cancer Therapy?
Bonsignore, G., Martinotti, S., & Ranzato, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021566 · Cited by 86
Recent advances in anti-inflammation via AMPK activation
Xu, Y., Bai, L., Yang, X., Huang, J.-L., Wang, J., Wu, X., & Shi, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33670 · Cited by 71
“It suggests that mangiferin regulates endothelium homeostasis and may help treat diabetes-related cardiovascular problems [107].”
Background
Roles and Therapeutic Implications of Endoplasmic Reticulum Stress and Oxidative Stress in Cardiovascular Diseases
Zhou, Y., Murugan, D., Khan, H., Huang, Y., & Wai, S.-C.-A. (2021) · Antioxidants · doi:10.3390/antiox10081167 · Cited by 69
“Mangiferin, a widely used Chinese herb for treating diabetes mellitus, has been shown to inhibit ER stress and the associated oxidative stress, TXNIP expression, NLRP3 inflammasome activation, production of IL-1β and IL-6 whilst increasing NO release in endothelial cells exposed to high glucose [103,104].”
Background
Role of NLRP3 Inflammasome and Its Inhibitors as Emerging Therapeutic Drug Candidate for Alzheimer’s Disease: a Review of Mechanism of Activation, Regulation, and Inhibition
Sharma, B., Satija, G., Madan, A., Garg, M., Alam, M. M., Shaquiquzzaman, M., Khanna, S., Tiwari, P., Parvez, S., Iqubal, A., et al. (2022) · Inflammation · doi:10.1007/s10753-022-01730-0 · Cited by 77
Profile of crosstalk between glucose and lipid metabolic disturbance and diabetic cardiomyopathy: Inflammation and oxidative stress
Chen, M., Meng, X., Han, Y.-P., Yan, J.-L., Xiao, C., & Qian, L.-B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.983713 · Cited by 66
The management of diabetes mellitus by mangiferin: advances and prospects
Wang, M., Liang, Y., Chen, K., Wang, M., Long, X., Liu, H., Sun, Y., & He, B. (2022) · Nanoscale · doi:10.1039/d1nr06690k · Cited by 56
Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress‐Induced Endothelial Dysfunction
Amodio, G., Moltedo, O., Faraonio, R., & Remondelli, P. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4946289 · Cited by 58
“The xanthonoid mangiferin was shown to be effective in high-glucose-induced ED by inhibiting ER stress and ER stress-dependent OS, and as for other AMPK activators, the inhibition of NLRP3 inflammasome allowed restoration of NO production and endothelial homeostasis [92].”
The Natural Occurring Compounds Targeting Endoplasmic Reticulum Stress
Liu, H., Yang, J., Li, L., Shi, W., Yuan, X., & Wu, L. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/7831282 · Cited by 52
Natural antioxidants’ effects on endoplasmic reticulum stress-related diseases
Reyes-Fermín, L. M., Aparicio-Trejo, O. E., Avila-Rojas, S. H., Gómez-Sierra, T., Martínez-Klimova, E., & Pedraza-Chaverri, J. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111229 · Cited by 50
Acrylamide induces NLRP3 inflammasome activation via oxidative stress- and endoplasmic reticulum stress-mediated MAPK pathway in HepG2 cells.
Nan, B., Hong, Y.-L., Yang, C., Li, L., & Yuan, Y. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111679 · Cited by 50
Enhancement of Exercise Performance by 48 Hours, and 15-Day Supplementation with Mangiferin and Luteolin in Men
Gelabert-Rebato, M., Wiebe, J. C., Martin-Rincon, M., Galvan-Alvarez, V., Curtelin, D., Perez-Valera, M., Juan Habib, J., Pérez-López, A., Vega, T., Morales-Alamo, D., et al. (2019) · Nutrients · doi:10.3390/nu11020344 · Cited by 49
“Mangiferin + luteolin supplementation could have improved brain oxygenation during sprint exercise likely through its antioxidant properties, inhibitory action on endothelial NOX [81], suppressive effects on the endoplasmic reticulum-induced stress [96], and increasing the bioavailability of vascular NO [98].”
Background
Globular Adiponectin Inhibits Lipopolysaccharide-Primed Inflammasomes Activation in Macrophages via Autophagy Induction: The Critical Role of AMPK Signaling
Kim, M. J., Kim, E. H., Pun, N. T., Chang, J., Kim, J., Jeong, J., Choi, D. Y., Kim, S., & Park, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061275 · Cited by 50
“Moreover, mangiferin, a bioactive xanthonoid found in plants, was shown to inhibit high glucose-induced NLRP3 inflammasomes activation through AMPK-dependent mechanisms in endothelial cells [50].”
Background
Targeting NLRP3 Inflammasome in the Treatment Of Diabetes and Diabetic Complications: Role of Natural Compounds from Herbal Medicine
Bai, Y., Mu, Q., Bao, X., Zuo, J., Fang, X., Hua, J., Zhang, D., Jiang, G., Li, P., Gao, S., et al. (2021) · Aging and Disease · doi:10.14336/ad.2021.0318 · Cited by 56
“stress and reduce inflammation in vascular endothelial cells through blocking ROS/TXNIP/NLRP3 signaling [73, 89, 90].”
Background
NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis
Liu, Y., Li, C., Yin, H., Zhang, X., & Li, Y. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/1561342 · Cited by 49
“*ioredoxin interacting protein (TXNIP) expression was impeded, which inhibitedNLRP3 activation and IL-1β release [91].”
Background
The role of NLRP3 inflammasome in stroke and central poststroke pain
Li, S., Zhang, Y., Ma, S., Yi, Y., Yu, H., Pei, L., & Feng, D. (2018) · Medicine · doi:10.1097/md.0000000000011861 · Cited by 50
Endoplasmic reticulum stress and NLRP3 inflammasome: Crosstalk in cardiovascular and metabolic disorders
Ji, T., Han, Y., Yang, W., Xu, B., Sun, M., Jiang, S., Yu, Y., Jin, Z., Ma, Z., Yang, Y., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28275 · Cited by 42
“The activation of the NLRP3 inflammasome promotes mitochondrial damage, ROS production and mitochondrial cell death (Murakami et al., 2012; Song et al., 2015; Zhao et al., 2015).”
BackgroundInfluential
Ganoderma atrum Polysaccharide Ameliorates Hyperglycemia-Induced Endothelial Cell Death via a Mitochondria-ROS Pathway
Li, W., Nie, S., Yao, Y.-F., Liu, X., Shao, D.-Y., Gong, D., Cui, S. W., Phillips, G. O., He, M., & Xie, M. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b03462 · Cited by 48
Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer’s disease: flavonoids and phenols
Zhang, M., Hu, G., Shao, N., Qin, Y.-P., Chen, Q., Wang, Y., Zhou, P., & Cai, B. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00861-4 · Cited by 46
Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate.
Song, J., Meng, Y.-M., Wang, M., Li, L.-Z., Liu, Z., Zheng, K., Wu, L.-F., Liu, B.-L., Hou, F.-J., & Li, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104845 · Cited by 38
Self-citation
The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches
Habtemariam, S. (2020) · Biomedicines · doi:10.3390/biomedicines8040090 · Cited by 42
Endogenous hydrogen sulfide‐mediated MAPK inhibition preserves endothelial function through TXNIP signaling
Tian, D.-Y., Dong, J., Jin, S., Teng, X., & Wu, Y.-M. (2017) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2017.06.016 · Cited by 37
The Efficacy and Safety of the Chinese Herbal Formula, JTTZ, for the Treatment of Type 2 Diabetes with Obesity and Hyperlipidemia: A Multicenter Randomized, Positive-Controlled, Open-Label Clinical Trial
Yu, X., Xu, L., Zhou, Q., Wu, S., Tian, J., Piao, C., Guo, H., Zhang, J., Li, L., Wu, S., et al. (2018) · International Journal of Endocrinology · doi:10.1155/2018/9519231 · Cited by 39
Deactivation of the NLRP3 inflammasome in infiltrating macrophages by duodenal-jejunal bypass surgery mediates improvement of beta cell function in type 2 diabetes
Wu, D., Yan, Z.-B., Cheng, Y., Zhong, M., Liu, S.-Z., Zhang, G., & Hu, S. (2017) · Metabolism · doi:10.1016/j.metabol.2017.10.015 · Cited by 40
Mangiferin Mitigates Lipopolysaccharide-Induced Lung Injury by Inhibiting NLRP3 Inflammasome Activation
Li, N., Xiong, R., He, R., Liu, B., Wang, B., & Geng, Q. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s304492 · Cited by 34
Self-citation
Potential therapeutic role of pyroptosis mediated by the NLRP3 inflammasome in type 2 diabetes and its complications
Li, X., Xiao, G.-Y., Guo, T., Song, Y., & Li, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.986565 · Cited by 38
Mangiferin suppresses endoplasmic reticulum stress in perivascular adipose tissue and prevents insulin resistance in the endothelium
Xu, X., Chen, Y., Song, J., Hou, F., Ma, X., Liu, B., & Huang, F. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1441-z · Cited by 35
Self-citation
Mangiferin alleviates hypertension induced by hyperuricemia via increasing nitric oxide releases.
Yang, H., Bai, W.-W., Gao, L.-H., Jiang, J.-X., Tang, Y.-X., Niu, Y.-F., Lin, H., & Li, L. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2018.05.008 · Cited by 31
Dual/Multitargeted Xanthone Derivatives for Alzheimer'S Disease: Where Do We Stand?
Cruz, M. I., Cidade, H. M., & Pinto, M. M. M. (2017) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0086 · Cited by 34
Homoplantaginin Inhibits Palmitic Acid-induced Endothelial Cells Inflammation by Suppressing TLR4 and NLRP3 Inflammasome
He, B.-Q., Zhang, B., Wu, F., Wang, L., Shi, X., Qin, W., Lin, Y., Ma, S., & Liang, J. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000318 · Cited by 37
“PA-induced ROS serve as a potent instigator of NLRP3 inflammasome.(38) This study showed that PA incited endothelial ROS generation was time-dependent within 6 hours (Figs.”
Background
Recent progress of endoplasmic reticulum stress in the mechanism of atherosclerosis
Ni, L., Yang, L., & Lin, Y. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1413441 · Cited by 32
The Role of the Effects of Endoplasmic Reticulum Stress on NLRP3 Inflammasome in Diabetes
Lv, S.-Y., Li, X.-T., & Wang, H.-G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.663528 · Cited by 29
Mangiferin inhibits lipopolysaccharide‐induced epithelial‐mesenchymal transition ( EMT ) and enhances the expression of tumor suppressor gene PER1 in non‐small cell lung cancer cells
Lin, Y., Tsai, K., Chen, J., & Wu, C.-S. (2020) · Environmental Toxicology · doi:10.1002/tox.22943 · Cited by 34
“Recent studies have determined that mangiferin protects against liver injury and endothelial dysfunction by inhibiting NLRP3 inflammasome activation in liver and endothelial cells.(50,51) Cao et al.”
Background
Salidroside protects against homocysteine‐induced injury in human umbilical vein endothelial cells via the regulation of endoplasmic reticulum stress
Zhu, L., Jia, F., Wei, J., Yu, Y., Yu, T.-H., Wang, Y., Sun, J.-H., & Luo, G.-H. (2017) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12234 · Cited by 28
The Compound of Mangiferin-Berberine Salt Has Potent Activities in Modulating Lipid and Glucose Metabolisms in HepG2 Cells
Wang, C., Jiang, J., Wu, W., & Kong, W. (2016) · BioMed Research International · doi:10.1155/2016/8753436 · Cited by 28
Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis
Fu, T.-L., Li, G.-R., Li, D.-H., He, R.-Y., Liu, B.-H., Xiong, R., Xu, C.-Z., Lu, Z.-L., Song, C.-K., Qiu, H.-L., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01202-7 · Cited by 27
Self-citation
TRPM8 downregulation by angiotensin II in vascular smooth muscle cells is involved in hypertension
Huang, F., Ni, M., Zhang, J.-M., Li, D., & Shen, F. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6158 · Cited by 32
Oleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice
Kim, M., Han, J.-Y., Kim, S. H., Jeon, D., Kim, H.-Y., Lee, S. W., Rho, M., & Lee, K. (2018) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2018.03.001 · Cited by 30
Mangiferin protects against alcoholic liver injury via suppression of inflammation-induced adipose hyperlipolysis
Dong, M., Li, L., Li, G., Song, J., Liu, B., Liu, X., & Wang, M. (2020) · Food & Function · doi:10.1039/d0fo01436b · Cited by 26
Self-citation
The Role of NLRP3 Inflammasome in Type 2 Diabetes Mellitus and Its Macrovascular Complications
Karamitsos, K., Oikonomou, E. K., Theofilis, P., Ikonomidis, I., Kassi, E. N., Lambadiari, V., GIALAFOS, E. J., Tsatsaragkou, A., Mystakidi, V. C., Zisimos, K., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134606 · Cited by 32
2-Bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction
Dong, Z.-B., Wang, Y.-J., Cheng, M.-L., Wang, B., Lu, H., Zhu, H.-L., Liu, L., & Xie, M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275428 · Cited by 24
“Our previous research and published articles indicated that inflammation induced mitochondrial dysfunction is closely related to the activation of NLRP3 inflammasome [43, 44].”
Inhibition of Apoptosis Reduces Diploidization of Haploid Mouse Embryonic Stem Cells during Differentiation
Zhang, W., Tian, Y., Gao, Q., Li, X., Li, Y., Zhang, J., Yao, C., Wang, Y., Wang, H., Zhao, Y., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.05.004 · Cited by 28
Mangiferin Enhanced Autophagy via Inhibiting mTORC1 Pathway to Prevent High Glucose-Induced Cardiomyocyte Injury
Hou, J., Zheng, D., Xiao, W., Li, D., Ma, J., & Hu, Y.-H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00383 · Cited by 24
In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin
Kaurav, M., Kanoujia, J., Gupta, M., Goyal, P., Pant, S., Rai, S., Sahu, K. K., Bhatt, P., & Ghai, R. (2023) · Phytomedicine Plus · doi:10.1016/j.phyplu.2023.100445 · Cited by 28
Anti-inflammatory Property of AMP-activated Protein Kinase
Noor, H. B., Mou, N. A., Salem, L., Shimul, M. F. A., Biswas, S., Akther, R., Khan, S., Raihan, S., Mohib, M. M., & Sagor, M. A. T. (2019) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523018666190830100022 · Cited by 34
Selected Plant-Derived Polyphenols as Potential Therapeutic Agents for Peripheral Artery Disease: Molecular Mechanisms, Efficacy and Safety
Froldi, G., & Ragazzi, E. (2022) · Molecules · doi:10.3390/molecules27207110 · Cited by 27
The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment
Chen, F., Wang, N., Tian, X., Su, J., Yan, Q., He, R., & He, X. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061568 · Cited by 25
“In addition, MGF has been shown to significantly improve memory and cognitive impairment [61,84] and inhibit ERS-related oxidative stress by reducing IRE1α phosphorylation and ROS production [85].”
Background
Mangiferin Attenuates Murine Lupus Nephritis by Inducing CD4+Foxp3+ Regulatory T Cells via Suppression of mTOR Signaling
Liang, C.-L., Lu, W., Zhou, J., Chen, Y., Zhang, Q., Liu, H., Qiu, F., & Dai, Z. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000494654 · Cited by 25
Preparation and Evaluations of Mangiferin-Loaded PLGA Scaffolds for Alveolar Bone Repair Treatment Under the Diabetic Condition
Li, H., Liao, H., Bao, C., Xiao, Y., & Wang, Q. (2016) · AAPS PharmSciTech · doi:10.1208/s12249-016-0536-9 · Cited by 22
Roles of AMPK and Its Downstream Signals in Pain Regulation
Wang, S., & Dai, Y. (2021) · Life · doi:10.3390/life11080836 · Cited by 21
“AMPK can inhibit NLRP3 inflammasome complex formation by regulating autophagy [159,160], PGC-1α involvement in mitochondrial function [161] and endoplasmic reticulum stress [162,163].”
Background
Recent advances in polyphenols improving vascular endothelial dysfunction induced by endogenous toxicity
Xie, Y., Wang, H., & He, Z. (2020) · Journal of Applied Toxicology · doi:10.1002/jat.4123 · Cited by 24
A Single Dose of The Mango Leaf Extract Zynamite® in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women
Gelabert‐Rebato, M., Martín-Rincón, M., Galván-Álvarez, V., Gallego-Selles, Á., Martinez‐Canton, M., Vega-Morales, T., Wiebe, J. C., Castillo, C. F.-D., Castilla-Hernandez, E., Diaz-Tiberio, O., et al. (2019) · Nutrients · doi:10.3390/nu11112592 · Cited by 20
“However, each polyphenolic compound has unique chemical properties which determine some specific actions in different cellular compartments [38,39].”
Background
Mangiferin protects mitochondrial function by preserving mitochondrial hexokinase-II in vessel endothelial cells
Song, J., Li, Y., Jun-mei, S., Hou, F., Liu, B., & Li, A. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.05.001 · Cited by 21
Self-citation
Endoplasmic Reticulum Stress, a Driver or an Innocent Bystander in Endothelial Dysfunction Associated with Hypertension?
Cunard, R. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0762-x · Cited by 17
NLR family pyrin domain containing 3 (NLRP3) inflammasomes and peripheral neuropathic pain - Emphasis on microRNAs (miRNAs) as important regulators
Basu, P., Maier, C. G.-A., Averitt, D. L., & Basu, A. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175901 · Cited by 17
Natural Compounds Play Therapeutic Roles in Various Human Pathologies via Regulating Endoplasmic Reticulum Pathway
Ma, R., Ni, Z., Thakur, K., Zhang, F., Zhang, Y., Zhang, J., & Wei, Z. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100065 · Cited by 16
Inflammasomes and Natural Ingredients towards New Anti-Inflammatory Agents
Dutartre, P. (2016) · Molecules · doi:10.3390/molecules21111492 · Cited by 14
“In vitro endothelial cells, which were stressed by a high-glucose medium, were protected by mangiferin with a decrease of TXNIP NLRP3 interaction and AMP-activated protein kinase (AMPK) function [74].”
Lipidomics of the erythrocyte membrane and network pharmacology to explore the mechanism of mangiferin from Anemarrhenae rhizoma in treating type 2 diabetes mellitus rats.
Zhong, Y.-M., Xu, Y.-Y., Tan, Y.-Z., Zhang, X.-X., Wang, R.-L., Chen, D.-M., Wang, Z.-T., & Zhong, X.-L. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115386 · Cited by 13
The NLRP3 inflammasome is dispensable for ER stress-induced pancreatic β-cell damage in Akita mice
Wang, J., Song, M.-Y., Lee, J. Y., Kwon, K. S., & Park, B. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.009 · Cited by 14
Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine
Zhong, Y.-M., Li, X.-Y., Liang, T., Ding, B., Ma, K., Ren, W., & Liang, W. (2024) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-024-3655-2 · Cited by 12
Phytochemicals as potential target on thioredoxin-interacting protein (TXNIP) for the treatment of cardiovascular diseases
Zhou, P., Ma, Y.-Y., Zhao, X.-N., & Hua, F. (2023) · Inflammopharmacology · doi:10.1007/s10787-022-01130-8 · Cited by 14
“1 3 stress-induced TXNIP/NLRP3 inflammasome activation in endothelial cells (Song et al. 2015).”
Background
Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells
Buyandelger, U., Walker, D. G., Taguchi, H., Yanagisawa, D., & Tooyama, I. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.08.114 · Cited by 14
Effects of a Singular Dose of Mangiferin–Quercetin Supplementation on Basketball Performance: A Double-Blind Crossover Study of High-Level Male Players
Bourdas, D. I., Travlos, A. K., Souglis, A. G., Stavropoulou, G., Zacharakis, E., Gofas, D. C., & Bakirtzoglou, P. (2024) · Nutrients · doi:10.3390/nu16010170 · Cited by 12
“…compounds such as mangiferin and quercetin possess distinct chemical characteristics that influence their specific interactions within various cellular compartments [42,43], and both polyphenols (mangiferin and quercetin) exhibit significant capabilities in neutralizing free radicals [10,14].”
Background
The effects of mango consumption on vascular health and immune function
Castro, R. J., Pedroza, K., & Hong, M. Y. (2023) · Metabolism Open · doi:10.1016/j.metop.2023.100260 · Cited by 12
“It is possible that the antioxidant properties of mangiferin in mangos may be reducing endothelial dysfunction and maintaining homeostasis by reducing endoplasmic reticulum stress induced TXNIP/NLRP3 inflammasome activation, or by the positive regulation of AMPK activity [23].”
Background
Empagliflozin reduces endoplasmic reticulum stress associated TXNIP/NLRP3 activation in tunicamycin-stimulated aortic endothelial cells
Campeau, M., & Leask, R. (2023) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-023-02607-1 · Cited by 9
“The increased expressions of TXNIP and NLRP3 and the attenuating effect of EMPA were concomitant, supporting a direct activation of NLRP3 by TXNIP in oxidized conditions (Yin et al. 2017; Mohamed et al. 2014; Liu et al. 2014; Zhao et al. 2015; Song et al. 2015; Li et al. 2015).”
TGP attenuates endoplasmic reticulum stress and regulates the expression of thioredoxin-interacting protein in the kidneys of diabetic rats.
Shao, Y.-X., Qi, X.-M., Xu, X., Wang, K., Wu, Y.-G., & Xia, L.-L. (2016) · BioScience Trends · doi:10.5582/bst.2016.01188 · Cited by 9
Ameliorative effects of hispidulin on high glucose-mediated endothelial dysfunction via inhibition of PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling in endothelial cells
Qin, W., Xi, J., He, B.-Q., Zhang, B., Luan, H., & Wu, F. (2016) · doi:10.1016/j.jff.2016.09.021 · Cited by 9
Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I
Garrido-Suárez, B. B., Garrido, G., Castro-Labrada, M., Pardo-Ruíz, Z., Menéndez, A. B., Spencer, E., Godoy-Figueiredo, J., Ferreira, S. H., & Delgado-Hernández, R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01119 · Cited by 8
Mangiferin prevents glucolipotoxicity-induced pancreatic beta-cell injury through modulation of autophagy via AMPK-mTOR signaling pathway
Liu, C., Wu, L., Fu, L., Li, X., Zhao, B., & Zhang, H. (2024) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2024.2387697 · Cited by 7
“The AMPK-mTOR pathway is the classical pathway in autophagy regulation and MG is discovered to motivate AMPK in many cell types (Song et al. 2015, Rahman and Kim 2020, Fan et al. 2023).”
Bioactive lead compounds and molecular targets for the treatment of heart diseases
Ezzat, S. M., Salama, M. M., & Salem, M. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817890-4.00005-6 · Cited by 7
Edible Plant-Derived Xanthones as Functional Food Components for Metabolic Syndrome Mitigation: Bioactivities and Mechanisms
Shataer, D., Chen, S., Wu, Y., Fen, L., Liu, H., Lu, J., Li, B., Zhao, L., Qiu, S., & Jumai, A. (2025) · Foods · doi:10.3390/foods14132344 · Cited by 7
“In diabetic nephropathy models, mangiferin ( 47 ) provided renoprotective effects by inhibiting the MAPK/NF-κ B axis, activating the phosphorylated IRS-1/PI3K/Akt pathway, and mitigat-Foods ing renal ferroptosis through enhanced antioxidant activity and reduced pro-ferroptotic lipid production…”
Decoding interaction between mitochondria and endoplasmic reticulum in ischemic myocardial injury: targeting natural medicines
Zhang, C.-X., Chang, X., Zhao, D., He, Y., Dong, G., & Gao, L. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1536773 · Cited by 6
Forsythiaside A alleviates myocardial injury in streptozotocin-induced diabetes via endoplasmic reticulum stress-NLRP3 inflammasome pathway.
Shen, C., & Zhang, Q. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113956 · Cited by 6
Thioredoxin-1 regulates IRE1α to ameliorate sepsis-induced NLRP3 inflammasome activation and oxidative stress in Raw 264.7 cell
Shao, R., Lou, X., Xue, J., Yang, Y., Ning, D., Chen, G., & Jiang, L. (2022) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2022.2138431 · Cited by 6
Association between Endothelial Activation and Stress Index and mortality in diabetic nephropathy ICU patients: A retrospective cohort study
Chen, S., Guo, L., Ma, X.-H., Wang, S.-K., Wu, J.-C., Wu, L.-L., Zhang, T., & Gao, H.-J. (2025) · PLoS ONE · doi:10.1371/journal.pone.0329233 · Cited by 5
“Moreover, oxidative stress can activate the endoplasmic reticulum stress pathway, exacerbating endothelial dysfunction by promoting inflammation and apoptosis [9].”
AMPK–NLRP3 Inflammasome Crosstalk: Structural Insights, Molecular Mechanisms, and Therapeutic Implications for Inflammation and Neuroinflammation
Kodi, T., Nandakumar, K., & Kishore, A. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05932-7 · Cited by 6
“Moreover, prolonged ER stress leads to cell death, inflammation, and oxidative stress [118–123].”
JIP3 knockout protects mice against high fat diet-induced liver injury.
Ma, X.-J., Xing, H.-Z., Ren, G.-F., Rao, X.-J., & Li, Z.-Z. (2018) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2018.01.178 · Cited by 4
WITHDRAWN: JIP3 deficiency protects mice from high fat diet-induced liver injury.
Rao, X.-J., Wu, Y.-M., Wang, Y., & Shi, S. (2017) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2017.09.109 · Cited by 1
Retracted
Mangiferin: A multifunctional natural xanthone with therapeutic applications and in silico insights
Bhardwaj, S., Kapil, A., Gora, R., Garud, N., & Kumar, D. (2026) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2026.100701
South African Herbal Teas and Diabetes‐Mediated Mitochondrial Dysfunction: Emerging Evidence and Mechanistic Insights
Reddy, S., Abdul, N. S., Docrat, T. F., & Marnewick, J. L. (2026) · Journal of Food Science · doi:10.1111/1750-3841.71351

Authors: Song, J., Li, J., Hou, F., Wang, X., & Liu, B.
Affiliations: Hebei University of Chinese Medicine (CN)
Nanjing University of Chinese Medicine (CN)
Corresponding author: Liu, Baolin
ORCID: Song, Junna
Li, Jia
Wang, Xiaona
Liu, Baolin
Venue: Metabolism
Publisher: Elsevier BV
Published: 2015-03
Volume: 64
Issue: 3
Pages: 428-437
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2014.11.008
OpenAlex: W2009497505
Cited by: 109
References: 0
Citations by year: 2026: 4 · 2025: 3 · 2024: 8 · 2023: 10 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 7 · 2018: 13 · 2017: 13 · 2016: 12 · 2015: 6
FWCI: 22.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Hebei University of Chinese Medicine College (QNZ 4014016)
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords: mangiferin, endoplasmic reticulum stress, TXNIP, NLRP3 inflammasome, AMPK, endothelial dysfunction, endothelial cells, high glucose, oxidative stress, IRE1α, IL-1β, interleukin-6, mitochondrial membrane potential, caspase-3, apoptosis, endothelin-1, nitric oxide, cardiovascular complications of diabetes
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Carrier Proteins, Endoribonucleases, Humans, Hypoglycemic Agents, Inflammation, Nitric Oxide, Cytokines, Apoptosis, Protein Serine-Threonine Kinases, Reactive Oxygen Species, MAP Kinase Signaling System, Endothelial Cells, Xanthones, Membrane Potential, Mitochondrial, Endoplasmic Reticulum Stress, Human Umbilical Vein Endothelial Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks