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Activation and Inhibition of the Receptor Histidine Kinase AgrC Occurs through Opposite Helical Transduction Motions
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“given the reduced affinity of AgrC for ATP (KM = ~1.5 mM, ~1 order of magnitude above other histidine kinases), phosphorylation of AgrA would require high intracellular ATP levels (18).”
From Lack of nutritional immunity in diabetic skin infections promotes Staphylococcus aureus virulence (2020) · cites this paper as [18]
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“The sensor kinase AgrC belongs to the HPK-10 family of histidine kinases with variations at key conserved Asp residues.”
From Lack of nutritional immunity in diabetic skin infections promotes Staphylococcus aureus virulence (2020) · cites this paper as [18]
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“The Asp to Asn variation results in roughly a 10-fold reduction in affinity toward ATP for AgrC compared with other families of two-component systems (18).”
From Lack of nutritional immunity in diabetic skin infections promotes Staphylococcus aureus virulence (2020) · cites this paper as [18]
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Research works printed but not linked: 38
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Cited by
Structural insights into the signalling mechanisms of two-component systems
Jacob-Dubuisson, F., Mechaly, A., Betton, J.-M., & Antoine, R. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0055-7 · Cited by 308
Lack of nutritional immunity in diabetic skin infections promotes Staphylococcus aureus virulence
Thurlow, L. R., Stephens, A. C., Hurley, K. E., & Richardson, A. R. (2020) · Science Advances · doi:10.1126/sciadv.abc5569 · Cited by 116
A Small Molecule That Inhibits the Quorum Sensing Receptor AgrC in Staphylococcus aureus
Polaske, T. J., Vulpis, T. D., Nelson, A. E., Zhao, K., & Blackwell, H. E. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c21051 · Cited by 3
Metadata
- Authors
- Wang, B., Zhao, A., Novick, R. P., & Muir, T. W.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 53
- Issue
- 6
- Pages
- 929-940
- ISSN
- 1097-2765
- Cited by
- 123
- References
- 0
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
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- Wang, B., Zhao, A., Novick, R. P., & Muir, T. W. (2014). Activation and Inhibition of the Receptor Histidine Kinase AgrC Occurs through Opposite Helical Transduction Motions. Molecular Cell. https://doi.org/10.1016/j.molcel.2014.02.029
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