High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

Functional Characterization of the <i>S. cerevisiae</i> Genome by Gene Deletion and Parallel Analysis

Winzeler, E. A., Shoemaker, D. D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J. D., Bussey, H., et al. (1999) · Science · doi:10.1126/science.285.5429.901 · Cited by 3,953 · see citing works

The Genetic Landscape of a Cell

Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E. D., Sevier, C. S., Ding, H., Koh, J. L. Y., Toufighi, K., Mostafavi, S., et al. (2010) · Science · doi:10.1126/science.1180823 · Cited by 2,162 · see citing works

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

Stebbins, C. E., Russo, A. A., Schneider, C. B., Rosen, N. X., Hartl, F. U., & Pavletich, N. P. (1997) · Cell · doi:10.1016/s0092-8674(00)80203-2 · Cited by 1,370 · see citing works

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

Hillenmeyer, M. E., Fung, E., Wildenhain, J., Pierce, S. E., Hoon, S. S., Lee, W., Proctor, M. J., St.Onge, R. P., Tyers, M., Koller, D., et al. (2008) · Science · doi:10.1126/science.1150021 · Cited by 978 · see citing works

Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile

Schuldiner, M., Collins, S. R., Thompson, N. J., Denic, V., Bhamidipati, A., Punna, T., Ihmels, J., Andrews, B., Boone, C., Greenblatt, J. F., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.031 · Cited by 870 · see citing works

Inhibition of actin polymerization by latrunculin A

Coué, M., Brenner, S. L., Spector, I., & Korn, E. D. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81513-2 · Cited by 824 · see citing works

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

Parsons, A. B., Brost, R. L., Ding, H., Li, Z., Zhang, C., Sheikh, B., Brown, G. W., Kane, P. M., Hughes, T. R., & Boone, C. M. (2003) · Nature Biotechnology · doi:10.1038/nbt919 · Cited by 651 · see citing works

hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures.

Borkovich, K. A., Farrelly, F. W., Finkelstein, D. B., Taulien, J., & Lindquist, S. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.9.3919 · Cited by 641 · see citing works

An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site

Rock, F. L., Mao, W., Yaremchuk, A. D., Tukalo, M. A., Crépin, T., Zhou, H., Zhang, Y.-K., Hernandez, V. S., Akama, T., Baker, S. J., et al. (2007) · Science · doi:10.1126/science.1142189 · Cited by 639 · see citing works

Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin

Frederick, C. A., Williams, L. D., Ughetto, G., MAREL, G. A. V. D., BOOM, J. H. V., Rich, A., & Wang, A. H. ‐. (1990) · Biochemistry · doi:10.1021/bi00462a016 · Cited by 578 · see citing works

Genomic profiling of drug sensitivities via induced haploinsufficiency

Giaever, G. N., Shoemaker, D. D., Jones, T., Liang, H., Winzeler, E. A., Astromoff, A., & Davis, R. W. (1999) · Nature Genetics · doi:10.1038/6791 · Cited by 570 · see citing works

Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast

Giaever, G. N., Flaherty, P., Kumm, J., Proctor, M. J., Nislow, C., Jaramillo, D. F., Chu, A. M., Jordan, M. I., Arkin, A. P., & Davis, R. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307490100 · Cited by 506 · see citing works

DNA topoisomerase-targeting antitumor drugs can be studied in yeast.

Nitiss, J. L., & Wang, J. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.20.7501 · Cited by 503 · see citing works

The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism

Lill, R., Hoffmann, B., Molik, S., Pierik, A. J., Rietzschel, N., Stehling, O., Uzarska, M. A., Webert, H., Wilbrecht, C., & Mühlenhoff, U. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.009 · Cited by 501 · see citing works

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

Parsons, A. B., López, A., Givoni, I. E., Williams, D. E., Gray, C. A., Porter, J., Chua, G., Sopko, R., Brost, R. L., Ho, C.-H., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.040 · Cited by 500 · see citing works

Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes

Lum, P. Y., Armour, C. D., Stepaniants, S. B., Cavet, G., Wolf, M. K., Butler, J. S., Hinshaw, J. C., Garnier, P., Prestwich, G. D., Leonardson, A. S., et al. (2004) · Cell · doi:10.1016/s0092-8674(03)01035-3 · Cited by 481 · see citing works

Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases

Droese, S., Bindseil, K. U., Bowman, E. J., Siebers, A., Zeeck, A., & Altendorf, K. (1993) · Biochemistry · doi:10.1021/bi00066a008 · Cited by 410 · see citing works

Role of the ubiquitin‐selective CDC48UFD1/NPL4 chaperone (segregase) in ERAD of OLE1 and other substrates

Braun, S. J., Matuschewski, K., Rapé, M., Thoms, S., & Jentsch, S. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.615 · Cited by 330 · see citing works

The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together

Lomakin, I. B., Xiong, Y., & Steitz, T. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.013 · Cited by 250 · see citing works

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures

Pierce, S. E., Davis, R. W., Nislow, C., & Giaever, G. N. (2007) · Nature Protocols · doi:10.1038/nprot.2007.427 · Cited by 208 · see citing works

An integrated platform of genomic assays reveals small-molecule bioactivities

Hoon, S. S., Smith, A. M., Wallace, I. M., Suresh, S., Miranda, M., Fung, E., Proctor, M. J., Shokat, K. M., Zhang, C., Davis, R. W., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.100 · Cited by 201 · see citing works

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

Eberhard, Y., McDermott, S., Wang, X., Gronda, M., Venugopal, A. L., Wood, T. E., Hurren, R., Datti, A., Batey, R. A., Wrana, J. L., et al. (2009) · Blood · doi:10.1182/blood-2009-03-209965 · Cited by 183 · see citing works

Temperature-sensitive yeast mutants defective in mitochondrial inheritance.

McConnell, S. J., Stewart, L. C., Talin, A. A., & Yaffe, M. P. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.3.967 · Cited by 167 · see citing works

Old Yellow Enzyme. The discovery of multiple isozymes and a family of related proteins.

Stott, K. M., Saito, K., Thiele, D. J., & Massey, V. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53224-5 · Cited by 165 · see citing works

MGA2 or SPT23 Is Required for Transcription of the Δ9 Fatty Acid Desaturase Gene, OLE1, and Nuclear Membrane Integrity in Saccharomyces cerevisiae

Zhang, S., Skalsky, Y., & Garfinkel, D. J. (1999) · Genetics · doi:10.1093/genetics/151.2.473 · Cited by 160 · see citing works

Confronting the challenges of natural product-based antifungal discovery

Roemer, T., Xu, D., Singh, S. B., Parish, C. A., Harris, G., Wang, H., Davies, J. E., & Bills, G. F. (2011) · Chemistry &amp; Biology · doi:10.1016/j.chembiol.2011.01.009 · Cited by 147 · see citing works

Ergosterol promotes pheromone signaling and plasma membrane fusion in mating yeast

Jin, H., McCaffery, J. M., & Grote, E. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200705076 · Cited by 142 · see citing works

Inhibition of the fungal fatty acid synthase type I multienzyme complex

Johansson, P., Wiltschi, B., Kumari, P., Keßler, B., Vonrhein, C., Vonck, J., Oesterhelt, D., & Grininger, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805827105 · Cited by 127 · see citing works

A unique and universal molecular barcode array

Pierce, S. E., Fung, E., Jaramillo, D. F., Chu, A. M., Davis, R. W., Nislow, C., & Giaever, G. N. (2006) · Nature Methods · doi:10.1038/nmeth905 · Cited by 115 · see citing works

Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action

Hillenmeyer, M. E., Ericson, E., Davis, R. W., Nislow, C., Koller, D., & Giaever, G. (2010) · Genome Biology · doi:10.1186/gb-2010-11-3-r30 · Cited by 112 · see citing works

Metalloregulation of yeast membrane steroid receptor homologs

Lyons, T. J., Villa, N., Regalla, L. M., Kupchak, B. R., Vagstad, A. L., & Eide, D. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306324101 · Cited by 102 · see citing works

Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway

Butcher, R. A., Bhullar, B., Perlstein, E. O., Marsischky, G., LaBaer, J., & Schreiber, S. L. (2006) · Nature Chemical Biology · doi:10.1038/nchembio762 · Cited by 99 · see citing works

A role for unsaturated fatty acids in mitochondrial movement and inheritance.

Stewart, L. C., & Yaffe, M. P. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.5.1249 · Cited by 97 · see citing works

Systematic identification of gene annotation errors in the widely used yeast mutation collections

Ben-Shitrit, T., Yosef, N., Shemesh, K., Sharan, R., Ruppin, E., & Kupiec, M. (2012) · Nature Methods · doi:10.1038/nmeth.1890 · Cited by 95 · see citing works

Tracing intracellular proteolytic pathways. Proteolysis of fatty acid synthase and other cytoplasmic proteins in the yeast Saccharomyces cerevisiae.

Egner, R., Thumm, M., Straub, M., Simeon, A., Schüller, H., & Wolf, D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74245-8 · Cited by 83 · see citing works

Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects

Cheng, W.-C., Teng, X., Park, H.-K., Tucker, C. M., Dunham, M. J., & Hardwick, J. M. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.117 · Cited by 66 · see citing works

COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae

Maytal‐Kivity, V., Piran, R., Pick, E., Hofmann, K., & Glickman, M. H. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf235 · Cited by 66 · see citing works

Redox transitions of chromium, manganese, iron, cobalt and nickel protoporphyrins in aqueous solution

de Groot, M. T., & Koper, M. T. M. (2007) · Physical Chemistry Chemical Physics · doi:10.1039/b714727a · Cited by 62 · see citing works

Regulation of Unsaturated Fatty Acid Biosynthesis in Saccharomyces

Kandasamy, P., Vemula, M., Oh, C., Chellappa, R., & Martin, C. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401557200 · Cited by 53 · see citing works

Kei1: A Novel Subunit of Inositolphosphorylceramide Synthase, Essential for Its Enzyme Activity and Golgi Localization

Sato, K., Noda, Y., & Yoda, K. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-03-0235 · Cited by 53 · see citing works

Superoxide anions regulate TORC1 and its ability to bind Fpr1:rapamycin complex

Neklesa, T. K., & Davis, R. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807712105 · Cited by 52 · see citing works

Lipid-dependent Subcellular Relocalization of the Acyl Chain Desaturase in Yeast

Tatzer, V. C., Zellnig, G., Kohlwein, S. D., & Schneiter, R. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-04-0196 · Cited by 37 · see citing works

Binding Characteristics and Regulatory Mechanisms of the Transcription Factors Controlling Oleate-responsive Genes in Saccharomyces cerevisiae

Karpichev, I. V., Durand-Heredia, J. M., Luo, Y., & Small, G. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708215200 · Cited by 33 · see citing works

Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II

Baldwin, E. L. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki246 · Cited by 33 · see citing works

The acetyl‐CoA synthetase gene ACS2 of the yeast Saccharomyces cerevisiae is coregulated with structural genes of fatty acid biosynthesis by the transcriptional activators Ino2p and Ino4p

Hiesinger, M., Wagner, C., & Schüller, H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01085-5 · Cited by 32 · see citing works

Structural, physical and biological characteristics of RNA.DNA binding agent N8-actinomycin D

Shinomiya, M., Chu, W., Carlson, R. G., Weaver, R. F., & Takusagawa, F. (1995) · Worldwide Protein Data Bank · doi:10.2210/pdb209d/pdb · Cited by 29 · see citing works

A Global Perspective of the Genetic Basis for Carbonyl Stress Resistance

Hoon, S. S., Gebbia, M., Costanzo, M., Davis, R. W., Giaever, G. N., & Nislow, C. (2011) · G3 Genes Genomes Genetics · doi:10.1534/g3.111.000505 · Cited by 27 · see citing works

Approaches towards the synthesis of a novel class of 2-amino-5-arylazonicotinate, pyridazinone and pyrido[2,3-d]pyrimidine derivatives as potent antimicrobial agents

Ibrahim, H. M., Behbehani, H., & ELNAGDI, M. H. (2013) · Chemistry Central Journal · doi:10.1186/1752-153x-7-123 · Cited by 27 · see citing works

Structural, Physical, and Biological Characteristics of RNA.cntdot.DNA Binding Agent N8-Actinomycin D

Shinomiya, M., Chu, W., Carlson, R. G., Weaver, R. F., & Takusagawa, F. (1995) · Biochemistry · doi:10.1021/bi00026a032 · Cited by 24 · see citing works

Overexpression of Ssl2p confers resistance to adriamycin and actinomycin D in Saccharomyces cerevisiae

Furuchi, T., Nitta, K., Takahashi, T., & Naganuma, A. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.160 · Cited by 17 · see citing works

A global genetic interaction network maps a wiring diagram of cellular function

Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., et al. (2016) · Science · doi:10.1126/science.aaf1420 · Cited by 1,240 · see citing works

Global Genetic Networks and the Genotype-to-Phenotype Relationship

Costanzo, M., Kuzmin, E., van Leeuwen, J., Mair, B., Moffat, J., Boone, C., & Andrews, B. (2019) · Cell · doi:10.1016/j.cell.2019.01.033 · Cited by 241 · see citing works

Identifying compound efficacy targets in phenotypic drug discovery

Schirle, M., & Jenkins, J. L. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.08.001 · Cited by 164 · see citing works

Systematic Functional Annotation and Visualization of Biological Networks

Baryshnikova, A. (2016) · Cell Systems · doi:10.1016/j.cels.2016.04.014 · Cited by 148 · see citing works

Biosynthesis of fragin is controlled by a novel quorum sensing signal

Jenul, C., Sieber, S., Daeppen, C., Mathew, A., Lardi, M., Pessi, G., Hoepfner, D., Neuburger, M. A., Linden, A., Gademann, K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03690-2 · Cited by 139 · see citing works

Dark chemical matter as a promising starting point for drug lead discovery

Wassermann, A. M., Lounkine, E., Hoepfner, D., Goff, G. L., King, F. J., Studer, C., Peltier, J. M., Grippo, M. L., Prindle, V. C., Tao, J., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1936 · Cited by 135 · see citing works

Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity

Vincent, B. M., Tardiff, D. F., Piotrowski, J. S., Aron, R., Lucas, M. C., Chung, C. Y., Bacherman, H., Chen, Y., Pires, M., Subramaniam, R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.028 · Cited by 133 · see citing works

Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells

Thangamani, S., Eldesouky, H. E., Mohammad, H. T., Pascuzzi, P. E., Avramova, L. V., Hazbun, T. R., & Seleem, M. N. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.09.029 · Cited by 113 · see citing works

Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti‐Cancer Properties

Krastel, P., Roggo, S. P., Schirle, M., Ross, N. T., Perruccio, F., Aspesi, P., Aust, T., Buntin, K., Estoppey, D., Liechty, B., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201505069 · Cited by 107 · see citing works

Functional annotation of chemical libraries across diverse biological processes

Piotrowski, J. S., Li, S. C., Deshpande, R., Simpkins, S. W., Nelson, J., Yashiroda, Y., Barber, J. M., Safizadeh, H., Wilson, E. H., Okada, H., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2436 · Cited by 93 · see citing works

Why haploinsufficiency persists

Morrill, S. A., & Amon, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1900437116 · Cited by 91 · see citing works

Mapping Causal Variants with Single-Nucleotide Resolution Reveals Biochemical Drivers of Phenotypic Change

She, R., & Jarosz, D. F. (2018) · Cell · doi:10.1016/j.cell.2017.12.015 · Cited by 89 · see citing works

A Prion Epigenetic Switch Establishes an Active Chromatin State

Harvey, Z. H., Chakravarty, A. K., Futia, R. A., & Jarosz, D. F. (2019) · Cell · doi:10.1016/j.cell.2020.02.014 · Cited by 86 · see citing works

The Monoterpene Carvacrol Generates Endoplasmic Reticulum Stress in the Pathogenic Fungus Candida albicans

Chaillot, J., Tebbji, F., Remmal, A., Boone, C., Brown, G. W., Bellaoui, M., & Sellam, A. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00551-15 · Cited by 82 · see citing works

The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase

Estoppey, D., Lee, C. M., Janoschke, M., Lee, B. H., Wan, K. F., Dong, H., Mathys, P., Filipuzzi, I., Schuhmann, T., Riedl, R., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.071 · Cited by 76 · see citing works

The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells

Kallifatidis, G., Hoepfner, D., Jaeg, T., Guzmán, E. A., & Wright, A. E. (2013) · Marine Drugs · doi:10.3390/md11093500 · Cited by 71 · see citing works

Exposure to selenomethionine causes selenocysteine misincorporation and protein aggregation in Saccharomyces cerevisiae

Plateau, P., Saveanu, C., Lestini, R., Dauplais, M., Decourty, L., Jacquier, A., Blanquet, S., & Lazard, M. (2017) · Scientific Reports · doi:10.1038/srep44761 · Cited by 71 · see citing works

Discovery of a ZIP7 inhibitor from a Notch pathway screen

Nolin, E., Gans, S., Llamas, L., Bandyopadhyay, S., Brittain, S. M., Bernasconi-Elias, P., Carter, K. P., Loureiro, J., Thomas, J. R., Schirle, M., et al. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0200-7 · Cited by 68 · see citing works

Decatransin, a novel natural product inhibiting protein translocation at the Sec61/SecY translocon

Junne, T., Wong, J., Studer, C., Aust, T., Bauer, B. W., Beibel, M., Bhullar, B., Bruccoleri, R., Eichenberger, J., Estoppey, D., et al. (2015) · Journal of Cell Science · doi:10.1242/jcs.165746 · Cited by 67 · see citing works

A LAPF/phafin1-like protein regulates TORC1 and lysosomal membrane permeabilization in response to endoplasmic reticulum membrane stress

Kim, A., & Cunningham, K. W. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-08-0581 · Cited by 67 · see citing works

The Novolactone Natural Product Disrupts the Allosteric Regulation of Hsp70

Hassan, A., Kirby, C. A., Zhou, W., Schuhmann, T., Kityk, R., Kipp, D. R., Baird, J., Chen, J., Chen, Y., Chung, F. S., et al. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.11.007 · Cited by 62 · see citing works

Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis

Bar-Yosef, H., Gonzalez, N. V., Ben‐Aroya, S., Kron, S. J., & Kornitzer, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-05741-y · Cited by 58 · see citing works

Identification of Essential Genes and Fluconazole Susceptibility Genes in <i>Candida glabrata</i> by Profiling <i>Hermes</i> Transposon Insertions

Gale, A. N., Sakhawala, R. M., Levitan, A., Sharan, R., Berman, J., Timp, W., & Cunningham, K. W. (2020) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.120.401595 · Cited by 56 · see citing works

Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function

Aulakh, S. K., Varma, S. J., & Ralser, M. (2022) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2022.101987 · Cited by 56 · see citing works

Recent gene selection and drug resistance underscore clinical adaptation across Candida species

Schikora-Tamarit, M. À., & Gabaldón, T. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01547-z · Cited by 54 · see citing works

A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion

Garcia, C. A., Burgain, A., Chaillot, J., Pic, É., Khemiri, I., & Sellam, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-29973-8 · Cited by 50 · see citing works

Yeast toxicogenomics: Lessons from a eukaryotic cell model and cell factory

dos Santos, S. C., & Sá-Correia, I. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.03.001 · Cited by 49 · see citing works

Biological factors and statistical limitations prevent detection of most noncanonical proteins by mass spectrometry

Wacholder, A. C., & Carvunis, A. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002409 · Cited by 47 · see citing works

Can Saccharomyces cerevisiae keep up as a model system in fungal azole susceptibility research?

Demuyser, L., & Dijck, P. V. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.02.002 · Cited by 41 · see citing works

Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control

Winz, M., Peil, L., Turowski, T. W., Rappsilber, J., & Tollervey, D. W. (2019) · Nature Communications · doi:10.1038/s41467-019-08382-z · Cited by 41 · see citing works

Multiplex navigation of global regulatory networks (MINR) in yeast for improved ethanol tolerance and production

Liu, R., Liang, L., Choudhury, A., Garst, A. D., Eckert, C. A., Oh, E. J., Winkler, J. D., & Gill, R. T. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.07.007 · Cited by 40 · see citing works

A simple and inexpensive quantitative technique for determining chemical sensitivity in Saccharomyces cerevisiae

Hung, C., Martínez-Márquez, J. Y., Javed, F. T., & Duncan, M. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-30305-z · Cited by 40 · see citing works

A systematic approach to identify recycling endocytic cargo depending on the GARP complex

Eising, S., Thiele, L., & Fröhlich, F. (2019) · eLife · doi:10.7554/elife.42837 · Cited by 39 · see citing works

Finding the needle in a haystack: Mapping antifungal drug resistance in fungal pathogen by genomic approaches

Sanglard, D. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007478 · Cited by 39 · see citing works

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells

Estoppey, D., Hewett, J. W., Guy, C. T., Harrington, E. M., Thomas, J. R., Schirle, M., Cuttat, R., Waldt, A., Gerrits, B., Yang, Z., et al. (2017) · Scientific Reports · doi:10.1038/srep42728 · Cited by 37 · see citing works

Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import

Filipuzzi, I., Steffen, J., Germain, M., Goepfert, L., Conti, M. A., Potting, C., Cerino, R., Pfeifer, M., Krastel, P., Hoepfner, D., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2493 · Cited by 37 · see citing works

Quantitative high-content imaging identifies novel regulators of Neo1 trafficking at endosomes

Dalton, L. E., Bean, B. D. M., Davey, M., & Conibear, E. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-11-0772 · Cited by 36 · see citing works

Candida glabrata Transcription Factor Rpn4 Mediates Fluconazole Resistance through Regulation of Ergosterol Biosynthesis and Plasma Membrane Permeability

Pais, P., Califórnia, R., Galocha, M., Viana, R., Ola, M., Cavalheiro, M., Takahashi‐Nakaguchi, A., Chibana, H., Butler, G., & Teixeira, M. C. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00554-20 · Cited by 36 · see citing works

Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol

Fu, Y., Estoppey, D., Roggo, S. P., Pistorius, D., Fuchs, F., Studer, C., Ibrahim, A. S., Aust, T., Grandjean, F., MIHALIC, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17221-5 · Cited by 35 · see citing works

Global analysis of the yeast knockout phenome

Turco, G. M., Chang, C., Wang, R. Y., Kim, G., Stoops, E. H., Richardson, B., Sochat, V., Rust, J., Oughtred, R., Thayer, N. H., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg5702 · Cited by 33 · see citing works

Targeting fungal lipid synthesis for antifungal drug development and potentiation of contemporary antifungals

Gutierrez-Perez, C., & Cramer, R. A. (2025) · npj Antimicrobials and Resistance · doi:10.1038/s44259-025-00093-4 · Cited by 33 · see citing works

Altered sterol metabolism in budding yeast affects mitochondrial iron-sulfur (Fe-S) cluster synthesis

Ward, D. M., Chen, O. S., Li, L., Kaplan, J., Bhuiyan, S. A., Natarajan, S. K., Bard, M., & Cox, J. E. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.001781 · Cited by 32 · see citing works

Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation

Naranjo, S., Smith, J., Artieri, C. G., Zhang, M., Zhou, Y., Palmer, M. E., & Fraser, H. B. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005751 · Cited by 30 · see citing works

Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties

Pries, V., Nöcker, C., Khan, D., Johnen, P., Hong, Z., Tripathi, A., Keller, A., Fitz, M., Perruccio, F., Filipuzzi, I., et al. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2017.12.007 · Cited by 29 · see citing works

Herbicide glufosinate inhibits yeast growth and extends longevity during wine fermentation

Vallejo, B., Picazo, C., Orozco, H., Matallana, E., & Aranda, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-12794-6 · Cited by 27 · see citing works

Spatial Analysis of Functional Enrichment (SAFE) in Large Biological Networks

Baryshnikova, A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8618-7_12 · Cited by 27 · see citing works

From beer to breadboards: yeast as a force for biological innovation

Gaikani, H. K., Stolar, M., Kriti, D., Nislow, C., & Giaever, G. N. (2024) · Genome biology · doi:10.1186/s13059-023-03156-9 · Cited by 26 · see citing works

Genome wide functional genetics in haploid cells

Elling, U., & Penninger, J. M. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.06.032 · Cited by 26 · see citing works

High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines

Filipuzzi, I., Cotesta, S., Perruccio, F., Knapp, B., Fu, Y., Studer, C., Pries, V., Riedl, R., Helliwell, S. B., Petrović, K., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006374 · Cited by 26 · see citing works

Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments

Simpkins, S. W., Deshpande, R., Nelson, J., Li, S. C., Piotrowski, J. S., Ward, H. N., Yashiroda, Y., Osada, H., Yoshida, M., Boone, C. M., et al. (2019) · Nature Protocols · doi:10.1038/s41596-018-0099-1 · Cited by 26 · see citing works

The anti-cancer drug 5-fluorouracil affects cell cycle regulators and potential regulatory long non-coding RNAs in yeast

Xie, B., Becker, E., Stuparević, I., Wéry, M., Szachnowski, U., Morillon, A., & Primig, M. (2019) · RNA Biology · doi:10.1080/15476286.2019.1581596 · Cited by 25 · see citing works

Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast

Ottilie, S., Goldgof, G. M., Calvet, C. M., Jennings, G. K., LaMonte, G., Schenken, J., Vigil, E., Kumar, P., McCall, L., Lopes, E. S. C., et al. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b01037 · Cited by 25 · see citing works

Natural products as probes in pharmaceutical research

Schmitt, E. K., Hoepfner, D., & Krastel, P. (2015) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-015-1691-9 · Cited by 23 · see citing works

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p

Helliwell, S. B., Karkare, S., Bergdoll, M., Rahier, A., Leighton-Davis, J. R., Fioretto, C., Aust, T., Filipuzzi, I., Frederiksen, M. U., Gounarides, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms9613 · Cited by 23 · see citing works

Amyloid properties of the yeast cell wall protein Toh1 and its interaction with prion proteins Rnq1 and Sup35

Sergeeva, A. V., Sopova, J. V., Belashova, T. A., Siniukova, V. A., Chirinskaite, A. V., Galkin, A. P., & Zadorsky, S. P. (2018) · Prion · doi:10.1080/19336896.2018.1558763 · Cited by 23 · see citing works

Calcineurin-dependent contributions to fitness in the opportunistic pathogen <i>Candida glabrata</i>

Pavesic, M. W., Gale, A. N., Nickels, T. J., Harrington, A. A., Bussey, M., & Cunningham, K. W. (2024) · mSphere · doi:10.1128/msphere.00554-23 · Cited by 22 · see citing works

A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis

Arlia‐Ciommo, A., Svistkova, V., Mohtashami, S., & Titorenko, V. I. (2015) · Oncotarget · doi:10.18632/oncotarget.6440 · Cited by 22 · see citing works

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

Morgens, D. W., Chan, C., Kane, A. J., Weir, N. R., Li, A., Dubreuil, M. M., Tsui, C. K., Hess, G. T., Lavertu, A., Han, K., et al. (2019) · eLife · doi:10.7554/elife.48434 · Cited by 22 · see citing works

A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors

Taubenschmid, J., Orthofer, M., Laemmerer, A., Krauditsch, C., Rozsova, M., Studer, C., Lötsch, D., Gojo, J., Gabler, L., Dyczynski, M., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216959 · Cited by 21 · see citing works

Modes‐of‐action of antifungal compounds: Stressors and (target‐site‐specific) toxins, toxicants, or toxin–stressors

Noël, D., Hallsworth, J. E., Gelhaye, É., Darnet, S. H., Sormani, R., & Morel‐Rouhier, M. (2023) · Microbial Biotechnology · doi:10.1111/1751-7915.14242 · Cited by 21 · see citing works

Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide

Snyder, N. A., Kim, A., Kester, L., Gale, A. N., Studer, C., Hoepfner, D., Roggo, S. P., Helliwell, S. B., & Cunningham, K. W. (2019) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200748 · Cited by 21 · see citing works

Mechanisms of Azole Potentiation: Insights from Drug Repurposing Approaches

Xiong, J., Lu, H., & Jiang, Y. (2025) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00657 · Cited by 20 · see citing works

Natural variation in yeast reveals multiple paths for acquiring higher stress resistance

Scholes, A. N., Stuecker, T. N., Hood, S. E., Locke, C. J., Stacy, C., Zhang, Q., & Lewis, J. A. (2024) · BMC Biology · doi:10.1186/s12915-024-01945-7 · Cited by 20 · see citing works

Transcriptome and network analyses in Saccharomyces cerevisiae reveal that amphotericin B and lactoferrin synergy disrupt metal homeostasis and stress response

Pang, C. N. I., Lai, Y.-W., Campbell, L. T., Chen, S. C.-A., Carter, D. A., & Wilkins, M. R. (2017) · Scientific Reports · doi:10.1038/srep40232 · Cited by 19 · see citing works

Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity

Tavella, T. A., da Silva, N. S. M., Spillman, N. J., Kayano, A. C. A. V., Cassiano, G. C., de Vasconcelos, A. A., Camargo, A. P., Baía-da-Silva, D. C., Fontinha, D., Alvarez, L. C. S., et al. (2021) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00454 · Cited by 18 · see citing works

Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress

Acton, E., Lee, A. H., Zhao, P., Flibotte, S., Neira, M., Sinha, S., Chiang, J., Flaherty, P., Nislow, C., & Giaever, G. N. (2017) · Open Biology · doi:10.1098/rsob.160330 · Cited by 18 · see citing works

The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting

Whitfield, S. T., Burston, H. E., Bean, B. D. M., Raghuram, N., Maldonado‐Báez, L., Davey, M., Wendland, B., & Conibear, E. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-09-0621 · Cited by 17 · see citing works

Chemical Genomic Profiling Unveils the in Vitro and in Vivo Antiplasmodial Mechanism of Acaı ( Euterpe oleracea Mart.) Polyphenols

Ferreira, L. T., Venâncio, V. P., Kawano, T., Abrão, L. C. D. C., Tavella, T. A., Almeida, L. D., Pires, G. S., Bilsland, E., Sunnerhagen, P., Azevedo, L. C., et al. (2019) · ACS Omega · doi:10.1021/acsomega.9b02127 · Cited by 17 · see citing works

The haploinsufficiency profile of α-hederin suggests a caspofungin-like antifungal mode of action

Prescott, T. A. K., Rigby, L. P., Veitch, N. C., & Simmonds, M. S. J. (2014) · Phytochemistry · doi:10.1016/j.phytochem.2014.01.022 · Cited by 16 · see citing works

Advantages and Challenges of Phenotypic Screens: The Identification of Two Novel Antifungal Geranylgeranyltransferase I Inhibitors

Pries, V., Cotesta, S., Riedl, R., Aust, T., Schuierer, S., Tao, J., Filipuzzi, I., & Hoepfner, D. (2015) · SLAS DISCOVERY · doi:10.1177/1087057115610488 · Cited by 15 · see citing works

Previously Uncharacterized Vacuolar-type ATPase Binding Site Discovered from Structurally Similar Compounds with Distinct Mechanisms of Action

Wang, A. C., Pham, H. T., Lipps, J., Brittain, S. M., Harrington, E. M., Wang, Y., King, F., Russ, C., Pan, X., Hoepfner, D., et al. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00656 · Cited by 15 · see citing works

Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput

Almeida, L. D., Silva, A. S. F., Mota, D. C., de Vasconcelos, A. A., Camargo, A. P., Pires, G. S., Furlan, M., Freire, H. M. R. D. C., Klippel, A. H., Silva, S. F., et al. (2021) · mBio · doi:10.1128/mbio.03221-21 · Cited by 15 · see citing works

Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization

Pham, T. T., Walden, E. A., Huard, S., Pezacki, J. P., Fullerton, M. D., & Baetz, K. (2022) · Genetics · doi:10.1093/genetics/iyac086 · Cited by 15 · see citing works

Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions

Simpkins, S. W., Nelson, J., Deshpande, R., Li, S. C., Piotrowski, J. S., Wilson, E. H., Gebre, A. A., Safizadeh, H., Okamoto, R., Yoshimura, M., et al. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006532 · Cited by 15 · see citing works

Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin

Rusch, M., Thevenon, A., Hoepfner, D., Aust, T., Studer, C., Patoor, M., Rollin, P., Livendahl, M., Ranieri, B., Schmitt, E. K., et al. (2018) · ChemBioChem · doi:10.1002/cbic.201800587 · Cited by 15 · see citing works

MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action

Nelson, J., Simpkins, S. W., Safizadeh, H., Li, S. C., Piotrowski, J. S., Hirano, H., Yashiroda, Y., Osada, H., Yoshida, M., Boone, C. M., et al. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx732 · Cited by 15 · see citing works

Chemical genomic guided engineering of gamma-valerolactone tolerant yeast

Bottoms, S., Dickinson, Q., McGee, M. A., Hinchman, L., Higbee, A. J., Hebert, A. S., Serate, J., Xie, D., Zhang, Y., Coon, J. J., et al. (2018) · Microbial Cell Factories · doi:10.1186/s12934-017-0848-9 · Cited by 14 · see citing works

Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax

Ferreira, L. T., Rodrigues, J., Cassiano, G. C., Tavella, T. A., Tomaz, K. C. P., Baía-da-Silva, D. C., Souza, M. F., Lima, M. N. D. N., Mottin, M., Almeida, L. D., et al. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02041-19 · Cited by 14 · see citing works

YFR016c/Aip5 is part of an actin nucleation complex in yeast

Glomb, O., Bareis, L., & Johnsson, N. (2019) · Biology Open · doi:10.1242/bio.044024 · Cited by 14 · see citing works

Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities

Li, W., Whiteway, M., Hang, S., Yu, J., Lu, H., & Jiang, Y. (2025) · Nature Communications · doi:10.1038/s41467-025-62131-z · Cited by 13 · see citing works

Adaptor protein complex-1 (AP-1) is recruited by the HEATR5 protein Laa1 and its co-factor Laa2 in yeast

Zysnarski, C. J., Lahiri, S., Javed, F. T., Martínez-Márquez, J. Y., Trowbridge, J. W., & Duncan, M. C. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005253 · Cited by 13 · see citing works

An Optimized Competitive-Aging Method Reveals Gene-Drug Interactions Underlying the Chronological Lifespan of Saccharomyces cerevisiae

Avelar‐Rivas, J. A., Munguía-Figueroa, M., Juárez‐Reyes, A., Garay, E., Campos, S. E., Noam Shoresh, F., & DeLuna, A. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00468 · Cited by 13 · see citing works

Exploiting homologous recombination increases SATAY efficiency for loss- and gain-of-function screeningPreprint

Michel, A. H., van Schie, S. N. S., Mosbach, A., Scalliet, G., & Kornmann, B. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/866483 · Cited by 13 · see citing works

Two low complexity ultra-high throughput methods to identify diverse chemically bioactive molecules using Saccharomyces cerevisiae

Petrović, K., Pfeifer, M., Parker, C. N., Schuierer, S., Tallarico, J. A., Hoepfner, D., Movva, N. R., Scheel, G., & Helliwell, S. B. (2017) · Microbiological Research · doi:10.1016/j.micres.2017.02.004 · Cited by 12 · see citing works

A Mini HIP HOP Assay Uncovers a Central Role for Copper and Zinc in the Antifungal Mode of Action of Allicin

Prescott, T. A. K., & Panaretou, B. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b00250 · Cited by 12 · see citing works

Network-assisted target identification for haploinsufficiency and homozygous profiling screens

Wang, S., & Peng, J. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005553 · Cited by 12 · see citing works

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast

Decourty, L., Malabat, C., Frachon, E., Jacquier, A., & Saveanu, C. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab680 · Cited by 10 · see citing works

Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti‐Cancer Properties

Krastel, P., Roggo, S. P., Schirle, M., Ross, N. T., Perruccio, F., Aspesi, P., Aust, T., Buntin, K., Estoppey, D., Liechty, B., et al. (2015) · Angewandte Chemie · doi:10.1002/ange.201505069 · Cited by 10 · see citing works

Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis

Ušaj, M. M., Prelec, M., Brložnik, M., Primo, C., Curk, T., Ščančar, J., Yenush, L., & Petrovič, U. (2015) · Metallomics · doi:10.1039/c5mt00095e · Cited by 10 · see citing works

Kendomycin Cytotoxicity against Bacterial, Fungal, and Mammalian Cells Is Due to Cation Chelation

Tranter, D., Filipuzzi, I., Lochmann, T., Knapp, B., Kellosalo, J., Estoppey, D., Pistorius, D., Meissner, A., Paavilainen, V. O., & Hoepfner, D. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b00826 · Cited by 10 · see citing works

Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide

Filipuzzi, I., Thomas, J. R., Pries, V., Estoppey, D., Salcius, M., Studer, C., Schirle, M., & Hoepfner, D. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00385 · Cited by 10 · see citing works

Chemogenomic profiling to understand the antifungal action of a bioactive aurone compound

Alqahtani, F. M., Arivett, B. A., Taylor, Z. E., Handy, S. T., Farone, A. L., & Farone, M. B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226068 · Cited by 9 · see citing works

Known Antimicrobials Versus Nortriptyline in Candida albicans: Repositioning an Old Drug for New Targets

Caldara, M., & Marmiroli, N. (2020) · Microorganisms · doi:10.3390/microorganisms8050742 · Cited by 8 · see citing works

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components

Raj, S., Krishnan, K., Askew, D. S., Helynck, O., Suzanne, P., Lesnard, A., Rault, S., Zeidler, U., d’Enfert, C., Latgé, J., et al. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02239-15 · Cited by 8 · see citing works

A Chemogenomic Screen Reveals Novel Snf1p/AMPK Independent Regulators of Acetyl-CoA Carboxylase

Bozaquel-Morais, B. L., Madeira, J. B., Venâncio, T. M., Pacheco-Rosa, T., Masuda, C. A., & Montero-Lomelı́, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169682 · Cited by 8 · see citing works

Yeast Chemogenomic Profiling Reveals Iron Chelation To Be the Principle Cell Inhibitory Mode of Action of Gossypol

Prescott, T. A. K., Jaeg, T., & Hoepfner, D. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00692 · Cited by 8 · see citing works

A series of pyrimidine-based antifungals with anti-mold activity disrupt ER function in Aspergillus fumigatus

Kelty, M. T., Miron-Ocampo, A., & Beattie, S. R. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01045-24 · Cited by 7 · see citing works

Loss of cytoplasmic actin filaments raises nuclear actin levels to drive INO80C-dependent chromosome fragmentation

Hurst, V., Gerhold, C., Tarashev, C. V. D., Challa, K., Seeber, A., Yamazaki, S., Knapp, B., Helliwell, S. B., Bodenmiller, B., Harata, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54141-0 · Cited by 7 · see citing works

TORC2 inhibition triggers yeast chromosome fragmentation through misregulated Base Excision Repair of clustered oxidation events

Shimada, K., Tarashev, C. V. D., Bregenhorn, S., Gerhold, C., van Loon, B., Roth, G., Hurst, V., Jiricny, J., Helliwell, S. B., & Gasser, S. M. (2024) · Nature Communications · doi:10.1038/s41467-024-54142-z · Cited by 7 · see citing works

The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures

Barazandeh, M., Kriti, D., Nislow, C., & Giaever, G. N. (2022) · BMC Genomics · doi:10.1186/s12864-022-08395-x · Cited by 7 · see citing works

Data from: High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

Hoepfner, D., Helliwell, S. B., Sadlish, H., Schuierer, S., Filipuzzi, I., Brachat, S., Bhullar, B., Plikat, U., Abraham, Y., Altorfer, M., et al. (2013) · Data Archiving and Networked Services (DANS) · doi:10.5061/dryad.v5m8v · Cited by 2 · see citing works

Integrating yeast chemical genomics and mammalian cell pathway analysis

Zhou, F.-L., Li, S. C., Zhu, Y., Guo, W.-J., Shao, L.-J., Nelson, J., Simpkins, S. W., Yang, D., Liu, Q., Yashiroda, Y., et al. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0231-y · Cited by 3 · see citing works

Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast

Giaever, G. N., Flaherty, P., Kumm, J., Proctor, M. J., Nislow, C., Jaramillo, D. F., Chu, A. M., Jordan, M. I., Arkin, A. P., & Davis, R. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307490100 · Cited by 506 · see citing works

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

Parsons, A. B., Brost, R. L., Ding, H., Li, Z., Zhang, C., Sheikh, B., Brown, G. W., Kane, P. M., Hughes, T. R., & Boone, C. M. (2003) · Nature Biotechnology · doi:10.1038/nbt919 · Cited by 651 · see citing works

Chemical genomics in yeast: linking biologically active compounds to their intracellular targets

Parsons, A. B. (2006) · TSpace (University of Toronto)