Cited by 179Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromatin Remodeling and Cancer

The DOI matches its Crossref record; 86 of the 87 references it cites were found in a registry or an index.

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Open access

Hogg, Simon J., Motorna, Olga, Cluse, Leonie A., Johanson, Timothy M., Coughlan, Hannah D., Raviram, Ramya, Myers, Robert M., Costacurta, Matteo, Todorovski, Izabela, Pijpers, Lizzy, Bjelosevic, Stefan, Williams, Tobias, Huskins, Shannon N., Kearney, Conor J., Devlin, Jennifer R., Fan, Zheng, Jabbari, Jafar S., Martin, Ben P., Fareh, Mohamed, Kelly, Madison J., Dupéré-Richer, Daphné, Sandow, Jarrod J., Feran, Breon, Knight, Deborah, Khong, Tiffany, Spencer, Andrew, Harrison, Simon J., Gregory, Gareth, Wickramasinghe, Vihandha O., Webb, Andrew I., Taberlay, Phillippa C., Bromberg, Kenneth D., Lai, Albert, Papenfuss, Anthony T., Smyth, Gordon K., Allan, Rhys S., Licht, Jonathan D., Landau, Dan A., Abdel-Wahab, Omar, Shortt, Jake, Vervoort, Stephin J., Johnstone, Ricky W.·2021·Molecular Cell

DOI 10.1016/j.molcel.2021.04.015PMC PMC8183601

Open this paper in CoChat — free account Open PDF

Abstract

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigenomic and transcriptomic analyses following acute inhibition of major cellular lysine acetyltransferases P300 and CBP in hematological malignancies. We found that catalytic P300/CBP inhibition dynamically perturbs steady-state acetylation kinetics and suppresses oncogenic transcriptional networks in the absence of changes to chromatin accessibility. CRISPR-Cas9 screening identified NCOR1 and HDAC3 transcriptional co-repressors as the principal antagonists of P300/CBP by counteracting acetylation turnover kinetics. Finally, deacetylation of H3K27 provides nucleation sites for reciprocal methylation switching, a feature that can be exploited therapeutically by concomitant KDM6A and P300/CBP inhibition. Overall, this study indicates that the steady-state histone acetylation-methylation equilibrium functions as a molecular rheostat governing cellular transcription that is amenable to therapeutic exploitation as an anti-cancer regimen.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.molcel.2021.04.015

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Self-citation
HISAT: a fast spliced aligner with low memory requirements
Kim, D., Langmead, B., & Salzberg, S. L. (2015) · Nature Methods · doi:10.1038/nmeth.3317 · Cited by 24,112
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
Fast, sensitive and accurate integration of single-cell data with Harmony
Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
Rao, S. S. P., Huntley, M. H., Durand, N. C., Stamenova, E. K., Bochkov, I. D., Robinson, J. T., Sanborn, A. L., Machol, I., Omer, A. D., Lander, E. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.021 · Cited by 9,212

Show all 87 references

Research works printed but not linked: 1

Fang, 2020, SnapATAC: a comprehensive analysis package for single cell ATAC-seq, bioRxiv

Sorted by citations

Modulation of cellular processes by histone and non-histone protein acetylation
Shvedunova, M., & Akhtar, A. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00441-y · Cited by 1,007
Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents
Chen, Q., Yang, B.-H., Liu, X., Zhang, X. D., Zhang, L., & Liu, T. (2022) · Theranostics · doi:10.7150/thno.73223 · Cited by 285
Circulating tumor cells: from new biological insights to clinical practice
Gu, X., Wei, S., & Lv, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01938-6 · Cited by 204
Targeting transcription cycles in cancer
Vervoort, S. J., Devlin, J. R., Kwiatkowski, N. P., Teng, M., Gray, N. S., & Johnstone, R. W. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00411-8 · Cited by 170
Chromatin accessibility: methods, mechanisms, and biological insights
Mansisidor, A., & Risca, V. I. (2022) · Nucleus · doi:10.1080/19491034.2022.2143106 · Cited by 168
LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and Collaborates with ACSL4 and YAP to Determine Ferroptosis Sensitivity
Cui, J., Wang, Y., Tian, X., Miao, Y., Ma, L., Zhang, C., Xu, X., Wang, J., Fang, W., & Zhang, X. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0237 · Cited by 140
Epigenetic regulation in cancer
Gu, M., Ren, B., Fang, Y., Ren, J., Liu, X., Wang, X., Zhou, F., Xiao, R., Luo, X., You, L., et al. (2024) · MedComm · doi:10.1002/mco2.495 · Cited by 126
CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging Therapeutic Targets in Prostate and Breast Cancers
Waddell, A. R., Huang, H., & Liao, D. (2021) · Cancers · doi:10.3390/cancers13122872 · Cited by 110
Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function
Chen, Y.-J. C., Koutelou, E., & Dent, S. (2022) · Molecular Cell · doi:10.1016/j.molcel.2021.12.004 · Cited by 110
The Role of CREBBP/EP300 and Its Therapeutic Implications in Hematological Malignancies
Zhu, Y., Wang, Z., Li, Y., Peng, H., Liu, J., Zhang, J., & Xiao, X. (2023) · Cancers · doi:10.3390/cancers15041219 · Cited by 100
Mechanisms and cross-talk of regulated cell death and their epigenetic modifications in tumor progression
He, R., Liu, Y., Fu, W., He, X., Liu, S., Xiao, D., & Tao, Y. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02172-y · Cited by 109
Effects of the Acetyltransferase p300 on Tumour Regulation from the Novel Perspective of Posttranslational Protein Modification
Zeng, Q.-M., Wang, K., Zhao, Y., Ma, Q., Chen, Z., & Huang, W. (2023) · Biomolecules · doi:10.3390/biom13030417 · Cited by 79
Structural insights into p300 regulation and acetylation-dependent genome organisation
Ibrahim, Z., Wang, T., Destaing, O., Salvi, N., Hoghoughi, N., Chabert, C., Rusu, A., Gao, J., Feletto, L., Reynoird, N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35375-2 · Cited by 64
Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription
Morgan, M. A., & Shilatifard, A. (2023) · Science Advances · doi:10.1126/sciadv.adg6593 · Cited by 71
Targeting lysine acetylation readers and writers
Zhou, M., & Cole, P. A. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01080-6 · Cited by 68
Targeting epigenetic modulators using PROTAC degraders: Current status and future perspective
Webb, T., Craigon, C., & Ciulli, A. (2022) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2022.128653 · Cited by 58
Pharmacological targeting of the cancer epigenome
Mabe, N. W., Perry, J. A., Malone, C. F., & Stegmaier, K. (2024) · Nature Cancer · doi:10.1038/s43018-024-00777-2 · Cited by 61
Acetyl-CoA metabolism as a therapeutic target for cancer
Chen, G., Bao, B., Cheng, Y., Tian, M., Song, J., Zheng, L., & Tong, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115741 · Cited by 54
HDACs and the epigenetic plasticity of cancer cells: target the complexity
Brancolini, C., Gagliano, T., & Minisini, M. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108190 · Cited by 55
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation
Xiao, Y., Hale, S. M., Awasthee, N., Meng, C., Zhang, X., Liu, Y., Ding, H., Huo, Z., Lv, D., Zhang, W., et al. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.07.010 · Cited by 54
Autoimmune disease: a view of epigenetics and therapeutic targeting
Mu, S., Wang, W., Liu, Q., Ke, N., Li, H., Sun, F., Zhang, J., & Zhu, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1482728 · Cited by 57
Proteomic characterization of post-translational modifications in drug discovery
Zhai, L., Chen, K., Hao, B., & Tan, M. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01017-y · Cited by 53
Protein lysine acetyltransferase CBP/p300: A promising target for small molecules in cancer treatment
Gou, P., & Zhang, W. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116130 · Cited by 53
Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies
Yang, J., Zhou, F., Luo, X., Fang, Y., Wang, X., Liu, X., Xiao, R., Jiang, D., Tang, Y., Yang, G., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02366-3 · Cited by 56
The role of protein acetylation in carcinogenesis and targeted drug discovery
Yang, J., Song, C., & Zhan, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.972312 · Cited by 42
Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma
Welsh, S. J., Barwick, B. G., Meermeier, E. W., Riggs, D. L., Shi, C.-X., Zhu, Y. X., Sharik, M. E., Du, M. T., Rocha, L. D. A., Garbitt, V. M., et al. (2023) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-23-0062 · Cited by 44
Emerging Pharmacotherapeutic Strategies to Overcome Undruggable Proteins in Cancer
Lu, Y., Yang, Y., Zhu, G., Zeng, H., Fan, Y., Guo, F., Xu, D., Wang, B., Chen, D., & Ge, G. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.83026 · Cited by 42
Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition
Bishop, T. R., Subramanian, C., Bilotta, E. M., Garnar-Wortzel, L., Ramos, A. R., Zhang, Y., Asiaban, J. N., Ott, C. J., Rock, C. O., & Erb, M. A. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01320-7 · Cited by 43
Small molecule targeting of chromatin writers in cancer
Conery, A. R., Rocnik, J. L., & Trojer, P. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00920-5 · Cited by 36
ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma
Neri, P. E., Barwick, B. G., Jung, D., Patton, J. C., Maity, R., Tagoug, I., Stein, C. K., Tilmont, R., Leblay, N., Ahn, S., et al. (2023) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-23-0061 · Cited by 35
CRISPR screens identify gene targets at breast cancer risk loci
Tuano, N. K., Beesley, J., Manning, M., Shi, W., Perlaza-Jimenez, L., Malaver-Ortega, L. F., Paynter, J. M., Black, D., Civitarese, A., McCue, K., et al. (2023) · Genome Biology · doi:10.1186/s13059-023-02898-w · Cited by 30
“This is consistent with reports showing that CREBBP can act as a tumor-suppressor or an oncogene in a cell type specific manner [25, 26].”
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer
Luo, J., Chen, Z., Qiao, Y., Tien, J. C.-Y., Young, E., Mannan, R., Mahapatra, S., Bhattacharyya, R., Xiao, L., He, T., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02336-6 · Cited by 39
Dietary Fiber‐Derived Microbial Butyrate Suppresses ILC2‐Dependent Airway Inflammation in COPD
Jiang, M., Wang, J., Li, Z., Xu, D., Jing, J., Li, F., Ding, J., & Li, Q. (2024) · Mediators of Inflammation · doi:10.1155/2024/6263447 · Cited by 39
The roles of lactate and the interplay with m6A modification in diseases
Tang, F., Xiao, D., Li, X., & Qiao, L. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09951-9 · Cited by 32
KATs off: Biomedical insights from lysine acetyltransferase inhibitors
Whedon, S. D., & Cole, P. A. (2022) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2022.102255 · Cited by 32
PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution
Asante, Y., Benischke, K., Osman, I., Ngo, Q. A., Wurth, J., Laubscher, D., Kim, H., Udhayakumar, B., Khan, M. I. H., Chin, D. H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43780-4 · Cited by 34
The important role of the histone acetyltransferases p300/CBP in cancer and the promising anticancer effects of p300/CBP inhibitors
Wu, X., Zhang, X., Tang, S., & Wang, Y. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09984-0 · Cited by 28
Molecular Mechanisms of Cereblon-Interacting Small Molecules in Multiple Myeloma Therapy
Costacurta, M., He, J., Thompson, P. E., & Shortt, J. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11111185 · Cited by 27
Genetic dysregulation of EP300 in cancers in light of cancer epigenome control – targeting of p300-proficient and -deficient cancers
Gronkowska, K., & Robaszkiewicz, A. (2024) · Molecular Therapy Oncology · doi:10.1016/j.omton.2024.200871 · Cited by 28
KDM6A regulates immune response genes in multiple myeloma
Dupéré-Richer, D., Riva, A., Maji, S., Barwick, B. G., Román, H. L. C., Sobh, A., Quickstad, G., Li, J., De, U., Piper, C., et al. (2024) · Blood · doi:10.1182/blood.2024024518 · Cited by 22
LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression
Chen, W., Wang, F., Yu, X., Qi, J., Dong, H., Cui, B., Zhang, Q., Wu, Y., An, J., Ni, N., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02883-4 · Cited by 22
H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition in airway epithelial cells
Liu, S., He, Y., Jin, L., Shi, S., Zhang, J., Xie, W., Yang, M., Zhang, Q., & Kong, H. (2025) · Toxicology · doi:10.1016/j.tox.2025.154109 · Cited by 21
CRISPR/Cas9 technology: applications in oocytes and early embryos
Zhang, Y., Yin, T., & Zhou, L. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04610-9 · Cited by 26
Chromatin-based memory as a self-stabilizing influence on cell identity
Bell, C. C., Faulkner, G. J., & Gilan, O. (2024) · Genome biology · doi:10.1186/s13059-024-03461-x · Cited by 22
HDAC8 drives spindle organization during meiotic maturation of porcine oocytes
Chen, Y., Pan, C., Lu, Y., Miao, Y., & Xiong, B. (2021) · Cell Proliferation · doi:10.1111/cpr.13119 · Cited by 20
Hepatic NCoR1 deletion exacerbates alcohol-induced liver injury in mice by promoting CCL2-mediated monocyte-derived macrophage infiltration
Yin, F., Wu, M., Wei, X., Ren, R., Liu, M., Chen, C., Liu, Y., Xie, R.-Q., Jiang, S., Wang, X.-F., et al. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00863-0 · Cited by 20
CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells
Bommi‐Reddy, A., Park-Chouinard, S., Mayhew, D. N., Terzo, E., Hingway, A., Steinbaugh, M. J., Wilson, J. E., Sims, R. J., & Conery, A. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262378 · Cited by 19
Incomplete erasure of histone marks during epigenetic reprogramming in medaka early developmentPreprint
Fukushima, H. S., Takeda, H., & Nakamura, R. (2023) · Genome Research · doi:10.1101/gr.277577.122 · Cited by 18
Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation
Marsh, A. J., Пирогов, С. А., Kaur, Y., Ruffridge, A. J., Sajwan, S., Gibson, T. J., Hunt, G., Harrison, M. M., & Mannervik, M. (2024) · Molecular Cell · doi:10.1016/j.molcel.2025.05.009 · Cited by 22
High levels of Histone H3 K27 acetylation and tri-methylation are associated with shorter survival in Oral Squamous Cell Carcinoma patients
Shahhosseini, A., a-Flin, E. B., Derakhshan, S., Aminishakib, P., & Goudarzi, A. (2023) · Biomedicine · doi:10.37796/2211-8039.1391 · Cited by 17
Regulation of SUMOylation on RNA metabolism in cancers
Cao, Y., Huang, C., Zhao, X., & Yu, J. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1137215 · Cited by 17
Activation, decommissioning, and dememorization: enhancers in a life cycle
Wu, X., Wu, X., & Xie, W. (2023) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2023.04.005 · Cited by 15
Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming
Yang, Y., Zhang, X., Cai, D., Zheng, X., Zhao, X., Zou, J. X., Zhang, J., Borowsky, A. D., Dall’Era, M., Corey, E., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2411321121 · Cited by 17
Plasma Cell–Free DNA Chromatin Immunoprecipitation Profiling Depicts Phenotypic and Clinical Heterogeneity in Advanced Prostate Cancer
Sipola, J., Munzur, A. D., Kwan, E. M., Seo, C. C. Y., Hauk, B. J., Parekh, K., Liao, Y. J., Bernales, C. Q., Donnellan, G., Bloise, I., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-2052 · Cited by 18
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors
Crawford, M. C., Tripu, D. R., Barritt, S. A., Jing, Y., Gallimore, D., Kales, S. C., Bhanu, N. V., Xiong, Y., Fang, Y., Butler, K. A. T., et al. (2023) · ACS Chemical Biology · doi:10.1021/acschembio.3c00293 · Cited by 15
Histone methylation and acetylation in cancer: mechanism, progression, and targets
Bu, S., Ye, T., Gao, H., Song, H., & Zhu, Y. (2024) · ONCOLOGIE · doi:10.1515/oncologie-2024-0324 · Cited by 14
Ncor1 Deficiency Promotes Osteoclastogenesis and Exacerbates Periodontitis
Ma, X. X., Meng, X.-Q., Wang, Y., Liu, Y., Shi, X., Shao, S., Duan, S., & Lu, H. (2022) · Journal of Dental Research · doi:10.1177/00220345221116927 · Cited by 14
Novel insights into lncRNAs as key regulators of post-translational modifications in cancer: mechanisms and therapeutic potential
Han, Y., Li, S., Oyang, L., Cui, S., Zhang, W., Yang, W., Peng, M., Tan, S., Xia, L., Lin, J., et al. (2025) · Cellular Oncology · doi:10.1007/s13402-025-01086-1 · Cited by 14
Histone methylation modification and diabetic kidney disease: Potential molecular mechanisms and therapeutic approaches (Review)
Qu, P., Li, L., Jin, Q., Liu, D., Qiao, Y., Zhang, Y., Sun, Q., Ran, S., Li, Z., Liu, T., et al. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5428 · Cited by 13
Epigenetic programming of TBX2/CX43 mediates lower sperm quality in male offspring induced by prenatal dexamethasone exposure
Liu, Y., Liu, Y., Chen, G., & Wang, H. (2023) · Toxicological Sciences · doi:10.1093/toxsci/kfad016 · Cited by 13
VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300
Guo, S., Hu, X., Cotton, J. L., Ma, L., Li, Q., Cui, J., Wang, Y., Thakare, R., Tao, Z., Ip, Y. T., et al. (2024) · eLife · doi:10.7554/elife.98386 · Cited by 14
Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens
Sood, V., Holewinski, R. J., Andrésson, Þ., Larson, D. R., & Misteli, T. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.01.022 · Cited by 16
The histone modifier KAT2A presents a selective target in a subset of well-differentiated microsatellite-stable colorectal cancers
Kufrin, V., Seiler, A., Brilloff, S., Rothfuß, H., Küchler, S., Schäfer, S., Rahimian, E., Baumgarten, J., Ding, L., Buchholz, F., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01479-7 · Cited by 11
Unravelling the Role of P300 and TMPRSS2 in Prostate Cancer: A Literature Review
Gioukaki, C., Georgiou, A., Gkaralea, L. E., Κroupis, C., Lazaris, A. C., Alamanis, C., & Thomopoulou, G. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411299 · Cited by 11
EP300 promotes lung cancer cell proliferation by regulating the oncogenic transcription of Hippo-YAP signaling pathway
Li, S., Shi, J., Wang, L., Zhang, D., & Zhang, H. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149330 · Cited by 11
EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
Huttunen, J., Aaltonen, N., Helminen, L., Rilla, K. J., & Paakinaho, V. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05209-z · Cited by 10
Histone deacetylase 3 inhibition alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis via epigenetically upregulating Nrf2/HO-1 signaling pathway
Zhou, W., Zeng, D., Liu, S., Huang, Y., Lv, F., & Zhou, W. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111107 · Cited by 9
Bromodomain inhibitor treatment leads to overexpression of multiple kinases in cancer cells
Chandrashekar, D. S., Afaq, F., Karthikeyan, S. K., Athar, M., Shrestha, S., Singh, R., Manne, U., & Varambally, S. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101046 · Cited by 10
It’s all in the combination: decoding the epigenome for cancer research and diagnostics
Furth, N., & Shema, E. (2022) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2022.101899 · Cited by 9
Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer
Hogg, S. J., Motorna, O., Kearney, C. J., Derrick, E. B., House, I. G., Todorovski, I., Kelly, M. J., Zethoven, M., Bromberg, K. D., Lai, A., et al. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01316-5 · Cited by 8
LncRNA-Histone Modification Crosstalk: Orchestrating Cancer Pathobiology
Jasim, S. A., Pallathadka, H., Hjazi, A., Sanghvi, G. V., Rekha, M. M., Agarwal, M., Arya, R., Alasheqi, M. Q., KADHIM, A. J., & Kariem, M. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04402-6 · Cited by 10
Expanding the landscape of lysine acetylation stoichiometry and clinical impact
Encarnación‐Guevara, S., & Gil, J. (2025) · Journal of Proteomics · doi:10.1016/j.jprot.2025.105522 · Cited by 10
The adverse effects of developmental exposure to polystyrene nanoparticles on cognitive function in weaning rats and the protective role of trihydroxy phenolacetone
Wang, H., Qiao, C., Gao, Y., Geng, Y., Niu, F., Yang, R., Wang, Z., Jiang, W., & Sun, H. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123632 · Cited by 9
FAK-LINC01089 negative regulatory loop controls chemoresistance and progression of small cell lung cancer
Wang, X., Li, X., Niu, L., Lv, F., Guo, T., Gao, Y., Ran, Y., Huang, W., & Wang, B. (2024) · Oncogene · doi:10.1038/s41388-024-03027-y · Cited by 9
Epigenetic reprogramming in multiple myeloma—Challenges and opportunities
Kumar, S., Kats, L. M., & Gruber, E. (2025) · International Journal of Cancer · doi:10.1002/ijc.35426 · Cited by 8
Metabolite-derived protein modifications modulating oncogenic signaling
Liu, Y., Vandekeere, A., Xu, M., Fendt, S., & Altea‐Manzano, P. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.988626 · Cited by 7
TMEM120A-mediated regulation of chemotherapy sensitivity in colorectal cancer cells
Wang, L., & Liu, X. (2023) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-023-04594-9 · Cited by 7
SEMA3C promotes thyroid cancer via the Wnt/β-catenin pathway
Li, S., Cheng, Y., Gao, C., Yuan, Q., & Lu, X. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114378 · Cited by 6
Development of p300-targeting degraders with enhanced selectivity and onset of degradation
Marsh, G. P., Cooper, M. S., Goggins, S., Reynolds, S. J., Wheeler, D. F., Cresser-Brown, J. O., Arnold, R. E., Babcock, E. G., Hughes, G., Bosnakovski, D., et al. (2025) · RSC Medicinal Chemistry · doi:10.1039/d4md00969j · Cited by 6
Histone Deacetylase 2 in Alzheimer’s Disease: A Comprehensive Molecular Blueprint for Therapeutic Targeting
Asadi, K., Radha, K., Satarker, S., & Gurram, P. C. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05264-y · Cited by 7
Co-activation of the super-enhancer complex SOX2 and HDAC1 confers temozolomide resistance by promoting PDGFB transcription in glioblastoma
Xie, H., Ji, T., Zhang, C., Cheng, M., Wang, R., Wu, Y., Wang, J., Wang, H., Yang, J., Xu, S., et al. (2025) · Neuro-Oncology · doi:10.1093/neuonc/noaf219 · Cited by 7
Histone acetylation homeodynamics navigates cell survival and apoptosis
Li, K., Tian, L., Cao, W., Zhang, J., Zhang, W., Lin, T., Huang, S., Qiu, Y., Ruan, Z., Deng, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66405-4 · Cited by 7
Genetic and Epigenetic Mechanisms Underlying Reversible Adaptive Responses in Fungi
Dan, L., Liu, S., Qiang, Z., Ye, X., & Zhang, J. (2026) · Journal of Fungi · doi:10.3390/jof12050309 · Cited by 8
Therapeutic Discovery for Chromatin Complexes: Where Do We Stand?
Owens, D. D. G., Maitland, M. E. R., Arrowsmith, C. H., & Baršytė-Lovejoy, D. (2024) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-062822-110356 · Cited by 7
Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape
Marrone, L., D’Agostino, M., Giordano, C., Giacomo, V. D., Urzini, S., Malasomma, C., Gammella, M., Tufano, M., Romano, S., & Romano, M. F. (2023) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2023.028392 · Cited by 8
Tissue-scale mechanics controls differentiation strategy and dynamics of epithelial multilayeringPreprint
Villeneuve, C., Azote, S., Albu, M., Rübsam, M., Biggs, L. C., Vinzens, S., Kruse, K., Prakash, A., Zentis, P., Lawson-Keister, E., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.08.704529 · Cited by 6
Acetylation and deacetylation dynamics in stress response to cancer and infections
Li, L., Zeng, Y., Cheng, G., & Yang, H. (2025) · Seminars in Immunology · doi:10.1016/j.smim.2025.101957 · Cited by 5
High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA
Hu, W., Wang, X., Fang, Z. H., Zhang, J., Tirumalasetty, M. B., & Miao, Q. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115947 · Cited by 5
Valemetostat–SAHA-Driven Acetylation of p53 via SET/TAF-Iβ Displacement and p300 Activation Modulates Cell Cycle Regulators in Pancreatic Cancer Cells
Crosta, M. D., Ragone, F. C., Benedetti, R., D’Orazi, G., Santarelli, R., Montani, M. S. G., & Cirone, M. (2025) · Biomedicines · doi:10.3390/biomedicines13092279 · Cited by 5
The interplay of epigenetic remodelling and transposon-mediated genomic instability in ageing and longevity
Lemus, A. J. J., Tewelde, E., Bhala, R., Guan, A., Xu, A., & Benayoun, B. A. (2026) · Open Biology · doi:10.1098/rsob.250093 · Cited by 7
BRD4 orchestrates the metabolic-epigenetic regulation of GM-CSF expression and secretion to drive PD-L1⁺ macrophage-mediated immune evasion in triple-negative breast cancer
Diao, H., Chen, J., Zhang, Y., Hua, H., Dong, M., Jin, W., Chen, J., Shan, B., Cao, Y., Han, X., et al. (2026) · Oncogene · doi:10.1038/s41388-026-03681-4 · Cited by 5
BANCR-containing extracellular vesicles enhance breast cancer resistance
Song, X., Liu, S., Zeng, Y., Cai, Y., & Luo, H. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108304 · Cited by 5
[Coactivator p300-induced H3K27 acetylation mediates lipopolysaccharide-induced inflammatory mediator synthesis].
Hu, K., Cao, X., Li, Y., Liu, L., Chen, Y., Chen, L., Huang, M., Tan, B., & Yin, H. (2022) · PubMed Central · doi:10.12122/j.issn.1673-4254.2022.03.02 · Cited by 5
New Inhibitors of the Human p300/CBP Acetyltransferase Are Selectively Active against the Arabidopsis HAC Proteins
Longo, C., Lepri, A., Paciolla, A., Messore, A., Vita, D. D., di Patti, M. C. B., Amadei, M., Madia, V. N., Ialongo, D., Santo, R. D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810446 · Cited by 5
Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin
Cashman, T. J., Saheera, S., Blau, A., Otabil, E. M., Nagy, N. Y., Samenuk, T. D., Fitzgibbons, T. P., McManus, D. D., & Trivedi, C. M. (2025) · JCI Insight · doi:10.1172/jci.insight.188562 · Cited by 4
NAA10 (N-Alpha-Acetyltransferase 10): A Multifunctional Regulator in Development, Disease, and Cancer
Yang, Z. Q., Campeanu, I. J., Lopez, I., Syed, M., Jiang, Y., & Afisllari, H. (2025) · Cells · doi:10.3390/cells14120863 · Cited by 4
GALNT4 promotes the stemness of non-small cell lung cancer through O-glycosylation of MUC5AC via ITGB4/PI3K/AKT signaling pathway
Guo, Y., Xing, R., Li, Q., Zhou, W., Qi, X., & Li, S. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111934 · Cited by 4
Decreased adenosine 3′,5′-cyclic monophosphate is a driving factor of P300/SIRT1-mediated histone hyperacetylation in obesity-related hypertension
Wang, Y., Zhang, Q., Shen, C., Wang, H., Li, Y., Wu, H., Sun, X., & Shi, L. (2025) · Journal of Hypertension · doi:10.1097/hjh.0000000000003981 · Cited by 4
Catching active enhancers via H2B N-terminal acetylation
Huang, C., & Helin, K. (2023) · Nature Genetics · doi:10.1038/s41588-023-01347-5 · Cited by 4
Transcriptional synergy in human aortic endothelial cells is vulnerable to combination p300/CBP and BET bromodomain inhibition
Bracken, R. C., Davison, L. M., Buehler, D. P., Fulton, M. E., Carson, E. E., Sheng, Q., Stolze, L. K., Guillermier, C., Steinhauser, M. L., & Brown, J. D. (2024) · iScience · doi:10.1016/j.isci.2024.110011 · Cited by 4

Authors: Hogg, S. J., Motorna, O., Cluse, L. A., Johanson, T. M., Coughlan, H. D., Raviram, R., Myers, R. M., Costacurta, M., Todorovski, I., Pijpers, L., Bjelosevic, S., Williams, T., Huskins, S. N., Kearney, C. J., Devlin, J. R., Fan, Z., Jabbari, J. S., Martin, B. P., Fareh, M., Kelly, M. J., Dupéré-Richer, D., Sandow, J. J., Feran, B., Knight, D., Khong, T., Spencer, A., Harrison, S. J., Gregory, G., Wickramasinghe, V. O., Webb, A. I., Taberlay, P. C., Bromberg, K. D., Lai, A., Papenfuss, A. T., Smyth, G. K., Allan, R. S., Licht, J. D., Landau, D. A., Abdel-Wahab, O., Shortt, J., Vervoort, S. J., & Johnstone, R. W.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
The University of Melbourne (AU)
Peter MacCallum Cancer Centre (AU)
New York Genome Center (US)
University of Tasmania (AU)
University of Florida (US)
Monash University (AU)
The Royal Melbourne Hospital (AU)
Monash Medical Centre (AU)
AbbVie (United States) (US)
Corresponding author: Vervoort, Stephin J.
Johnstone, Ricky W.
ORCID: Hogg, Simon J.
Motorna, Olga
Cluse, Leonie A.
Johanson, Timothy M.
Coughlan, Hannah D.
Raviram, Ramya
Myers, Robert M.
Costacurta, Matteo
Todorovski, Izabela
Pijpers, Lizzy
Bjelosevic, Stefan
Williams, Tobias
Kearney, Conor J.
Devlin, Jennifer R.
Jabbari, Jafar S.
Fareh, Mohamed
Kelly, Madison J.
Dupéré-Richer, Daphné
Sandow, Jarrod J.
Knight, Deborah
Khong, Tiffany
Spencer, Andrew
Harrison, Simon J.
Gregory, Gareth
Wickramasinghe, Vihandha O.
Webb, Andrew I.
Taberlay, Phillippa C.
Lai, Albert
Papenfuss, Anthony T.
Smyth, Gordon K.
Allan, Rhys S.
Licht, Jonathan D.
Landau, Dan A.
Abdel-Wahab, Omar
Shortt, Jake
Vervoort, Stephin J.
Johnstone, Ricky W.
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2021-05
Volume: 81
Issue: 10
Pages: 2183-2200.e13
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2021.04.015
PMC: PMC8183601
OpenAlex: W3163735930
Cited by: 170
References: 87
Citations by year: 2026: 32 · 2025: 44 · 2024: 37 · 2023: 30 · 2022: 21 · 2021: 6
FWCI: 8.08
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 384 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
UTAS Research Repository (submittedVersion)
Figshare (submittedVersion, cc-by)
Minerva Access (University of Melbourne) (submittedVersion)
Funders: National Institutes of Health
National Health and Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: histone acetylation, P300, CBP, oncogenic transcription, chromatin accessibility, H3K27 methylation, KDM6A, NCOR1, HDAC3, corepressors, hematologic malignancies
MeSH terms: Histone Deacetylase 3, Acetylation, Cell Line, Chromatin, Histone Deacetylases, Histones, Humans, Kinetics, Methylation, Models, Biological, Oncogenes, RNA Polymerase II, Transcription, Genetic, Genome, Conserved Sequence, Evolution, Molecular, p300-CBP Transcription Factors, Gene Regulatory Networks, Biocatalysis, Co-Repressor Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks