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Mucosal biofilms of Candida albicans
Open accessAbstract
Biofilms are microbial communities that form on surfaces and are embedded in an extracellular matrix. C. albicans forms pathogenic mucosal biofilms that are evoked by changes in host immunity or mucosal ecology. Mucosal surfaces are inhabited by many microbial species; hence these biofilms are polymicrobial. Several recent studies have applied paradigms of biofilm analysis to study mucosal C. albicans infections. These studies reveal that the Bcr1 transcription factor is a master regulator of C. albicans biofilm formation under diverse conditions, though the most relevant Bcr1 target genes can vary with the biofilm niche. An important determinant of mucosal biofilm formation is the interaction with host defenses. Finally, studies of interactions between bacterial species and C. albicans provide insight into the communication mechanisms that endow polymicrobial biofilms with unique properties.
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“In this review, we focus on C. albicans biofilms, which colonize implanted medical devices and mucosal surfaces, from which they can seed systemic infections in humans (46, 47, 64, 89, 97, 161, 172).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [64]
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“It is a member of the healthy microbiota, asymptomatically colonizing the gastrointestinal (GI) tract, reproductive tract, oral cavity, and skin of most humans (1, 64, 87, 97, 99).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [64]
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Cites
Lewis, K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134306 · Cited by 1,858
Survival strategies of infectious biofilms
Fux, C. A., Costerton, J. W., Stewart, P. S., & Stoodley, P. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.11.010 · Cited by 1,797
Characterization of the oral fungal microbiome (mycobiome) in healthy individuals
Ghannoum, M. A., Jurevic, R. J., Mukherjee, P. K., Cui, F., Sikaroodi, M., Naqvi, A., & Gillevet, P. M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000713 · Cited by 1,150
Conti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W., Hai, J. H., Yu, J. J., Jung, J. W., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081463 · Cited by 1,024
Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
Onishi, R. M., & Gaffen, S. L. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03240.x · Cited by 894
Vulvovaginal candidiasis: Epidemiologic, diagnostic, and therapeutic considerations
Sobel, J. D., Faro, S., Force, R. W., Foxman, B., Ledger, W. J., Nyirjesy, P., Reed, B. D., & Summers, P. R. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)80001-x · Cited by 694
Oral Biofilm Architecture on Natural Teeth
Zijnge, V., van Leeuwen, M. B. M., Degener, J. E., Abbas, F., Thurnheer, T., Gmür, R., & Harmsen, H. J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009321 · Cited by 689
Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1.
Staab, J., Bradway, S. D., Fidel, P., & Sundstrom, P. (1999) · Science · doi:10.1126/science.283.5407.1535 · Cited by 683
Genetic control of Candida albicans biofilm development
Finkel, J. S., & Mitchell, A. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2475 · Cited by 641
Self-citationMedically important bacterial-fungal interactions
Peleg, A. Y., Hogan, D. A., & Mylonakis, E. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2313 · Cited by 619
Antifungal Resistance of Candidal Biofilms Formed on Denture Acrylic in vitro
Chandra, J., Mukherjee, P. K., Leidich, S. D., Faddoul, F., Hoyer, L. L., Douglas, L., & Ghannoum, M. A. (2001) · Journal of Dental Research · doi:10.1177/00220345010800031101 · Cited by 588
Candida biofilms on implanted biomaterials: a clinically significant problem
Ramage, G., MartÃnez, J. P., & López-Ribot, J. L. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00117.x · Cited by 575
How to build a biofilm: a fungal perspective
Blankenship, J. R., & Mitchell, A. P. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.10.003 · Cited by 530
Self-citationHarriott, M. M., & Noverr, M. C. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00657-09 · Cited by 526
Critical Role of Bcr1-Dependent Adhesins in C. albicans Biofilm Formation In Vitro and In Vivo
Nobile, C. J., Andes, D. R., Nett, J. E., Smith, F. J., Yue, F., Phan, Q.-T., Edwards, J. E., Filler, S. G., & Mitchell, A. P. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020063 · Cited by 507
Self-citationKhader, S. A., Gaffen, S. L., & Kolls, J. K. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.100 · Cited by 496
The oral microbiota: Living with a permanent guest
Avila, M., Ojcius, D. M., & Yilmaz, Ö. (2009) · DNA and Cell Biology · doi:10.1089/dna.2009.0874 · Cited by 482
Dispersion as an Important Step in the Candida albicans Biofilm Developmental Cycle
Uppuluri, P., Chaturvedi, A. K., Srinivasan, A., Banerjee, M., Ramasubramaniam, A. K., Köhler, J. R., Kadosh, D., & Lopez-Ribot, J. L. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000828 · Cited by 432
Putative Role of β-1,3 Glucans in Candida albicans Biofilm Resistance
Nett, J., Lincoln, L., Marchillo, K., Massey, R., Holoyda, K., Hoff, B., VanHandel, M., & Andes, D. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01056-06 · Cited by 407
Cross-kingdom interactions:Candida albicansand bacteria
Shirtliff, M. E., Peters, B. M., & Jabra‐Rizk, M. A. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01668.x · Cited by 399
Function of Candida albicans Adhesin Hwp1 in Biofilm Formation
Nobile, C. J., Nett, J. E., Andes, D. R., & Mitchell, A. P. (2006) · Eukaryotic Cell · doi:10.1128/ec.00194-06 · Cited by 395
Self-citationAndes, D., Nett, J., Oschel, P., Albrecht, R., Marchillo, K., & Pitula, A. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.6023-6031.2004 · Cited by 389
Moyes, D. L., Runglall, M., Murciano, C., Shen, C., Nayar, D., Thavaraj, S., Kohli, A., Islam, A., Mora-Montes, H. M., Challacombe, S., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.08.002 · Cited by 382
Ramage, G., VandeWalle, K., López-Ribot, J. L., & Wickes, B. L. (2002) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(02)00853-4 · Cited by 334
Candida albicans forms biofilms on the vaginal mucosa
Harriott, M. M., Lilly, E. A., Rodriguez, T. E., Fidel, P. L., & Noverr, M. C. (2010) · Microbiology · doi:10.1099/mic.0.039354-0 · Cited by 301
Bamford, C. V., d'Mello, A., Nobbs, A. H., Dutton, L. C., Vickerman, M. M., & Jenkinson, H. F. (2009) · Infection and Immunity · doi:10.1128/iai.00438-09 · Cited by 291
Peters, B. M., Jabra‐Rizk, M. A., Scheper, M. A., Leid, J. G., Costerton, J. W., & Shirtliff, M. E. (2010) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2010.00710.x · Cited by 288
Oral mucosal fungal infections
Samaranayake, L. P., Leung, W. K., & Jin, L. (2008) · Periodontology 2000 · doi:10.1111/j.1600-0757.2008.00291.x · Cited by 279
Candida albicans Interactions with Bacteria in the Context of Human Health and Disease
Morales, D. K., & Hogan, D. A. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000886 · Cited by 270
Webb, B. C., Thomas, C. J., Willcox, M. D. P., Harty, D. W. S., & Knox, K. W. (1998) · Australian Dental Journal · doi:10.1111/j.1834-7819.1998.tb00152.x · Cited by 251
ALTERNATIVECANDIDA ALBICANSLIFESTYLES: Growth on Surfaces
Kumamoto, C. A., & Vinces, M. D. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121034 · Cited by 247
Precarious Balance: Th17 Cells in Host Defense
Peck, A., & Mellins, E. (2009) · Infection and Immunity · doi:10.1128/iai.00929-09 · Cited by 241
Silverman, R. J., Nobbs, A. H., Vickerman, M. M., Barbour, M. E., & Jenkinson, H. F. (2010) · Infection and Immunity · doi:10.1128/iai.00685-10 · Cited by 219
Characterization of Mucosal Candida albicans Biofilms
Dongari‐Bagtzoglou, A. I., Kashleva, H., Dwivedi, P., Diaz, P. I., & Vasilakos, J. P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007967 · Cited by 214
Biofilm formation in clinical Candida isolates and its association with virulence
Hasan, F., Xess, I., Wang, X., Jain, N., & Fries, B. C. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.04.018 · Cited by 206
An Extensive Circuitry for Cell Wall Regulation in Candida albicans
Blankenship, J. R., Fanning, S., Hamaker, J. J., & Mitchell, A. P. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000752 · Cited by 201
Self-citationStreptococcus mutans Competence-Stimulating Peptide Inhibits Candida albicans Hypha Formation
Jarosz, L. M., Deng, D. M., van der Mei, H. C., Crielaard, W., & Krom, B. P. (2009) · Eukaryotic Cell · doi:10.1128/ec.00070-09 · Cited by 187
Self-Regulation of Candida albicans Population Size during GI Colonization
White, S. J., Rosenbach, A., Lephart, P., Nguyen, D. T., Benjamin, A., Tzipori, S. R., Whiteway, M. S., Mecsas, J. C., & Kumamoto, C. A. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030184 · Cited by 185
Vediyappan, G., Rossignol, T., & d'Enfert, C. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01638-09 · Cited by 183
Rabbit Model of Candida albicans Biofilm Infection: Liposomal Amphotericin B Antifungal Lock Therapy
Schinabeck, M. K., Long, L. A., Hossain, M. A., Chandra, J., Mukherjee, P. K., Mohamed, S., & Ghannoum, M. A. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.5.1727-1732.2004 · Cited by 180
Candida albicans Als3p is required for wild-type biofilm formation on silicone elastomer surfaces
Zhao, X., Daniels, K. J., Oh, S.-H., Green, C. B., Yeater, K. M., Soll, D. R., & Hoyer, L. L. (2006) · Microbiology · doi:10.1099/mic.0.28959-0 · Cited by 179
Time Course Global Gene Expression Analysis of an In Vivo Candida Biofilm
Nett, J. E., Lepak, A. J., Marchillo, K., & Andes, D. R. (2009) · The Journal of Infectious Diseases · doi:10.1086/599838 · Cited by 162
Development and Validation of an In Vivo Candida albicans Biofilm Denture Model
Nett, J. E., Marchillo, K., Spiegel, C. A., & Andes, D. R. (2010) · Infection and Immunity · doi:10.1128/iai.00480-10 · Cited by 161
Green, C. B., Cheng, G., Chandra, J., Mukherjee, P. K., Ghannoum, M. A., & Hoyer, L. L. (2004) · Microbiology · doi:10.1099/mic.0.26699-0 · Cited by 159
Bonhomme, J., Chauvel, M., Goyard, S., Roux, P., Rossignol, T., & d'Enfert, C. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07626.x · Cited by 144
Adaptations of Candida albicans for Growth in the Mammalian Intestinal Tract
Rosenbach, A., Dignard, D., Pierce, J. V., Whiteway, M., & Kumamoto, C. A. (2010) · Eukaryotic Cell · doi:10.1128/ec.00034-10 · Cited by 143
Candida albicans Hyr1p Confers Resistance to Neutrophil Killing and Is a Potential Vaccine Target
Luo, G., Ibrahim, A. S., Spellberg, B., Nobile, C. J., Mitchell, A. P., & Fu, Y. (2010) · The Journal of Infectious Diseases · doi:10.1086/652407 · Cited by 125
Self-citationNew Model of Oropharyngeal Candidiasis in Mice
Kamai, Y., Kubota, M., Kamai, Y., Hosokawa, T., Fukuoka, T., & Filler, S. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.11.3195-3197.2001 · Cited by 125
Nobbs, A. H., Vickerman, M. M., & Jenkinson, H. F. (2010) · Eukaryotic Cell · doi:10.1128/ec.00103-10 · Cited by 112
Dwivedi, P., Thompson, A., Xie, Z., Kashleva, H., Ganguly, S., Mitchell, A. P., & Dongari-Bagtzoglou, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016218 · Cited by 110
Self-citationPathogenesis of invasive candidiasis
van de Veerdonk, F. L., Kullberg, B. J., & Netea, M. G. (2010) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e32833e046e · Cited by 90
Coudeyras, S., Jugie, G., Vermerie, M., & Forestier, C. (2008) · Infectious Diseases in Obstetrics and Gynecology · doi:10.1155/2008/549640 · Cited by 89
Martinez, R. C. R., Seney, S. L., Summers, K. L., Nomizo, A., Martinis, E. C. P. D., & Reid, G. (2009) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2009.00154.x · Cited by 86
Fitzsimmons, N., & BERRY, D. R. (1994) · PubMed · Cited by 62
Severe Candida spp. infections: new insights into natural immunity
van der Meer, J. W. M., van de Veerdonk, F. L., Joosten, L. A. B., Kullberg, B. J., & Netea, M. G. (2010) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2010.11.013 · Cited by 60
Transcriptional Responses of Candida albicans to Epithelial and Endothelial Cells
Park, H., Liu, Y., Solis, N. V., Spotkov, J., Hamaker, J. J., Blankenship, J. R., Yeaman, M. R., Mitchell, A. P., Liu, H., & Filler, S. G. (2009) · Eukaryotic Cell · doi:10.1128/ec.00165-09 · Cited by 59
Self-citationDevelopment of a novel three-dimensional in vitro model of oral Candida infection
Dongari‐Bagtzoglou, A. I., & Kashleva, H. (2006) · Microbial Pathogenesis · doi:10.1016/j.micpath.2006.02.004 · Cited by 44
Murine Models of Candida Vaginal Infections
Fidel, P. L., & Sobel, J. D. (1999) · Elsevier eBooks · doi:10.1016/b978-012775390-4/50229-3 · Cited by 30
Bahri, R., Curt, S., Saidane‐Mosbahi, D., & Rouabhia, M. (2010) · Mediators of Inflammation · doi:10.1155/2010/940383 · Cited by 26
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Nobile, C. J., & Johnson, A. D. (2015) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104330 · Cited by 1,057
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“Als3 which is the target of Bcr1 plays a crucial role in the formation of biofilm on the abiotic surface [43].”
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Metadata
- Authors
- Ganguly, S., & Mitchell, A. P.
- Affiliations
- Carnegie Mellon University (US)
- Corresponding author
- Mitchell, Aaron P
- ORCID
- Mitchell, Aaron P
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 14
- Issue
- 4
- Pages
- 380-385
- ISSN
- 1369-5274 (ISSN-L)
- PMC
- PMC3159763
- OpenAlex
- W1994403582
- Cited by
- 200
- References
- 59
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 7 · 2023: 15 · 2022: 15 · 2021: 16 · 2020: 20 · 2019: 15 · 2018: 17 · 2017: 19 · 2016: 14 · 2015: 14 · 2014: 12 · 2013: 13 · 2012: 7
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01 AI067703)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Candida albicans, biofilm formation, host-pathogen interaction, polymicrobial biofilms, extracellular matrix, host immunity, fungal virulence
- MeSH terms
- Candida albicans, Candidiasis, Oral, Candidiasis, Vulvovaginal, Female, Genes, Fungal, Humans, Immunity, Innate, Mucous Membrane, Stomatitis, Denture, Transcription Factors, Gene Expression Regulation, Fungal, Biofilms, Host-Pathogen Interactions
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