PGC-1α and Myokines in the Aging Muscle – A Mini-Review
Abstract
Aging is associated with far-reaching changes in physiological functions resulting in morbidity and ultimately death. Age-related frailty, insecurity and reduced physical activity contribute to a progressive loss of muscle mass and function, commonly referred to as sarcopenia. Due to the increase in life expectancy in many countries, loss of muscle mass and its consequences gain in relevance for public health. At the same time, the molecular mechanisms that underlie sarcopenia are poorly understood and therefore, therapeutic approaches are limited. Interestingly though, endurance, strength and stretching exercise is significantly superior to all known pharmacological, nutritional and hormonal interventions for stabilizing, alleviating and reversing sarcopenia. Thus, increased knowledge about the plastic changes of skeletal muscle after physical activity and the signaling factors that mediate the beneficial effects of exercise on other organs might yield a better understanding of the disease and open new avenues for treatment. Here, we discuss how current discoveries about the peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), a key exercise factor in muscle, and myokines, factors produced and secreted by active muscle fibers, expand our view of the pathological changes and the therapeutic options for sarcopenia.
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PGC-1α and PGC-1β activity decreases across ageing tissues.
“the activity of the master mitochondrial regulators PGC-1α and PGC-1β decreases across ageing tissues7,8.”
From Telomere dysfunction induces metabolic and mitochondrial compromise (2011) · cites this paper as [8]
Cites
2 retracted
Wenz, T., Rossi, S. G., Rotundo, R. L., Spiegelman, B. M., & Moraes, C. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911570106 · Cited by 600 · see citing works
RetractedWenz, T., Diaz, F., Spiegelman, B. M., & Moraes, C. T. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.006 · Cited by 297 · see citing works
RetractedTranscriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268 · see citing works
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · cited 1× · see citing works
“Interestingly though, in the endurance trained muscle, most signaling pathways that are activated subsequent to motor neuron activity, mechanical stress and altered nutrient and energy state converge on the peroxisome proliferator-activated receptor ? coactivator-1a (PGC-1a) by either inducing PPARGC1A gene expression…”
BackgroundSelf-citationInvited Review: Aging and sarcopenia
Doherty, T. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00347.2003 · Cited by 1,764 · see citing works
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
Finck, B. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27794 · Cited by 1,427 · see citing works
Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.013 · Cited by 1,162 · see citing works
Notch-Mediated Restoration of Regenerative Potential to Aged Muscle
Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121 · see citing works
Handschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0037 · Cited by 1,090 · see citing works
Self-citationThe role of exercise and PGC1α in inflammation and chronic disease
Handschin, C., & Spiegelman, B. M. (2008) · Nature · doi:10.1038/nature07206 · Cited by 1,083 · see citing works
Self-citationImmune function in sport and exercise
Gleeson, M. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00008.2007 · Cited by 1,016 · see citing works
Sandri, M., Lin, J., Handschin, C., Yang, W., Arany, Z. P., Lecker, S. H., Goldberg, A. L., & Spiegelman, B. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607795103 · Cited by 974 · see citing works
Self-citationLeone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951 · see citing works
Conboy, I. M., & Rando, T. A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00254-x · Cited by 905 · see citing works
Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle
Pilegaard, H., Saltin, B., & Neufer, P. D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034850 · Cited by 885 · see citing works
Signaling in Muscle Atrophy and Hypertrophy
Sandri, M. (2008) · Physiology · doi:10.1152/physiol.00041.2007 · Cited by 830 · see citing works
Handschin, C., Rhee, J., Lin, J., Tarr, P. T., & Spiegelman, B. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232352100 · Cited by 729 · see citing works
Self-citationThe diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk
Pedersen, B. K. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179515 · Cited by 631 · see citing works
Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., Rizza, R. A., Coenen-Schimke, J. M., & Nair, K. S. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1888 · Cited by 631 · see citing works
Handschin, C., Chin, S., Li, P., Liu, F., Maratos-Flier, E., LeBrasseur, N. K., Yan, Z., & Spiegelman, B. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704817200 · Cited by 611 · see citing works
Self-citationReview Article: Sarcopenia: Causes, Consequences, and Preventions
Marcell, T. J. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.10.m911 · Cited by 536 · see citing works
Aging, adiposity, and calorie restriction
Fontana, L. (2007) · JAMA · doi:10.1001/jama.297.9.986 · Cited by 526 · see citing works
Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy.
Booth, F., Chakravarthy, M., Gordon, S., & Spangenburg, E. (2002) · Journal of applied physiology · doi:10.1152/japplphysiol.00073.2002 · Cited by 467 · see citing works
Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness
Ryall, J. G., Schertzer, J. D., & Lynch, G. S. (2008) · Biogerontology · doi:10.1007/s10522-008-9131-0 · Cited by 423 · see citing works
Role of dietary protein in the sarcopenia of aging.
Paddon-Jones, D., Short, K., Campbell, W., Volpi, E., & Wolfe, R. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1562s · Cited by 403 · see citing works
Contraction-Induced Myokine Production and Release: Is Skeletal Muscle an Endocrine Organ?
Febbraio, M. A., & Pedersen, B. K. (2005) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200507000-00003 · Cited by 402 · see citing works
Roubenoff, R., Parise, H., Payette, H., Abad, L. W., D’Agostino, R. B., Jacques, P. F., Wilson, P. W. F., Dinarello, C. A., & Harris, T. B. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.05.001 · Cited by 397 · see citing works
Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α
Handschin, C., Lin, J. D., Rhee, J., Peyer, A., Chin, S., Wu, P., Meyer, U., & Spiegelman, B. M. (2005) · Cell · doi:10.1016/j.cell.2005.06.040 · Cited by 380 · see citing works
Self-citationAging, exercise, and muscle protein metabolism
Koopman, R., & van Loon, L. J. C. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91551.2008 · Cited by 371 · see citing works
A systematic look at an old problem
Kirkwood, T. B. L. (2008) · Nature · doi:10.1038/451644a · Cited by 365 · see citing works
PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophyPreprint
Handschin, C., Kobayashi, Y. M., Chin, S., Seale, P., Campbell, K. P., & Spiegelman, B. M. (2007) · Genes & Development · doi:10.1101/gad.1525107 · Cited by 355 · see citing works
Self-citationSkeletal muscle apoptosis, sarcopenia and frailty at old age
Marzetti, E., & Leeuwenburgh, C. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.08.011 · Cited by 346 · see citing works
Handschin, C., Choi, C. S., Chin, S., Kim, S., Kawamori, D., Kurpad, A. J., Neubauer, N., Hu, J., Mootha, V. K., Kim, Y.-B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31785 · Cited by 335 · see citing works
Self-citationFlück, M. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02149 · Cited by 303 · see citing works
Ling, C., Poulsen, P., Carlsson, E., Ridderstråle, M., Almgren, P., Wojtaszewski, J. F. P., Beck‐Nielsen, H., Groop, L., & Vaag, A. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421889 · Cited by 300 · see citing works
Ling, C., Poulsen, P., Carlsson, E., Ridderstråle, M., Almgren, P., Wojtaszewski, J., Beck-Nielsen, H., Groop, L., & Vaag, A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21889 · Cited by 300 · see citing works
Sarcopenia—consequences, mechanisms, and potential therapies
Greenlund, L. J. S. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00196-3 · Cited by 289 · see citing works
Sarcopenia: Effects on Body Composition and Function
Roubenoff, R. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.11.m1012 · Cited by 282 · see citing works
The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity
Hanai, J., Cao, P., Tanksale, P., Imamura, S., Koshimizu, E., Zhao, J., Kishi, S., Yamashita, M., Phillips, P. S., Sukhatme, V. P., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32741 · Cited by 281 · see citing works
The impact of sarcopenia and exercise training on skeletal muscle satellite cells
Snijders, T., Verdijk, L. B., & van Loon, L. J. C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.003 · Cited by 245 · see citing works
Edward F. Adolph Distinguished Lecture: Muscle as an endocrine organ: IL-6 and other myokines
Pedersen, B. K. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00734.2009 · Cited by 214 · see citing works
SIR2: a potential target for calorie restriction mimetics
Chen, D., & Guarente, L. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.004 · Cited by 185 · see citing works
Sarcopenia of aging: Underlying cellular mechanisms and protection by calorie restriction
Marzetti, E., Lees, H. A., Wohlgemuth, S. E., & Leeuwenburgh, C. (2009) · BioFactors · doi:10.1002/biof.5 · Cited by 182 · see citing works
Adipokines, Myokines and Cardiovascular Disease
Walsh, K. X. (2008) · Circulation Journal · doi:10.1253/circj.cj-08-0961 · Cited by 177 · see citing works
Resistance training, sarcopenia, and the mitochondrial theory of aging
Johnston, A. P. W., De Lisio, M., & Parise, G. (2008) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h07-141 · Cited by 174 · see citing works
Physical Activity, Inflammation, and Muscle Loss
Roubenoff, R. (2007) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00364.x · Cited by 142 · see citing works
Modulation of GH/IGF-1 axis: Potential strategies to counteract sarcopenia in older adults
Giovannini, S., Marzetti, E., Borst, S. E., & Leeuwenburgh, C. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.08.001 · Cited by 136 · see citing works
Leick, L., Lyngby, S. S., Wojtaszewski, J. F. P., & Pilegaard, H. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.011 · Cited by 116 · see citing works
Powerful signals for weak muscles
Saini, A., Faulkner, S., Al-Shanti, N., & Stewart, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.02.001 · Cited by 109 · see citing works
The biology of PGC-1α and its therapeutic potential
Handschin, C. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.03.006 · Cited by 108 · see citing works
Self-citationCalcineurin and skeletal muscle growth
Michel, R. N., Dunn, S. E., & Chin, E. R. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004362 · Cited by 107 · see citing works
Baker, D. J., Betik, A. C., Krause, D. J., & Hepple, R. T. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.7.675 · Cited by 89 · see citing works
Febbraio, M. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00414.2007 · Cited by 70 · see citing works
Prokopchuk, O., Liu, Y., Wang, L., WIRTH, K. J., Schmidtbleicher, D., & Steinacker, J. M. (2007) · PubMed · Cited by 56 · see citing works
Sarcopenia--A Critical Perspective
Hepple, R. T. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.46.pe31 · Cited by 52 · see citing works
Betik, A. C., Thomas, M. M., Wright, K. J., Riel, C. D., & Hepple, R. T. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90959.2008 · Cited by 52 · see citing works
Handschin, C. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05275.x · Cited by 38 · see citing works
Self-citationCaloric Restriction and Longevity
Mehta, L. H., & Roth, G. S. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04409.x · Cited by 28 · see citing works
Live Fast, Die Young: New Lessons in Mammalian Longevity
Cox, L. S. (2009) · Rejuvenation Research · doi:10.1089/rej.2009.0894 · Cited by 12 · see citing works
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Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319 · see citing works
Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226 · see citing works
“The role of myokines has previously been reviewed (7, 11-37), identifying more than 650 myokines (38).”
BackgroundSarcopenia: Definition, Epidemiology, and Pathophysiology
Kim, T. N., & Choi, K. M. (2013) · Journal of Bone Metabolism · doi:10.11005/jbm.2013.20.1.1 · Cited by 505 · see citing works
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise
Schnyder, S., & Handschin, C. (2015) · Bone · doi:10.1016/j.bone.2015.02.008 · Cited by 419 · see citing works
Self-citationBiolo, G., Cederholm, T., & Muscaritoli, M. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.03.007 · Cited by 406 · see citing works
Role of PGC-1α Signaling in Skeletal Muscle Health and Disease
Kang, C., & Li Ji, L. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06738.x · Cited by 291 · see citing works
The influence of skeletal muscle on systemic aging and lifespan
Demontis, F., Piccirillo, R., Goldberg, A. L., & Perrimon, N. (2013) · Aging Cell · doi:10.1111/acel.12126 · Cited by 238 · see citing works
Pharmacologic Options for the Treatment of Sarcopenia
Morley, J. E. (2016) · Calcified Tissue International · doi:10.1007/s00223-015-0022-5 · Cited by 225 · see citing works
Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
Valerio, A., D'Antona, G., & Nisoli, E. (2011) · Aging · doi:10.18632/aging.100322 · Cited by 196 · see citing works
Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
Goodman, C. A., Mayhew, D. L., & Hornberger, T. A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.07.013 · Cited by 178 · see citing works
Exercise-induced hormesis and skeletal muscle health
Ji, L. L., Kang, C., & Zhang, Y. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.025 · Cited by 176 · see citing works
Mitochondria and PGC-1α in Aging and Age-Associated Diseases
Wenz, T. (2011) · Journal of Aging Research · doi:10.4061/2011/810619 · Cited by 149 · see citing works
The many roles of PGC-1α in muscle — recent developments
Chan, M. C., & Arany, Z. P. (2014) · Metabolism · doi:10.1016/j.metabol.2014.01.006 · Cited by 125 · see citing works
Thyroid Hormone Signaling and Homeostasis During Aging
Bowers, J., Terrien, J., Clerget-Froidevaux, M. S., Gothié, J. D., Rozing, M. P., Westendorp, R. G. J., van Heemst, D., & Demeneix, B. A. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1056 · Cited by 117 · see citing works
Muscle-Organ Crosstalk: Focus on Immunometabolism
Bay, M. L., & Pedersen, B. K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.567881 · Cited by 110 · see citing works
Autophagy as a Potential Target for Sarcopenia: AUTOPHAGY REGULATION IN SARCOPENIA
Fan, J., Kou, X., Jia, S., Yang, X., Yang, Y., & Chen, N. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25260 · Cited by 101 · see citing works
Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse
Dillon, L. M., Williams, S. L., Hida, A., Peacock, J. D., Prolla, T. A., Lincoln, J., & Moraes, C. T. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds049 · Cited by 98 · see citing works
Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α
Arnold, A., Gill, J. F., Christe, M., Ruiz, R., McGuirk, S., St‐Pierre, J., Tabares, L., & Handschin, C. (2014) · Nature Communications · doi:10.1038/ncomms4569 · Cited by 91 · see citing works
Self-citationMyokines, physical activity, insulin resistance and autoimmune diseases
Díaz, B. B., González, D. A., Gannar, F., Pérez, M. C. R., & de León, A. C. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.09.002 · Cited by 82 · see citing works
Immune and Neuroprotective Effects of Physical Activity on the Brain in Depression
Phillips, C., & Fahimi, A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00498 · Cited by 83 · see citing works
The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective
Franceschi, C., Ostan, R., Mariotti, S., Monti, D., & Vitale, G. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00170 · Cited by 72 · see citing works
Sellami, M., Bragazzi, N. L., Aboghaba, B., & Elrayess, M. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.631873 · Cited by 61 · see citing works
Kelly, D. P. (2011) · Nature · doi:10.1038/nature09896 · Cited by 57 · see citing works
Bonuccelli, G., Peiris‐Pagès, M., Ózsvári, B., Martinez‐Outschoorn, U., Sotgia, F., & Lisanti, M. P. (2016) · Oncotarget · doi:10.18632/oncotarget.14196 · Cited by 55 · see citing works
Mormeneo, E., Jimenez-Mallebrera, C., Palomer, X., Nigris, V. D., Vázquez‐Carrera, M., Orozco, A., Nascimento, A., Colomer, J., Lerín, C., & Gómez-Foix, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029985 · Cited by 54 · see citing works
Serum C1q as a novel biomarker of sarcopenia in older adults
Watanabe, S., Sato, K., Hasegawa, N., Kurihara, T., Matsutani, K., Sanada, K., Hamaoka, T., Fujita, S., & Iemitsu, M. (2014) · The FASEB Journal · doi:10.1096/fj.14-262154 · Cited by 54 · see citing works
Redox Signaling and Sarcopenia: Searching for the Primary Suspect
Foreman, N. A., Hesse, A. S., & Ji, L. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169045 · Cited by 52 · see citing works
Sarcopenia – Endocrinological and Neurological Aspects
Stangl, M. K., Böcker, W., Chubanov, V., Ferrari, U., Fischereder, M., Gudermann, T. W., Hesse, E., Meinke, P., Reincke, M., Reisch, N., et al. (2018) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0672-1007 · Cited by 54 · see citing works
External physical and biochemical stimulation to enhance skeletal muscle bioengineering
Handschin, C., Mortezavi, A., Plock, J. A., & Eberli, D. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.10.021 · Cited by 48 · see citing works
Self-citationQuinn, L. S., Anderson, B. G., Conner, J. D., Wolden-Hanson, T., & Marcell, T. J. (2014) · Endocrinology · doi:10.1210/en.2013-1645 · Cited by 40 · see citing works
Yang, B., Yang, X., Sun, X., Shi, J., Shen, Y., & Chen, R. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9148246 · Cited by 39 · see citing works
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Ji, L. L., & Zhang, Y. (2013) · Free Radical Research · doi:10.3109/10715762.2013.844341 · Cited by 39 · see citing works
The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling
Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo‐Mallafré, V., Fernández‐Veledo, S., Vendrell, J. J., et al. (2018) · Metabolism · doi:10.1016/j.metabol.2018.03.005 · Cited by 38 · see citing works
Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway
Kim, H., Cho, S. C., Jeong, H., Lee, H., Jeong, M., Pyun, J., Ryu, D., Kim, M., Lee, Y., Kim, M. S., et al. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12558 · Cited by 37 · see citing works
Role of PGC-1α in muscle function and aging
Kang, C., & Ji, L. L. (2013) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2013.03.005 · Cited by 37 · see citing works
(Pro)renin receptor accelerates development of sarcopenia via activation of Wnt/YAP signaling axis
Yoshida, N., Endo, J., Kinouchi, K., Kitakata, H., Moriyama, H., Kataoka, M., Yamamoto, T., Shirakawa, K., Morimoto, S., Nishiyama, A., et al. (2019) · Aging Cell · doi:10.1111/acel.12991 · Cited by 32 · see citing works
Thornton, S. M., Krolopp, J. E., & Abbott, M. J. (2016) · PPAR Research · doi:10.1155/2016/5465804 · Cited by 31 · see citing works
Jia, X., Nie, Q. H., Lamont, S. J., & Zhang, X. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.221 · Cited by 29 · see citing works
Torabi, A., Reisi, J., Kargarfard, M., & Mansourian, M. (2024) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_76_23 · Cited by 28 · see citing works
The Impact of CRISPR-Cas9 on Age-related Disorders: From Pathology to Therapy
Caobi, A., Dutta, R. K., Garbinski, L. D., Esteban-López, M., Ceyhan, Y., Andre, M., Manevski, M., Ojha, C. R., Lapierre, J., Tiwari, S., et al. (2020) · Aging and Disease · doi:10.14336/ad.2019.0927 · Cited by 24 · see citing works
Bae, J., Jo, A., Cho, S. C., Lee, Y., Kam, T., You, C.-L., Jeong, H., Kim, H., Jeong, M., Jeong, Y., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abh3489 · Cited by 23 · see citing works
Drosophila exercise, an emerging model bridging the fields of exercise and aging in human
Ding, M., Li, H., & Zheng, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.966531 · Cited by 17 · see citing works
Ghanemi, A., Yoshioka, M., & St‐Amand, J. (2023) · Diseases · doi:10.3390/diseases11010033 · Cited by 17 · see citing works
The Association of Nutrition Quality with Frailty Syndrome among the Elderly
Rolf, K., Santoro, A., Martucci, M., & Pietruszka, B. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063379 · Cited by 12 · see citing works
Bonnet, M., Tournayre, J., & Cassar‐Malek, I. (2016) · Molecular BioSystems · doi:10.1039/c6mb00224b · Cited by 12 · see citing works
Hayashi, F., Kaibori, M., Sakaguchi, T., Matsui, K., Ishizaki, M., Kwon, A., Iwasaka, J., Kimura, Y., & Habu, D. (2017) · Hepatology Research · doi:10.1111/hepr.13000 · Cited by 12 · see citing works
Kikuchi, R., Takoi, H., Ishiwari, M., Toriyama, K., Kono, Y., Togashi, Y., & Abe, S. (2021) · Thoracic Cancer · doi:10.1111/1759-7714.14294 · Cited by 11 · see citing works
Dai, Y., Zhao, C., Liang, X., Dai, R., & Dong, F. (2015) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201400423 · Cited by 5 · see citing works
Sarkopenia pada Lansia: Problem Diagnosis dan Tatalaksana
Sanglah, R., & Aryana, I. G. P. S. (2021) · Baswara Press eBooks · doi:10.53638/9786239795580 · Cited by 5 · see citing works
Lynch, G. S. (2010) · Springer eBooks · doi:10.1007/978-90-481-9713-2_1 · Cited by 5 · see citing works
The application of life style diseases-animal models to the research for sarcopenia
Sugimoto, K. (2013) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.50.766 · Cited by 4 · see citing works
Generalidades y tratamiento de la Sarcopenia
de Cuba, M. D. S. P., Hernández‐Rodríguez, J., Licea-Puig, M. E., & de Cuba, M. D. S. P. (2017) · Revista Médicas UIS · doi:10.18273/revmed.v30n2-2017008 · Cited by 4 · see citing works
The role of mitochondrial function in skeletal muscle and myokines in the pathogenesis of sarcopenia
Sugimoto, K. (2012) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.49.199 · Cited by 2 · see citing works
Is Sarcopenia a Geriatric Syndrome?
Michel, J., & Cruz-Jentoft, A. J. (2012) · doi:10.1002/9781118338032.ch7
DiMauro, S., Schon, E. A., & Hirano, M. (2011) · doi:10.1002/9781444398311.ch4
Skład ciała i zaburzenia depresyjne u osób z zespołem metabolicznym po 55. roku życia
Anna, K., Bażydło, M., Zabielska, P., Karakiewicz, B., & Lubkowska, A. (2016) · Family Medicine & Primary Care Review
Impact of Sarcopenia in Healthy Aging and Suggested Interventions
Erdoğan, T., Bahat, G., & Karan, M. A. (2018) · Springer eBooks · doi:10.1007/978-981-13-1699-9_20
Angewandte Biochemie VII: Genetisches Maximum
Michalk, C. (2019) · Springer eBooks · doi:10.1007/978-3-662-58231-2_10
Wiek i aktywność fizyczna mężczyzn w czasie wolnym a ich sprawność fizyczna
Jopkiewicz, A., & Bogdan, N. S. (2018) · Rocznik Lubuski.
Role of Antioxidant Signaling in Mitochondrial Adaptation to Muscle Contraction
Ji, L. L. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_195
Ji, L. L., & Yeo, D. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_437
Ji, L. L., & Yeo, D. (2020) · Springer eBooks · doi:10.1007/978-3-319-69892-2_437-1
Aqua Jogging Moderate Intensity Training is Conditioning a Sense of Well-being in Seniors
Krawczyk-Suszek, M., Banaś, A., & Martowska, B. (2022) · Journal of Health Study and Medicine · doi:10.2478/jhsm-2022-0002
Beyer, L. (2024) · Manuelle Medizin · doi:10.1007/s00337-024-01037-1
UTSUMI, Y., TAKASE, K., Murakami, N., NAKAGAWA, T., OBAYASHI, T., Ogura, R., & Hosokawa, S. (2024) · Physical Therapy Research · doi:10.1298/ptr.e10286
- Authors
- Arnold, A.-S., Egger, A., & Handschin, C.
- Affiliations
- University of Basel (CH)
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 2010-02-04
- Volume
- 57
- Issue
- 1
- Pages
- 37-43
- ISSN
- 0304-324X (ISSN-L)
- 1423-0003
- OpenAlex
- W2048210492
- Cited by
- 65
- References
- 59
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 5
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gerontology (publishedVersion)
- PubMed (publishedVersion)
- edoc (University of Basel) (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- PGC-1α, myokines, sarcopenia, muscle aging, physical activity, skeletal muscle plasticity, age-related frailty, muscle mass loss, exercise therapy
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Aged, Aging, Exercise Therapy, Heat-Shock Proteins, Humans, Models, Biological, Muscle Proteins, Transcription Factors, Muscle, Skeletal, Sarcopenia
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