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Cited by 319

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

Syntichaki, Popi, Troulinaki, Kostoula, Tavernarakis, Nektarios·2007·Nature
DOI 10.1038/nature05603
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Abstract

Regulation of protein synthesis is critical for cell growth and maintenance. Ageing in many organisms, including humans, is accompanied by marked alterations in both general and specific protein synthesis. Whether these alterations are simply a corollary of the ageing process or have a causative role in senescent decline remains unclear. An array of protein factors facilitates the tight control of messenger RNA translation initiation. The eukaryotic initiation factor 4E (eIF4E), which binds the 7-monomethyl guanosine cap at the 5' end of all nuclear mRNAs, is a principal regulator of protein synthesis. Here we show that loss of a specific eIF4E isoform (IFE-2) that functions in somatic tissues reduces global protein synthesis, protects from oxidative stress and extends lifespan in Caenorhabditis elegans. Lifespan extension is independent of the forkhead transcription factor DAF-16, which mediates the effects of the insulin-like signalling pathway on ageing. Furthermore, IFE-2 deficiency further extends the lifespan of long-lived age and daf nematode mutants. Similarly, lack of IFE-2 enhances the long-lived phenotype of clk and dietary-restricted eat mutant animals. Knockdown of target of rapamycin (TOR), a phosphatidylinositol kinase-related kinase that controls protein synthesis in response to nutrient cues, further increases the longevity of ife-2 mutants. Thus, signalling via eIF4E in the soma is a newly discovered pathway influencing ageing in C. elegans.

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Crossref · 10.1038/nature05603

Cites

3 of 3 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Genetic inhibition of mTORC1 or downstream pathways extends lifespan in yeast, worms, and flies.

    “Studies in yeast, worms and flies found that genetic inhibition of mTORC1 or signaling pathways downstream of mTORC1, including S6K and translation initiation factors, extends lifespan 5–11.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [10]

  • Experiments in model organisms have shown that deletion or knockdown of ribosomal subunits, S6K1, or translation initiation factors results in increased lifespan.

    “In agreement with such a model, experiments in model organisms have shown that deletion or knockdown of ribosomal subunits, S6K1, or translation initiation factors results in increased lifespan 6,10.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [10]

  • Studies in C. elegans have shown that the lifespan of worms lacking eIF4E can be further increased by knockdown of the gene encoding TOR.

    “Studies in C. elegans have shown that the lifespan of worms lacking eukaryotic translation initiation factor 4E (eIF4E), which are long-lived and have a global reduction in protein synthesis, can be still further increased by knockdown of the gene encoding TOR 10.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [10]

Citations

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Research works printed but not linked: 29

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Metadata

Authors
Syntichaki, P., Troulinaki, K., & Tavernarakis, N.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2007-02
Volume
445
Issue
7130
Pages
922-926
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/nature05603
Cited by
319
References
3
Language
en
Licence
www.springer.com/tdm (tdm)

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