The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm
Open accessAbstract
Summary FTO, the first RNA demethylase discovered, mediates the demethylation of internal N6-methyladenosine (m6A) and N6, 2-O-dimethyladenosine (m6Am) at the +1 position from the 5’ cap in mRNA. Here, we demonstrate that the cellular distribution of FTO is distinct among different cell lines, affecting the access of FTO to different RNA substrates. We find that FTO binds multiple RNA species, including mRNA, snRNA, and tRNA, and can demethylate internal m6A and cap m6A in mRNA, internal m6m A in U6 RNA, internal and cap m6Am in snRNAs, and N1-methyladenosine (m1A) in tRNA. FTO-mediated demethylation shows a greater impact on the transcript levels of mRNAs possessing internal m6A than the ones with cap m6Am in the tested cells. We also show that FTO can directly repress translation by catalyzing m1A tRNA demethylation. Collectively, FTO-mediated RNA demethylation occurs to m6A and m6Am in mRNA and snRNA as well as m1A in tRNA.
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Metadata
- Authors
- Wei, J., Liu, F., Lu, Z., Fei, Q., Ai, Y., He, P. C., Shi, H., Cui, X., Su, R., Klungland, A., Jia, G., Chen, J., & He, C.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 71
- Issue
- 6
- Pages
- 973-985.e5
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2891713480
- Cited by
- 783
- References
- 58
- FWCI
- 19.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wei, J., Liu, F., Lu, Z., Fei, Q., Ai, Y., He, P. C., Shi, H., Cui, X., Su, R., Klungland, A., Jia, G., Chen, J., & He, C. (2018). Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. Molecular Cell. https://doi.org/10.1016/j.molcel.2018.08.011
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