Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading

The biology of chromatin remodeling complexes.

Clapier, C. R., & Cairns, B. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.062706.153223 · Cited by 2,384 · see citing works

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198 · see citing works

Pioneer transcription factors: establishing competence for gene expression

Zaret, K. S., & Carroll, J. S. (2011) · Genes & Development · doi:10.1101/gad.176826.111 · Cited by 1,589 · see citing works

Transcriptional architecture and chromatin landscape of the core circadian clock in mammals

Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464 · see citing works

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

Cho, H., Zhao, X., Hatori, M., Yu, R. T., Barish, G. D., Lam, M. T., Chong, L.-W., DiTacchio, L., Atkins, A. R., Glass, C. K., et al. (2012) · Nature · doi:10.1038/nature11048 · Cited by 1,037 · see citing works

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

Solt, L. A., Wang, Y., Banerjee, S., Hughes, T., Kojetin, D. J., Lundåsen, T., Shin, Y., Liu, J., Cameron, M. D., Noël, R., et al. (2012) · Nature · doi:10.1038/nature11030 · Cited by 835 · see citing works

A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism

Feng, D., Liu, T., Sun, Z., Bugge, A., Mullican, S. E., Alenghat, T., Liu, X. S., & Lazar, M. A. (2011) · Science · doi:10.1126/science.1198125 · Cited by 701 · see citing works

Crosstalk between components of circadian and metabolic cycles in mammals

Asher, G., & Schibler, U. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.006 · Cited by 601 · see citing works

Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic functionPreprint

Bugge, A. K., Feng, D., Everett, L. J., Briggs, E. R., Mullican, S. E., Wang, F., Jager, J., & Lazar, M. A. (2012) · Genes & Development · doi:10.1101/gad.186858.112 · Cited by 503 · see citing works

Clocks not winding down: unravelling circadian networks

Zhang, E. E., & Kay, S. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2995 · Cited by 446 · see citing works

A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells

Zhang, E. E., Liu, A. C., Hirota, T., Miraglia, L. J., Welch, G. L., Pongsawakul, P. Y., Liu, X., Atwood, A., Huss, J. W., Janes, J. O., et al. (2009) · Cell · doi:10.1016/j.cell.2009.08.031 · Cited by 432 · see citing works

Analysis of the Human Endogenous Coregulator Complexome

Malovannaya, A., Lanz, R. B., Jung, S. Y., Bulynko, Y., Le, N. T., Chan, D. W., Ding, C., Shi, Y., Yucer, N., Krenciute, G., et al. (2011) · Cell · doi:10.1016/j.cell.2011.05.006 · Cited by 432 · see citing works

Redundant Function of REV-ERBα and β and Non-Essential Role for Bmal1 Cycling in Transcriptional Regulation of Intracellular Circadian Rhythms

Liu, A. C., Tran, H. G., Zhang, E. E., Priest, A. A., Welsh, D. K., & Kay, S. A. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000023 · Cited by 396 · see citing works

Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock

Zhang, Y., Fang, B., Emmett, M. J., Damle, M., Sun, Z., Feng, D., Armour, S. M., Remsberg, J. R., Jager, J., Soccio, R. E., et al. (2015) · Science · doi:10.1126/science.aab3021 · Cited by 315 · see citing works

Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism

Voss, T. C., Schiltz, R. L., Sung, M.-H., Yen, P. M., Stamatoyannopoulos, J. A., Biddie, S. C., Johnson, T. A., Miranda, T. B., John, S., & Hager, G. L. (2011) · Cell · doi:10.1016/j.cell.2011.07.006 · Cited by 307 · see citing works

Clocks, metabolism, and the epigenome

Feng, D., & Lazar, M. A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.026 · Cited by 271 · cited 1× · see citing works

Selectivity of chromatin-remodelling cofactors for ligand-activated transcription

Lemon, B. D., Inouye, C. J., King, D., & Tjian, R. (2001) · Nature · doi:10.1038/414924a · Cited by 263 · see citing works

Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo

Fang, B., Everett, L. J., Jager, J., Briggs, E. R., Armour, S. M., Feng, D., Roy, A., Gerhart‐Hines, Z., Sun, Z., & Lazar, M. A. (2014) · Cell · doi:10.1016/j.cell.2014.10.022 · Cited by 262 · see citing works

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

Vierstra, J. D., Rynes, E., Sandstrom, R. S., Zhang, M., Canfield, T. K., Hansen, R. S., Stehling-Sun, S., Sabo, P. J., Byron, R., Humbert, R., et al. (2014) · Science · doi:10.1126/science.1246426 · Cited by 253 · see citing works

CLOCK:BMAL1 is a pioneer-like transcription factorPreprint

Menet, J. S., Pescatore, S., & Rosbash, M. (2014) · Genes & Development · doi:10.1101/gad.228536.113 · Cited by 252 · see citing works

PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genesPreprint

Yan, Z., Cui, K., Murray, D., Chen, L., Xue, Y., Gerstein, A. V., Parsons, R. E., Zhao, K., & Wang, W. (2005) · Genes & Development · doi:10.1101/gad.1323805 · Cited by 247 · see citing works

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1

Lee, H.-M., Chen, R., Kim, H., Etchegaray, J., Weaver, D. R., & Lee, C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107178108 · Cited by 185 · see citing works

A riot of rhythms: neuronal and glial circadian oscillators in the mediobasal hypothalamus

Guilding, C., Hughes, A. T. L., Brown, T. M., Namvar, S., & Piggins, H. D. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-28 · Cited by 171 · see citing works

Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease

Chopra, A. R., Louet, J., Saha, P., An, J., DeMayo, F. J., Xu, J., York, B., Karpen, S. J., Finegold, M. J., Moore, D. D., et al. (2008) · Science · doi:10.1126/science.1164847 · Cited by 161 · see citing works

Circadian rhythms – from genes to physiology and disease

Bollinger, T., & Schibler, U. (2014) · Swiss Medical Weekly · doi:10.4414/smw.2014.13984 · Cited by 152 · see citing works

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

Takeda, Y., Jothi, R., Birault, V., & Jetten, A. M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks630 · Cited by 146 · see citing works

Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour

Banerjee, S., Wang, Y., Solt, L. A., Griffett, K., Kazantzis, M., Amador, A., Elgendy, B., Huitrón‐Reséndiz, S., Roberts, A. J., Shin, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms6759 · Cited by 132 · see citing works

Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner

Meng, Q., McMaster, A., Beesley, S., Lu, W., Gibbs, J. E., Parks, D. J., Collins, J. L., Farrow, S. N., Donn, R. P., Ray, D. W., et al. (2008) · Journal of Cell Science · doi:10.1242/jcs.035048 · Cited by 126 · see citing works

Proteomic Analysis of Coregulators Bound to ERα on DNA and Nucleosomes Reveals Coregulator Dynamics

Foulds, C. E., Feng, Q. F., Chen, D., Bailey, S., Hunsaker, T. L., Malovannaya, A., Hamilton, R. A., Gates, L. A., Zhang, Z., Li, C., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.06.007 · Cited by 119 · see citing works

Nuclear receptors rock around the clock

Zhao, X., Cho, H., Yu, R. T., Atkins, A. R., Downes, M., & Evans, R. M. (2014) · EMBO Reports · doi:10.1002/embr.201338271 · Cited by 108 · see citing works

Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor

Kim, J. Y., Kwak, P. B., & Weitz, C. J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.10.017 · Cited by 96 · see citing works

SRC-2 Is an Essential Coactivator for Orchestrating Metabolism and Circadian Rhythm

Stashi, E., Lanz, R. B., Mao, J., Michailidis, G. C., Zhu, B., Kettner, N. M., Putluri, N., Reineke, E. L., Reineke, L. C., Dasgupta, S., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.027 · Cited by 76 · see citing works

Behavioral Changes and Dopaminergic Dysregulation in Mice Lacking the Nuclear Receptor Rev-erbα

Jager, J., O’Brien, W. T., Manlove, J., Krizman, E. N., Fang, B., Gerhart‐Hines, Z., Robinson, M. B., Klein, P. S., & Lazar, M. A. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1351 · Cited by 74 · see citing works

Essential Role of ARID2 Protein-containing SWI/SNF Complex in Tissue-specific Gene Expression

Xu, F., Flowers, S. J., & Morán, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.279968 · Cited by 73 · see citing works

Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes

Takeda, Y., Kang, H. S., Lih, F. B., Jiang, H., Blaner, W. S., & Jetten, A. M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku766 · Cited by 49 · see citing works

Research Resource: Loss of the Steroid Receptor Coactivators Confers Neurobehavioral Consequences

Stashi, E., Wang, L., Mani, S. K., York, B., & O’Malley, B. W. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1192 · Cited by 20 · see citing works

SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis

Fleet, T., Zhang, B., Lin, F., Zhu, B., Dasgupta, S., Stashi, E., Tackett, B. C., Thevananther, S., Rajapakshe, K., Gonzales, N. M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519073112 · Cited by 13 · see citing works

Transcriptional architecture of the mammalian circadian clock

Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,639 · see citing works

Regulation of circadian clock transcriptional output by CLOCK:BMAL1

Trott, A. J., & Menet, J. S. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007156 · Cited by 184 · see citing works

Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application

Chen, Y., Liang, R., Li, Y., Jiang, L., Ma, D., Luo, Q., & Song, G. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02030-9 · Cited by 174 · see citing works

Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems

Chen, Z., Yoo, S. H., & Takahashi, J. S. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052645 · Cited by 153 · see citing works

A cell-autonomous mammalian 12 hr clock coordinates metabolic and stress rhythms

Zhu, B., Zhang, Q., Pan, Y., Mace, E. M., York, B., Antoulas, A. C., Dacso, C. C., & O’Malley, B. W. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.004 · Cited by 146 · see citing works

Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space

Kim, Y. H., & Lazar, M. A. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa014 · Cited by 146 · see citing works

Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

Goldstein, I., Baek, S., Presman, D. M., Paakinaho, V., Swinstead, E. E., & Hager, G. L. (2017) · Genome Research · doi:10.1101/gr.212175.116 · Cited by 121 · see citing works

Genetic and epigenomic mechanisms of mammalian circadian transcription

Papazyan, R., Zhang, Y., & Lazar, M. A. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3324 · Cited by 112 · see citing works

CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity

Jordan, S. D., Kriebs, A., Vaughan, M. E., Duglan, D., Fan, W., Henriksson, E., Huber, A., Papp, S. J., Nguyen, M., Afetian, M. E., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.002 · Cited by 112 · see citing works

Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics

Gomez-Lamarca, M. J., Sanjuan, J. F., Stojnic, R., Rehman, S. A., Mureşan, L., Jones, M. L., Pillidge, Z., Cerda‐Moya, G., Yuan, Z., Baloul, S., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.020 · Cited by 99 · see citing works

Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading

Goldstein, I., Paakinaho, V., Baek, S., Sung, M.-H., & Hager, G. L. (2017) · Nature Communications · doi:10.1038/s41467-017-02055-5 · Cited by 97 · see citing works

REV-ERBα and REV-ERBβ function as key factors regulating Mammalian Circadian Output

Ikeda, R., Tsuchiya, Y., Koike, N., Umemura, Y. M., Inokawa, H., Ono, R., Inoue, M., Sasawaki, Y., Grieten, T., Okubo, N., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-46656-0 · Cited by 93 · see citing works

Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis

Huo, M., Huang, Y., Qu, D. C., Zhang, H., Wong, W. T., Chawla, A., Huang, Y., & Tian, X. Y. (2016) · The FASEB Journal · doi:10.1096/fj.201601030r · Cited by 87 · see citing works

REVERBa couples the circadian clock to hepatic glucocorticoid action

Caratti, G., Iqbal, M., Hunter, L., Kim, D., Wang, P., Vonslow, R. M., Begley, N., Knight, A., Woodburn, J., Pariollaud, M., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96138 · Cited by 82 · see citing works

REV-ERBα ameliorates heart failure through transcription repression.

Zhang, L.-L., Zhang, R., Tien, C.-L., Chan, R., Sugi, K., Fu, C., Griffin, A. C., Shen, Y.-Y., Burris, T., Liao, X., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.95177 · Cited by 72 · see citing works

Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation

Yoo, S. H., Kojima, S., Shimomura, K., Koike, N., Buhr, E. D., Furukawa, T., Ko, C. H., Gloston, G. F., Ayoub, C. A., Nohara, K., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706611114 · Cited by 80 · see citing works

Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging

Gloston, G. F., Yoo, S. H., & Chen, Z. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00100 · Cited by 73 · see citing works

12-h clock regulation of genetic information flow by XBP1s

Pan, Y., Ballance, H., Meng, H., Gonzalez, N., Kim, S.-M., Abdurehman, L., York, B., Chen, X., Schnytzer, Y., Levy, O., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000580 · Cited by 70 · see citing works

Implications of Circadian Rhythm in Dopamine and Mood Regulation

Kim, J., Jang, S.-W., Choe, H. K., Chung, S., Son, G. H., & Kim, K. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.0065 · Cited by 69 · see citing works

Unveiling “Musica Universalis” of the Cell: A Brief History of Biological 12-Hour Rhythms

Zhu, B., Dacso, C. C., & O’Malley, B. W. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00113 · Cited by 63 · see citing works

Transcriptional repression of SIRT3 potentiates mitochondrial aconitase activation to drive aggressive prostate cancer to the bone

Dessai, A. S., Domínguez, M. P., Chen, U.-I., Hasper, J., Prechtl, C., Yu, C. R., Katsuta, E., Dai, T., Zhu, B., Jung, S. Y., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-1708 · Cited by 57 · see citing works

Four-dimensional nuclear speckle phase separation dynamics regulate proteostasis

Dion, W. A., Ballance, H. I., Lee, J., Pan, Y., Irfan, S., Edwards, C., Sun, M., Zhang, J., Zhang, X., Liu, S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl4150 · Cited by 52 · see citing works

International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023

Burris, T. P., de Vera, I. M. S., Côté, I., Flaveny, C. A., Wanninayake, U. S., Chatterjee, A., Walker, J. K., Steinauer, N., Zhang, J., Coons, L. A., et al. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000436 · Cited by 53 · see citing works

Circadian regulation of cardiac metabolism

Zhang, L., & Jain, M. K. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148276 · Cited by 49 · see citing works

Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor

Cohen, D. M., & Steger, D. J. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.04.001 · Cited by 45 · see citing works

The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid‐inducible gene‐I‐like receptor signalling and is a potential prognostic biomarker for colon cancer

Shu, X., Zhao, Y., Sun, Y., Zhong, L., Cheng, Y., Zhang, Y., Ning, K., Tao, Q., Wang, Y., & Ying, Y. (2017) · The Journal of Pathology · doi:10.1002/path.4986 · Cited by 46 · see citing works

Restoration of the molecular clock is tumor suppressive in neuroblastoma

Moreno‐Smith, M., Milazzo, G., Tao, L., Fekry, B., Zhu, B., Mohammad, M. A., Giacomo, S. D., Borkar, R., Reddy, K. R. K., Capasso, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24196-4 · Cited by 45 · see citing works

Structures and consequences of pioneer factor binding to nucleosomes

Luzete-Monteiro, E., & Zaret, K. S. (2022) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2022.102425 · Cited by 44 · see citing works

Clocking In, Working Out: Circadian Regulation of Exercise Physiology

Duglan, D., & Lamia, K. A. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.04.003 · Cited by 41 · see citing works

Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease

Xiao, Y., Kim, M., & Lazar, M. A. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101119 · Cited by 39 · see citing works

The role of circadian clocks in cancer: Mechanisms and clinical implications

Liu, H., Liu, Y., Hai, R., Liao, W., & Luo, X. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.05.014 · Cited by 35 · see citing works

The Three Ds of Transcription Activation by Glucagon: Direct, Delayed, and Dynamic

Goldstein, I., & Hager, G. L. (2017) · Endocrinology · doi:10.1210/en.2017-00521 · Cited by 32 · see citing works

Choline Kinase Alpha Is a Novel Transcriptional Target of the Brg1 in Hepatocyte: Implication in Liver Regeneration

Kong, M., Dong, W., Xu, H., Fan, Z., Miao, X., Guo, Y., Li, C., Ye, Q., Wang, Y., & Xu, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.705302 · Cited by 28 · see citing works

Decoding the function and regulation of the mammalian 12-h clock

Zhu, B. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa021 · Cited by 27 · see citing works

Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism

Meng, H., Gonzales, N. M., Jung, S. Y., Lu, Y., Putluri, N., Zhu, B., Dacso, C. C., Lonard, D. M., & O’Malley, B. W. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110491 · Cited by 22 · see citing works

Dynamic enhancer function in the chromatin context

Goldstein, I., & Hager, G. L. (2018) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1390 · Cited by 25 · see citing works

Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology

Fleet, T., Stashi, E., Zhu, B., Rajapakshe, K., Marcelo, K. L., Kettner, N. M., Gorman, B. K., Coarfa, C., Fu, L., O’Malley, B. W., et al. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416657921 · Cited by 25 · see citing works

The circadian clock has roles in mesenchymal stem cell fate decision

Gao, W., Li, R., Ye, M., Zhang, L., Zheng, J., Yang, Y., Wei, X., & Zhao, Q. S. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02878-0 · Cited by 23 · see citing works

Chromatin reprogramming in breast cancer

Swinstead, E. E., Paakinaho, V., & Hager, G. L. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0033 · Cited by 23 · see citing works

Clock-controlled rhythmic transcription: is the clock enough and how does it work?

Beytebiere, J. R., Greenwell, B. J., Sahasrabudhe, A., & Menet, J. S. (2019) · Transcription · doi:10.1080/21541264.2019.1673636 · Cited by 23 · see citing works

Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological health

Kim, E., Yoo, S. H., & Chen, Z. (2022) · F1000Research · doi:10.12688/f1000research.126364.1 · Cited by 21 · see citing works

SR9009 improves heart function after pressure overload independent of cardiac REV-ERB

Li, H., Song, S., Tien, C., Qi, L., Graves, A., Nasiotis, E. T., Burris, T. P., Zhao, Y., Sun, Z., & Zhang, L. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.952114 · Cited by 20 · see citing works

Glucocorticoid receptor action in prostate cancer: the role of transcription factor crosstalk

Hiltunen, J., Helminen, L., & Paakinaho, V. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1437179 · Cited by 18 · see citing works

SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer

Suresh, S., Durakoglugil, D., Zhou, X.-R., Zhu, B.-K., Comerford, S., Xing, C., Xie, X.-J., York, B., & O’Donnell, K. A. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006650 · Cited by 18 · see citing works

Molecular link between circadian clocks and cardiac function: a network of core clock, slave clock, and effectors

Xu, W., Jain, M. K., & Zhang, L. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.10.006 · Cited by 18 · see citing works

Roles of circadian clocks in macrophage metabolism: implications in inflammation and metabolism of lipids, glucose, and amino acids

Dar, M. I., Hussain, Y., & Pan, X. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00009.2025 · Cited by 18 · see citing works

Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis

Brooks, R. C., Monzy, J., Aaron, B., Zhang, X., Kossenkov, A. V., Hayden, J. E., Keeney, F., Speicher, D. W., Zhang, L., & Dang, C. V. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111514 · Cited by 18 · see citing works

LEF1 isoforms regulate cellular senescence and aging

Jia, M., Sayed, K., Kapetanaki, M. G., Dion, W. A., Rosas, L., Irfan, S., Valenzi, E., Mora, A. L., Lafyatis, R., Rojas, M. M., et al. (2023) · Aging Cell · doi:10.1111/acel.14024 · Cited by 15 · see citing works

SON-dependent nuclear speckle rehabilitation alleviates proteinopathies

Dion, W. A., Tao, Y., Chambers, M., Zhao, S., Arbuckle, R. K., Sun, M., Kubra, S., Schaich, M. A., Nie, Y., Ye, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62242-7 · Cited by 14 · see citing works

Metabolic regulation of CTCF expression and chromatin association dictates starvation response in mice and flies

Sen, D., Maniyadath, B., Chowdhury, S., Kaur, A., Khatri, S., Chakraborty, A., Mehendale, N., Nadagouda, S., Sandra, U. S., Kamat, S. S., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107128 · Cited by 10 · see citing works

Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits

Hunter, L., & Ray, D. W. (2019) · Biology · doi:10.3390/biology8040079 · Cited by 9 · see citing works

Changes in searching behaviour of CSL transcription complexes in Notch active conditions

Baloul, S., Roussos, C. S., Gomez-Lamarca, M. J., Mureşan, L., & Bray, S. J. (2023) · Life Science Alliance · doi:10.26508/lsa.202302336 · Cited by 8 · see citing works

Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family

Pecenova, L., & Farkas, R. (2016) · Endocrine Regulations · doi:10.1515/enr-2016-0019 · Cited by 7 · see citing works

Feedback loops interlocked at competitive binding sites amplify and facilitate genetic oscillations

Uriu, K., & Tei, H. (2017) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2017.06.005 · Cited by 7 · see citing works

Chronotherapeutic Approaches

Gubin, D. G. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839167553-00536 · Cited by 6 · see citing works

Lung physiology and defense

Ince, L. M., Pariollaud, M., & Gibbs, J. E. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.04.005 · Cited by 6 · see citing works

Circadian Rhythm and Nuclear Receptors

Ray, D. W. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-11836-4_8 · Cited by 6 · see citing works

Gene activation and repression by the glucocorticoid receptor are mediated by sequestering Ep300 and two modes of chromatin bindingPreprint

Sarusi-Portuguez, A., Grbeša, I., Tal, M., Deitch, R., Raz, D., Weismann, R., Schwartz, M., Loza, O., Sung, M., Kaplan, T., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/764480 · Cited by 6 · see citing works

Logic of the Temporal Compartmentalization of the Hepatic Metabolic Cycle

Zhu, B. (2022) · Physiology · doi:10.1152/physiol.00003.2022 · Cited by 4 · see citing works

Chromatin Regulation and Transcription Factor Cooperation in Liver Cells

Goldstein, I. (2020) · Wiley eBooks · doi:10.1002/9781119436812.ch81 · Cited by 4 · see citing works

PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback

Letkova, D., Peticca, A., Sery, D., Seki, M., Suzuki, Y., & Padmanabhan, K. (2025) · Nature Communications · doi:10.1038/s41467-025-64045-2 · Cited by 3 · see citing works

12h-clock control of central dogma information flow by XBP1sPreprint

Pan, Y., Ballance, H. I., Meng, H., Gonzalez, N., Dacso, C. C., Chen, X., Levy, O., Coarfa, C., O’Malley, B. W., & Zhu, B. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/559039 · Cited by 3 · see citing works

The SET1/COMPASS subunit RBBP5 orchestrates epigenetic control of global proteostasis and the 12h oscillator to safeguard metabolic and cellular homeostasisPreprint

Kubra, S., Sun, M., Dion, W. A., Catak, A., Luong, H., Wang, H., Pan, Y., Liu, J., Ponna, A., Liu, L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.13.612812 · Cited by 3 · see citing works

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

Nie, X. Y., & Menet, J. S. (2025) · FEBS Letters · doi:10.1002/1873-3468.70232 · Cited by 2 · see citing works

Chronobiomaterials for circadian-aligned brain therapeutics

Garg, S., Walters, B., & Fernandez, D. C. (2026) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2026.05.005 · Cited by 1 · see citing works

Exploring the molecular pathways linking sleep phenotypes and POGZ-associated neurodevelopmental disorder

Marquezini, B. P., Moysés‐Oliveira, M., Kloster, A. K., Cunha, L., Deconto, T. B., Mosini, A. C., Guerreiro, P., Paschalidis, M., Adami, L. N. G., Andersen, M. L., et al. (2024) · Journal of Medical Genetics · doi:10.1136/jmg-2023-109508 · Cited by 1 · see citing works

Developing Circadian Therapeutics Against Age-Related Metabolic Decline

Nohara, K., Yoo, S. H., & Chen, Z. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-64543-8_11 · Cited by 1 · see citing works

Faculty Opinions recommendation of Transcriptional architecture of the mammalian circadian clock.

Ueda, H. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727120964.793558641

Faculty Opinions recommendation of Period2 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.

Ueda, H. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731737087.793558647

Women in Cardiovascular Genetics and Systems Medicine

(2024) · Frontiers research topics · doi:10.3389/978-2-8325-4796-0

Additional file 1 of The circadian clock has roles in mesenchymal stem cell fate decision

Gao, W., Li, R., Ye, M., Zhang, L., Zheng, J., Yang, Y., Wei, X., & Qing, Z. (2022) · Figshare · doi:10.6084/m9.figshare.19777951

Distinct associations of pioneer factor Ascl1-E12a with nucleosomes drive changes in cell fate

Zhou, B., Luzete-Monteiro, E., Zhang, J., Takenaka, N., Tang, H., García, M. F., Coradin, M., Frederick, M., Donahue, G., Garcia, B., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.05.020 · Cited by 1 · see citing works

RORα as a context-dependent transcriptional stabilizer in the nervous system

Zhang, H., Li, J., Liu, H., Hu, X., Zhang, S., Yu, Q., Kuang, G., Liu, L., Wang, Z., Yu, D., et al. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106970

Disruption of SWI/SNF ATPases in the mouse liver impairs diurnal gene expression associated with specific promoter features

Toft, N. I., Goitea, V. E., Præstholm, S. M., Correia, C. M., Heyde, I., Siersbæk, M. S., Oster, H., & Grøntved, L. (2026) · Nature Communications · doi:10.1038/s41467-026-77798-1

The histone methyltransferase complex subunit RBBP5 serves as a central epigenetic regulator of proteostasis dynamics

Kubra, S., Sun, M., Dion, W. A., Bian, Y., Catak, A., Luong, H., Wang, H., Pan, Y., Liu, J.-J., Ponna, A., et al. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3004048

Rev-erbα Dynamically Modulates Chromatin Looping to Control Circadian Gene Transcription

Kim, Y. H., Marhon, S. A., Zhang, Y.-X., Steger, D. J., Won, K.-J., & Lazar, M. (2018) · Science · doi:10.1126/science.aao6891 · Cited by 195 · see citing works

The Orphan Nuclear Receptor Rev-erb Recruits the N-CoR/Histone Deacetylase 3 Corepressor to Regulate the

Gene, C. B., Yin, L., & Lazar, M. A. (2015)

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198 · see citing works

Dissecting the Rev-erbα Cistrome and the Mechanisms Controlling Circadian Transcription in LiverPreprint

Fang, B., & Lazar, M. A. (2015) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2015.80.027508 · Cited by 19 · see citing works

Circadian organization of the genome

de Lima, C. D. M., & Göndör, A. (2018) · Science · doi:10.1126/science.aat0934 · Cited by 10 · see citing works