The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Destabilization of TIP60 by Human Papillomavirus E6 Results in Attenuation of TIP60-Dependent Transcriptional Regulation and Apoptotic Pathway
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“E6 can further abrogate apoptotic signalling by interacting with the proapoptotic protein Bak and mediating its degradation via the E6AP ubiquitin ligase [187,188,189]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [187]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
Bonner, W. M., Redon, C. E., Dickey, J. S., Nakamura, A. J., Sedelnikova, O. A., Solier, S., & Pommier, Y. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2523 · Cited by 1,623
Huibregtse, J. M., Scheffner, M., & Howley, P. M. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04990.x · Cited by 879
Acetylation of the p53 DNA-binding domain regulates apoptosis induction.
Sykes, S. M., Mellert, H. S., Holbert, M. A., Li, K., Marmorstein, R., Lane, W. S., & McMahon, S. B. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.026 · Cited by 752
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
Sun, Y., Jiang, X., Chen, S., Fernandes, N., & Price, B. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504211102 · Cited by 738
Murr, R., Loizou, J. I., Yang, Y.-G., Cuenin, C., Li, H., Wang, Z.-Q., & Herceg, Z. (2006) · Nature Cell Biology · doi:10.1038/ncb1343 · Cited by 613 · cited 2×
“…11, 2010 ª2010 Elsevier Inc. complex is recruited to these sites and plays an important role in dephosphorylating phosphoH2AX for termination of the DNA damage response (Ikura et al., 2007; Jha et al., 2008; Kusch et al., 2004; Murr et al., 2006; Sapountzi et al., 2006; Squatrito et al., 2006).”
DNA Damage-Induced Acetylation of Lysine 3016 of ATM Activates ATM Kinase Activity
Sun, Y., Xu, Y., Roy, K., & Price, B. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01382-07 · Cited by 319
Research works printed but not linked: 54
- Bauknecht, 1992, Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1, EMBO J., 11, 4607, 10.1002/j.1460-2075.1992.tb05563.x · DOI
- Bhoumik, 2008, Regulation of TIP60 by ATF2 modulates ATM activation, J. Biol. Chem., 283, 17605, 10.1074/jbc.M802030200 · DOI
- Bird, 2002, Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair, Nature, 419, 411, 10.1038/nature01035 · DOI
- Chowdhury, 2005, gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair, Mol. Cell, 20, 801, 10.1016/j.molcel.2005.10.003 · DOI
- Col, 2005, HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses, EMBO J., 24, 2634, 10.1038/sj.emboj.7600734 · DOI
- Cooper, 2003, Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53, Virology, 306, 87, 10.1016/S0042-6822(02)00012-0 · DOI
- Doyon, 2004, The highly conserved and multifunctional NuA4 HAT complex, Curr. Opin. Genet. Dev., 14, 147, 10.1016/j.gde.2004.02.009 · DOI
- Frank, 2003, MYC recruits the TIP60 histone acetyltransferase complex to chromatin, EMBO Rep., 4, 575, 10.1038/sj.embor.embor861 · DOI
- Gaughan, 2002, Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor, J. Biol. Chem., 277, 25904, 10.1074/jbc.M203423200 · DOI
- Genovese, 2008, Casein kinase II motif-dependent phosphorylation of human papillomavirus E7 protein promotes p130 degradation and S-phase induction in differentiated human keratinocytes, J. Virol., 82, 4862, 10.1128/JVI.01202-07 · DOI
- Gorrini, 2007, Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response, Nature, 448, 1063, 10.1038/nature06055 · DOI
- Grm, 2004, Degradation of hDlg and MAGIs by human papillomavirus E6 is E6-AP-independent, J. Gen. Virol., 85, 2815, 10.1099/vir.0.80035-0 · DOI
- Handa, 2007, E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein, J. Virol., 81, 1379, 10.1128/JVI.01712-06 · DOI
- Howley, 2009, Small DNA tumor viruses: large contributors to biomedical sciences, Virology, 384, 256, 10.1016/j.virol.2008.12.006 · DOI
- Huibregtse, 1993, Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins, Mol. Cell. Biol., 13, 4918, 10.1128/MCB.13.8.4918 · DOI · Paper page
- Ikura, 2000, Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis, Cell, 102, 463, 10.1016/S0092-8674(00)00051-9 · DOI · Paper page
- Ikura, 2007, DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics, Mol. Cell. Biol., 27, 7028, 10.1128/MCB.00579-07 · DOI
- Jha, 2009, RVB1/RVB2: running rings around molecular biology, Mol. Cell, 34, 521, 10.1016/j.molcel.2009.05.016 · DOI
- Jha, 2008, Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage, Mol. Cell. Biol., 28, 2690, 10.1128/MCB.01983-07 · DOI
- Jing, 2007, Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins, J. Virol., 81, 2231, 10.1128/JVI.01979-06 · DOI
- Karnani, 2007, Pan-S replication patterns and chromosomal domains defined by genome-tiling arrays of ENCODE genomic areas, Genome Res., 17, 865, 10.1101/gr.5427007 · DOI
- Keogh, 2006, A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery, Nature, 439, 497, 10.1038/nature04384 · DOI
- Kuballa, 2007, The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins, J. Biol. Chem., 282, 65, 10.1074/jbc.M605117200 · DOI · Paper page
- Kusch, 2004, Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions, Science, 306, 2084, 10.1126/science.1103455 · DOI
- Lace, 2009, Cellular factor YY1 downregulates the human papillomavirus 16 E6/E7 promoter, P97, in vivo and in vitro from a negative element overlapping the transcription-initiation site, J. Gen. Virol., 90, 2402, 10.1099/vir.0.012708-0 · DOI
- Legube, 2002, Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation, EMBO J., 21, 1704, 10.1093/emboj/21.7.1704 · DOI
- Li, 2009, Axin determines cell fate by controlling the p53 activation threshold after DNA damage, Nat. Cell Biol., 11, 1128, 10.1038/ncb1927 · DOI
- Mao, 2008, REGgamma, a proteasome activator and beyond?, Cell. Mol. Life Sci., 65, 3971, 10.1007/s00018-008-8291-z · DOI
- Martinato, 2008, Analysis of Myc-induced histone modifications on target chromatin, PLoS ONE, 3, e3650, 10.1371/journal.pone.0003650 · DOI
- Matsumoto, 2006, Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6, J. Med. Virol., 78, 501, 10.1002/jmv.20568 · DOI
- Munger, 2002, Human papillomavirus immortalization and transformation functions, Virus Res., 89, 213, 10.1016/S0168-1702(02)00190-9 · DOI
- Nakagawa, 2000, Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase, Mol. Cell. Biol., 20, 8244, 10.1128/MCB.20.21.8244-8253.2000 · DOI · Paper page
- Pim, 2000, HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligase, Oncogene, 19, 719, 10.1038/sj.onc.1203374 · DOI
- Ralph, 2006, CCAAT/enhancer-binding protein beta represses human papillomavirus 11 upstream regulatory region expression through a promoter-proximal YY1-binding site, J. Gen. Virol., 87, 51, 10.1099/vir.0.81207-0 · DOI
- Robert, 2004, Global position and recruitment of HATs and HDACs in the yeast genome, Mol. Cell, 16, 199, 10.1016/j.molcel.2004.09.021 · DOI
- Ruthenburg, 2007, Multivalent engagement of chromatin modifications by linked binding modules, Nat. Rev. Mol. Cell Biol., 8, 983, 10.1038/nrm2298 · DOI
- Sapountzi, 2006, Cellular functions of TIP60, Int. J. Biochem. Cell Biol., 38, 1496, 10.1016/j.biocel.2006.03.003 · DOI
- Scheffner, 1990, The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53, Cell, 63, 1129, 10.1016/0092-8674(90)90409-8 · DOI · Paper page
- Scheffner, 1993, The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53, Cell, 75, 495, 10.1016/0092-8674(93)90384-3 · DOI · Paper page
- Schneider-Gadicke, 1986, Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes, EMBO J., 5, 2285, 10.1002/j.1460-2075.1986.tb04496.x · DOI
- Schweiger, 2007, Brd4-independent transcriptional repression function of the papillomavirus e2 proteins, J. Virol., 81, 9612, 10.1128/JVI.00447-07 · DOI
- Shai, 2007, HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP, Oncogene, 26, 3321, 10.1038/sj.onc.1210130 · DOI
- Shirasawa, 1994, Transcription-modulatory activity of full-length E6 and E6∗I proteins of human papillomavirus type 16, Virology, 203, 36, 10.1006/viro.1994.1452 · DOI
- Smith, 1998, ESA1 is a histone acetyltransferase that is essential for growth in yeast, Proc. Natl. Acad. Sci. USA, 95, 3561, 10.1073/pnas.95.7.3561 · DOI
- Smith, 2010, Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression, Proc. Natl. Acad. Sci. USA, 107, 3752, 10.1073/pnas.0914818107 · DOI
- Squatrito, 2006, Tip60 in DNA damage response and growth control: many tricks in one HAT, Trends Cell Biol., 16, 433, 10.1016/j.tcb.2006.07.007 · DOI
- Sterner, 2000, Acetylation of histones and transcription-related factors, Microbiol. Mol. Biol. Rev., 64, 435, 10.1128/MMBR.64.2.435-459.2000 · DOI
- Tang, 2006, Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis, Mol. Cell, 24, 827, 10.1016/j.molcel.2006.11.021 · DOI
- Taverna, 2007, How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers, Nat. Struct. Mol. Biol., 14, 1025, 10.1038/nsmb1338 · DOI
- Thomas, 2005, E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation, Mol. Cell, 17, 251, 10.1016/j.molcel.2004.12.016 · DOI · Paper page
- Wang, 2009, Robust production and passaging of infectious HPV in squamous epithelium of primary human keratinocytes, Genes Dev., 23, 181, 10.1101/gad.1735109 · DOI
- Wu, 2006, Brd4 links chromatin targeting to HPV transcriptional silencing, Genes Dev., 20, 2383, 10.1101/gad.1448206 · DOI
- Zhang, 2006, The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation, Proc. Natl. Acad. Sci. USA, 103, 437, 10.1073/pnas.0510012103 · DOI · Paper page
- zur Hausen, 2002, Papillomaviruses and cancer: from basic studies to clinical application, Nat. Rev. Cancer, 2, 342, 10.1038/nrc798 · DOI
Cited by
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Lum, K. K., & Cristea, I. M. (2016) · Expert Review of Proteomics · doi:10.1586/14789450.2016.1147353 · Cited by 113
Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway.
Dar, A., Shibata, E., & Dutta, A. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00358-13 · Cited by 83
Self-citationReitsma, J. M., Savaryn, J. P., Faust, K., Sato, H., Halligan, B. D., & Terhune, S. S. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.01.006 · Cited by 64
Metadata
- Authors
- Jha, S., Vande Pol, S., Banerjee, N. S., Dutta, A. B., Chow, L. T., & Dutta, A.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 38
- Issue
- 5
- Pages
- 700-711
- ISSN
- 1097-2765
- PMC
- PMC2886028
- Cited by
- 120
- References
- 7
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Destabilization of TIP60 by Human Papillomavirus E6 Results in Attenuation of TIP60-Dependent Transcriptional Regulation and Apoptotic Pathway. https://app.cochat.ai/papers/10.1016/j.molcel.2010.05.020
- The paper
- Jha, S., Vande Pol, S., Banerjee, N. S., Dutta, A. B., Chow, L. T., & Dutta, A. (2010). Destabilization of TIP60 by Human Papillomavirus E6 Results in Attenuation of TIP60-Dependent Transcriptional Regulation and Apoptotic Pathway. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.05.020