Rapid emergence of FKS mutations in Candida glabrata isolates in a peritoneal candidiasis
Open accessAbstract
We report a rapid acquisition of echinocandin resistance after 12 days of micafungin treatment, without prior exposure, in a patient with peritoneal candidiasis due to C. glabrata . Isolates recovered before and after treatment were compared by multilocus sequence typing . Results of antifungal susceptibility testing and FKS mutations were reported. The interest of repeating antifungal susceptibility testing for echinocandin molecules during the treatment is discussed and a strategy to research FKS mutations proposed.
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Intrinsic resistance to echinocandins is rare and primarily only observed in Candida parapsilosis.
“Intrinsic resistance to echinocandins is rare and primarily only observed in Candida parapsilosis [103].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [103]
The prevalence of echinocandin resistance among Candida strains remains low, with around 4% observed in C. glabrata and less than 1% in C. albicans.
“The prevalence of echinocandin resistance among Candida strains remains low, with around 4% observed in C. glabrata and less than 1% in C. albicans [103].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [103]
Sasso et al. reported increasing isolation of echinocandin-resistant C. glabrata strains, significantly associated with FKS1 and FKS2 gene mutations.
“However, Sasso et al. [103] reported increasing isolation of echinocandin C. glabrata-resistant strains, significantly associated with FKS1 and FKS2 gene mutations.”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [103]
Resistance acquired through mutation (amino acid changes) of critical regions in FKS1 and FKS2 genes, which encode β-1,3-d-glucan synthase, the potential target enzyme of echinocandins.
“The resistance acquired through mutation (amino acid changes) of the critical regions in FKS1 and FKS2 genes encode β-1,3-d-glucan synthase, the potential target enzyme echinocandins [51,103].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [103]
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- Authors
- Sasso, M., Roger, C., & Lachaud, L.
- Affiliations
- Centre Hospitalier Universitaire de Nîmes (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Corresponding author
- Lachaud, Laurence
- Venue
- Medical Mycology Case Reports
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 16
- Pages
- 28-30
- ISSN
- 2211-7539 (ISSN-L)
- PMC
- PMC5413194
- OpenAlex
- W2608783038
- Cited by
- 20
- References
- 14
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 3 · 2017: 2
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Medical Mycology Case Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida glabrata, echinocandin resistance, micafungin, antifungal susceptibility testing, multilocus sequence typing, antifungal therapy
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