Glia Crosstalk in Neuroinflammatory Diseases
Open accessAbstract
Neuroinflammation constitutes a fundamental cellular process to signal the loss of brain homeostasis. Glial cells play a central role in orchestrating these neuroinflammation processes in both deleterious and beneficial ways. These cellular responses depend on their intercellular interactions with neurons, astrocytes, the blood-brain barrier (BBB), and infiltrated T cells in the central nervous system (CNS). However, this intercellular crosstalk seems to be activated by specific stimuli for each different neurological scenario. This review summarizes key studies linking neuroinflammation with certain neurodegenerative diseases such as Alzheimer disease (AD), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) and for the development of better therapeutic strategies based on immunomodulation.
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Gliosis is consistent with the presence of neuroinflammation.
“Gliosis is consistent with the presence of neuroinflammation [46].”
From Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease (2023) · cites this paper as [46]
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Alzheimer’s disease and its treatment by different approaches: A review
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Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease
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The Regulation of Phoenixin: A Fascinating Multidimensional Peptide
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Alternative Targets to Fight Alzheimer’s Disease: Focus on Astrocytes
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Critical Involvement of Glial Cells in Manganese Neurotoxicity
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Cerebral Organoids and Antisense Oligonucleotide Therapeutics: Challenges and Opportunities
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Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity
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- Authors
- Bernaus, A., Blanco, S., & Sevilla, A.
- Affiliations
- Universitat de Barcelona (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Sevilla, Ana
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2020-07-29
- Volume
- 14
- Pages
- 209-209
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC7403442
- OpenAlex
- W3046216659
- Cited by
- 157
- References
- 134
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 39 · 2023: 29 · 2022: 32 · 2021: 20 · 2020: 1
- FWCI
- 7.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministerio de Ciencia y Tecnología (RYC-2016-19962)
- Ministerio de Ciencia, Innovación y Universidades (PGC2018-098626-B100)
- Merck Company Foundation
- Fundación Científica Asociación Española Contra el Cáncer
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- neuroinflammation, astrocytes, blood-brain barrier, infiltrating T cells, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, immunomodulation, neuron-glia interactions
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