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Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
Open accessAbstract
To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigenomic and transcriptomic analyses following acute inhibition of major cellular lysine acetyltransferases P300 and CBP in hematological malignancies. We found that catalytic P300/CBP inhibition dynamically perturbs steady-state acetylation kinetics and suppresses oncogenic transcriptional networks in the absence of changes to chromatin accessibility. CRISPR-Cas9 screening identified NCOR1 and HDAC3 transcriptional co-repressors as the principal antagonists of P300/CBP by counteracting acetylation turnover kinetics. Finally, deacetylation of H3K27 provides nucleation sites for reciprocal methylation switching, a feature that can be exploited therapeutically by concomitant KDM6A and P300/CBP inhibition. Overall, this study indicates that the steady-state histone acetylation-methylation equilibrium functions as a molecular rheostat governing cellular transcription that is amenable to therapeutic exploitation as an anti-cancer regimen.
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“It is important to note that these HATs can be coopted, in different cancer contexts, to sustain the transcriptional addiction required for cell fitness (Hogg et al., 2021).”
From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Hogg et al., 2021
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The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Self-citationHISAT: a fast spliced aligner with low memory requirements
Kim, D., Langmead, B., & Salzberg, S. L. (2015) · Nature Methods · doi:10.1038/nmeth.3317 · Cited by 24,112
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
Fast, sensitive and accurate integration of single-cell data with Harmony
Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
Rao, S. S. P., Huntley, M. H., Durand, N. C., Stamenova, E. K., Bochkov, I. D., Robinson, J. T., Sanborn, A. L., Machol, I., Omer, A. D., Lander, E. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.021 · Cited by 9,212
Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
Lieberman-Aiden, E., van Berkum, N. L., Williams, L., Imakaev, M., Ragoczy, T., Telling, A., Amit, I., Lajoie, B. R., Sabo, P. J., Dorschner, M. O., et al. (2009) · Science · doi:10.1126/science.1181369 · Cited by 8,898
voom: precision weights unlock linear model analysis tools for RNA-seq read counts
Law, C. W., Chen, Y., Shi, W., & Smyth, G. K. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r29 · Cited by 6,155
Improved vectors and genome-wide libraries for CRISPR screening
Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239
McCarthy, D. J., Chen, Y., & Smyth, G. K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks042 · Cited by 5,195
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Patel, A. P., Tirosh, I., Trombetta, J. J., Shalek, A. K., Gillespie, S. M., Wakimoto, H., Cahill, D. P., Nahed, B. V., Curry, W. T., Martuza, R. L., et al. (2014) · Science · doi:10.1126/science.1254257 · Cited by 5,063
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
Doench, J. G., Fusi, N., Sullender, M., Hegde, M., Vaimberg, E. W., Donovan, K. F., Smith, I., Tothova, Z., Wilen, C., Orchard, R., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3437 · Cited by 4,637
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E., Levine, S. S., Zucker, J. P., Guenther, M. G., Kumar, R. M., Murray, H. L., Jenner, R. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.020 · Cited by 4,505
deepTools: a flexible platform for exploring deep-sequencing data
Ramírez, F., Dündar, F., Diehl, S., Grüning, B. A., & Manke, T. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku365 · Cited by 3,738
Defining a Cancer Dependency Map
Tsherniak, A., Vazquez, F., Montgomery, P. G., Weir, B. A., Kryukov, G., Cowley, G. S., Gill, S., Harrington, W. F., Pantel, S., Krill-Burger, J. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.010 · Cited by 3,276
The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote
Liao, Y., Smyth, G. K., & Shi, W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt214 · Cited by 3,064
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.017 · Cited by 2,888
Li, W., Xu, H., Xiao, T., Cong, L., Love, M. I., Zhang, F., Irizarry, R. A., Liu, J. S., Brown, M., & Liu, X. S. (2014) · Genome Biology · doi:10.1186/s13059-014-0554-4 · Cited by 2,684
An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
Corces, M. R., Trevino, A. E., Hamilton, E. G., Greenside, P. G., Sinnott-Armstrong, N. A., Vesuna, S., Satpathy, A. T., Rubin, A. J., Montine, K. S., Wu, B., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4396 · Cited by 2,496
The CBP co-activator is a histone acetyltransferase
Bannister, A. J., & Kouzarides, T. (1996) · Nature · doi:10.1038/384641a0 · Cited by 1,828
Structure and ligand of a histone acetyltransferase bromodomain
Dhalluin, C., Carlson, J. E., Zeng, L., He, C., Aggarwal, A. K., Zhou, M.-M., & Zhou, M.-M. (1999) · Nature · doi:10.1038/20974 · Cited by 1,732
Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
Lewis, P. W., Müller, M. M., Koletsky, M. S., Cordero, F., Lin, S., Banaszynski, L. A., Garcia, B. A., Muir, T. W., Becher, O. J., & Allis, C. D. (2013) · Science · doi:10.1126/science.1232245 · Cited by 1,345
Jang, M. K., Mochizuki, K., Zhou, M., Jeong, H., Brady, J. N., & Ozato, K. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.06.027 · Cited by 1,301
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
Tirosh, I., Venteicher, A. S., Hebert, C. M., Escalante, L. E., Patel, A. P., Yizhak, K., Fisher, J. M., Rodman, C., Mount, C., Filbin, M. G., et al. (2016) · Nature · doi:10.1038/nature20123 · Cited by 1,245
Transcriptional Addiction in Cancer
Bradner, J. E., Hnisz, D., & Young, R. A. (2017) · Cell · doi:10.1016/j.cell.2016.12.013 · Cited by 1,229
Recruitment of P-TEFb for Stimulation of Transcriptional Elongation by the Bromodomain Protein Brd4
Yang, Z., Yik, J. H. N., Chen, R., He, N., Jang, M. K., Ozato, K., & Zhou, Q. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.06.029 · Cited by 1,141
Phipson, B., Lee, S., Majewski, I. J., Alexander, W. S., & Smyth, G. K. (2016) · The Annals of Applied Statistics · doi:10.1214/16-aoas920 · Cited by 1,013
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
Lasko, L. M., Jakob, C. G., Edalji, R. P., Qiu, W., Montgomery, D., Digiammarino, E. L., Hansen, T. M., Risi, R. M., Frey, R., Manaves, V., et al. (2017) · Nature · doi:10.1038/nature24028 · Cited by 858
IRF4 addiction in multiple myeloma
Shaffer, A. L., Emre, N. C. T., Lamy, L., Ngo, V. N., Wright, G., Xiao, W., Powell, J., Dave, S., Yu, X., Zhao, H., et al. (2008) · Nature · doi:10.1038/nature07064 · Cited by 730
The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis
Dey, A., Chitsaz, F., Abbasi, A., Misteli, T., & Ozato, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1433065100 · Cited by 672
Targeting the epigenetic regulation of antitumour immunity
Hogg, S. J., Beavis, P. A., Dawson, M. A., & Johnstone, R. W. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0077-5 · Cited by 665
CBP-mediated acetylation of histone H3 lysine 27 antagonizesDrosophilaPolycomb silencing
Tie, F., Banerjee, R., Stratton, C. A., Prasad-Sinha, J., Stepanik, V. A., Zlobin, A., Dı́az, M. O., Scacheri, P. C., & Harte, P. J. (2009) · Development · doi:10.1242/dev.037127 · Cited by 612
The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3
Guenther, M. G., Barak, O., & Lazar, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6091-6101.2001 · Cited by 611
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
Fujisawa, T., & Filippakopoulos, P. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.143 · Cited by 607
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle
Deardorff, M. A., Bando, M., Nakato, R., Watrin, E., Itoh, T., Minamino, M., Saitoh, K., Komata, M., Katou, Y., Clark, D., et al. (2012) · Nature · doi:10.1038/nature11316 · Cited by 577
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
Qi, W., Chan, H., Teng, L., Li, L., Chuai, S., Zhang, R., Zeng, J., Li, M., Fan, H. X., Lin, Y., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210371110 · Cited by 557
Chromatin disruption and modification
Wolffe, A. P., & Hayes, J. J. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.3.711 · Cited by 551
Epigenetic balance of gene expression by Polycomb and COMPASS families
Piunti, A., & Shilatifard, A. (2016) · Science · doi:10.1126/science.aad9780 · Cited by 524
Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome
Weinert, B. T., Narita, T., Satpathy, S., Srinivasan, B., Hansen, B. K., Scholz, C. W., Hamilton, W. B., Zucconi, B. E., Wang, W., Liu, W. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.04.033 · Cited by 523
Quantitative ChIP-Seq normalization reveals global modulation of the epigenome
Orlando, D. A., Chen, M. W., Brown, V. E., Solanki, S., Choi, Y. J., Olson, E. R., Fritz, C. C., Bradner, J. E., & Guenther, M. G. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.018 · Cited by 503
Lun, A. T. L., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1191 · Cited by 503
Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion
Ben-Shahar, T. R., Heeger, S., Lehane, C., East, P., Flynn, H. R., Skehel, M. J., & Uhlmann, F. (2008) · Science · doi:10.1126/science.1157774 · Cited by 498
Winter, G. E., Mayer, A., Buckley, D. L., Erb, M. A., Roderick, J. E., Vittori, S., Reyes, J. M., di Iulio, J., Souza, A., Ott, C. J., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.06.004 · Cited by 465
A Molecular Determinant for the Establishment of Sister Chromatid Cohesion
Ünal, E., Heidinger-Pauli, J. M., Kim, W., Guacci, V., Onn, I., Gygi, S. P., & Koshland, D. E. (2008) · Science · doi:10.1126/science.1157880 · Cited by 460
Comprehensive analysis of single cell ATAC-seq data with SnapATAC
Fang, R., Preissl, S., Li, Y., Hou, X., Lucero, J., Wang, X., Motamedi, A., Shiau, A. K., Zhou, X., Xie, F., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21583-9 · Cited by 455
Maintaining cell identity: PRC2-mediated regulation of transcription and cancer
Comet, I. V., Riising, E. M., Leblanc, B., & Helin, K. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.83 · Cited by 441
Pasini, D., Malatesta, M., Jung, H. R., Walfridsson, J., Willer, A., Olsson, L., Skotte, J., Wutz, A., Porse, B. T., Jensen, O. N., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq244 · Cited by 413
Aubrey, B. J., Kelly, G. L., Kueh, A. J., Brennan, M. S., O’Connor, L., Milla, L., Wilcox, S., Tai, L., Strasser, A., & Herold, M. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.002 · Cited by 393
Roe, J., Mercan, F., Rivera, K. D., Pappin, D., & Vakoc, C. R. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.04.011 · Cited by 343
Lund, S. P., Nettleton, D. S., McCarthy, D. J., & Smyth, G. K. (2012) · Statistical Applications in Genetics and Molecular Biology · doi:10.1515/1544-6115.1826 · Cited by 322
Hogg, S. J., Vervoort, S. J., Deswal, S., Ott, C. J., Li, J., Cluse, L. A., Beavis, P. A., Darcy, P. K., Martin, B. P., Spencer, A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.011 · Cited by 308
Models of human core transcriptional regulatory circuitriesPreprint
Saint‐André, V., Alexander Joel Federation, Lin, C. Y., Abraham, B. J., Reddy, J., Lee, T. I., Bradner, J. E., & Young, R. A. (2016) · Genome Research · doi:10.1101/gr.197590.115 · Cited by 303
Durbin, A. D., Zimmerman, M. W., Dharia, N. V., Abraham, B. J., Iniguez, A. B., Weichert‐Leahey, N., He, S., Krill-Burger, J. M., Root, D. E., Vázquez, F., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0191-z · Cited by 279
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Jiang, Y., Ortega-Molina, A., Geng, H., Ying, H.-Y., Hatzi, K., Parsa, S., McNally, D., Wang, L., Doane, A. S., Agirre, X., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0975 · Cited by 278
Liu, Y., Taverna, S. D., Muratore‐Schroeder, T. L., Shabanowitz, J., Hunt, D. F., & Allis, C. D. (2007) · Genes & Development · doi:10.1101/gad.1544207 · Cited by 257
Sun, Z., Feng, D., Fang, B., Mullican, S. E., You, S.-H., Lim, H., Everett, L. J., Nabel, C. S., Li, Y., Selvakumaran, V., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.022 · Cited by 251
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2
Højfeldt, J. W., Laugesen, A., Willumsen, B. M., Damhofer, H., Hedehus, L., Tvardovskiy, A., Mohammad, F., Jensen, O. N., & Helin, K. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0036-6 · Cited by 235
Narita, T., Ito, S., Higashijima, Y., Chu, W. K., Neumann, K., Walter, J., Satpathy, S., Liebner, T., Hamilton, W. B., Maskey, E., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.008 · Cited by 228
HDAC3: taking the SMRT-N-CoRrect road to repression
Karagianni, P., & Wong, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210612 · Cited by 221
diffHic: a Bioconductor package to detect differential genomic interactions in Hi-C data
Lun, A. T. L., & Smyth, G. K. (2015) · BMC Bioinformatics · doi:10.1186/s12859-015-0683-0 · Cited by 202
Phanstiel, D. H., Boyle, A. P., Araya, C. L., & Snyder, M. P. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu379 · Cited by 179
Meyer, S. N., Scuoppo, C., Vlasevska, S., Bal, É., Holmes, A. B., Holloman, M., Garcia‐Ibanez, L., Nataraj, S. E., Duval, R., Vantrimpont, T., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.006 · Cited by 164
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma
Gryder, B. E., Pomella, S., Sayers, C. M., Wu, X., Song, Y., Chiarella, A. M., Bagchi, S., Chou, H.-C., Sinniah, R., Walton, A., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0534-4 · Cited by 164
Tie, F., Banerjee, R., Conrad, P. A., Scacheri, P. C., & Harte, P. J. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06392-11 · Cited by 146
Chemical genomics reveals histone deacetylases are required for core regulatory transcription
Gryder, B. E., Wu, L., Woldemichael, G. M., Pomella, S., Quinn, T. R., Park, P. M. C., Cleveland, A. H., Stanton, B. Z., Song, Y., Rota, R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11046-7 · Cited by 146
Ezponda, T., Dupéré-Richer, D., Will, C., Small, E. C., Varghese, N., Patel, T., Nabet, B., Popovic, R., Oyer, J. A., Bulic, M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.078 · Cited by 141
SCAF4 and SCAF8, mRNA Anti-Terminator Proteins
Gregersen, L. H., Mitter, R., Ugalde, A. P., Nojima, T., Proudfoot, N. J., Agami, R., Stewart, A., & Svejstrup, J. Q. (2019) · Cell · doi:10.1016/j.cell.2019.04.038 · Cited by 140
Jamieson, K., Wiles, E. T., McNaught, K. J., Sidoli, S., Leggett, N. A., Shao, Y., Garcia, B. A., & Selker, E. U. (2015) · Genome Research · doi:10.1101/gr.194555.115 · Cited by 138
Smith, E. R., Lee, M. G., Winter, B., Droz, N. M., Eissenberg, J. C., Shiekhattar, R., & Shilatifard, A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01504-07 · Cited by 129
Shpargel, K. B., Starmer, J., Yee, D., Pohlers, M., & Magnuson, T. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004507 · Cited by 127
Pelham‐Webb, B., Polyzos, A., Wojenski, L., Kloetgen, A., Li, J., Giammartino, D. C. D., Sakellaropoulos, T., Tsirigos, A., Core, L. J., & Apostolou, E. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.02.032 · Cited by 121
Transcription-factor-mediated supervision of global genome architecture maintains B cell identity
Johanson, T. M., Lun, A. T. L., Coughlan, H. D., Tan, T., Smyth, G. K., Nutt, S. L., & Allan, R. S. (2018) · Nature Immunology · doi:10.1038/s41590-018-0234-8 · Cited by 109
Ezponda, T., & Licht, J. D. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2499 · Cited by 97
Krajewski, W. A., & Becker, P. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1540 · Cited by 93
Hogg, S. J., Newbold, A., Vervoort, S. J., Cluse, L. A., Martin, B. P., Gregory, G. P., Lefebure, M., Vidacs, E., Tothill, R. W., Bradner, J. E., et al. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0924 · Cited by 76
Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies
Matthews, G. M., Mehdipour, P., Cluse, L. A., Falkenberg, K. J., Wang, E., Roth, M., Santoro, F., Vidacs, E., Stanley, K. L., House, C. M., et al. (2015) · Blood · doi:10.1182/blood-2015-03-632984 · Cited by 60
Thermal Denaturation Studies of Acetylated Nucleosomes and Oligonucleosmes
Yau, P. M., Thorne, A. W., Imai, B. S., Matthews, H. R., & Bradbury, E. M. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb07050.x · Cited by 55
Huang, M., Chen, Y., Yang, M., Guo, A., Xu, Y., Xu, L., & Koeffler, H. P. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx796 · Cited by 41
Interaction between N-terminal domain of H4 and DNA is regulated by the acetylation degree
Puig, Ó., Bellés, E., López‐Rodas, G., Sendra, R., & Tordera, V. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00008-6 · Cited by 22
Ji, Z., Clark, R. F., Bhat, V., Hansen, T. M., Lasko, L. M., Bromberg, K. D., Manaves, V., Algire, M. A., Martin, R. L., Qiu, W., et al. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.127854 · Cited by 22
Research works printed but not linked: 1
- Fang, 2020, SnapATAC: a comprehensive analysis package for single cell ATAC-seq, bioRxiv
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Chromatin accessibility: methods, mechanisms, and biological insights
Mansisidor, A., & Risca, V. I. (2022) · Nucleus · doi:10.1080/19491034.2022.2143106 · Cited by 168
Metadata
- Authors
- Hogg, S. J., Motorna, O., Cluse, L. A., Johanson, T. M., Coughlan, H. D., Raviram, R., Myers, R. M., Costacurta, M., Todorovski, I., Pijpers, L., Bjelosevic, S., Williams, T., Huskins, S. N., Kearney, C. J., Devlin, J. R., Fan, Z., Jabbari, J. S., Martin, B. P., Fareh, M., Kelly, M. J., Dupéré-Richer, D., Sandow, J. J., Feran, B., Knight, D., Khong, T., Spencer, A., Harrison, S. J., Gregory, G., Wickramasinghe, V. O., Webb, A. I., Taberlay, P. C., Bromberg, K. D., Lai, A., Papenfuss, A. T., Smyth, G. K., Allan, R. S., Licht, J. D., Landau, D. A., Abdel-Wahab, O., Shortt, J., Vervoort, S. J., & Johnstone, R. W.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- The University of Melbourne (AU)
- Peter MacCallum Cancer Centre (AU)
- New York Genome Center (US)
- University of Tasmania (AU)
- University of Florida (US)
- Monash University (AU)
- The Royal Melbourne Hospital (AU)
- Monash Medical Centre (AU)
- AbbVie (United States) (US)
- Corresponding author
- Vervoort, Stephin J.
- Johnstone, Ricky W.
- ORCID
- Hogg, Simon J.
- Motorna, Olga
- Cluse, Leonie A.
- Johanson, Timothy M.
- Coughlan, Hannah D.
- Raviram, Ramya
- Myers, Robert M.
- Costacurta, Matteo
- Todorovski, Izabela
- Pijpers, Lizzy
- Bjelosevic, Stefan
- Williams, Tobias
- Kearney, Conor J.
- Devlin, Jennifer R.
- Jabbari, Jafar S.
- Fareh, Mohamed
- Kelly, Madison J.
- Dupéré-Richer, Daphné
- Sandow, Jarrod J.
- Knight, Deborah
- Khong, Tiffany
- Spencer, Andrew
- Harrison, Simon J.
- Gregory, Gareth
- Wickramasinghe, Vihandha O.
- Webb, Andrew I.
- Taberlay, Phillippa C.
- Lai, Albert
- Papenfuss, Anthony T.
- Smyth, Gordon K.
- Allan, Rhys S.
- Licht, Jonathan D.
- Landau, Dan A.
- Abdel-Wahab, Omar
- Shortt, Jake
- Vervoort, Stephin J.
- Johnstone, Ricky W.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 81
- Issue
- 10
- Pages
- 2183-2200.e13
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC8183601
- OpenAlex
- W3163735930
- Cited by
- 170
- References
- 87
- Citations by year
- 2026: 32 · 2025: 44 · 2024: 37 · 2023: 30 · 2022: 21 · 2021: 6
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 384 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UTAS Research Repository (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion)
- Funders
- National Institutes of Health
- National Health and Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- histone acetylation, P300, CBP, oncogenic transcription, chromatin accessibility, H3K27 methylation, KDM6A, NCOR1, HDAC3, corepressors, hematologic malignancies
- MeSH terms
- Histone Deacetylase 3, Acetylation, Cell Line, Chromatin, Histone Deacetylases, Histones, Humans, Kinetics, Methylation, Models, Biological, Oncogenes, RNA Polymerase II, Transcription, Genetic, Genome, Conserved Sequence, Evolution, Molecular, p300-CBP Transcription Factors, Gene Regulatory Networks, Biocatalysis, Co-Repressor Proteins
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