High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women
Abstract
Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4ɛ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4ɛ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.
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VAR2CSA antibodies can block adhesion of infected erythrocytes to chondroitin sulfate A in vitro.
“These antibodies can block adhesion of IEs to CSA in vitro (4,5) and are associated with protection from placental malaria and other adverse delivery outcomes (6,7).”
From Clinical outcomes of submicroscopic infections and correlates of protection of VAR2CSA antibodies in a longitudinal study of pregnant women in Colombia (2018) · cites this paper as [4]
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- Authors
- Magistrado, P. A., Minja, D., Doritchamou, J., Tuikue Ndam, N., John, D., Schmiegelow, C., Massougbodji, A., Dahlbäck, M., Ditlev, S. B., Pinto, V. V., Resende, M., Lusingu, J., Theander, T. G., Salanti, A., & Nielsen, M. A.
- Affiliations
- National Institute for Medical Research (TZ)
- Université d'Abomey-Calavi (BJ)
- University of Copenhagen (DK)
- ORCID
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 29
- Issue
- 3
- Pages
- 437-443
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2092804337
- Cited by
- 49
- References
- 49
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 5 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 4
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- National Institute for Medical Research
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Keywords
- malaria in pregnancy, Plasmodium falciparum, VAR2CSA, chondroitin sulfate A, placental adhesions, antibody binding inhibition, recombinant protein immunization, clinical isolates, malaria vaccine
- MeSH terms
- Antibodies, Protozoan, Antigens, Protozoan, Benin, Cell Adhesion, Erythrocytes, Female, Humans, Immunoglobulin G, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Infectious, Recombinant Proteins, Tanzania, Transcription Factors, Malaria, Falciparum, Malaria Vaccines, DNA Repair Enzymes
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