Candida Biofilms: Threats, Challenges, and Promising Strategies

Cavalheiro, Mafalda; Teixeira, Miguel Cacho

doi:10.3389/fmed.2018.00028

Cited by 690Antifungal resistance and susceptibilityFungal and yeast genetics researchBacterial biofilms and quorum sensing

Candida Biofilms: Threats, Challenges, and Promising Strategies

Open access

Cavalheiro, Mafalda, Teixeira, Miguel Cacho·2018·Frontiers in Medicine

DOI 10.3389/fmed.2018.00028PMC PMC5816785

Open this paper in CoChat — free account Open PDF

Abstract

Candida species are fungal pathogens known for their ability to cause superficial and systemic infections in the human host. These pathogens are able to persist inside the host due to the development of pathogenicity and multidrug resistance traits, often leading to the failure of therapeutic strategies. One specific feature of Candida species pathogenicity is their ability to form biofilms, which protects them from external factors such as host immune system defences and antifungal drugs. This review focuses on the current threats and challenges when dealing with biofilms formed by Candida albicans, Candida glabrata, Candida tropicalis and Candida parapsilosis, highlighting the differences between the four species. Biofilm characteristics depend on the ability of each species to produce extracellular polymeric substances (EPS) and display dimorphic growth, but also on the biofilm substratum, carbon source and other factors. Additionally, the transcriptional control over processes like adhesion, biofilm formation, filamentation and EPS production displays great complexity and diversity within pathogenic yeasts of the Candida genus. These differences not only have implications in the persistence of colonization and infections, but also on antifungal resistance typically found in Candida biofilm cells, potentiated by EPS, that functions as a barrier to drug diffusion, and by the overexpression of drug resistance transporters. The ability to interact with different species in in vivo Candida biofilms is also a key factor to consider when dealing with this problem. Despite many challenges, the most promising strategies that are currently available or under development to limit biofilm formation or to eradicate mature biofilms are discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fmed.2018.00028

Cites

163 of 163 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Biofilms are known to hinder the penetration of antifungal drugs and host immune effectors and also trigger the formation of Candida persister cells, leading to poor clinical outcomes.
“biofilms are known to hinder the penetration of antifungal drugs and host immune effectors and also trigger the formation of Candida persister cells, leading to poor clinical outcomes [52,53].”
From Aprepitant, an antiemetic agent, interferes with metal ion homeostasis ofCandida aurisand displays potent synergistic interactions with azole drugs (2020) · cites this paper as [52]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The biofilm matrix
Flemming, H.-C., & Wingender, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2415 · Cited by 10,137 · see citing works
Biofilm formation as microbial development
O'Toole, G., Kaplan, H. B., & Kolter, R. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.49 · Cited by 3,571 · see citing works
Persister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052 · see citing works
Riddle of Biofilm Resistance
Lewis, K. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.4.999-1007.2001 · Cited by 1,988 · see citing works
Biofilm Formation by the Fungal Pathogen Candida albicans : Development, Architecture, and Drug Resistance
Chandra, J., Kuhn, D. M., Mukherjee, P. K., Hoyer, L. L., McCormick, T., & Ghannoum, M. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.18.5385-5394.2001 · Cited by 1,578 · see citing works
Guidelines for the management of intravascular catheter-related infections
Mermel, L. A., Farr, B. M., Sherertz, R. J., Raad, I. I., O'Grady, N., Harris, J. S., & Craven, D. E. (2001) · Clinical Infectious Diseases · doi:10.1086/320001 · Cited by 1,449 · see citing works
Biofilms and Device-Associated Infections
Donlan, R. M. (2001) · Emerging infectious diseases · doi:10.3201/eid0702.010226 · Cited by 1,425 · see citing works
Candida biofilms and their role in infection
Douglas, L. J. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(02)00002-1 · Cited by 1,150 · see citing works
Candida Infections of Medical Devices
Kojic, E. M., & Darouiche, R. O. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.255-267.2004 · Cited by 1,055 · see citing works
Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol
Hornby, J. M., Jensen, E. C., Lisec, A. D., Tasto, J. J., Jahnke, B., Shoemaker, R., Dussault, P., & Nickerson, K. W. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.7.2982-2992.2001 · Cited by 983 · see citing works
Poly-ε-caprolactone Coated and Functionalized Porous Titanium and Magnesium Implants for Enhancing Angiogenesis in Critically Sized Bone Defects
Roland, L., Grau, M., Matena, J., Teske, M., Gieseke, M., Kampmann, A., Beyerbach, M., Escobar, H. M., Haferkamp, H., Gellrich, N., et al. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms17010001 · Cited by 862 · see citing works
Antifungal Susceptibility of Candida Biofilms: Unique Efficacy of Amphotericin B Lipid Formulations and Echinocandins
Kuhn, D. M., George, T., Chandra, J., Mukherjee, P. K., & Ghannoum, M. A. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1773-1780.2002 · Cited by 765 · see citing works
Multi-species biofilms: living with friendly neighbors
Elias, S., & Banin, E. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2012.00325.x · Cited by 764 · see citing works
Cell Wall and Secreted Proteins ofCandida albicans: Identification, Function, and Expression
Chaffin, W. L., López-Ribot, J. L., Casanova, M., Gozalbo, D., & Martínez, J. P. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.130-180.1998 · Cited by 726 · see citing works
A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
Nobile, C. J., Fox, E. P., Nett, J. E., Sorrells, T. R., Mitrovich, Q. M., Hernday, A. D., Tuch, B. B., Andes, D. R., & Johnson, A. D. (2012) · Cell · doi:10.1016/j.cell.2011.10.048 · Cited by 711 · see citing works
Inhibition of Candida albicans Biofilm Formation by Farnesol, a Quorum-Sensing Molecule
Ramage, G., Saville, S. P., Wickes, B. L., & Lopez-Ribot, J. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.11.5459-5463.2002 · Cited by 702 · see citing works
Epidemiology and risk factors for invasive candidiasis
Yapar, N. (2014) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s40160 · Cited by 610 · see citing works
Biofilm formation by Candida species on the surface of catheter materials in vitro
Hawser, S. P., & Douglas, L. J. (1994) · Infection and Immunity · doi:10.1128/iai.62.3.915-921.1994 · Cited by 599 · see citing works
Flocculation, adhesion and biofilm formation in yeasts
Verstrepen, K. J., & Klis, F. M. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05072.x · Cited by 589 · see citing works
Pseudomonas - Candida Interactions: An Ecological Role for Virulence Factors
Hogan, D. A., & Kolter, R. (2002) · Science · doi:10.1126/science.1070784 · Cited by 580 · see citing works
A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology
Hogan, D. A., Vik, Å., & Kolter, R. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04349.x · Cited by 575 · see citing works
Forging a Link Between Biofilms and Disease
Potera, C. (1999) · Science · doi:10.1126/science.283.5409.1837 · Cited by 550 · see citing works
Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance
Al-Fattani, M. A., & Douglas, L. J. (2006) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46569-0 · Cited by 548 · see citing works
How to build a biofilm: a fungal perspective
Blankenship, J. R., & Mitchell, A. P. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.10.003 · Cited by 530 · see citing works
Candida albicans and Staphylococcus aureus Form Polymicrobial Biofilms: Effects on Antimicrobial Resistance
Harriott, M. M., & Noverr, M. C. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00657-09 · Cited by 526 · see citing works
Candida albicans Biofilms Produce Antifungal-Tolerant Persister Cells
LaFleur, M. D., Kumamoto, C. A., & Lewis, K. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00684-06 · Cited by 521 · see citing works
Critical Role of Bcr1-Dependent Adhesins in C. albicans Biofilm Formation In Vitro and In Vivo
Nobile, C. J., Andes, D. R., Nett, J. E., Smith, F. J., Yue, F., Phan, Q.-T., Edwards, J. E., Filler, S. G., & Mitchell, A. P. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020063 · Cited by 507 · see citing works
Tyrosol is a quorum-sensing molecule in Candida albicans
Chen, H., Fujita, M., Feng, Q., Clardy, J., & Fink, G. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401416101 · Cited by 500 · see citing works
Comparison of Biofilms Formed byCandidaalbicansandCandidaparapsilosison Bioprosthetic Surfaces
Kuhn, D. M., Chandra, J., Mukherjee, P. K., & Ghannoum, M. A. (2002) · Infection and Immunity · doi:10.1128/iai.70.2.878-888.2002 · Cited by 485 · see citing works
Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms
Ramage, G. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf049 · Cited by 468 · see citing works
Regulation of Cell-Surface Genes and Biofilm Formation by the C. albicans Transcription Factor Bcr1p
Nobile, C. J., & Mitchell, A. P. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.047 · Cited by 464 · see citing works
Resistance of Candida albicans biofilms to antifungal agents in vitro
Hawser, S., & Douglas, L. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.9.2128 · Cited by 407 · see citing works
Putative Role of β-1,3 Glucans in Candida albicans Biofilm Resistance
Nett, J., Lincoln, L., Marchillo, K., Massey, R., Holoyda, K., Hoff, B., VanHandel, M., & Andes, D. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01056-06 · Cited by 407 · see citing works
Biofilms of non-Candida albicans Candidaspecies: quantification, structure and matrix composition
Silva, S., Henriques, M., Martins, A., Oliveira, R., Williams, D., & Azeredo, J. (2009) · Medical Mycology · doi:10.3109/13693780802549594 · Cited by 390 · see citing works
Development and Characterization of an In Vivo Central Venous Catheter Candida albicans Biofilm Model
Andes, D., Nett, J., Oschel, P., Albrecht, R., Marchillo, K., & Pitula, A. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.6023-6031.2004 · Cited by 389 · see citing works
Mixed species biofilms of Candida albicans and Staphylococcus epidermidis
ADAM, B., Baillie, G. S., & Douglas, L. (2002) · Journal of Medical Microbiology · doi:10.1099/0022-1317-51-4-344 · Cited by 374 · see citing works
NRG1, a repressor of filamentous growth in C.albicans, is down‐regulated during filament induction
Braun, B. R., Kadosh, D., & Johnson, A. D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4753 · Cited by 345 · see citing works
Adherence of Candida albicans to denture-base materials with different surface finishes
Radford, D. R., Sweet, S. P., Challacombe, S., & Walter, J. D. (1998) · Journal of Dentistry · doi:10.1016/s0300-5712(97)00034-1 · Cited by 338 · see citing works
Biofilm Matrix Regulation by Candida albicans Zap1
Nobile, C. J., Nett, J. E., Hernday, A. D., Homann, O. R., Deneault, J.-S., Nantel, A., Andes, D. R., Johnson, A. D., & Mitchell, A. P. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000133 · Cited by 337 · see citing works
The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development inCandida albicans
Ramage, G., VandeWalle, K., LÃ³pez-Ribot, J. L., & Wickes, B. L. (2002) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(02)00853-4 · Cited by 334 · see citing works
Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa
Cugini, C., Calfee, M. W., Farrow, J. M., Morales, D. K., Pesci, E. C., & Hogan, D. A. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05840.x · Cited by 334 · see citing works
Adhesins in human fungal pathogens: glue with plenty of stick.
de Groot, P. W. J., Bader, O., de Boer, A. D., Weig, M., & Chauhan, N. (2013) · Eukaryotic Cell · doi:10.1128/ec.00364-12 · Cited by 319 · see citing works
Biofilm lifestyle of Candida: a mini review
Seneviratne, C., Jin, L., & Samaranayake, L. (2008) · Oral Diseases · doi:10.1111/j.1601-0825.2007.01424.x · Cited by 317 · see citing works
Novel Entries in a Fungal Biofilm Matrix Encyclopedia
Zarnowski, R., Westler, W. M., Lacmbouh, G. A., Marita, J. M., Bothe, J. R., Bernhardt, J., Lounes-Hadj Sahraoui, A., Fontaine, J., Sanchez, H., Hatfield, R. D., et al. (2014) · mBio · doi:10.1128/mbio.01333-14 · Cited by 315 · see citing works
Role of dimorphism in the development of Candida albicans biofilms
BAILLIE, G. S., & DOUGLAS, L. J. (1999) · Journal of Medical Microbiology · doi:10.1099/00222615-48-7-671 · Cited by 304 · see citing works
Streptococcus gordonii Modulates Candida albicans Biofilm Formation through Intergeneric Communication
Bamford, C. V., d'Mello, A., Nobbs, A. H., Dutton, L. C., Vickerman, M. M., & Jenkinson, H. F. (2009) · Infection and Immunity · doi:10.1128/iai.00438-09 · Cited by 291 · see citing works
Induction of theCandida albicansFilamentous Growth Program by Relief of Transcriptional Repression: A Genome-wide Analysis
Kadosh, D., & Johnson, A. D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0073 · Cited by 285 · see citing works
Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture
Jiang, H. X., Du, H., Wang, L. M., Wang, P. Z., & Bai, X. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00001 · Cited by 275 · see citing works
Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1 - and SIR -dependent transcriptional silencing
De Las Peñas, A., Pan, S.-J., Castaño, I., Alder, J., Cregg, R., & Cormack, B. P. (2003) · Genes & Development · doi:10.1101/gad.1121003 · Cited by 268 · see citing works
Biofilm formation of Candida albicans is variably affected by saliva and dietary sugars
Jin, Y., Samaranayake, L. P., Samaranayake, Y. H., & Yip, H. K. (2004) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2004.04.011 · Cited by 266 · see citing works
The Candida albicans HYR1 gene, which is activated in response to hyphal development, belongs to a gene family encoding yeast cell wall proteins
Bailey, D., Feldmann, P. J. F., Bovey, M., Gow, N. A., & Brown, A. J. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.18.5353-5360.1996 · Cited by 259 · see citing works
Production of Tyrosol by Candida albicans Biofilms and Its Role in Quorum Sensing and Biofilm Development
Alem, M. A. S., Oteef, M. D. Y., Flowers, T. H., & Douglas, L. (2006) · Eukaryotic Cell · doi:10.1128/ec.00219-06 · Cited by 254 · see citing works
Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans
Birse, C., Irwin, M. Y., Fonzi, W. A., & Sypherd, P. S. (1993) · Infection and Immunity · doi:10.1128/iai.61.9.3648-3655.1993 · Cited by 248 · see citing works
Candida albicans ALS3 and insights into the nature of the ALS gene family
Hoyer, L. L., Payne, T. L., Bell, M., Myers, A. M., & Scherer, S. (1998) · Current Genetics · doi:10.1007/s002940050359 · Cited by 242 · see citing works
Control of Candida albicans Metabolism and Biofilm Formation by Pseudomonas aeruginosa Phenazines
Morales, D. K., Grahl, N., Okegbe, C., Dietrich, L. E. P., Jacobs, N. J., & Hogan, D. A. (2013) · mBio · doi:10.1128/mbio.00526-12 · Cited by 241 · see citing works
Farnesol‐induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi
Semighini, C. P., Hornby, J. M., Dumitru, ‎., Nickerson, K. W., & Harris, S. D. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04976.x · Cited by 232 · see citing works
The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans
Schweizer, A., Rupp, S., Taylor, B. N., Röllinghoff, M., & Schröppel, K. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02132.x · Cited by 232 · see citing works
APSES Proteins Regulate Morphogenesis and Metabolism in Candida albicans
Doedt, T., Krishnamurthy, S., Bockmühl, D. P., Tebarth, B., Stempel, C., Russell, C. L., Brown, A. J. P., & Ernst, J. F. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0782 · Cited by 232 · see citing works
Coaggregation of Streptococcus sanguis and other streptococci with Candida albicans
Jenkinson, H. F., Lala, H. C., & Shepherd, M. G. (1990) · Infection and Immunity · doi:10.1128/iai.58.5.1429-1436.1990 · Cited by 231 · see citing works
Portrait of Candida albicans Adherence Regulators
Finkel, J. S., Xu, W., Huang, D., Hill, E. M., Desai, J. V., Woolford, C. A., Nett, J. E., Taff, H., Norice, C. T., Andes, D. R., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002525 · Cited by 228 · see citing works
DNA Array Studies Demonstrate Convergent Regulation of Virulence Factors by Cph1, Cph2, and Efg1 in Candida albicans
Lane, S., Birse, C., Zhou, S., Matson, R., & Liu, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104484200 · Cited by 220 · see citing works
Interaction of Candida albicans Cell Wall Als3 Protein with Streptococcus gordonii SspB Adhesin Promotes Development of Mixed-Species Communities
Silverman, R. J., Nobbs, A. H., Vickerman, M. M., Barbour, M. E., & Jenkinson, H. F. (2010) · Infection and Immunity · doi:10.1128/iai.00685-10 · Cited by 219 · see citing works
Characterization of Mucosal Candida albicans Biofilms
Dongari‐Bagtzoglou, A. I., Kashleva, H., Dwivedi, P., Diaz, P. I., & Vasilakos, J. P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007967 · Cited by 212 · see citing works
Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1
Murad, A. M. A., D'Enfert, C., Gaillardin, C., Tournu, H., Tekaia, F., Talibi, D., Marechal, D., Marchais, V., Cottin, J., & Brown, A. J. P. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02713.x · Cited by 208 · see citing works
Mucosal biofilms of Candida albicans
Ganguly, S., & Mitchell, A. P. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.06.001 · Cited by 200 · see citing works
Let LuxS speak up in AI-2 signaling
Keersmaecker, S. C. J. D., Sonck, K., & Vanderleyden, J. (2006) · Trends in Microbiology · doi:10.1016/j.tim.2006.01.003 · Cited by 185 · see citing works
Production of extracellular matrix by Candida albicans biofilms
Hawser, S., Baillie, G. S., & Douglas, L. (1998) · Journal of Medical Microbiology · doi:10.1099/00222615-47-3-253 · Cited by 184 · see citing works
Community participation in biofilm matrix assembly and function
Mitchell, K. F., Zarnowski, R., Sanchez, H., Edward, J. A., Reinicke, E. L., Nett, J. E., Mitchell, A. P., & Andes, D. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421437112 · Cited by 183 · see citing works
Interaction of Candida albicans Biofilms with Antifungals: Transcriptional Response and Binding of Antifungals to Beta-Glucans
Vediyappan, G., Rossignol, T., & d'Enfert, C. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01638-09 · Cited by 183 · see citing works
EFG1 is a major regulator of cell wall dynamics in Candida albicans as revealed by DNA microarrays
Sohn, K., Urban, C. F., Brunner, H., & Rupp, S. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03300.x · Cited by 181 · see citing works
The effect of Streptococcus mutans and Candida glabrata on Candida albicans biofilms formed on different surfaces
Pereira‐Cenci, T., Deng, D., Kraneveld, E. A., Manders, E. M. M., Cury, A. A. D. B., ten Cate, J. M., & Wim Crielaard, A. (2008) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2008.02.015 · Cited by 181 · see citing works
The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence
Kelly, M. T., MacCallum, D. M., Clancy, S. D., Odds, F. C., Brown, A. J. P., & Butler, G. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04185.x · Cited by 175 · see citing works
Developmental Expression of a Tandemly Repeated, Proline- and Glutamine-rich Amino Acid Motif on Hyphal Surfaces of Candida albicans
Staab, J. F., Ferrer, C. A., & Sundstrom, P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6298 · Cited by 175 · see citing works
Ability of Candida albicans Mutants To Induce Staphylococcus aureus Vancomycin Resistance during Polymicrobial Biofilm Formation
Harriott, M. M., & Noverr, M. C. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00573-10 · Cited by 173 · see citing works
Characteristics of biofilm formation by Candida tropicalis and antifungal resistance
Bizerra, F. C., Nakamura, C. V., Poersch, C. D. O., Svidzinski, T. I. E., Quesada, R. M. B., Goldenberg, S., Krieger, M. A., & Yamada‐Ogatta, S. F. (2008) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2007.00347.x · Cited by 170 · see citing works
Terpenoids of plant origin inhibit morphogenesis, adhesion, and biofilm formation byCandida albicans
Raut, J. S., Shinde, R. B., Chauhan, N. M., & Karuppayil, S. M. (2012) · Biofouling · doi:10.1080/08927014.2012.749398 · Cited by 169 · see citing works
Candida Biofilms: Development, Architecture, and Resistance
Chandra, J., & Mukherjee, P. K. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mb-0020-2015 · Cited by 169 · see citing works
Rfg1, a Protein Related to the Saccharomyces cerevisiae Hypoxic Regulator Rox1, Controls Filamentous Growth and Virulence in Candida albicans
Kadosh, D., & Johnson, A. D. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.7.2496-2505.2001 · Cited by 166 · see citing works
Biofilm Formation by Candida dubliniensis
Ramage, G., Walle, K. V., Wickes, B. L., & Lopez-Ribot, J. L. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.9.3234-3240.2001 · Cited by 160 · see citing works
Nosocomial Infections and Multidrug-resistant Organisms in Germany
Geffers, C., & Gastmeier, P. (2011) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2011.0087 · Cited by 158 · see citing works
Bloodstream Infections Due to Candida Species in the Intensive Care Unit: Identifying Especially High-Risk Patients to Determine Prevention Strategies
Wenzel, R. P., & Gennings, C. (2005) · Clinical Infectious Diseases · doi:10.1086/430923 · Cited by 158 · see citing works
Broad Spectrum Antibacterial and Antifungal Polymeric Paint Materials: Synthesis, Structure–Activity Relationship, and Membrane-Active Mode of Action
Hoque, J., Akkapeddi, P., Yadav, V., Manjunath, G. B., Uppu, D. S. S. M., Konai, M. M., Yarlagadda, V., Sanyal, K., & Haldar, J. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am507482y · Cited by 156 · see citing works
High frequency of Candida parapsilosis on the hands of healthy hosts
Bonassoli, L. A., Bertoli, M., & Svidzinski, T. I. E. (2004) · Journal of Hospital Infection · doi:10.1016/j.jhin.2004.06.033 · Cited by 149 · see citing works
Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans
Bonhomme, J., Chauvel, M., Goyard, S., Roux, P., Rossignol, T., & d'Enfert, C. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07626.x · Cited by 144 · see citing works
Modification of Surface Properties of Biomaterials Influences the Ability of Candida albicans To Form Biofilms
Chandra, J., Patel, J. D., Li, J., Zhou, G., Mukherjee, P. K., McCormick, T. S., Anderson, J. M., & Ghannoum, M. A. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8795-8801.2005 · Cited by 142 · see citing works
Environmental distribution ofCryptococcus neoformansandC. gattiiaround the Mediterranean basin
Cogliati, M., D’Amicis, R., Zani, A., Montagna, M. T., Caggiano, G., Giglio, O. D., Balbino, S., Donno, A. D., Serio, F., Susever, S., et al. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow045 · Cited by 138 · see citing works
Phenotype switching affects biofilm formation by Candida parapsilosis
Laffey, S. F., & Butler, G. (2005) · Microbiology · doi:10.1099/mic.0.27739-0 · Cited by 132 · see citing works
Comparative Phenotypic Analysis of the Major Fungal Pathogens Candida parapsilosis and Candida albicans
Holland, L., Schröder, M., Turner, S. A., Taff, H. T., Andes, D. R., Grózer, Z., Gácser, A., Ames, L., Haynes, K., Higgins, D. G., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004365 · Cited by 132 · see citing works
Candida albicans Transcription Factor Ace2 Regulates Metabolism and Is Required for Filamentation in Hypoxic Conditions
Mulhern, S. M., Logue, M. E., & Butler, G. (2006) · Eukaryotic Cell · doi:10.1128/ec.00155-06 · Cited by 130 · see citing works
Quorum sensing and Candida albicans
Kruppa, M. (2008) · Mycoses · doi:10.1111/j.1439-0507.2008.01626.x · Cited by 129 · see citing works
Invasive candidiasis in immunocompromised hospitalized patients.
Sims, C. R., Ostrosky-Zeichner, L., & Rex, J. H. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.05.015 · Cited by 124 · see citing works
The Basic Helix-Loop-Helix Transcription Factor Cph2 Regulates Hyphal Development in CandidaalbicansPartly via Tec1
Lane, S., Zhou, S., Pan, T., Dai, Q., & Liu, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6418-6428.2001 · Cited by 118 · see citing works
Biofilm formation by five species of Candida on three clinical materials
Estivill, D., Arias, Á., Lana, Á. T., Carrillo‐Muñoz, A. J., & Arévalo, M. P. (2011) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2011.05.019 · Cited by 112 · see citing works
In vitro interactions between farnesol and fluconazole, amphotericin B or micafungin against Candida albicans biofilms
Katragkou, A., McCarthy, M. W., Alexander, E. L., Antachopoulos, C., Meletiadis, J., Jabra‐Rizk, M. A., Petraitis, V., Roilides, E., & Walsh, T. J. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku374 · Cited by 111 · see citing works
Pseudomonas aeruginosa inhibits in-vitro Candida biofilm development
Bandara, N., Yau, J., Watt, R., Jin, L., & Samaranayake, L. P. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-125 · Cited by 110 · see citing works
Candida albicans biofilm formation in a new in vivo rat model
Řičicová, M., Kucharíková, S., Tournu, H., Hendrix, J., Bujdáková, H., Eldere, J. V., Lagrou, K., & Dijck, P. V. (2009) · Microbiology · doi:10.1099/mic.0.033530-0 · Cited by 110 · see citing works
In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections
Wong, S. S. W., Kao, R. Y. T., Yuen, K. Y., Wang, Y., Yang, D., Samaranayake, L. P., & Seneviratne, C. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085836 · Cited by 107 · see citing works
Suppression of fungal growth exhibited by Pseudomonas aeruginosa
Kerr, J. R. (1994) · Journal of Clinical Microbiology · doi:10.1128/jcm.32.2.525-527.1994 · Cited by 102 · see citing works
The antibiotic-lock technique for therapy of ‘highly needed’ infected catheters
Carratalà, J. (2002) · Clinical Microbiology and Infection · doi:10.1046/j.1469-0691.2002.00388.x · Cited by 99 · see citing works
The DNA Binding Protein Rfg1 Is a Repressor of Filamentation in Candida albicans
Khalaf, R. A., & Zitomer, R. S. (2001) · Genetics · doi:10.1093/genetics/157.4.1503 · Cited by 97 · see citing works
Hypoxic Adaptation by Efg1 Regulates Biofilm Formation by Candida albicans
Stichternoth, C., & Ernst, J. F. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00098-09 · Cited by 94 · see citing works
Conserved and Divergent Roles of Bcr1 and CFEM Proteins in Candida parapsilosis and Candida albicans
Ding, C., Vidanes, G. M., Maguire, S. L., Guida, A., Synnott, J. M., Andes, D. R., & Butler, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028151 · Cited by 93 · see citing works
“It’s a gut feeling” – Escherichia coli biofilm formation in the gastrointestinal tract environment
Rossi, E., Cimdins, A., Lüthje, P., Brauner, A., Sjöling, Å., Landini, P., & Römling, U. (2018) · Critical reviews in microbiology · doi:10.1080/1040841x.2017.1303660 · Cited by 93 · see citing works
Virulence and pathogenicity ofCandida albicansis enhanced in biofilms containing oral bacteria
Cavalcanti, Y. W., Morse, D. J., da Silva, W. J., Cury, A. A. D. B., Wei, X., Wilson, M. J., Milward, P. J., Lewis, M. A. O., Bradshaw, D. J., & Williams, D. W. (2015) · Biofouling · doi:10.1080/08927014.2014.996143 · Cited by 92 · see citing works
Characterization of biofilms formed by Candida parapsilosis, C. metapsilosis, and C. orthopsilosis
Lattif, A. A., Mukherjee, P. K., Chandra, J., Swindell, K., Lockhart, S. R., Diekema, D. J., Pfaller, M. A., & Ghannoum, M. A. (2009) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2009.09.001 · Cited by 92 · see citing works
Role of Ndt80p in Sterol Metabolism Regulation and Azole Resistance in Candida albicans
Sellam, A., Tebbji, F., & Nantel, A. (2009) · Eukaryotic Cell · doi:10.1128/ec.00074-09 · Cited by 91 · see citing works
The Extracellular Matrix of Fungal Biofilms
Mitchell, K. F., Żarnowski, R., & Andes, D. R. (2016) · Advances in experimental medicine and biology · doi:10.1007/5584_2016_6 · Cited by 88 · see citing works
Multi-species biofilm of Candida albicans and non-Candida albicans Candida species on acrylic substrate
Pathak, A., Sharma, S., & Shrivastva, P. (2012) · Journal of Applied Oral Science · doi:10.1590/s1678-77572012000100013 · Cited by 87 · see citing works
Farnesol signalling in Candida albicans – more than just communication
Polke, M., Leonhardt, I., Kurzai, O., & Jacobsen, I. D. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2017.1337711 · Cited by 87 · see citing works
BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence
Cleary, I. A., Lazzell, A. L., Monteagudo, C. C., Thomas, D. P., & Saville, S. P. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08127.x · Cited by 85 · see citing works
Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans
Holcombe, L. J., McAlester, G., Munro, C. A., Enjalbert, B., Brown, A. J. P., Gow, N. A. R., Ding, C., Butler, G., O'Gara, F., & Morrissey, J. P. (2010) · Microbiology · doi:10.1099/mic.0.037549-0 · Cited by 82 · see citing works
Comparison of the Microbial Composition of Voice Prosthesis Biofilms from Patients Requiring Frequent versus Infrequent Replacement
Elving, G. J., van der Mei, H. C., van Weissenbruch, R., Busscher, H. J., & Albers, F. W. J. (2002) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348940211100302 · Cited by 82 · see citing works
Development of a Gene Knockout System in Candida parapsilosis Reveals a Conserved Role for BCR1 in Biofilm Formation
Ding, C., & Butler, G. (2007) · Eukaryotic Cell · doi:10.1128/ec.00136-07 · Cited by 81 · see citing works
Role of Transcription Factor CaNdt80p in Cell Separation, Hyphal Growth, and Virulence in Candida albicans
Sellam, A., Askew, C., Epp, E., Tebbji, F., Mullick, A., Whiteway, M. S., & Nantel, A. (2010) · Eukaryotic Cell · doi:10.1128/ec.00325-09 · Cited by 80 · see citing works
The quorum‐sensing molecule E , E ‐farnesol—its variable secretion and its impact on the growth and metabolism of Candida species
Weber, K., Schulz, B., & Ruhnke, M. (2010) · Yeast · doi:10.1002/yea.1769 · Cited by 79 · see citing works
Polyelectrolyte Multilayers Fabricated from Antifungal β-Peptides: Design of Surfaces that Exhibit Antifungal Activity Against Candida albicans
Karlsson, A. J., Flessner, R. M., Gellman, S. H., Lynn, D. M., & Palecek, S. P. (2010) · Biomacromolecules · doi:10.1021/bm100424s · Cited by 75 · see citing works
Transcriptional Response of Candida parapsilosis following Exposure to Farnesol
Rossignol, T., Logue, M. E., Reynolds, K., Grenon, M., Lowndes, N. F., & Butler, G. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01438-06 · Cited by 75 · see citing works
Adherence of Candida sp. to host tissues and cells as one of its pathogenicity features.
Modrzewska, B., & Kurnatowski, P. (2015) · PubMed · Cited by 74 · see citing works
Proteomics of drug resistance in Candida glabrata biofilms
Seneviratne, C. J., Wang, Y., Jin, L., Abiko, Y., & Samaranayake, L. P. (2010) · PROTEOMICS · doi:10.1002/pmic.200900611 · Cited by 74 · see citing works
Structure-Informed Design of an Enzymatically Inactive Vaccine Component for Group A Streptococcus
Henningham, A., Ericsson, D. J., Langer, K., Casey, L. W., Jovcevski‬, B., Chhatwal, G. S., Aquilina, J. A., Batzloff, M. R., Kobe, B., & Walker, M. J. (2013) · mBio · doi:10.1128/mbio.00509-13 · Cited by 72 · see citing works
Candida glabrata STE12 is required for wild‐type levels of virulence and nitrogen starvation induced filamentation
Calcagno-Pizarelli, A. M., Bignell, E., Warn, P. A., Jones, M. D., Denning, D. W., Mühlschlegel, F. A., Rogers, T. R., & Haynes, K. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03755.x · Cited by 70 · see citing works
Anti-biofilm activity of low-molecular weight chitosan hydrogel against Candida species
Silva-Dias, A., Palmeira‐de‐Oliveira, A., Miranda, I. M., Branco, J., Cobrado, L., Monteiro‐Soares, M., Queiroz, J. A., Pina‐Vaz, C., & Rodrigues, A. G. (2013) · Medical Microbiology and Immunology · doi:10.1007/s00430-013-0311-4 · Cited by 65 · see citing works
Pathogenesis and Antifungal Drug Resistance of the Human Fungal Pathogen Candida glabrata
Tscherner, M., Schwarzmüller, T., & Kuchler, K. (2011) · Pharmaceuticals · doi:10.3390/ph4010169 · Cited by 60 · see citing works
ThePlasmodiumrhoptry associated protein complex is important for parasitophorous vacuole membrane structure and intraerythrocytic parasite growth
Ghosh, S., Kennedy, K., Sanders, P. R., Matthews, K. M., Ralph, S. A., Counihan, N. A., & de Koning‐Ward, T. F. (2017) · Cellular Microbiology · doi:10.1111/cmi.12733 · Cited by 60 · see citing works
The APSES transcription factor Efg 1 is a global regulator that controls morphogenesis and biofilm formation in C andida parapsilosis
Connolly, L. A., Riccombeni, A., Grózer, Z., Holland, L., Lynch, D. B., Andes, D. R., Gácser, A., & Butler, G. (2013) · Molecular Microbiology · doi:10.1111/mmi.12345 · Cited by 58 · see citing works
Photodynamic antimicrobial chemotherapy (PACT) inhibits biofilm formation by Candida albicans, increasing both ROS production and membrane permeability
Rosseti, I. B., Chagas, L. R., & Costa, M. S. (2013) · Lasers in Medical Science · doi:10.1007/s10103-013-1473-4 · Cited by 56 · see citing works
C. albicansgrowth, transition, biofilm formation, and gene expression modulation by antimicrobial decapeptide KSL-W
Theberge, S., Semlali, A., Alamri, A. M., Leung, K. P., & Rouabhia, M. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-246 · Cited by 55 · see citing works
Biofilm formation inCandida glabrata: What have we learnt from functional genomics approaches?
d’Enfert, C., & Janbon, G. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov111 · Cited by 54 · see citing works
In vivo Candida glabrata biofilm development on foreign bodies in a rat subcutaneous model
Kucharíková, S., Neirinck, B., Sharma, N., Vleugels, J., Lagrou, K., & Dijck, P. V. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku447 · Cited by 53 · see citing works
Candida albicans aspects of novel silane system–coated titanium and zirconia implant surfaces
Villard, N. M., Seneviratne, C. J., Tsoi, J. K. H., Heinonen, M., & Matinlinna, J. P. (2014) · Clinical Oral Implants Research · doi:10.1111/clr.12338 · Cited by 52 · see citing works
Effect of Antimicrobial Denture Base Resin on Multi-Species Biofilm Formation
Zhang, K., Ren, B., Zhou, X., Xu, H. H. K., Chen, Y. Z., Han, Q., Li, B., Weir, M. D., Li, M., Feng, M., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071033 · Cited by 52 · see citing works
Identification and Functional Characterization of Rca1, a Transcription Factor Involved in both Antifungal Susceptibility and Host Response in Candida albicans
Vandeputte, P., Pradervand, S., Ischer, F., Coste, A. T., Ferrari, S., Harshman, K., & Sanglard, D. (2012) · Eukaryotic Cell · doi:10.1128/ec.00134-12 · Cited by 51 · see citing works
Phenylpropanoids of Plant Origin as Inhibitors of Biofilm Formation by Candida albicans
Raut, J. S., Shinde, R. B., Chauhan, N. M., & Karuppayil, S. M. (2014) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1402.02056 · Cited by 49 · see citing works
Possible role of azole and echinocandin lock solutions in the control of Candida biofilms associated with silicone
Cateau, E., Berjeaud, J., & Imbert, C. (2011) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2010.12.016 · Cited by 48 · see citing works
The Use of Chitosan to Enhance Photodynamic Inactivation against Candida albicans and Its Drug-Resistant Clinical Isolates
Chien, H., Chen, C.-P., Chen, C.-P., Chang, P.-H., Tsai, T., & Chen, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14047445 · Cited by 47 · see citing works
Membrane Proteome-Wide Response to the Antifungal Drug Clotrimazole in Candida glabrata: Role of the Transcription Factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2
Pais, P., Costa, C., Pires, C. M. B. F., Shimizu, K., Chibana, H., & Teixeira, M. C. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.045344 · Cited by 46 · see citing works
Self-citation
Anticandidal activity of Pseudomonas aeruginosa strains isolated from clinical specimens
Kaleli̇, İ., Cevahir, N., Demi̇r, M., Yıldırım, U., & Şahin, R. (2006) · Mycoses · doi:10.1111/j.1439-0507.2006.01322.x · Cited by 46 · see citing works
Biofilm formation and C andida albicans morphology on the surface of denture base materials
Susewind, S., Lang, R., & Hahnel, S. (2015) · Mycoses · doi:10.1111/myc.12420 · Cited by 46 · see citing works
The Host’s Reply to Candida Biofilm
Nett, J. E. (2016) · Pathogens · doi:10.3390/pathogens5010033 · Cited by 46 · see citing works
Different Consequences of ACE2 and SWI5 Gene Disruptions for Virulence of Pathogenic and Nonpathogenic Yeasts
MacCallum, D. M., Findon, H., Kenny, C. C., Butler, G., Haynes, K., & Odds, F. C. (2006) · Infection and Immunity · doi:10.1128/iai.00817-06 · Cited by 45 · see citing works
Regulation of filamentation in the human fungal pathogen C andida tropicalis
Zhang, Q., Li, T., Guan, G., Yue, H., Liang, W., Cao, C., Dai, Y., & Huang, G. (2015) · Molecular Microbiology · doi:10.1111/mmi.13247 · Cited by 44 · see citing works
New regulators of biofilm development in Candida glabrata
Riera, M., Mogensen, E., d’Enfert, C., & Janbon, G. (2012) · Research in Microbiology · doi:10.1016/j.resmic.2012.02.005 · Cited by 43 · see citing works
A Novel Downstream Regulatory Element Cooperates with the Silencing Machinery to Repress EPA1 Expression in Candida glabrata
Gallegos-García, V., Pan, S., Juárez-Cepeda, J., Ramírez-Zavaleta, C., Martin-del-Campo, M. B., Martínez-Jiménez, V., Castaño, I., Cormack, B., & Peñas, A. D. L. (2012) · Genetics · doi:10.1534/genetics.111.138099 · Cited by 41 · see citing works
Influence of Acetylsalicylic Acid (Aspirin) on Biofilm Production byCandidaSpecies
Stepanović, S., Vuković, D., Jesic, M. M., & Ranin, L. T. (2004) · Journal of Chemotherapy · doi:10.1179/joc.2004.16.2.134 · Cited by 38 · see citing works
Could liposomal amphotericin B (L-AMB) lock solutions be useful to inhibit Candida spp. biofilms on silicone biomaterials?
Toulet, D., Debarre, C., & Imbert, C. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr473 · Cited by 38 · see citing works
The Role of Saliva and Serum inCandida albicansBiofllm Formation on Denture Acrylic Surfaces
Nikawa, H., Nishimura, H., Yamamoto, T., Hamada, T., & Samaranayake, L. P. (1996) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v9i1.8290 · Cited by 37 · see citing works
Effectiveness of Minocycline and Rifampin vs Chlorhexidine and Silver Sulfadiazine-Impregnated Central Venous Catheters in Preventing Central Line-Associated Bloodstream Infection in a High-Volume Academic Intensive Care Unit: A Before and after Trial
Bonne, S. L., Mazuski, J. E., Sona, C., Schallom, M. E., Boyle, W., Buchman, T. G., Bochicchio, G. V., Coopersmith, C. M., & Schuerer, D. J. E. (2015) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2015.05.013 · Cited by 34 · see citing works
Growth, biofilm formation, antifungal susceptibility and oxidative stress resistance of Candida glabrata are affected by different glucose concentrations
Ng, T. S., Desa, M. N. M., Sandai, D. A., Chong, P. P., & Than, L. T. L. (2015) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2015.09.004 · Cited by 34 · see citing works
Molecular investigation of two consecutive nosocomial clusters of Candida tropicalis candiduria using pulsed-field gel electrophoresis.
Rho, J., Shin, J. H., Song, J. W., Park, M., Kee, S. J., Jang, S. J., Park, Y. K., Suh, S., & Ryang, D. W. (2004) · PubMed · Cited by 34 · see citing works
The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogenCandida glabrata
Santos, R., Costa, C., Mil‐Homens, D., Romão, D., de Carvalho, C. C. C. R., Pais, P., Mira, N. P., Fialho, A. M., & Teixeira, M. C. (2016) · Cellular Microbiology · doi:10.1111/cmi.12686 · Cited by 33 · see citing works
Self-citation
Shear stress modulates the thickness and architecture of Candida albicans biofilms in a phase‐dependent manner
Mukherjee, P. K., Chand, D. V., Chandra, J., Anderson, J. M., & Ghannoum, M. A. (2008) · Mycoses · doi:10.1111/j.1439-0507.2008.01632.x · Cited by 32 · see citing works
Expression ofCgCDR1,CgCDR2, andCgERG11inCandida glabratabiofilms formed by bloodstream isolates
Song, J. W., Shin, J. H., Kee, S., Kim, S. H., Shin, M., Suh, S., & Ryang, D. W. (2008) · Medical Mycology · doi:10.1080/13693780802210726 · Cited by 32 · see citing works
Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison
Pais, P., Costa, C., Cavalheiro, M., Romão, D., & Teixeira, M. C. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00131 · Cited by 32 · see citing works
Self-citation
A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli
Waldhuber, A., Snyder, G. A., Römmler, F., Cirl, C., Müller, T., Xiao, T. S., Svanborg, C., & Miethke, T. (2016) · Pathogens · doi:10.3390/pathogens5010025 · Cited by 31 · see citing works
Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome
Stead, D., Walker, J., Holcombe, L. J., Gibbs, S. R. S., Yin, Z., Selway, L., Butler, G., Brown, A. J. P., & Haynes, K. (2009) · PROTEOMICS · doi:10.1002/pmic.200800706 · Cited by 29 · see citing works
CandidaSpecies Adhesion to Oral Epithelium: Factors Involved and Experimental Methodology Used
Henriques, M., Azeredo, J., & Oliveira, R. (2006) · Critical Reviews in Microbiology · doi:10.1080/10408410601023524 · Cited by 29 · see citing works
The Role of Saliva and Serum inCandida albicansBiofllm Formation on Denture Acrylic Surfaces
Nikawa, H., NISHIMURA, H., Yamamoto, T., Hamada, T., & Samaranayake, L. P. (1996) · Microbial Ecology in Health and Disease · doi:10.3109/08910609609167727 · Cited by 29 · see citing works
Management of Candida Biofilms: State Of Knowledge and New Options for Prevention and Eradication
Bujdáková, H. (2016) · Future Microbiology · doi:10.2217/fmb.15.139 · Cited by 25 · see citing works
Mapping of functional domains and characterization of the transcription factor Cph1 that mediate morphogenesis in Candida albicans
Maiti, P., Ghorai, P., Ghosh, S., Kamthan, M., Tyagi, R. K., & Datta, A. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.08.004 · Cited by 22 · see citing works
Antifungal Lock Therapy With Combined 70% Ethanol and Micafungin in a Critically Ill Infant
Piersigilli, F., Auriti, C., Bersani, I., Goffredo, B. M., Bianco, G., Savarese, I., & Dotta, A. (2013) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000000116 · Cited by 21 · see citing works
Effectiveness of the Photoactive Dye Methylene Blue versus Caspofungin on the C andida parapsilosis Biofilm in vitro and ex vivo
Černáková, L., Dekkerová, J., Židlíková, K., & Bujdáková, H. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12480 · Cited by 20 · see citing works
Quorum sensing in Candida albicans: farnesol versus farnesoic acid
Riekhof, W. R., & Nickerson, K. W. (2017) · FEBS Letters · doi:10.1002/1873-3468.12694 · Cited by 19 · see citing works
Adhesion and biofilm formation in artificial saliva and susceptibility of yeasts isolated from chronic kidney patients undergoing haemodialysis
Queiroz, P. A., Godoy, J. S. R., Mendonca, P., Pedroso, R. B., Svidzinski, T. I. E., & Negri, M. (2015) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000122 · Cited by 10 · see citing works

Flagged first, then by citations

Sorted by citations

Candida albicans—The Virulence Factors and Clinical Manifestations of Infection
Talapko, J., Juzbašić, M., Matijević, T., Pustijanac, E., Bekić, S., Kotris, I., & Škrlec, I. (2021) · Journal of Fungi · doi:10.3390/jof7020079 · Cited by 794 · see citing works
Biocontrol yeasts: mechanisms and applications
Freimoser, F. M., Rueda-Mejia, M. P., Tilocca, B., & Migheli, Q. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2728-4 · Cited by 462 · see citing works
Architecture of the dynamic fungal cell wall
Gow, N. A. R., & Lenardon, M. D. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00796-9 · Cited by 447 · see citing works
Candida parapsilosis: from genes to the bedside
Tóth, R., Nosek, J., Mora-Montes, H. M., Gabaldon, T., Bliss, J. M., Nosanchuk, J. D., Turner, S. A., Butler, G., Vágvölgyi, C., & Gácser, A. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00111-18 · Cited by 327 · see citing works
Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium
Arastehfar, A. A., Gabaldón, T., Garcia‐Rubio, R., Jenks, J. D., Hoenigl, M., Salzer, H. J. F., İlkit, M., Lass‐Flörl, C., & Perlin, D. S. (2020) · Antibiotics · doi:10.3390/antibiotics9120877 · Cited by 294 · see citing works
Candida albicans biofilms and polymicrobial interactions
Ponde, N. O., Lortal, L., Ramage, G., Naglik, J. R., & Richardson, J. P. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1843400 · Cited by 281 · see citing works
Mechanistic Understanding of Candida albicans Biofilm Formation and Approaches for Its Inhibition
Atriwal, T., Azeem, K., Husain, F. M., Hussain, A., Khan, M. N., Alajmi, M. F., & Abid, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.638609 · Cited by 210 · see citing works
Invasive candidiasis: current clinical challenges and unmet needs in adult populations
Soriano, À., Honoré, P. M., Puerta‐Alcalde, P., García‐Vidal, C., Pagotto, A., Gonçalves, D. C., & Verweij, P. E. (2023) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkad139 · Cited by 201 · see citing works
Invasive fungal disease in humans: are we aware of the real impact?
Firacative, C. (2020) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760200430 · Cited by 190 · see citing works
Promising Therapeutic Strategies Against Microbial Biofilm Challenges
Zhang, K., Li, X., Yu, C., & Wang, Y. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00359 · Cited by 189 · see citing works
Antimicrobial Activity of Lemongrass Essential Oil (Cymbopogon flexuosus) and Its Active Component Citral Against Dual-Species Biofilms of Staphylococcus aureus and Candida Species
Gao, S., Liu, G., Li, J., Chen, J., Li, L., Li, Z., Zhang, X., Zhang, S., Thorne, R. F., & Zhang, S. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.603858 · Cited by 181 · see citing works
Candida albicans and Candida glabrata : global priority pathogens
Katsipoulaki, M., Stappers, M. H. T., Malavia, D., Brunke, S., Hube, B., & Gow, N. A. R. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00021-23 · Cited by 174 · see citing works
Biofilm formation in medically important Candida species
Malinovská, Z., Čonková, E., & Váczi, P. (2023) · Journal of Fungi · doi:10.3390/jof9100955 · Cited by 167 · see citing works
Plant-Derived Products as Antibacterial and Antifungal Agents in Human Health Care
Kokoška, L., Klouček, P., Leuner, O., & Nový, P. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180831144344 · Cited by 165 · see citing works
Biofilms and vulvovaginal candidiasis
Rodríguez‐Cerdeira, C., Carnero-Gregorio, M., Molares-Vila, A., López-Bárcenas, A., Fabbrocini, G., Bardhi, B., Sinani, A., Sánchez-Blanco, E., Arenas, R., & Hernández‐Castro, R. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.11.011 · Cited by 154 · see citing works
Thymus vulgaris essential oil and thymol inhibit biofilms and interact synergistically with antifungal drugs against drug resistant strains of Candida albicans and Candida tropicalis
Jafri, H., & Ahmad, I. (2019) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2019.100911 · Cited by 153 · see citing works
Candida spp./Bacteria Mixed Biofilms
Rodrigues, M. E., Gomes, F., & Rodrigues, C. F. (2019) · Journal of Fungi · doi:10.3390/jof6010005 · Cited by 149 · see citing works
The Quiet and Underappreciated Rise of Drug-Resistant Invasive Fungal Pathogens
Arastehfar, A., Lass-Flörl, C., Garcia-Rubio, R., Daneshnia, F., Ilkit, M., Boekhout, T., Gabaldon, T., & Perlin, D. S. (2020) · Journal of Fungi · doi:10.3390/jof6030138 · Cited by 145 · see citing works
Mechanism of Candida pathogenesis: Revisiting the vital drivers
Mba, I. E., & Nweze, E. I. (2020) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-03912-w · Cited by 143 · see citing works
Candida parapsilosis Virulence and Antifungal Resistance Mechanisms: A Comprehensive Review of Key Determinants
Branco, J., Miranda, I. M., & Rodrigues, A. G. (2023) · Journal of Fungi · doi:10.3390/jof9010080 · Cited by 133 · see citing works
Adapting to survive: How Candida overcomes host-imposed constraints during human colonization
Alves, R. M. A., Barata-Antunes, C., Casal, M., Brown, A. J. P., Dijck, P. V., & Paiva, S. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008478 · Cited by 122 · see citing works
Pathogenesis and Clinical Relevance of Candida Biofilms in Vulvovaginal Candidiasis
Rodríguez‐Cerdeira, C., Martínez-Herrera, E. O., Carnero-Gregorio, M., López-Bárcenas, A., Fabbrocini, G., Fida, M., El-Samahy, M., & González-Cespón, J. L. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.544480 · Cited by 119 · see citing works
Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants
Ceresa, C., Fracchia, L., Fedeli, E., Porta, C., & Banat, I. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040466 · Cited by 116 · see citing works
Prevalence of biofilms in Candida spp. bloodstream infections: A meta-analysis
Atiencia-Carrera, M. B., Cabezas-Mera, F. S., Tejera, E., & Machado, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263522 · Cited by 112 · see citing works
Palmitic Acid Inhibits the Virulence Factors of Candida tropicalis: Biofilms, Cell Surface Hydrophobicity, Ergosterol Biosynthesis, and Enzymatic Activity
Prasath, K. G., Tharani, H., Kumar, M. S., & Pandian, S. K. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00864 · Cited by 111 · see citing works
The role of Lactobacillus species in the control of Candida via biotrophic interactions
Zangl, I., Pap, I.-J., Aspöck, C., & Schüller, C. (2020) · Microbial Cell · doi:10.15698/mic2020.01.702 · Cited by 108 · see citing works
Antifungal Activity of the Natural Coumarin Scopoletin Against Planktonic Cells and Biofilms From a Multidrug-Resistant Candida tropicalis Strain
Lemos, A. S. D. O., Florêncio, J. R., Pinto, N. D. C. C., Campos, L. M., Silva, T. P. D., Grazul, R. M., Pinto, P. D. F., Tavares, G. D., Scio, E., Apolônio, A. C. M., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01525 · Cited by 106 · see citing works
Yeasts as a Potential Biological Agent in Plant Disease Protection and Yield Improvement—A Short Review
Kowalska, J., Krzymińska, J., & Tyburski, J. (2022) · Agriculture · doi:10.3390/agriculture12091404 · Cited by 106 · see citing works
Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin
Galocha, M., Pais, P., Cavalheiro, M., Pereira, D., Viana, R., & Teixeira, M. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092345 · Cited by 105 · see citing works
Self-citation
Candida Biofilms: An Update on Developmental Mechanisms and Therapeutic Challenges
de Barros, P. P., Rossoni, R. D., de Souza, C. M., Scorzoni, L., Fenley, J. D. C., & Junqueira, J. C. (2020) · Mycopathologia · doi:10.1007/s11046-020-00445-w · Cited by 99 · see citing works
Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms
Kovács, R., & Majoros, L. (2020) · Journal of Fungi · doi:10.3390/jof6030099 · Cited by 96 · see citing works
Candidemia: Evolution of Drug Resistance and Novel Therapeutic Approaches
Tortorano, A. M., Prigitano, A., Morroni, G., Brescini, L., & Barchiesi, F. (2021) · Infection and Drug Resistance · doi:10.2147/idr.s274872 · Cited by 96 · see citing works
Camphor and Eucalyptol—Anticandidal Spectrum, Antivirulence Effect, Efflux Pumps Interference and Cytotoxicity
Ivanov, M., Kannan, A., Stojković, D. S., Glamočlija, J., Calhelha, R. C., Ferreira, I. C. F. R., Sanglard, D., & Sokóvić, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020483 · Cited by 92 · see citing works
Surfactants of microbial origin as antibiofilm agents
Paraszkiewicz, K., Moryl, M., Płaza, G. A., Bhagat, D., Satpute, S., & Bernat, P. (2019) · International Journal of Environmental Health Research · doi:10.1080/09603123.2019.1664729 · Cited by 84 · see citing works
Bioactive Peptides Against Fungal Biofilms
Oshiro, K. G. N., Rodrigues, G. R., Monges, B. E. D., Cardoso, M. H. E. S., & Franco, O. L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02169 · Cited by 83 · see citing works
Mechanisms and Control Strategies of Antibiotic Resistance in Pathological Biofilms
Ying, L., Yang, Q., Zhang, D., & Yan, W. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2010.10021 · Cited by 82 · see citing works
Antifungal Activity of the Phenolic Compounds Ellagic Acid (EA) and Caffeic Acid Phenethyl Ester (CAPE) against Drug-Resistant Candida auris
Rossatto, F. C. P., Tharmalingam, N., Escobar, I. E., d’Azevedo, P. A., Zimmer, K. R., & Mylonakis, E. E. (2021) · Journal of Fungi · doi:10.3390/jof7090763 · Cited by 81 · see citing works
COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies
Ahmed, N., Mahmood, M. S., Ullah, M. A., Araf, Y., Rahaman, T. I., Moin, A. T., & Hosen, M. J. (2022) · Current Microbiology · doi:10.1007/s00284-022-02824-6 · Cited by 79 · see citing works
Candida glabrata Antifungal Resistance and Virulence Factors, a Perfect Pathogenic Combination
León, M. G. F.-D., Hernández‐Castro, R., Conde-Cuevas, E., García-Coronel, I. H., Vázquez-Aceituno, V. A., Soriano-Ursua, M. A., Farfán‐García, E. D., Ocharan-Hernández, M. E., Rodríguez‐Cerdeira, C., Arenas, R., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101529 · Cited by 78 · see citing works
Challenges and solutions in polymer drug delivery for bacterial biofilm treatment: A tissue-by-tissue account
Kasza, K., Gurnani, P., Hardie, K. R., Cámara, M., & Alexander, C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113973 · Cited by 78 · see citing works
Synergistic Effect of Plant Compounds in Combination with Conventional Antimicrobials against Biofilm of Staphylococcus aureus, Pseudomonas aeruginosa, and Candida spp.
Bonincontro, G., Scuderi, S. A., Marino, A., & Simonetti, G. (2023) · Pharmaceuticals · doi:10.3390/ph16111531 · Cited by 74 · see citing works
Candida biofilm production is associated with higher mortality in patients with candidaemia
Vitális, E., Nagy, F., Tóth, Z., Forgács, L., Bozó, A., Kardos, G., Majoros, L., & Kovács, R. (2020) · Mycoses · doi:10.1111/myc.13049 · Cited by 72 · see citing works
Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections
Giordani, B., Basnet, P., Mishchenko, E. V., Luppi, B., & Škalko‐Basnet, N. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics12010009 · Cited by 70 · see citing works
From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris
Allert, S., Schulz, D., Kämmer, P., Großmann, P., Wolf, T., Schäuble, S., Panagiotou, G., Brunke, S., & Hube, B. (2022) · Virulence · doi:10.1080/21505594.2022.2026037 · Cited by 66 · see citing works
Effectiveness of Phytoactive Molecules on Transcriptional Expression, Biofilm Matrix, and Cell Wall Components of Candida glabrata and Its Clinical Isolates
Gupta, P., Gupta, S., Sharma, M., Kumar, N., Pruthi, V., & Poluri, K. M. (2018) · ACS Omega · doi:10.1021/acsomega.8b01856 · Cited by 64 · see citing works
Mixed biofilms of pathogenic Candida-bacteria: regulation mechanisms and treatment strategies
Khan, F., Bamunuarachchi, N. I., Pham, D. T. N., Tabassum, N., Khan, M. S., & Kim, Y. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1921696 · Cited by 61 · see citing works
Evaluation of the biofilm life cycle between Candida albicans and Candida tropicalis
Atiencia-Carrera, M. B., Cabezas-Mera, F. S., Vizuete, K. S., Debut, A., Tejera, E., & Machado, A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.953168 · Cited by 61 · see citing works
Virulence and Biofilms As Promising Targets in Developing Antipathogenic Drugs Against Candidiasis
Khan, M. S., Alshehrei, F. M., Alghamdi, S., Bamaga, M. A., Althubiani, A. S., & Alam, M. Z. (2020) · Future Science OA · doi:10.2144/fsoa-2019-0027 · Cited by 60 · see citing works
Candida albicans enhances meropenem tolerance of Pseudomonas aeruginosa in a dual-species biofilm
Alam, F., Catlow, D., Maio, A. D., Blair, J. M. A., & Hall, R. A. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz514 · Cited by 59 · see citing works
Advances in Biomaterials for the Prevention and Disruption of Candida Biofilms
Vera‐González, N., & Shukla, A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.538602 · Cited by 59 · see citing works
Antifungal drug resistance in Candida: a special emphasis on amphotericin B
Ahmady, L., Gothwal, M., Mukkoli, M. M., & Bari, V. K. (2024) · Apmis · doi:10.1111/apm.13389 · Cited by 58 · see citing works
RcAlb-PepII, a synthetic small peptide bioinspired in the 2S albumin from the seed cake of Ricinus communis, is a potent antimicrobial agent against Klebsiella pneumoniae and Candida parapsilosis
Dias, L. P., Souza, P. F. N., Oliveira, J. T. A., Vasconcelos, I. M., Araújo, N. M. S., van Tilburg, M. F., Guedes, M. I. F., Carneiro, R. F., Lopes, J. L. D. S., & Sousa, D. O. B. (2019) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2019.183092 · Cited by 57 · see citing works
Repurposing approach identifies pitavastatin as a potent azole chemosensitizing agent effective against azole-resistant Candida species
Eldesouky, H. E., Salama, E. A., Li, X., Hazbun, T. R., Mayhoub, A. S., & Seleem, M. N. (2020) · Scientific Reports · doi:10.1038/s41598-020-64571-7 · Cited by 55 · see citing works
Recent gene selection and drug resistance underscore clinical adaptation across Candida species
Schikora-Tamarit, M. À., & Gabaldón, T. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01547-z · Cited by 54 · see citing works
Identification of a Phenylthiazole Small Molecule with Dual Antifungal and Antibiofilm Activity Against Candida albicans and Candida auris
Mohammad, H. T., Eldesouky, H. E., Hazbun, T. R., Mayhoub, A. S., & Seleem, M. N. (2019) · Scientific Reports · doi:10.1038/s41598-019-55379-1 · Cited by 54 · see citing works
The in vivo anti-Candida albicans activity of flavonoids
Nguyen, W., Grigori, L., Just, E., Santos, C., & Seleem, D. (2021) · Journal of Oral Biosciences · doi:10.1016/j.job.2021.03.004 · Cited by 54 · see citing works
Evaluation of Antimicrobial and Anti-Biofilm Formation Activities of Novel Poly(vinyl alcohol) Hydrogels Reinforced with Crosslinked Chitosan and Silver Nano-Particles
Alfuraydi, R. T., Alminderej, F. M., & Mohamed, N. A. (2022) · Polymers · doi:10.3390/polym14081619 · Cited by 54 · see citing works
Nanozyme‐Based Robotics Approach for Targeting Fungal Infection
Oh, M. J., Yoon, S., Babeer, A., Liu, Y., Ren, Z. F., Xiang, Z., Miao, Y., Cormode, D. P., Chen, C., Steager, E. B., et al. (2023) · Advanced Materials · doi:10.1002/adma.202300320 · Cited by 53 · see citing works
Antifungal Carvacrol Loaded Chitosan Nanoparticles
Vitali, A., Stringaro, A., Colone, M., Muntiu, A., & Angiolella, L. (2021) · Antibiotics · doi:10.3390/antibiotics11010011 · Cited by 52 · see citing works
Synthesis of Natural Nano-Hydroxyapatite from Snail Shells and Its Biological Activity: Antimicrobial, Antibiofilm, and Biocompatibility
Ahmed, H. Y., Safwat, N. A., Shehata, R. M., Althubaiti, E. H., Kareem, S. A. E., Atef, A., Qari, S. H., Aljahani, A. H., Al-Meshal, A. S., Youssef, M., et al. (2022) · Membranes · doi:10.3390/membranes12040408 · Cited by 52 · see citing works
Insight Into the Properties and Immunoregulatory Effect of Extracellular Vesicles Produced by Candida glabrata, Candida parapsilosis, and Candida tropicalis Biofilms
Kulig, K., Karnas, E., Woźnicka, O., Kuleta, P., Zuba‐Surma, E. K., Pyza, E., Osyczka, A., Kozik, A., Rąpała‐Kozik, M., & Karkowska‐Kuleta, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.879237 · Cited by 52 · see citing works
Time to Conquer Fungal Infectious Diseases: Employing Nanoparticles as Powerful and Versatile Antifungal Nanosystems against a Wide Variety of Fungal Species
Jangjou, A., Zareshahrabadi, Z., Abbasi, M., Talaiekhozani, A., Kamyab, H., Chelliapan, S., Vaez, A., Golchin, A., Tayebi, L., Vafa, E., et al. (2022) · Sustainability · doi:10.3390/su141912942 · Cited by 52 · see citing works
Biofilm: The invisible culprit in catheter-induced candidemia
Wijaya, M., Halleyantoro, R., & Kalumpiu, J. F. (2023) · AIMS Microbiology · doi:10.3934/microbiol.2023025 · Cited by 52 · see citing works
Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection
Pais, P., Galocha, M., Viana, R., Cavalheiro, M., Pereira, D., & Teixeira, M. C. (2019) · Microbial Cell · doi:10.15698/mic2019.03.670 · Cited by 52 · see citing works
Self-citation
Analysis of Pathogenic Bacterial and Yeast Biofilms Using the Combination of Synchrotron ATR-FTIR Microspectroscopy and Chemometric Approaches
Cheeseman, S., Shaw, Z. L., Vongsvivut, J. P., Crawford, R. J., Dupont, M. F., Boyce, K. J., Gangadoo, S., Bryant, S. J., Bryant, G., Cozzolino, D., et al. (2021) · Molecules · doi:10.3390/molecules26133890 · Cited by 51 · see citing works
Eucalyptol/ β-cyclodextrin inclusion complex loaded gellan/PVA nanofibers as antifungal drug delivery system
Mishra, P., Gupta, P., Srivastava, A., Poluri, K. M., & Prasad, R. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121163 · Cited by 51 · see citing works
We need to talk about Candida tropicalis : Virulence factors and survival mechanisms
dos Santos, M. M., & Ishida, K. (2023) · Medical Mycology · doi:10.1093/mmy/myad075 · Cited by 50 · see citing works
Investigating Biofilms: Advanced Methods for Comprehending Microbial Behavior and Antibiotic Resistance
Almatroudi, A. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2904133 · Cited by 49 · see citing works
Silver nanoparticles coated with dodecanethiol used as fillers in non-cytotoxic and antifungal PBAT surface based on nanocomposites
Ferreira, F. V., Mariano, M., Lepesqueur, L. S. S., Pinheiro, I. F., Santos, L., Burga-Sánchez, J., Souza, D. H. S., Koga‐Ito, C. Y., Teixeira-Neto, A. A., Mei, L. H. I., et al. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.01.044 · Cited by 49 · see citing works
Extracellular Nucleic Acids Present in the Candida albicans Biofilm Trigger the Release of Neutrophil Extracellular Traps
Smolarz, M., Zawrotniak, M., Satała, D., & Rąpała‐Kozik, M. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.681030 · Cited by 49 · see citing works
Biocontrol and Probiotic Function of Non-Saccharomyces Yeasts: New Insights in Agri-Food Industry
Comitini, F., Canonico, L., Agarbati, A., & Ciani, M. (2023) · Microorganisms · doi:10.3390/microorganisms11061450 · Cited by 45 · see citing works
Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres
Guin, K., Chen, Y., Mishra, R., Muzaki, S. R. B. M., Thimmappa, B. C., O’Brien, C. E., Butler, G., Sanyal, A., & Sanyal, K. (2020) · eLife · doi:10.7554/elife.58556 · Cited by 45 · see citing works
Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration
Vallières, C., Hook, A. L., He, Y., Crucitti, V. C., Figueredo, G. P., Davies, C. R., Burroughs, L., Winkler, D. A., Wildman, R. D., Irvine, D. J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba6574 · Cited by 45 · see citing works
Antifungal and anti‐biofilm effects of 6‐shogaol againstCandida auris
Kim, H.-J., & Eom, Y. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14870 · Cited by 45 · see citing works
Biofilm inhibition/eradication: exploring strategies and confronting challenges in combatting biofilm
Srivastava, A., Verma, N., Kumar, V., Apoorva, P., & Agarwal, V. K. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-03938-0 · Cited by 43 · see citing works
Host-Pathogen Interactions Mediated by MDR Transporters in Fungi: As Pleiotropic as it Gets!
Cavalheiro, M., Pais, P., Galocha, M., & Teixeira, M. C. (2018) · Genes · doi:10.3390/genes9070332 · Cited by 42 · see citing works
Self-citation
Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance
Mehta, D., Saini, V., & Bajaj, A. (2023) · RSC Medicinal Chemistry · doi:10.1039/d3md00151b · Cited by 41 · see citing works
Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options
Amann, V., Kissmann, A., Firacative, C., & Rosenau, F. (2025) · Pharmaceuticals · doi:10.3390/ph18040460 · Cited by 41 · see citing works
Anti-biofilm activity of chlorhexidine digluconate against Candida albicans vaginal isolates
Alvendal, C., Mohanty, S., Bohm‐Starke, N., & Brauner, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238428 · Cited by 41 · see citing works
Effects of the binding of a Helianthus annuus lectin to Candida albicans cell wall on biofilm development and adhesion to host cells
Río, M. D., de la Canal, L., Pinedo, M., Mora-Montes, H. M., & Regente, M. C. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152875 · Cited by 40 · see citing works
Morphogenic plasticity: the pathogenic attribute of Candida albicans
Prasad, P., & Tippana, M. (2023) · Current Genetics · doi:10.1007/s00294-023-01263-5 · Cited by 40 · see citing works
Secreted Aspartyl Proteases Family: A Perspective Review on the Regulation Of Fungal Pathogenesis
Kulshrestha, A., & Gupta, P. (2023) · Future Microbiology · doi:10.2217/fmb-2022-0143 · Cited by 40 · see citing works
Disruption of Biofilm by Bacteriophages in Clinically Relevant Settings
Kovacs, C. J., Rapp, E. M., McKenzie, S. M., Mazur, M. Z., Mchale, R. P., Brasko, B., Min, M. Y., Burpo, F. J., & Barnhill, J. C. (2023) · Military Medicine · doi:10.1093/milmed/usad385 · Cited by 40 · see citing works
Mechanistic insights into Candida biofilm eradication potential of eucalyptol
Gupta, P., Pruthi, V., & Poluri, K. M. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14940 · Cited by 40 · see citing works
Evaluation of the antimicrobial and anti-biofilm activity of novel salicylhydrazido chitosan derivatives impregnated with titanium dioxide nanoparticles
Elmehbad, N. Y., Mohamed, N. A., & El‐Ghany, N. A. A. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.03.076 · Cited by 40 · see citing works
Pathophysiological microenvironments in oral candidiasis
Jørgensen, M. R. (2024) · Apmis · doi:10.1111/apm.13412 · Cited by 40 · see citing works
Dissecting the anti-biofilm potency of kappa-carrageenan capped silver nanoparticles against Candida species
Gupta, P., Goel, A., Singh, K. R., Meher, M. K., Gulati, K., & Poluri, K. M. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.01.035 · Cited by 39 · see citing works
Medicinal benefits, biological, and nanoencapsulation functions of riboflavin with its toxicity profile: A narrative review
Lee, T. Y., Farah, N., Chin, V. K., Lim, J. C. W., Chong, P. P., Basir, R., Lim, W. F., & Loo, Y. S. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.08.010 · Cited by 38 · see citing works
Aprepitant, an antiemetic agent, interferes with metal ion homeostasis ofCandida aurisand displays potent synergistic interactions with azole drugs
Eldesouky, H. E., Lanman, N. A., Hazbun, T. R., & Seleem, M. N. (2020) · Virulence · doi:10.1080/21505594.2020.1838741 · Cited by 37 · see citing works
In Vitro Susceptibility Tests in the Context of Antifungal Resistance: Beyond Minimum Inhibitory Concentration in Candida spp.
Franconi, I., & Lupetti, A. (2023) · Journal of Fungi · doi:10.3390/jof9121188 · Cited by 37 · see citing works
Suppression of hyphal formation and virulence of Candida albicans by natural and synthetic compounds
Khan, F., Bamunuarachchi, N. I., Tabassum, N., Jo, D., Khan, P. D. M. M., & Kim, Y. (2021) · Biofouling · doi:10.1080/08927014.2021.1948538 · Cited by 37 · see citing works
Antifungal activity of ribavirin used alone or in combination with fluconazole against Candida albicans is mediated by reduced virulence
Zhang, M., Yan, H., Lü, M., Wang, D., & Sun, S. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.09.008 · Cited by 36 · see citing works
Candida Pathogenicity and Interplay with the Immune System
Valand, N., & Girija, U. V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-67452-6_11 · Cited by 36 · see citing works
Evaluation of the Antifungal Activity of the Licania Rigida Leaf Ethanolic Extract against Biofilms Formed by Candida Sp. Isolates in Acrylic Resin Discs
de Freitas, M. A., Alves, A. I. D. S., Andrade, J. C., de Andrade, M. C. L., dos Santos, A. T. L., de Oliveira, T. F., dos Santos, F. D. A. G., Buonafina, M. D. S., Coutinho, H. D. M., de Menezes, I. R. A., et al. (2019) · Antibiotics · doi:10.3390/antibiotics8040250 · Cited by 35 · see citing works
Origanum vulgare L. essential oil inhibits virulence patterns of Candida spp. and potentiates the effects of fluconazole and nystatin in vitro
Chevecich, C. C., Müller-Sepúlveda, A., Jara, J. A., López‐Muñoz, R., Santander, R., Budini, M., Escobar, A. F., Quijada, R., Criollo, A., Díaz‐Dosque, M., et al. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03518-z · Cited by 35 · see citing works
Adhesion and biofilm formation by the opportunistic pathogen Candida tropicalis: what do we know?
de Souza, C. M., dos Santos, M. M., Furlaneto-Maia, L., & Furlaneto, M. C. (2023) · Canadian Journal of Microbiology · doi:10.1139/cjm-2022-0195 · Cited by 35 · see citing works
Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens
Singla, R. K., & Dubey, A. K. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666191025154834 · Cited by 35 · see citing works
In Vitro Activity of Selected Phenolic Compounds against Planktonic and Biofilm Cells of Food-Contaminating Yeasts
Kimani, B. G., Kerekes, E. B., Szebenyi, C., Krisch, J., Vágvölgyi, C., Papp, T., & Takó, M. (2021) · Foods · doi:10.3390/foods10071652 · Cited by 35 · see citing works
The catheterized bladder environment promotes Efg1- and Als1-dependent Candida albicans infection
Bella, A. A. L., Andersen, M. J., Gervais, N. C., Molina, J. J., Molesan, A., Stuckey, P. V., Wensing, L. F., Nobile, C. J., Shapiro, R. S., Santiago-Tirado, F. H., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade7689 · Cited by 34 · see citing works
Increasing Susceptibility of Drug-Resistant Candida albicans to Fluconazole and Terbinafine by 2(5H)-Furanone Derivative
Sharafutdinov, I., Ozhegov, G. D., Sabirova, A. E., Новикова, В. В., Lisovskaya, S. А., Мунавировна, Х. А., Рафаэловна, К. А., Bogachev, M. I., & Kayumov, A. R. (2020) · Molecules · doi:10.3390/molecules25030642 · Cited by 34 · see citing works

Biofilm Formation in Candida Species
Elibe, M. I., & Innocent, N. E. (2024) · Springer eBooks · doi:10.1007/978-981-97-4909-6_9 · Cited by 2 · see citing works
Candida Biofilms: An Update on Developmental Mechanisms and Therapeutic Challenges
de Barros, P. P., Rossoni, R. D., de Souza, C. M., Scorzoni, L., Fenley, J. D. C., & Junqueira, J. C. (2020) · Mycopathologia · doi:10.1007/s11046-020-00445-w · Cited by 99 · see citing works
Biofilm formation in medically important Candida species
Malinovská, Z., Čonková, E., & Váczi, P. (2023) · Journal of Fungi · doi:10.3390/jof9100955 · Cited by 167 · see citing works
Molecular Microbiology of Candida Biofilms
Samaranayake, L. P., Seneviratne, C., & Jin, L. (2010) · The HKU Scholars Hub (University of Hong Kong)
Studying Candida Biofilms Across Species: Experimental Models, Structural Diversity, and Clinical Implications
Squitieri, D., Rizzo, S., Torelli, R., Mariotti, M., Sanguinetti, M., Cacaci, M., & Bugli, F. (2025) · Pharmaceuticals · doi:10.3390/ph19010008 · Cited by 11 · see citing works

Authors: Cavalheiro, M., & Teixeira, M. C.
Affiliations: University of Lisbon (PT)
Corresponding author: Teixeira, Miguel Cacho
ORCID: Cavalheiro, Mafalda
Teixeira, Miguel Cacho
Venue: Frontiers in Medicine
Publisher: Frontiers Media SA
Published: 2018-02-13
Volume: 5
Pages: 28-28
ISSN: 2296-858X (ISSN-L)
DOI: 10.3389/fmed.2018.00028
PMC: PMC5816785
OpenAlex: W2792847166
Cited by: 690
References: 163
Citations by year: 2026: 57 · 2025: 85 · 2024: 96 · 2023: 103 · 2022: 114 · 2021: 94 · 2020: 87 · 2019: 38 · 2018: 14
FWCI: 8.53
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Medicine (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Fundação para a Ciência e a Tecnologia (PTDC/BBB-BIO/4004/2014, SFRH/BD/116946/2016, UID/BIO/04565/2013)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords: Candida biofilms, Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, extracellular polymeric substances, antifungal resistance, filamentation, fungal pathogenicity, host-pathogen interaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Candida Biofilms: Threats, Challenges, and Promising Strategies

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks