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Cited by 39

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling

Botteri, Gaia, Salvadó, Laia, Gumà, Anna, Lee Hamilton, D., Meakin, Paul J., Montagut, Gemma, Ashford, Michael L.J., Ceperuelo-Mallafré, Victoria, Fernández-Veledo, Sonia, Vendrell, Joan, Calderón-Dominguez, María, Serra, Dolors, Herrero, Laura, Pizarro, Javier, Barroso, Emma, Palomer, Xavier, Vázquez-Carrera, Manuel·2018·Metabolism
DOI 10.1016/j.metabol.2018.03.005
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  • Changes in BACE1 activity have been associated with physiological functions including maintenance of the blood-brain barrier, angiogenesis, protection against obesity, immune and antimicrobial properties, inflammatory response, and tumor suppression.

    “In addition to its neuronal roles, changes in BACE1 activity have been associated with physiological functions including maintenance of the blood–brain barrier (BBB), angiogenesis, protection against obesity, immune and antimicrobial properties, inflammatory response, and tumor suppression.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [44]

  • BACE1 inhibition can restore insulin signaling in the setting of palmitate-induced inflammation and ER stress, while mimicked by sAPPβ.

    “BACE1 inhibition can restore insulin signaling in this setting, while mimicked by sAPPβ.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [44]

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Research works printed but not linked: 37

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  8. Salvadó, 2013, Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism, Diabetologia, 56, 1372, 10.1007/s00125-013-2867-3 · DOI
  9. Salvadó, 2015, Targeting endoplasmic reticulum stress in insulin resistance, Trends Endocrinol Metab, 26, 438, 10.1016/j.tem.2015.05.007 · DOI
  10. Lipina, 2013, Mitochondrial substrate availability and its role in lipid-induced insulin resistance and proinflammatory signaling in skeletal muscle, Diabetes, 62, 3426, 10.2337/db13-0264 · DOI · Paper page
  11. Handschin, 2006, Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism, Endocr Rev, 27, 728, 10.1210/er.2006-0037 · DOI · Paper page
  12. Patti, 2003, Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1, Proc Natl Acad Sci U S A, 100, 8466, 10.1073/pnas.1032913100 · DOI · Paper page
  13. Mootha, 2003, PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes, Nat Genet, 34, 267, 10.1038/ng1180 · DOI · Paper page
  14. Gallagher, 2010, Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes, Genome Med, 2, 1, 10.1186/gm130 · DOI
  15. Strachan, 2001, Cognitive function, dementia and type 2 diabetes mellitus in the elderly, Nat Rev Endocrinol, 7, 108, 10.1038/nrendo.2010.228 · DOI
  16. Hamilton, 2014, Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes, Diabetologia, 57, 1684, 10.1007/s00125-014-3269-x · DOI · Paper page
  17. Meakin, 2012, Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice, Biochem J, 441, 285, 10.1042/BJ20110512 · DOI · Paper page
  18. Puglielli, 2003, Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis, J Biol Chem, 278, 19777, 10.1074/jbc.M300466200 · DOI
  19. Salvadó, 2014, PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism, Diabetologia, 57, 2126, 10.1007/s00125-014-3331-8 · DOI
  20. Herrero, 2005, Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the cell impairs glucose-induced insulin secretion, Diabetes, 54, 462, 10.2337/diabetes.54.2.462 · DOI
  21. Buggia-Prevot, 2008, NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42, J Biol Chem, 283, 10037, 10.1074/jbc.M706579200 · DOI
  22. Hehner, 1998, Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta, J Biol Chem, 273, 1288, 10.1074/jbc.273.3.1288 · DOI
  23. Zhou, 2009, Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance, Mol Pharmacol, 76, 596, 10.1124/mol.109.057067 · DOI
  24. Buroker, 2009, The IkappaBalpha gene is a peroxisome proliferator-activated receptor cardiac target gene, FEBS J, 276, 3247, 10.1111/j.1742-4658.2009.07039.x · DOI
  25. Vega, 2000, The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes, Mol Cell Biol, 20, 1868, 10.1128/MCB.20.5.1868-1876.2000 · DOI · Paper page
  26. Wenz, 2009, Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging, Proc Natl Acad Sci U S A, 106, 20405, 10.1073/pnas.0911570106 · DOI · Paper page
  27. Yoon, 2001, Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1, Nature, 413, 131, 10.1038/35093050 · DOI · Paper page
  28. Wu, 2006, Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells, Proc Natl Acad Sci U S A, 103, 14379, 10.1073/pnas.0606714103 · DOI · Paper page
  29. Herzig, 2001, CREB regulates hepatic gluconeogenesis through the coactivator PGC-1, Nature, 413, 179, 10.1038/35093131 · DOI · Paper page
  30. Gonzalez, 1989, Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133, Cell, 59, 675, 10.1016/0092-8674(89)90013-5 · DOI
  31. Chen, 2012, Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid, J Neurosci, 32, 11390, 10.1523/JNEUROSCI.0757-12.2012 · DOI · Paper page
  32. Shoji, 1979, Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3′:5′-monophosphate-dependent protein kinase, J Biol Chem, 254, 6211, 10.1016/S0021-9258(18)50345-8 · DOI
  33. Handschin, 2009, Peroxisome proliferator-activated receptor-gamma coactivator-1alpha in muscle links metabolism to inflammation, Clin Exp Pharmacol Physiol, 36, 1139, 10.1111/j.1440-1681.2009.05275.x · DOI
  34. Zhang, 2013, Amyloid-β induces hepatic insulin resistance in vivo via JAK2, Diabetes, 62, 1159, 10.2337/db12-0670 · DOI
  35. Wang, 2013, Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons, Cell Metab, 17, 685, 10.1016/j.cmet.2013.03.016 · DOI
  36. Tong, 2001, Beta-amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised, J Biol Chem, 276, 17301, 10.1074/jbc.M010450200 · DOI · Paper page
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Metadata

Authors
Botteri, G., Salvadó, L., Gumà, A., Lee Hamilton, D., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X., & Vázquez-Carrera, M.
Venue
Metabolism
Publisher
Elsevier BV
Published
2018-08
Volume
85
Pages
59-75
ISSN
0026-0495
DOI
10.1016/j.metabol.2018.03.005
Cited by
39
References
14
Language
en
Update notices
erratum (2019-07-01)
Licence
Funders
  • Ministerio de Economía y Competitividad (SAF2012-30708, SAF2015-64146-R, SAF2013-45887-R, SAF2014-52223-C2-1-R, SAF2015-65019-R, PI14/00228)
  • Generalitat de Catalunya (2014SGR-13, 2014SGR465)
  • Diabetes UK (08/0003681, 12/0004458)

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