Cited by 49Malaria Research and ControlBlood groups and transfusionMonoclonal and Polyclonal Antibodies Research

High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

Magistrado, Pamela A., Minja, Daniel, Doritchamou, Justin, Tuikue Ndam, Nicaise, John, Davis, Schmiegelow, Christentze, Massougbodji, Achille, Dahlbäck, Madeleine +7 more·2011·Vaccine

Abstract

Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4ɛ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4ɛ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.

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Crossref · 10.1016/j.vaccine.2010.10.080

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Authors
Magistrado, P. A., Minja, D., Doritchamou, J., Tuikue Ndam, N., John, D., Schmiegelow, C., Massougbodji, A., Dahlbäck, M., Ditlev, S. B., Pinto, V. V., Resende, M., Lusingu, J., Theander, T. G., Salanti, A., & Nielsen, M. A.
Affiliations
  • National Institute for Medical Research (TZ)
  • Université d'Abomey-Calavi (BJ)
  • University of Copenhagen (DK)
Venue
Vaccine
Publisher
Elsevier BV
Published
2011-01
Volume
29
Issue
3
Pages
437-443
ISSN
0264-410X (ISSN-L)
OpenAlex
W2092804337
Cited by
49
References
49
Citations by year
2023: 1 · 2022: 1 · 2021: 5 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 4
FWCI
6.34
Type
journal article
Language
en
Open access
closed
Locations
  • Vaccine (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
National Institute for Medical Research
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Hematology › Blood groups and transfusion
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
Keywords
malaria in pregnancy, Plasmodium falciparum, VAR2CSA, chondroitin sulfate A, placental adhesions, antibody binding inhibition, recombinant protein immunization, clinical isolates, malaria vaccine
MeSH terms
Antibodies, Protozoan, Antigens, Protozoan, Benin, Cell Adhesion, Erythrocytes, Female, Humans, Immunoglobulin G, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Infectious, Recombinant Proteins, Tanzania, Transcription Factors, Malaria, Falciparum, Malaria Vaccines, DNA Repair Enzymes

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