The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Redefining the gut as the motor of critical illness
Open accessAbstract
The gut is hypothesized to play a central role in the progression of sepsis and multiple organ dysfunction syndrome. Critical illness alters gut integrity by increasing epithelial apoptosis and permeability and by decreasing epithelial proliferation and mucus integrity. Additionally, toxic gut-derived lymph induces distant organ injury. Although the endogenous microflora ordinarily exist in a symbiotic relationship with the gut epithelium, severe physiologic insults alter this relationship, leading to induction of virulence factors in the microbiome, which, in turn, can perpetuate or worsen critical illness. This review highlights newly discovered ways in which the gut acts as the motor that perpetuates the systemic inflammatory response in critical illness.
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Cites
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Cited by
Mechanisms and treatment of organ failure in sepsis
Lelubre, C., & Vincent, J.-L. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0005-7 · Cited by 852
Extreme Dysbiosis of the Microbiome in Critical Illness
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Gut Microbiome: What We Do and Don't Know
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The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness
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Self-citationCytokine Tuning of Intestinal Epithelial Function
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Metadata
- Authors
- Mittal, R., & Coopersmith, C. M.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 20
- Issue
- 4
- Pages
- 214-223
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2064070606
- Cited by
- 340
- References
- 91
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
