Cited by 82Antifungal resistance and susceptibilityFungal Plant Pathogen ControlAntibiotic Resistance in Bacteria

Frequency of fks Mutations among Candida glabrata Isolates from a 10-Year Global Collection of Bloodstream Infection Isolates

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Castanheira, Mariana, Woosley, Leah N., Messer, Shawn A., Diekema, Daniel J., Jones, Ronald N., Pfaller, Michael A.·2014·Antimicrobial Agents and Chemotherapy

Abstract

Among 119 echinocandin non-wild-type (non-WT) Candida glabrata strains from two global surveys, mutations in fks hot spots (HSs) were detected in 28 (from 7 countries and 8 U.S. states): 24 strains (85.7%) had non-WT MICs for micafungin, 22 (78.6%) for anidulafungin, and 25 (89.3%) for caspofungin. The most common FKS substitutions among non-WT strains were at positions F659 (n = 7) and S663 (n = 7). Three isolates displaying WT MIC results had F625Y, L630I, and D632Y substitutions or non-HS mutations. Mutations that have been reported to decrease the echinocandin binding to the 1,3-β-d-glucan synthase were categorized as resistant by applying the new CLSI breakpoint criteria for all three echinocandins.

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Crossref · 10.1128/aac.01674-13

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13 of 13 references verified0 citation errors · 0 not checkable

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Authors
Castanheira, M., Woosley, L. N., Messer, S. A., Diekema, D. J., Jones, R. N., & Pfaller, M. A.
Affiliations
  • JMI Laboratories (US)
  • University of Iowa (US)
Venue
Antimicrobial Agents and Chemotherapy
Published
2014-01
Volume
58
Issue
1
Pages
577-580
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
OpenAlex
W2141937724
Cited by
82
References
13
Citations by year
2026: 5 · 2025: 6 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 13 · 2016: 6 · 2015: 11 · 2014: 10 · 2013: 1
FWCI
6.78
Type
journal article
Language
en
Open access
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Pfizer
  • Astellas Pharma
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Keywords
Candida glabrata, echinocandin resistance, 1,3-β-D-glucan synthase, micafungin, anidulafungin, caspofungin, bloodstream infection, antifungal susceptibility, CLSI breakpoints
MeSH terms
Caspofungin, Micafungin, Anidulafungin, Antifungal Agents, Microbial Sensitivity Tests, Mutation, Candida glabrata, Echinocandins, Lipopeptides

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