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Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence
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“The SAMTOR protein acts as an indirect sensor of methionine levels, inhibiting GATOR1 when levels of the methionine metabolite S-adenosylmethionine (SAM) are low (128). As SAM is extremely responsive to methionine levels, SAMTOR essentially functions as a sensor of methionine levels 172.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [172]
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Regulation of chromatin structure by site-specific histone H3 methyltransferases
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845
Histone methylation: a dynamic mark in health, disease and inheritance
Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241
One-Carbon Metabolism in Health and Disease
Ducker, G. S., & Rabinowitz, J. D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.009 · Cited by 2,239
L1 drives IFN in senescent cells and promotes age-associated inflammation
De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature · doi:10.1038/s41586-018-0784-9 · Cited by 1,255
Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery
Towbin, B. D., González-Aguilera, C., Sack, R., Gaidatzis, D., Kalck, V., Meister, P., Askjaer, P., & Gasser, S. M. (2012) · Cell · doi:10.1016/j.cell.2012.06.051 · Cited by 597
Booth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499
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Van Meter, M., Kashyap, M., Rezazadeh, S., Geneva, A. J., Morello, T. D., Seluanov, A., & Gorbunova, V. (2014) · Nature Communications · doi:10.1038/ncomms6011 · Cited by 456
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Molecular mechanisms of dietary restriction promoting health and longevity
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Self-citationTargeting the biology of aging with mTOR inhibitors
Mannick, J. B., & Lamming, D. W. (2023) · Nature Aging · doi:10.1038/s43587-023-00416-y · Cited by 372
Self-citationPak, H. H., Haws, S. A., Green, C. L., Koller, M., Lavarias, M. T., Richardson, N. E., Yang, S. E., Dumas, S. N., Sonsalla, M., Bray, L., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00466-9 · Cited by 171
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Metadata
- Authors
- Haws, S. A., Yu, D., Ye, C., Wille, C. K., Nguyen, L. C., Krautkramer, K. A., Tomasiewicz, J. L., Yang, S. E., Miller, B. R., Liu, W. H., Igarashi, K., Sridharan, R., Tu, B. P., Cryns, V. L., Lamming, D. W., & Denu, J. M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 78
- Issue
- 2
- Pages
- 210-223.e8
- ISSN
- 1097-2765
- PMC
- PMC7191556
- Cited by
- 94
- References
- 15
- Language
- en
- Licence
- Funders
- National Institutes of Health (R37 GM059785, T32 DK007665, AG041765, AG051974, AG056771, K99 GM129415, AG050135, R01 GM094314, F32 GM128399, AG062328, GM113033)
- School of Medicine and Public Health, University of Wisconsin-Madison
- College of Engineering, University of Wisconsin-Madison
- V Foundation for Cancer Research
- American Foundation for Aging Research
- Japan Society for the Promotion of Science (18H05374)
- U.S. Department of Veterans Affairs (I01-BX004031)
- American Heart Association (17PRE33410983)
- Glenn Foundation for Medical Research
- American Federation for Aging Research
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