The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to Transcription

Active Genes Are Tri-Methylated at K4 of Histone H3

Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138

Structure and ligand of a histone acetyltransferase bromodomain

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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

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Suppression of inflammation by a synthetic histone mimic

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Proteogenomic and metabolomic characterization of human glioblastoma

Wang, L.-B., Karpova, A., Gritsenko, M. A., Kyle, J. E., Cao, S., Li, Y., Rykunov, D., Colaprico, A., Rothstein, J. H., Hong, R., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.01.006 · Cited by 661

Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis

Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637

NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis

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The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

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Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

Morinière, J., Rousseaux, S., Steuerwald, U., Soler-López, M., Curtet, S., Vitte, A.-L., Govin, J., Gaucher, J., Sadoul, K., Hart, D. J., et al. (2009) · Nature · doi:10.1038/nature08397 · Cited by 469

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

Lockwood, W. W., Zejnullahu, K., Bradner, J. E., & Varmus, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216363109 · Cited by 327

BET proteins promote efficient murine leukemia virus integration at transcription start sites

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Brd2 disruption in mice causes severe obesity without Type 2 diabetes

Wang, F., Liu, H., Blanton, W. P., Belkina, A., Lebrasseur, N. K., & Denis, G. V. (2010) · Biochemical Journal · doi:10.1042/bj20090928 · Cited by 185

Double bromodomain‐containing gene Brd2 is essential for embryonic development in mouse

Shang, E., Wang, X., Wen, D., Greenberg, D. A., & Wolgemuth, D. J. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21911 · Cited by 156

Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus Integration

Gupta, S. S., Maetzig, T., Maertens, G. N., Sharif, A., Rothe, M., Weidner-Glunde, M., Galla, M., Schambach, A., Cherepanov, P., & Schulz, T. F. (2013) · Journal of Virology · doi:10.1128/jvi.01942-13 · Cited by 139

CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration

Nobles, C. L., Sherrill-Mix, S., Everett, J. K., Reddy, S., Fraietta, J. A., Porter, D. L., Frey, N., Gill, S. I., Grupp, S. A., Maude, S. L., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci130144 · Cited by 130

H2A.Z: a molecular rheostat for transcriptional control

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Pharmacological or transcriptional inhibition of both HDAC 1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma

Zhou, H., Cai, Y., Liu, D., Li, M., Sha, Y., Zhang, W., Wang, K., Gong, J., Tang, N., Huang, A., et al. (2018) · Cell Proliferation · doi:10.1111/cpr.12447 · Cited by 85

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells

LeRoy, G., Oksuz, O., Descostes, N., Aoi, Y., Ganai, R. A., Kara, H. O., Yu, J.-R., Lee, C.-H., Stafford, J., Shilatifard, A., et al. (2019) · Science Advances · doi:10.1126/sciadv.aay3068 · Cited by 89

Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins

LeRoy, G., Chepelev, I., DiMaggio, P. A., Blanco, M. A., Zee, B. M., Zhao, K., & Garcia, B. A. (2012) · Genome Biology · doi:10.1186/gb-2012-13-8-r68 · Cited by 84

Mass Spectrometric Analysis of Histone Proteoforms

Yuan, Z.-F., Arnaudo, A. M., & Garcia, B. A. (2014) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-071213-015959 · Cited by 64

RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point

Lee, J.-W., Kim, D.-M., Jang, J.-W., Park, T.-G., Song, S.-H., Lee, Y.-S., Chi, X.-Z., Park, I. Y., Hyun, J.-W., Ito, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09810-w · Cited by 57

The role of protein acetylation in carcinogenesis and targeted drug discovery

Yang, J., Song, C., & Zhan, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.972312 · Cited by 42