Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America
Open accessAbstract
It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.
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Enhanced infection control practices, including appropriate catheter use, antibiotic stewardship, and antifungal prophylaxis practices, might be responsible for some of the decreases in candidemia incidence.
“Enhanced infection control practices, including appropriate catheter use to limit catheter-related bloodstream infections (42–44), antibiotic stewardship, and antifungal prophylaxis practices, might be responsible for some of the decreases.”
From Population-Based Active Surveillance for Culture-Confirmed Candidemia — Four Sites, United States, 2012–2016 (2019) · cites this paper as [43]
Recommendation 13 advises early removal of a central venous catheter when it is the presumed source of candidemia and removal is safe. This supports appropriate catheter management, the part of the sentence to which the citation is attached, but does not establish that catheter practices caused the reported decreases in candidemia incidence. The cited passages have no page numbers. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThe 2016 IDSA guidelines recommend echinocandins as the initial therapy for treatment of most types of invasive candidiasis among adults.
“the 2016 guidelines recommend echinocandins as the initial therapy for treatment of most types of invasive candidiasis among adults (43).”
From Population-Based Active Surveillance for Culture-Confirmed Candidemia — Four Sites, United States, 2012–2016 (2019) · cites this paper as [43]
Women with RVVC may require long-term maintenance therapy.
“however, women with recurrent vulvovaginal candidiasis may require long-term maintenance therapy.”
From Clinical challenges in diagnosis and treatment of recurrent vulvovaginal candidiasis (2022) · cites this paper as [17]
Topical azole antifungals, widely used to treat VVC, are used less commonly in RVVC.
“Topical azole antifungals, widely used to treat VVC, are used less commonly in RVVC.17,20”
From Clinical challenges in diagnosis and treatment of recurrent vulvovaginal candidiasis (2022) · cites this paper as [17]
The treatment regimen for RVVC is dependent on causative yeast(s)/Candida species present, and azole susceptibility of cultured strains.
“The treatment regimen is dependent on causative yeast(s)/Candida species present, and azole susceptibility of cultured strains. 17”
From Clinical challenges in diagnosis and treatment of recurrent vulvovaginal candidiasis (2022) · cites this paper as [17]
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“In contrast with the 2009 Infectious Disease Society of America guidelines for the treatment of invasive candidiasis, in which echinocandins were recommended only for neutropenic patients and patients with previous exposure to antifungals (64), the 2016 guidelines recommend echinocandins as the initial therapy for tre…”
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- Authors
- Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., Zaoutis, T. E., & Sobel, J. D.
- Affiliations
- University of Alabama at Birmingham (US)
- University of Michigan (US)
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- Johns Hopkins University (US)
- University of Texas Health Science Center, Houston
- Cooper Medical School of Rowan University (US)
- University of Pennsylvania (US)
- Georgia Regents University, Augusta
- Cornell University (US)
- Children's Hospital of Pennsylvania, Philadelphia
- Wayne State University (US)
- Corresponding author
- Pappas, Peter G.
- ORCID
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-01-22
- Volume
- 62
- Issue
- 4
- Pages
- 409-417
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2260819425
- Cited by
- 1,298
- References
- 2
- Citations by year
- 2026: 31 · 2025: 37 · 2024: 41 · 2023: 35 · 2022: 56 · 2021: 75 · 2020: 219 · 2019: 231 · 2018: 250 · 2017: 232 · 2016: 86 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 244.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Pfizer
- Gilead Sciences
- Infectious Diseases Society of America
- University of Pittsburgh
- CSL Behring
- Cidara Therapeutics
- Revolution Medicines
- Astellas Pharma
- National Institutes of Health
- Centers for Disease Control and Prevention
- Genentech
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- candidiasis, antifungal therapy, fungal infection, treatment guidelines
- MeSH terms
- Candidiasis, Humans, Practice Guidelines as Topic
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