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Cited by 105Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersTreatment of Major Depression

Scaffolding proteins at the postsynaptic density: shank as the architectural framework

Kreienkamp, H. -J.·2008·Handbook of experimental pharmacology
DOI 10.1007/978-3-540-72843-6_15
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Abstract

Shank proteins are multidomain scaffold proteins of the postsynaptic density, connecting neurotransmitter receptors and other membrane proteins with signaling proteins and the actin cytoskeleton. By virtue of their protein interactions, Shank proteins assemble signaling platforms for G-protein-mediated signaling and the control of calcium homeostasis in dendritic spines. In addition, they participate in morphological changes, leading to maturation of dendritic spines and synapse formation. The importance of the Shank scaffolding function is demonstrated by genetically determined forms of mental retardation, which may be caused by haploinsufficiency for the SHANK3 gene. Consistent with its central function within the postsynaptic density, the availability of Shank is tightly controlled by local synthesis and degradation, as well as actin-dependent dynamic rearrangements within the dendritic spine.

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Crossref · 10.1007/978-3-540-72843-6_15

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78 of 78 references verified0 citation errors · 0 not checkable

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  • Shank1, Shank2, and Shank3 are synaptic scaffolding proteins that assemble a large protein complex at the postsynaptic density of excitatory glutamatergic synapses.

    “Shank family proteins (Shank1, Shank2, and Shank3) are synaptic scaffolding proteins that organize an extensive protein complex at the postsynaptic density (PSD) of excitatory glutamatergic synapses.”

    From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Kreienkamp, 2008

  • Shank family proteins are scaffolding proteins that organize a cytoskeleton-associated signaling complex at the postsynaptic density of nearly all excitatory glutamatergic synapses in the mammalian brain.

    “Shank family proteins are scaffolding proteins that organize a cytoskeleton-associated signaling complex at the postsynaptic density (PSD) of nearly all excitatory glutamatergic synapses in the mammalian brain (Grabrucker et al., 2011b; Gundelfinger et al., 2006; Kreienkamp, 2008; Sheng and Kim, 2000).”

    From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Kreienkamp, 2008

  • Shanks are scaffolding proteins that interact with many synaptic proteins in the postsynaptic density.

    “Shanks are scaffolding proteins that interact with many synaptic proteins in the PSD (Ehlers, 1999; Gundelfinger et al., 2006; Kreienkamp, 2008; Sheng and Kim, 2000).”

    From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Kreienkamp, 2008

  • Shank3-interacting proteins include receptors, ion channels, cytoskeletal proteins, scaffolding proteins, enzymes, and signaling molecules.

    “Shank3-interacting proteins include receptors, ion channels, cytoskeletal proteins, scaffolding proteins, enzymes, and signaling molecules (Grabrucker et al., 2011b; Kreienkamp, 2008).”

    From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Kreienkamp, 2008

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Authors
Kreienkamp, H. J.
Affiliations
University Medical Center Hamburg-Eppendorf (DE)
Corresponding author
Kreienkamp, H. -J.
ORCID
Kreienkamp, H. -J.
Venue
Handbook of experimental pharmacology
Publisher
Springer Berlin Heidelberg
Published
2008
Issue
186
Pages
365-380
ISSN
0171-2004 (ISSN-L)
DOI
10.1007/978-3-540-72843-6_15
OpenAlex
W89295468
Cited by
105
References
78
Citations by year
2026: 6 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 4 · 2019: 1 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 5 · 2014: 11 · 2013: 8 · 2012: 7
FWCI
5.88
Type
book chapter
Language
en
Open access
closed
Locations
  • Handbook of experimental pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
postsynaptic density, scaffold proteins, dendritic spines, synaptogenesis, actin cytoskeleton, G protein signaling, calcium homeostasis, SHANK3, intellectual disability, haploinsufficiency, protein degradation, synaptic plasticity
MeSH terms
Actins, Animals, Carrier Proteins, Cytoskeleton, Humans, Nerve Tissue Proteins, Synaptic Transmission, Synapses, Adaptor Proteins, Signal Transducing

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