Frequency of fks Mutations among Candida glabrata Isolates from a 10-Year Global Collection of Bloodstream Infection Isolates
Open accessAbstract
Among 119 echinocandin non-wild-type (non-WT) Candida glabrata strains from two global surveys, mutations in fks hot spots (HSs) were detected in 28 (from 7 countries and 8 U.S. states): 24 strains (85.7%) had non-WT MICs for micafungin, 22 (78.6%) for anidulafungin, and 25 (89.3%) for caspofungin. The most common FKS substitutions among non-WT strains were at positions F659 (n = 7) and S663 (n = 7). Three isolates displaying WT MIC results had F625Y, L630I, and D632Y substitutions or non-HS mutations. Mutations that have been reported to decrease the echinocandin binding to the 1,3-β-d-glucan synthase were categorized as resistant by applying the new CLSI breakpoint criteria for all three echinocandins.
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- Authors
- Castanheira, M., Woosley, L. N., Messer, S. A., Diekema, D. J., Jones, R. N., & Pfaller, M. A.
- Affiliations
- JMI Laboratories (US)
- University of Iowa (US)
- ORCID
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2014-01
- Volume
- 58
- Issue
- 1
- Pages
- 577-580
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC3910756
- OpenAlex
- W2141937724
- Cited by
- 82
- References
- 13
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 13 · 2016: 6 · 2015: 11 · 2014: 10 · 2013: 1
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Astellas Pharma
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- Candida glabrata, echinocandin resistance, 1,3-β-D-glucan synthase, micafungin, anidulafungin, caspofungin, bloodstream infection, antifungal susceptibility, CLSI breakpoints
- MeSH terms
- Caspofungin, Micafungin, Anidulafungin, Antifungal Agents, Microbial Sensitivity Tests, Mutation, Candida glabrata, Echinocandins, Lipopeptides
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