Differential expression and dendritic transcript localization of Shank family members: identification of a dendritic targeting element in the 3′ untranslated region of Shank1 mRNA
Abstract
Shank proteins are scaffolding proteins in the postsynaptic density of excitatory synapses in the mammalian brain. In situ hybridization revealed that Shank1/SSTRIP and Shank2/ProSAP1 mRNAs are widely expressed early in postnatal brain development whereas Shank3/ProSAP2 expression increases during postnatal development especially in the cerebellum and thalamus. Shank1 and Shank3 (but not Shank2) mRNAs are present in the molecular layers of the hippocampus, consistent with a dendritic transcript localization. Shank1 and Shank2 transcripts are detectable in the dendritic fields of Purkinje cells, whereas Shank3 mRNA is restricted to cerebellar granule cells. The appearance of dendritic Shank mRNAs in cerebellar Purkinje cells coincides with the onset of dendrite formation. Expression of reporter transcripts in hippocampal neurons identifies a 200-nucleotide dendritic targeting element (DTE) in the Shank1 mRNA. The widespread presence of Shank mRNAs in dendrites suggests a role for local synthesis of Shanks in response to stimuli that induce alterations in synaptic morphology.
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Shank3 shares a similar protein domain structure but has a different expression pattern and subcellular localization than Shank1 and Shank2.
“Shank3 shares a similar protein domain structure but has a different expression pattern and subcellular localization than Shank1 and Shank2 (Bockers et al., 2004; Peca et al., 2011; Tao-Cheng et al., 2010).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Bockers et al., 2004
RNA in situ hybridization in rat brain using a probe from exon 21 showed that Shank3 is widely expressed at low levels at birth and increases after 2 weeks of age in the striatum, hippocampus, cerebellum, and neocortical layers 1 and 2.
“RNA in situ hybridization in rat brain using a single probe from exon 21 encoding the proline-rich domain showed that Shank3 is widely expressed in all brain regions at a low level at birth but increases after 2 weeks of age in the striatum, hippocampus, cerebellum, and in layers 1 and 2 of the neocortex (Bockers et al., 2001; Bockers et al., 2004).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Bockers et al., 2004
Peak expression of Shank3 occurs at an important developmental stage of synaptic plasticity and experience-dependent circuit maturation.
“Peak expression of Shank3 occurs at an important developmental stage of synaptic plasticity and experience-dependent circuit maturation (Bockers et al., 2004).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Bockers et al., 2004
Expression patterns of Shank1 and Shank3 are different: high mRNA levels of Shank1 in cortex and hippocampus and of Shank3 in striatum and cortex.
“high mRNA levels of Shank1 in cortex and hippocampus and of Shank3 in striatum and cortex [36, 77]”
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- Authors
- Böckers, T. M., Segger-Junius, M., Iglauer, P., Bockmann, J., Gundelfinger, E. D., Kreutz, M. R., Richter, D., Kindler, S., & Kreienkamp, H.-J.
- Affiliations
- Universität Ulm (DE)
- Universität Hamburg (DE)
- Leibniz Institute for Neurobiology (DE)
- Corresponding author
- Kreienkamp, Hans-Jürgen
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 26
- Issue
- 1
- Pages
- 182-190
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W1994881764
- Cited by
- 149
- References
- 38
- Citations by year
- 2025: 5 · 2024: 14 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 10 · 2017: 9 · 2016: 6 · 2015: 10 · 2014: 7 · 2013: 13 · 2012: 11
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- Shank1, Shank2, SHANK3, dendritic mRNA localization, 3' untranslated region, postsynaptic density, excitatory synapses, postnatal brain development, cerebellum, hippocampus, Purkinje cells, cerebellar granule cells, dendrite formation, local protein synthesis, synaptic plasticity
- MeSH terms
- Animals, Brain, Carrier Proteins, Cerebellar Cortex, Dendrites, Genes, Regulator, Hippocampus, Nerve Tissue Proteins, Synaptic Transmission, RNA, Messenger, Synaptic Membranes, Genes, Reporter, Gene Expression Regulation, Developmental, 3' Untranslated Regions, Protein Transport, Adaptor Proteins, Signal Transducing, Rats
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