Cited by 56Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersRNA Research and Splicing

Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA

Kindler, Stefan, Rehbein, Monika, Classen, Bernhard, Richter, Dietmar, Böckers, Tobias M·2004·Molecular Brain Research

Abstract

The four members of the family of synapse-associated protein 90/postsynaptic density-95-associated proteins (SAPAP1-4) are adapter proteins of postsynaptic density (PSD). They interact with different synaptic scaffolding proteins, cytoskeletal components, and signalling components, and are therefore considered to assemble functional multiprotein units at synapses. Here, we analyzed the spatiotemporal expression of SAPAP1-SAPAP4 genes in postnatal rat brain by in situ hybridization. All four genes are expressed in many brain areas, leading to overlapping yet distinct mRNA distribution patterns. Moreover, two mRNAs encoding distinct SAPAP3 isoforms exhibit basically identical postnatal expression patterns. In the hippocampus, SAPAP1, SAPAP2, and SAPAP4 transcripts are restricted to cell body zones, whereas SAPAP3 mRNAs are also detected in molecular layers. Thus, SAPAP3 is one of the few PSD components whose local synthesis in dendrites may contribute to an input-specific adaptation of dendritic spine function.

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Crossref · 10.1016/j.molbrainres.2004.03.014

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  • Variable expression of Sapap3 during postnatal synapse maturation has been reported.

    “Clearly, the age mismatch for behavioral and neuronal phenotypes in the Sapap3-KO model needs to be addressed, particularly given that variable expression of Sapap3 during postnatal synapse maturation has been reported [24].”

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Authors
Kindler, S., Rehbein, M., Classen, B., Richter, D., & Böckers, T. M.
Affiliations
  • University Medical Center Hamburg-Eppendorf (DE)
  • Universität Ulm (DE)
Corresponding author
Kindler, Stefan
Venue
Molecular Brain Research
Publisher
Elsevier BV
Published
2004-07
Volume
126
Issue
1
Pages
14-21
ISSN
0169-328X (ISSN-L)
OpenAlex
W2010505153
Cited by
56
References
57
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 5
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
postsynaptic density, dendritic mRNA localization, postnatal brain development, hippocampus, molecular layer, dendritic spines, synaptic scaffolding proteins, rat brain
MeSH terms
SAP90-PSD95 Associated Proteins, Animals, Animals, Newborn, Brain, Dendrites, Gene Expression Regulation, Nerve Tissue Proteins, RNA, Messenger, Synapses, Time Factors, Rats, Wistar, In Situ Hybridization, Protein Isoforms, Rats

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