Cited by 81Gut microbiota and healthEscherichia coli research studiesClostridium difficile and Clostridium perfringens research

Enteric pathogen exploitation of the microbiota-generated nutrient environment of the gut

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Keeney, Kristie M, Finlay, B Brett·2011·Current Opinion in Microbiology

Abstract

Residing within the intestine is a large community of commensal organisms collectively termed the microbiota. This community generates a complex nutrient environment by breaking down indigestible food products into metabolites that are used by both the host and the microbiota. Both the invading intestinal pathogen and the microbiota compete for these metabolites, which can shape both the composition of the flora, as well as susceptibility to infection. After infection is established, pathogen mediated inflammation alters the composition of the microbiota, which further shifts the makeup of metabolites in the gastrointestinal tract. A greater understanding of the interplay between the microbiota, the metabolites they generate, and susceptibility to enteric disease will enable the discovery of novel therapies against infectious disease.

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Authors
Keeney, K. M., & Finlay, B. B.
Affiliations
University of British Columbia (CA)
Venue
Current Opinion in Microbiology
Publisher
Elsevier BV
Published
2011-02
Volume
14
Issue
1
Pages
92-98
ISSN
1369-5274 (ISSN-L)
OpenAlex
W1971280478
Cited by
81
References
55
Citations by year
2026: 1 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 7
FWCI
0.78
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (F32AI085761)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
  • Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Keywords
gut microbiota, enteric pathogens, microbial metabolites, host-microbe interactions, nutrient competition, infection susceptibility, intestinal inflammation, microbiota composition, enteric disease, host defense against infection
MeSH terms
Animals, Bacteria, Humans, Nutritional Physiological Phenomena, Virulence, Gastrointestinal Tract, Metagenome

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