Cited by 119Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAdvanced Glycation End Products research

Cognitive dysfunction: a growing link between diabetes and Alzheimer’s disease

Jash, Kavya, Gondaliya, Piyush, Kirave, Prathibha, Kulkarni, Bhagyashri, Sunkaria, Aditya, Kalia, Kiran·2020·Drug Development Research

Abstract

Diabetes mellitus (DM) is a gradually rising metabolic disease which is currently affecting millions of people worldwide. Diabetes is associated with various complications like nephropathy, neuropathy, retinopathy, diabetic foot, cognitive impairment, and many more. Evidence suggests that cognitive dysfunction is a rising complication of diabetes which adversely affects the brain of patients suffering from diabetes. Age-related memory impairment is a complication having its major effect on people suffering from diabetes and Alzheimer's. Patients suffering from diabetes are at two times higher risk of developing cognitive dysfunction as compared with normal individuals. Multiple factors which are involved in diabetes related complications are found to play a role in the development of neurodegeneration in Alzheimer's. The problem of insulin deficiency and insulin resistance is well reported in diabetes but there are many studies which suggest dysregulation of insulin levels as a reason behind the development of Alzheimer's. As the link between diabetes and Alzheimer disease (AD) is deepening, there is a need to understand the plausible tie-ins between the two. Emerging role of major factors like insulin imbalance, advanced glycation end products and micro-RNA's involved in diabetes and Alzheimer's have been discussed here. This review helps in understanding the plausible mechanism underlying the pathophysiology of amyloid beta (Aβ) plaque formation and tau hyperphosphorylation as well provides information about studies carried out in this area of research. The final thought is to enhance the scientific knowledge on this correlation and develop future therapeutics to treat the same.

Integrity signals

Registry

Crossref · 10.1002/ddr.21579

Cites

212 of 212 references verified0 citation errors · 0 not checkable

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  • Glycyrrhiza uralensis extracts may reduce the risk of Alzheimer's disease in persons with a genetic hereditary tendency to diabetes.

    “This plant's extracts possibly will be beneficial to reduce the danger of AD in persons having a tendency to develop diabetes due to genetic hereditary as with diabetes there is a greater likelihood of developing AD [87]”
  • Diabetes is associated with a greater likelihood of developing Alzheimer's disease.

    “as with diabetes there is a greater likelihood of developing AD [87]”

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Authors
Jash, K., Gondaliya, P., Kirave, P., Kulkarni, B., Sunkaria, A., & Kalia, K.
Affiliations
National Institute of Pharmaceutical Education and Research - Ahmedabad (IN)
Corresponding author
Kalia, Kiran
Venue
Drug Development Research
Publisher
Wiley
Published
2019-08-05
Volume
81
Issue
2
Pages
144-164
ISSN
  • 0272-4391 (ISSN-L)
  • 1098-2299
OpenAlex
W2964446625
Cited by
119
References
212
Citations by year
2026: 9 · 2025: 9 · 2024: 17 · 2023: 25 · 2022: 37 · 2021: 14 · 2020: 6 · 2019: 2
FWCI
1.73
Type
journal article
Language
en
Open access
closed
Locations
  • Drug Development Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Pharmaceutical Education and Research, Ahmedabad
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Keywords
diabetes mellitus, Alzheimer's disease, cognitive impairment, insulin resistance, insulin deficiency, advanced glycation end products, microRNA, amyloid plaques, tau hyperphosphorylation, neurodegeneration, age-related memory impairment, diabetes complications
MeSH terms
Alzheimer Disease, Diabetes Mellitus, Humans, Insulin Resistance, Phosphorylation, Amyloid beta-Peptides, tau Proteins, Glycation End Products, Advanced, MicroRNAs, Cognitive Dysfunction

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