The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
STIM1 Gates TRPC Channels, but Not Orai1, by Electrostatic Interaction
Open accessAbstract
Summary The receptor-evoked Ca2+ signal includes activation of the store-operated channels (SOCs) TRPC and Orai channels. Although both are gated by STIM1, it is not known how STIM1 gates the channels and whether STIM1 gates the TRPCs and Orais by the same mechanism. Here, we report the molecular mechanism by which STIM1 gates TRPC1, which involves interaction between two conserved, negatively charged aspartates in TRPC1(639DD640) with the positively charged STIM1(684KK685) in STIM1 polybasic domain. Charge swapping and functional analysis revealed that exact orientation of the charges on TRPC1 and STIM1 are required, but all positive-negative charge combinations on TRPC1 and STIM1, except STIM1(684EE685)+TRPC1(639RR640), are functional as long as they are reciprocal, indicating that STIM1 gates TRPC1 by intermolecular electrostatic interaction. Similar gating was observe with TRPC3(697DD698). STIM1 gates Orai1 by a different mechanism since the polybasic and S/P domains of STIM1 are not required for activation of Orai1 by STIM1.
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Cites
Calcium's Role in Mechanotransduction during Muscle Development
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STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx
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Self-citationStore-Operated Calcium Channels
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STIM1, an essential and conserved component of store-operated Ca2 + channel function
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CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca 2+ Entry
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Store-Operated Calcium Channels
Prakriya, M., & Lewis, R. S. (2015) · Physiological Reviews · doi:10.1152/physrev.00020.2014 · Cited by 1,239
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Hogan, P. G., Lewis, R. S., & Rao, A. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132550 · Cited by 760
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Lee, M. G., Ohana, E., Park, H. W., Yang, D., & Muallem, S. (2012) · Physiological Reviews · doi:10.1152/physrev.00011.2011 · Cited by 377
Self-citationFeske, S. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00818.x · Cited by 299
Activation and regulation of store‐operated calcium entry
Smyth, J. T., Hwang, S., Tomita, T., DeHaven, W. I., Mercer, J. C., & Putney, J. W. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01168.x · Cited by 288
Metadata
- Authors
- Zeng, W., Yuan, J. P., Kim, M. S., Choi, Y. J., Huang, G. N., Worley, P. F., & Muallem, S.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 32
- Issue
- 3
- Pages
- 439-448
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1976566307
- Cited by
- 306
- References
- 31
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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