The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers
Open accessAbstract
Cellular RNAs are naturally decorated with a variety of chemical modifications. The structural diversity of the modified nucleosides provides regulatory potential to sort groups of RNAs for organized metabolism and functions, thus affecting gene expression. Recent years have witnessed a burst of interest in and understanding of RNA modification biology, thanks to the emerging transcriptome-wide sequencing methods for mapping modified sites, highly-sensitive mass spectrometry for precise modification detection and quantification, and extensive characterization of the modification “effectors”, including enzymes (“writers” and “erasers”) that alter the modification level and binding proteins (“readers”) that recognize the chemical marks. However, challenges remain due to the vast heterogeneity in expression abundance of different RNA species, further complicated by divergent cell-type-specific and tissue-specific expression and localization of the effectors as well as modifications. In this review, we highlight recent progress in understanding the function of N6-methyladenosine (m6A), the most abundant internal mark on eukaryotic messenger RNA (mRNA), in light of the specific biological contexts of m6A effectors. We emphasize the importance of context for RNA modification regulation and function.
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N6-methyladenosine-dependent regulation of messenger RNA stability
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Self-citationComprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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Self-citationALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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Self-citationN6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Self-citationA METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
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Self-citationRecognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
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Self-citationNuclear m6A Reader YTHDC1 Regulates mRNA Splicing
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Self-citationm6A RNA methylation promotes XIST-mediated transcriptional repression
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Metadata
- Authors
- Shi, H., Wei, J., & He, C.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 74
- Issue
- 4
- Pages
- 640-650
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2946217053
- Cited by
- 1,931
- References
- 18
- FWCI
- 61.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shi, H., Wei, J., & He, C. (2019). Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.04.025
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