The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Mucosal biofilms of Candida albicans
Open accessAbstract
Biofilms are microbial communities that form on surfaces and are embedded in an extracellular matrix. C. albicans forms pathogenic mucosal biofilms that are evoked by changes in host immunity or mucosal ecology. Mucosal surfaces are inhabited by many microbial species; hence these biofilms are polymicrobial. Several recent studies have applied paradigms of biofilm analysis to study mucosal C. albicans infections. These studies reveal that the Bcr1 transcription factor is a master regulator of C. albicans biofilm formation under diverse conditions, though the most relevant Bcr1 target genes can vary with the biofilm niche. An important determinant of mucosal biofilm formation is the interaction with host defenses. Finally, studies of interactions between bacterial species and C. albicans provide insight into the communication mechanisms that endow polymicrobial biofilms with unique properties.
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“In this review, we focus on C. albicans biofilms, which colonize implanted medical devices and mucosal surfaces, from which they can seed systemic infections in humans (46, 47, 64, 89, 97, 161, 172).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [64]
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“It is a member of the healthy microbiota, asymptomatically colonizing the gastrointestinal (GI) tract, reproductive tract, oral cavity, and skin of most humans (1, 64, 87, 97, 99).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [64]
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Cites
Lewis, K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134306 · Cited by 1,858
Survival strategies of infectious biofilms
Fux, C. A., Costerton, J. W., Stewart, P. S., & Stoodley, P. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.11.010 · Cited by 1,797
Characterization of the oral fungal microbiome (mycobiome) in healthy individuals
Ghannoum, M. A., Jurevic, R. J., Mukherjee, P. K., Cui, F., Sikaroodi, M., Naqvi, A., & Gillevet, P. M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000713 · Cited by 1,150
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Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
Onishi, R. M., & Gaffen, S. L. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03240.x · Cited by 894
Vulvovaginal candidiasis: Epidemiologic, diagnostic, and therapeutic considerations
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Oral Biofilm Architecture on Natural Teeth
Zijnge, V., van Leeuwen, M. B. M., Degener, J. E., Abbas, F., Thurnheer, T., Gmür, R., & Harmsen, H. J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009321 · Cited by 689
Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1.
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Genetic control of Candida albicans biofilm development
Finkel, J. S., & Mitchell, A. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2475 · Cited by 641
Self-citationMedically important bacterial-fungal interactions
Peleg, A. Y., Hogan, D. A., & Mylonakis, E. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2313 · Cited by 619
Cited by
Sorted by citations
Sardi, J. C. O., Scorzoni, L., Bernardi, T., Fusco-Almeida, A. M., & Mendes Giannini, M. J. S. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.045054-0 · Cited by 1,184
Candida albicans Biofilms and Human Disease
Nobile, C. J., & Johnson, A. D. (2015) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104330 · Cited by 1,057
Candida albicans—The Virulence Factors and Clinical Manifestations of Infection
Talapko, J., Juzbašić, M., Matijević, T., Pustijanac, E., Bekić, S., Kotris, I., & Škrlec, I. (2021) · Journal of Fungi · doi:10.3390/jof7020079 · Cited by 794
“Als3 which is the target of Bcr1 plays a crucial role in the formation of biofilm on the abiotic surface [43].”
BackgroundCandida albicans biofilms: development, regulation, and molecular mechanisms
Gulati, M., & Nobile, C. J. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.01.002 · Cited by 738
Candida Biofilms: Threats, Challenges, and Promising Strategies
Cavalheiro, M., & Teixeira, M. C. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00028 · Cited by 690
Metadata
- Authors
- Ganguly, S., & Mitchell, A. P.
- Affiliations
- Carnegie Mellon University (US)
- Corresponding author
- Mitchell, Aaron P
- ORCID
- Mitchell, Aaron P
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 14
- Issue
- 4
- Pages
- 380-385
- ISSN
- 1369-5274 (ISSN-L)
- PMC
- PMC3159763
- OpenAlex
- W1994403582
- Cited by
- 200
- References
- 59
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 7 · 2023: 15 · 2022: 15 · 2021: 16 · 2020: 20 · 2019: 15 · 2018: 17 · 2017: 19 · 2016: 14 · 2015: 14 · 2014: 12 · 2013: 13 · 2012: 7
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01 AI067703)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Candida albicans, biofilm formation, host-pathogen interaction, polymicrobial biofilms, extracellular matrix, host immunity, fungal virulence
- MeSH terms
- Candida albicans, Candidiasis, Oral, Candidiasis, Vulvovaginal, Female, Genes, Fungal, Humans, Immunity, Innate, Mucous Membrane, Stomatitis, Denture, Transcription Factors, Gene Expression Regulation, Fungal, Biofilms, Host-Pathogen Interactions
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