Enteric pathogen exploitation of the microbiota-generated nutrient environment of the gut
Open accessAbstract
Residing within the intestine is a large community of commensal organisms collectively termed the microbiota. This community generates a complex nutrient environment by breaking down indigestible food products into metabolites that are used by both the host and the microbiota. Both the invading intestinal pathogen and the microbiota compete for these metabolites, which can shape both the composition of the flora, as well as susceptibility to infection. After infection is established, pathogen mediated inflammation alters the composition of the microbiota, which further shifts the makeup of metabolites in the gastrointestinal tract. A greater understanding of the interplay between the microbiota, the metabolites they generate, and susceptibility to enteric disease will enable the discovery of novel therapies against infectious disease.
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Bacteria compete for carbon and nitrogen sources that are essential to support their growth within the intestine.
“Bacteria compete for carbon and nitrogen sources that are essential to support their growth within the intestine [66–68].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [68]
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Cites
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · cited 2× · see citing works
“Metabolic function of the host microbiota The resident microbiota of the human gastrointestinal (GI) tract is incredibly dense and diverse, containing as many as 10(12) organisms per gram [1].”
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works
Colonic Health: Fermentation and Short Chain Fatty Acids
Wong, J. M. W., de Souza, R., Kendall, C. W. C., Emam, A., & Jenkins, D. J. A. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00015 · Cited by 2,739 · see citing works
Human gut microbiota in obesity and after gastric bypass
Zhang, H., DiBaise, J. K., Zuccolo, A., Kudrna, D., Braidotti, M., Yu, Y., Parameswaran, P., Crowell, M. D., Wing, R., Rittmann, B. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812600106 · Cited by 1,880 · see citing works
The control and consequences of bacterial fermentation in the human colon
Cummings, J. H., & Macfarlane, G. T. (1991) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1991.tb02739.x · Cited by 1,499 · see citing works
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310 · see citing works
Self-citationGut inflammation provides a respiratory electron acceptor for Salmonella
Winter, S., Thiennimitr, P., Winter, M. G., Butler, B. P., Huseby, D. L., Crawford, R. W., Russell, J. M., Bevins, C. L., Adams, L. G., Tsolis, R. M., et al. (2010) · Nature · doi:10.1038/nature09415 · Cited by 1,271 · see citing works
Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens
Servin, A. L. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.01.003 · Cited by 1,234 · see citing works
Molecular mechanisms of Escherichia coli pathogenicity
Croxen, M. A., & Finlay, B. B. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2265 · Cited by 1,222 · see citing works
Self-citationTransfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota
Hehemann, J.-H., Correc, G., Barbeyron, T., Helbert, W., Czjzek, M., & Michel, G. (2010) · Nature · doi:10.1038/nature08937 · Cited by 1,117 · see citing works
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer
Deplancke, B., & Gaskins, H. R. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1131s · Cited by 1,012 · see citing works
Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux
Wang, Q., Zhang, Y., Yang, C., Xiong, H., Lin, Y., Yao, J., Li, H., Xie, L., Zhao, W., Yao, Y., et al. (2010) · Science · doi:10.1126/science.1179687 · Cited by 1,008 · see citing works
Elder, R., Keen, J., Siragusa, G., Barkocy-Gallagher, G. A., Koohmaraie, M., & Laegreid, W. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.7.2999 · Cited by 952 · see citing works
Sonnenburg, E. D., Zheng, H., Joglekar, P., Higginbottom, S. K., Firbank, S. J., Bolam, D. N., & Sonnenburg, J. L. (2010) · Cell · doi:10.1016/j.cell.2010.05.005 · Cited by 745 · see citing works
Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla
Mahowald, M. A., Rey, F. E., Seedorf, H., Turnbaugh, P. J., Fulton, R. S., Wollam, A., Shah, N., Wang, C., Magrini, V. J., Wilson, R. K., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901529106 · Cited by 737 · see citing works
Identifying Genetic Determinants Needed to Establish a Human Gut Symbiont in Its Habitat
Goodman, A. L., McNulty, N. P., Zhao, Y., Leip, D., Mitra, R. D., Lozupone, C., Knight, R. D., & Gordon, J. I. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.08.003 · Cited by 713 · see citing works
Schroeckh, V., Scherlach, K., Nützmann, H., Shelest, E., Schmidt‐Heck, W., Schuemann, J., Martin, K., Hertweck, C., & Brakhage, A. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901870106 · Cited by 662 · see citing works
Adaptive prediction of environmental changes by microorganisms
Mitchell, A., Romano, G. H., Groisman, B., Yona, A., Dekel, E., Kupiec, M., Dahan, O., & Pilpel, Y. (2009) · Nature · doi:10.1038/nature08112 · Cited by 581 · see citing works
Rossi, M., Corradini, C., Amaretti, A., Nicolini, M., Pompei, A., Zanoni, S., & Matteuzzi, D. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.10.6150-6158.2005 · Cited by 546 · see citing works
Predictive Behavior Within Microbial Genetic Networks
Tagkopoulos, I., Liu, Y.-C., & Tavazoie, S. (2008) · Science · doi:10.1126/science.1154456 · Cited by 519 · see citing works
Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease
Jansson, J. K., Willing, B. P., Lucio, M., Fekete, A., Dicksved, J., Halfvarson, J., Tysk, C., & Schmitt‐Kopplin, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006386 · Cited by 512 · see citing works
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.08.002 · Cited by 501 · see citing works
Self-citationSekirov, I., Tam, N. M., Jogova, M., Robertson, M. L., Li, Y., Lupp, C., & Finlay, B. B. (2008) · Infection and Immunity · doi:10.1128/iai.00319-08 · Cited by 483 · see citing works
Self-citationGut microbiota: a potential new territory for drug targeting
Jia, W. P., Li, H., Zhao, L., & Nicholson, J. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2505 · Cited by 471 · see citing works
Stecher, B., Chaffron, S., Käppeli, R., Hapfelmeier, S., Freedrich, S., Weber, T. C., Kirundi, J., Suar, M., McCoy, K. D., von Mering, C., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000711 · Cited by 421 · see citing works
Hendrixson, D. R., & DiRita, V. J. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.03988.x · Cited by 401 · see citing works
Butyrate Specifically Down-Regulates Salmonella Pathogenicity Island 1 Gene Expression
Gantois, I., Ducatelle, R., Pasmans, F., Haesebrouck, F., Hautefort, I., Thompson, A., Hinton, J. C. D., & Immerseel, F. V. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.1.946-949.2006 · Cited by 378 · see citing works
Endt, K., Stecher, B., Chaffron, S., Slack, E. M. C., Tchitchek, N., Benecke, A., Maele, L. V., Sirard, J., Müller, A. J., Heikenwälder, M. F., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001097 · Cited by 340 · see citing works
Survival and Implantation of <i>Escherichia coli</i> in the Intestinal Tract
Freter, R., Brickner, H., Fekete, J., Vickerman, M. M., & Carey, K. E. (1983) · Infection and Immunity · doi:10.1128/iai.39.2.686-703.1983 · Cited by 318 · see citing works
Exploitation of the Intestinal Microflora by the Parasitic Nematode Trichuris muris
Hayes, K. S., Bancroft, A. J., Goldrick, M., Portsmouth, C., Roberts, I. S., & Grencis, R. K. (2010) · Science · doi:10.1126/science.1187703 · Cited by 316 · see citing works
Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation
Crawford, P. A., Crowley, J. R., Sambandam, N., Muegge, B. D., Costello, E. K., Hamady, M., Knight, R., & Gordon, J. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902366106 · Cited by 278 · see citing works
Sites of organic acid production and absorption in gastrointestinal tract of the pig
Argenzio, R., & Southworth, M. (1975) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1975.228.2.454 · Cited by 269 · see citing works
Revisiting the host as a growth medium
Brown, S. A., Palmer, K. L., & Whiteley, M. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1955 · Cited by 208 · see citing works
Schild, S., Tamayo, R., Nelson, E. J., Qadri, F., Calderwood, S. B., & Camilli, A. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.09.004 · Cited by 188 · see citing works
Elder, R. O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.060024897 · Cited by 161 · see citing works
Regulation of virulence by butyrate sensing in enterohaemorrhagic Escherichia coli
Nakanishi, N., Tashiro, K., Kuhara, S., Hayashi, T., Sugimoto, N., & Tobe, T. (2009) · Microbiology · doi:10.1099/mic.0.023499-0 · Cited by 156 · see citing works
Velayudhan, J., Jones, M. A., Barrow, P., & Kelly, D. J. (2003) · Infection and Immunity · doi:10.1128/iai.72.1.260-268.2004 · Cited by 152 · see citing works
Chemical sensing in mammalian host–bacterial commensal associations
Hughes, D. T., Terekhova, D. A., Liou, L. E., Hovde, C. J., Sahl, J. W., Patankar, A. V., González, J. E., Edrington, T. S., Rasko, D. A., & Sperandio, V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002551107 · Cited by 149 · see citing works
Garner, C. D., Antonopoulos, D. A., Wagner, B., Duhamel, G. E., Keresztes, I., Ross, D. A., Young, V. B., & Altier, C. (2009) · Infection and Immunity · doi:10.1128/iai.01570-08 · Cited by 134 · see citing works
Glycogen and Maltose Utilization by Escherichia coli O157:H7 in the Mouse Intestine
Jones, S. A., Jørgensen, M. J., Chowdhury, F. Z., Rodgers, R., Hartline, J., Leatham, M. P., Struve, C., Krogfelt, K. A., Cohen, P. S., & Conway, T. (2008) · Infection and Immunity · doi:10.1128/iai.00096-08 · Cited by 130 · see citing works
Effect of Bifidobacterium longum ingestion on experimental salmonellosis in mice
Silva, A. M., Barbosa, F. H. F., Duarte, R., Vieira, L. Q., Arantes, R. M. E., & Nicoli, J. R. (2004) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2004.02265.x · Cited by 111 · see citing works
de Sablet, T., Chassard, C., Bernalier‐Donadille, A., Vareille-Delarbre, M., Gobert, A. P., & Martin, C. (2008) · Infection and Immunity · doi:10.1128/iai.01048-08 · Cited by 110 · see citing works
Kantor, B., Ma, H., Webster-Cyriaque, J. Y., Monahan, P. E., & Kafri, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905859106 · Cited by 98 · see citing works
Formate Acts as a Diffusible Signal To InduceSalmonellaInvasion
Huang, Y., Suyemoto, M. M., Garner, C. D., et al. (2008) · Journal of Bacteriology · doi:10.1128/jb.00205-08 · Cited by 97 · see citing works
Energy Taxis Drives Campylobacter jejuni toward the Most Favorable Conditions for Growth
Vegge, C. S., Brøndsted, L., Li, Y., Bang, D. D., & Ingmer, H. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00287-09 · Cited by 95 · see citing works
Possemiers, S., Grootaert, C., Vermeiren, J., Gross, G., Marzorati, M., Verstraete, W., & de Wiele, T. V. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788489159 · Cited by 91 · see citing works
Genome Scale Reconstruction of a Salmonella Metabolic Model
AbuOun, M., Suthers, P. F., Jones, G. I., Carter, B., Saunders, M. P., Maranas, C. D., Woodward, M. J., & Anjum, M. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.005868 · Cited by 90 · see citing works
Petersen, A., Heegaard, P. M. H., Pedersen, A., Andersen, J. B., Sørensen, R. B., Frøkiær, H., Lahtinen, S. J., Ouwehand, A. C., Poulsen, M., & Licht, T. R. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-245 · Cited by 71 · see citing works
Lærke, H. N., Jensen, B. B., & Højsgaard, S. (2000) · Journal of Nutrition · doi:10.1093/jn/130.7.1772 · Cited by 67 · see citing works
Truusalu, K., Mikelsaar, R.-H., Naaber, P., Karki, T., Kullisaar, T., Zilmer, M., & Mikelsaar, M. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-132 · Cited by 58 · see citing works
Alpert, C., Scheel, J., Engst, W., Loh, G., & Blaut, M. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2008.01798.x · Cited by 33 · see citing works
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- Authors
- Keeney, K. M., & Finlay, B. B.
- Affiliations
- University of British Columbia (CA)
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 14
- Issue
- 1
- Pages
- 92-98
- ISSN
- 1369-5274 (ISSN-L)
- PMC
- PMC3039043
- OpenAlex
- W1971280478
- Cited by
- 81
- References
- 55
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (F32AI085761)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- gut microbiota, enteric pathogens, microbial metabolites, host-microbe interactions, nutrient competition, infection susceptibility, intestinal inflammation, microbiota composition, enteric disease, host defense against infection
- MeSH terms
- Animals, Bacteria, Humans, Nutritional Physiological Phenomena, Virulence, Gastrointestinal Tract, Metagenome
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