Why have clinical trials in sepsis failed?

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,317

Early goal-directed therapy in the treatment of severe sepsis and septic shock

Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Bernard, G. R., Vincent, J., Laterre, P., LaRosa, S. P., Dhainaut, J.-F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441001 · Cited by 6,124

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

Levy, M. M., Fink, M. P., Marshall, J. C., Abraham, E. H., Angus, D. C., Cook, D., Cohen, J., Opal, S. M., Vincent, J., & Ramsay, G. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000050454.01978.3b · Cited by 5,976

Intensive versus Conventional Glucose Control in Critically Ill Patients

(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810625 · Cited by 5,119

Genomic responses in mouse models poorly mimic human inflammatory diseases

Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

Herridge, M. S., Tansey, C. M., Matte, A. L., TOMLINSON, G. A., Diaz-Granados, N., Cooper, A., Guest, C. B., Mazer, C. D., Mehta, S., Stewart, T. E., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011802 · Cited by 2,892

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448

Plasma Exchange and Sepsis: An Opportunity to Transition from “All or Nothing” Medicine to Individualized Patient Centered Care

Keith, P. D., & Scott, L. K. (2024) · Intensive Care Research · doi:10.1007/s44231-024-00076-5 · Cited by 1

Comprehensive characterization of multi-omics landscapes between gut microbial metabolites and the druggable genome in sepsis

Liu, J., Li, T., Li, X., Li, X., Zhang, P., & Zhu, P. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1597676 · Cited by 2

Cannabinoids in preclinical research of sepsis: a scoping review

Inamassu, C. H., Sordi, R., & Marchioni, C. (2025) · Inflammation Research · doi:10.1007/s00011-025-02090-9 · Cited by 1

Flawed design and selection bias in critical care randomized controlled trials (RCTs): the patient safety risk of the “RCT mimic”

Lynn, L. A. (2025) · Patient Safety in Surgery · doi:10.1186/s13037-025-00456-w · Cited by 1

Delayed Immunomodulation Improves Immune Dysfunction in a Murine Model of Pics

Sengupta, S., Alatrash, N., Vaysburg, D. M., & Nomellini, V. (2026) · Shock · doi:10.1097/shk.0000000000002803 · Cited by 1

Structure-activity relationships and molecular mechanisms of natural products in sepsis-associated organ dysfunction: a narrative review

Wang, J., Cai, X., & Liang, Q. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1808772 · Cited by 1

Gut microbiome in sepsis: from dysbiotic biomarker to precision and palliative decision-making

Wang, L.-M., Chen, C., Danzheng, J., & Zhao, J. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1811304 · Cited by 1

Machine learning-based precision subtyping and risk prediction in sepsis: a retrospective analysis using MIMIC-IV database

Li, Y., Luo, W., Zhang, Q., Bai, F., Wei, J., Ling, T. A. N. G., Deng, Y., Zuo, D., Peng, T., Li, H., et al. (2026) · BMC Infectious Diseases · doi:10.1186/s12879-026-13279-6 · Cited by 1

Longitudinal blood transcriptome profiling reveals immune dynamics in sepsis

Hwang, J., Cha, J. H., Ahn, S., Park, J.-H., Kim, S., Jung, M., Choi, Y., Seok, H., Choi, W. S., Nam, M.-H., et al. (2026) · BMC Infectious Diseases · doi:10.1186/s12879-026-13416-1 · Cited by 1

Immune regulation and therapeutic targets in sepsis: insights from single-cell transcriptomics

Zhang, R., Lou, X., Huang, H., Zhou, J., Dai, Q., & Zheng, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1839417 · Cited by 2

An 11-gene blood transcriptomic signature reflects a sepsis-associated host-response pattern across public cohorts

Qin, C., Wang, W., Du, Q., Ba, T., Shuanglin, Z., & Li, G. X. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1844619 · Cited by 1

Wedelactone-loaded exosomes for sepsis-induced liver injury: a novel therapeutic strategy

Yin, Y., Zhang, L., Yin, Y., Zhao, J., Gong, R., Zhou, X., Zhang, H., Mu, F., & Wang, J. (2026) · Drug Delivery · doi:10.1080/10717544.2026.2693353 · Cited by 1

Reverse‐Engineered Lipid Nanoparticles Harness Protein Corona Formation for Cytokine Sequestration and Combination Immunomodulatory Therapy

Sung, J. J., Digholkar, G., & Pearson, R. M. (2026) · Small · doi:10.1002/smll.74914 · Cited by 2

Sepsis as CNS-governed metabolic triage

Yurtsever, B., & Demirkol, D. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1842915 · Cited by 1

Temporal analyses of immune responses in sepsis reveal asynchrony between clinical stage of illness and immune states

Fish, M., Rynne, J., Timms, E. M., Jennings, A., Lam, C., Arbane, G., Novellas, N. G., Campos, S., Sanderson, B., Bosco, P., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.08.003 · Cited by 5

How to improve quality of research in intensive care medicine

Schultz, M. J., Bos, L. D. J., & Dondorp, A. M. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.01.18 · Cited by 1

Effects of IL-7 on sepsis: a systematic review

de Moraes, F. O. C., Numakura, G. T. Y., Hokama, L. T., & Soriano, F. G. (2021) · Revista de Medicina · doi:10.11606/issn.1679-9836.v100i3p254-268 · Cited by 1

Pathophysiology of Inflammation and Immunosuppression in the Elderly After Sepsis

Inoue, S., Watanabe, N., & Inokuchi, S. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_134 · Cited by 1

Energy to Fight Infection

Griffiths, H. R., & Yahia, G. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_104 · Cited by 1

Management of critically ill septic patients with diabetes

Choudhury, A., Kumar, S., Kumar, N., & Bairwa, M. C. (2022) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20222889 · Cited by 1

The Role of Transcriptomics in Redefining Critical Illness

Pelaia, T. M., Shojaei, M., & McLean, A. S. (2023) · Annual update in intensive care and emergency medicine · doi:10.1007/978-3-031-23005-9_1 · Cited by 1

Rapid, High-Throughput Single-Cell Multiplex In Situ Tagging (MIST) Analysis of Immunological Disease with Machine Learning

Yang, L., Dutta, P., Davuluri, R. V., & Wang, J. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c01157 · Cited by 1

The Slippery Slope of Sepsis

Gernon, L. W. (2023) · Open Journal of Emergency Medicine · doi:10.4236/ojem.2023.113014 · Cited by 1

Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis

Lawler, P. R., Manvelian, G. Z., Coppi, A., Damask, A., Cantor, M. N., Ferreira, M. A. R., Paulding, C., Banerjee, N., Li, D., Jorgensen, S., et al. (2023) · Critical Care Explorations · doi:10.1097/cce.0000000000000997 · Cited by 1

Research Progress on Sepsis Complicated with ARDS

彭, 佐. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.13112485 · Cited by 1

Can Machine Learning Personalize Cardiovascular Therapy in Sepsis?

Catling, F. J. R., Nagendran, M., Festor, P., Bien, Z., Harris, S. K., Faisal, A. A., Gordon, A. C., & Komorowski, M. (2024) · Critical Care Explorations · doi:10.1097/cce.0000000000001087 · Cited by 1

Lessons from sheep models of transfusion

Fung, Y. L., Gabriela, S., & Tung, J. (2016) · ISBT Science Series · doi:10.1111/voxs.12253 · Cited by 1

Sepsis-Induced Acute Kidney Injury

Smith, J. A., & Schnellmann, R. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64189-2 · Cited by 1

Pathophysiology of Inflammation and Immunosuppression in the Elderly After Sepsis

Inoue, S., Watanabe, N., & Inokuchi, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_134-1 · Cited by 1

Endothelial Dysfunction of the Kidney in Sepsis

Guerci, P., & İnce, C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-44942-7.00089-3 · Cited by 1

Longitudinal patterns of cytokine expression at the individual level in humans after laparoscopic sleeve gastrectomy

Trahtemberg, U., Darawshe, F., Elazary, R., Ginsburg, I., Beil, M., van Heerden, P. V., & Sviri, S. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15309 · Cited by 1

Agentes inibidores da fosfodiesterase no tratamento da sepse e choque séptico

Delfrate, G., Fernandes, D., & Franco, G. C. N. (2021) · Research Society and Development · doi:10.33448/rsd-v10i1.12269 · Cited by 1

Disentangled Hyperspherical Clustering for Sepsis Phenotyping

Cheng, C., Kennedy, J. N., Seymour, C. W., & Weiss, J. C. (2021) · Lecture notes in computer science · doi:10.1007/978-3-030-77211-6_26 · Cited by 1

A Glimpse of Precision Medicine for Multiple-Organ Dysfunction Syndrome*

Buchman, T. G. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001974 · Cited by 1

“Multimorbidity states with high sepsis-related deaths: a data-driven analysis in critical care”Preprint

Zador, Z. E., Landry, A., Cusimano, M. D., & Geifman, N. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/491712 · Cited by 1

Emerging Treatments for Covid-19: DéJà Vu All Over Again?

Lima, R. A., & Ferreira, R. M. (2020) · Biomarkers in Medicine · doi:10.2217/bmm-2020-0524 · Cited by 1

Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis through dye-functionalized lipid nanocarriersPreprint

Press, A. T., Babic, P., Hoffmann, B., Müller, T., Foo, W., Hauswald, W., Benecke, J., Beretta, M., Cseresnyés, Z., Hoeppener, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.20.427305 · Cited by 1

Novel neutrophil subsets associated with sepsis, vascular dysfunction and metabolic alterations identified using systems immunologyPreprint

Parthasarathy, U., Kuang, Y., Thakur, G., Hogan, J., Wyche, T. P., Norton, J. E., Killough, J. R., Sana, T. R., Beakes, C., Shyong, B., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.01.478658 · Cited by 1

Machine learning driven identification of gene-expression signatures correlated with multiple organ dysfunction trajectories and complex sub-endotypes of pediatric septic shockPreprint

Atreya, M. R., Banerjee, S., Lautz, A. J., Alder, M. N., Varisco, B. M., Wong, H. R., Muszynski, J. A., Hall, M. W., Sanchez-Pinto, L. N., & Kamaleswaran, R. (2022) · Research Square · doi:10.21203/rs.3.rs-2093663/v1 · Cited by 1

Impact of hospital volume on mortality and cost in sepsis based on a Japanese nationwide medical claims database studyPreprint

Oami, T., Imaeda, T., Nakada, T., Aizimu, T., Takahashi, N., Abe, T., Yamao, Y., Nakagawa, S., Ogura, H., Shime, N., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2128824/v1 · Cited by 1

Aberrant STAT signaling drives T cell dysregulation in a targetable pediatric sepsis endotypePreprint

Lindell, R. B., Sayed, S. U., Campos, J. S., Sheetz, S. A., Babu, A., Knight, M., Mauracher, A. A., Hay, C. A., Conrey, P. E., Fitzgerald, J. C., et al. (2024) · medRxiv · doi:10.1101/2024.06.11.24308709 · Cited by 1

Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse SepsisPreprint

Rodhouse, C. E., Wang, D., Tang, H., Polcz, V. E., Hernández-Ríos, M., Yu, X., Balzano‐Nogueira, L., Rincon, J. C., Charles, A. M., Fujishima, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.06.680736 · Cited by 1

Identification of target sites in the VHR (DUSP3) enzyme unlocking potential avenues for future sepsis treatment

Wu, J., & Tautz, L. (2025) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2025.2584005 · Cited by 1

Erratum zu: Einsatz biologischer Netze bei der Bauchdeckenrekonstruktion. Ergebnisse einer Umfrage in Deutschland

Woeste, G., Isemer, F.-E., Strey, C. W., Schardey, H. M., Thielemann, H., Mihaljević, A. L., & Kleeff, J. H. (2014) · Der Chirurg · doi:10.1007/s00104-014-2840-9

高齢敗血症患者における炎症と免疫抑制の病態生理(Pathophysiology of inflammation and immunosuppression in the elderly after sepsis)

茂亮, 井., 伸央, 渡., 七実, 水., & 貞樹, 猪. (2015) · Nihon Kyukyu Igakukai Zasshi Journal of Japanese Association for Acute Medicine · doi:10.1002/jja2.12031

Making Airway Immunology Disease-Relevant

Kushwah, R., & Lee, C. (2014)

New initiatives in critical care: distinguishing hype from hope

Moran, J. L., & Solomon, P. J. (2016) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)00939-0

Critical Illness Needs Better Science, Not Clinical “Precision”

Teres, D. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002157

Materials, Surfaces, and Systems for Extracorporeal Therapies and Beyond

Weber, V., & Groth, T. (2017) · The International Journal of Artificial Organs · doi:10.5301/ijao.5000576

Functional analysis of epithelium-specific Ets transcription factor-1 in inflammation

Lee, C. M. (2016) · TSpace (University of Toronto)

Energy to Fight Infection

Griffiths, H. R., & Yahia, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_104-1

High serum levels of fatty acid–binding protein 7 in diabetic rats with experimental sepsis

Martins, E. D. P. A., de Lima, T. M., Barbeiro, H. V., Machado, M. C. C., & da Silva, F. P. (2018) · European Journal of Inflammation · doi:10.1177/2058739218764235

Hipotermia na sepse: desenvolvimento natural e valor biológico.

Fonseca, M. T. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2018.tde-05102018-104156

Long hidden sepsis subgroup may benefit from immune therapy

Tidswell, M. (2018) · Journal of Emergency and Critical Care Medicine · doi:10.21037/jeccm.2018.12.03

ИНТЕНСИВНАЯ ТЕРАПИЯ: КРАТКАЯ ИСТОРИЯ СТАНОВЛЕНИЯ, СОВРЕМЕННОЕ ЗНАЧЕНИЕ, ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ В ОБОЗРИМОМ БУДУЩЕМ

Руднов, В. А. (2019) · Messenger of Anesthesiology and Resuscitation · doi:10.21292/2078-5658-2019-16-2-15-24

Emergency department patients with sepsis: risk stratification and clinical prediction rules

Williams, J. M. (2019) · The University of Queensland · doi:10.14264/uql.2019.191

A systemic treatment confronts a systemic disease

Hightower, L. E. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00142.2019

Pro-resolution of Inflammation: New Hints to Manage Sepsis?

Liu, Y., Yu, H., Bhandari, S., & Jin, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-3353-8_8

Role of Covalent Modification of Hyaluronan with Inter-Alpha Inhibitor Heavy Chains During Acute Lung Injury

Ni, K. (2019) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1790

Welchen Einfluss hat der Erkenntniswandel bei der Sepsis auf den chirurgischen Alltag?

Dickmann, P., & Bauer, M. W. (2019) · Zentralblatt für Chirurgie - Zeitschrift für Allgemeine Viszeral- Thorax- und Gefäßchirurgie · doi:10.1055/a-0758-2374

Control of vascular integrity via endothelial growth factor and integrin cell adhesion receptor pathways

Hakanpää, L. (2020) · Työväentutkimus Vuosikirja

Shepherding knowledge : a case study of social interactions that support knowledge mobilisation for sepsis care in Scotland

Tooman, T. (2019) · St Andrews Research Repository (St Andrews Research Repository) · doi:10.17630/10023-19246

Therapeutic Efficacy of Mesenchymal Stromal Cell Derived Microparticles to Protect Against Pulmonary Capillary Barrier Permeability in Acute Respiratory Distress Syndrome

Maishan, M. (2018) · TSpace (University of Toronto)

Time-dependent changes to sepsis-specific networks in the plasma proteome are mechanistic readouts of sepsis progressionPreprint

Pimienta, G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.08.285221

Identifying and Analyzing Sepsis States: A Retrospective Study on Patients with Sepsis in ICUsPreprint

Fang, C.-H., Ravindra, V., Akhter, S., Adibuzzaman, M., Griffin, P. M., Subramaniam, S., & Grama, A. Y. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2009.10820

Assoziation des regulierenden Polymorphismus rs11536889 im TLR4-Gen mit Organ-spezifischer Morbidität und Mortalität bei Patienten mit Sepsis

von Gruben, L. (2020) · doi:10.53846/goediss-8178

Has outcome in sepsis improved? What works? What does not?

Vincent, J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-64068-8.00048-1

The use of Sprint in Scientific Thinking

Stelmaszewski, E. V., Santos, G. D., & Fregni, F. (2020) · Principles and Practice of Clinical Research Journal · doi:10.21801/ppcrj.2020.63.6

Sepsis and Septic Shock; Current Treatment Dilemma and Role of Stem Cell Therapy in Pediatrics

Dinç, G., Gönen, Z. B., Soltani, J., & Doğanay, M. (2021) · Archives of Pediatric Infectious Diseases · doi:10.5812/pedinfect.105301

Association between the nonHDLc/HDLc ratio and 30-day mortality for patients with sepsis: a retrospective observational cohort study based on a large multicentre critical care databasePreprint

Chang, L., Chen, X., & Ye, Z. (2021) · Research Square · doi:10.21203/rs.3.rs-229857/v1

Efferocytosis and Anthrax: Implications for Bacterial Sepsis?

Mytych, J. S., Pan, Z., & Farris, A. D. (2021) · Journal of Cellular Immunology · doi:10.33696/immunology.3.090

Circulating microvesicles as mediators of acute pulmonary vascular inflammation

Tan, Y. Y. (2020) · doi:10.25560/87247

Sensing dengue and chikungunya virus (co-) infections

Briseño, A. A. (2021) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.172910464

Association Between the Non-HDL-Cholesterol-to-HDL-Cholesterol Ratio and 28-Day Mortality in Septic Patients: A Cohort Study Based on the eICU Collaborative Research DatabasePreprint

Chang, L., Chen, X., & Lian, C. (2021) · Research Square · doi:10.21203/rs.3.rs-700309/v1

Pathophysiology of Sepsis and Heart-Lung Interactions: Part 1, Presentation and Mechanisms

Magder, S. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-73387-2_52

Artificial Intelligence in Critical Care

Vellido, A., & Ribas, V. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-58080-3_174-1

Vascular proteome responses precede organ dysfunction in sepsisPreprint

Sorrentino, J. T., Golden, G. J., Morris, C., Painter, C. D., Nizet, V., Campos, A. R., Smith, J. W., Karlsson, C. A. Q., Malmström, J. A., Lewis, N. E., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.07.471579

Human TLR4 and noncanonical inflammasome differ in their ability to respond to distinct lipid A variantsPreprint

Alexander-Floyd, J., Bass, A. R., Harberts, E. M., Grubaugh, D., Buxbaum, J. D., Brodsky, I. E., Ernst, R. K., & Shin, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.16.472937

Sustained Down Regulation of Plasma Tetranectin Contributes to Liver Injury in Pneumonia-Associated SepsisPreprint

Wang, S., Bai, Y., Guo, Y., Bai, Q., Wei, X., Zhang, Y., Chen, N., Miller, E. J., & Li, W. (2020) · doi:10.21203/rs.3.rs-96624/v1

Sepsis

Bauer, M. W. (2021) · Springer eBooks · doi:10.1007/978-3-030-57401-7_10056

Artificial Intelligence in Critical Care

Vellido, A., & Ribas, V. J. (2022) · Springer eBooks · doi:10.1007/978-3-030-64573-1_174

Sepsis

Bauer, M. W. (2021) · Springer eBooks · doi:10.1007/978-3-030-21573-6_10056-1

Assessment of Intravenous Immunoglobulin Indications in Pediatric Intensive Care

Sarı, F., Atakul, G., Ceylan, G., Sandal, Ö. S., & Ağın, H. (2022) · Journal of Dr Behcet Uz Children s Hospital · doi:10.4274/buchd.galenos.2021.69862

Diagnostische Grundlagen

Abele‐Horn, M., Kaufmann, M., & Stinner, B. (2021) · Springer eBooks · doi:10.1007/978-3-662-62508-8_2

Mitochondrial failure in sepsis

van der Slikke, K. (2022) · doi:10.33612/diss.222666046

Impact of hospital volume on mortality and cost in sepsis based on a Japanese nationwide medical claims database study—the Japan Sepsis Alliance study groupPreprint

Oami, T., Imaeda, T., Nakada, T., Aizimu, T., Takahashi, N., Abe, T., Yamao, Y., Nakagawa, S., Ogura, H., Shime, N., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1964450/v1

Investigação do potencial terapêutico dos receptores Fc de imunoglobulinas no câncer e sepse

Gonçalves, R. A. (2022) · doi:10.11606/t.5.2022.tde-22092022-160334

The data driven intensive care unit

Fleuren, L. M. (2023) · doi:10.5463/thesis.116

Anti-cytokine Therapy in Critical Illness: Is There a Role?

Marshall, J. C. (2023) · Lessons from the ICU · doi:10.1007/978-3-031-17572-5_17

Phenotypes

Heijnen, N. F. L., Calfee, C. S., & Bos, L. D. J. (2023) · Lessons from the ICU · doi:10.1007/978-3-031-17572-5_1

The Role of Steroids

Heming, N., & Annane, D. (2023) · Lessons from the ICU · doi:10.1007/978-3-031-17572-5_16

Papel do nervo esplâncnico na regulação imunológica em um modelo de peritonite séptica

Ferreira, G. C. S. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2023.tde-09102023-100420

Gastrodenol suppresses NLRP3/GSDMD mediated pyroptosis and ameliorates inflammatory diseasesPreprint

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The translational potential of inflammation-induced skin blister human models in exploring the pathogenesis of periodontitis and its systemic health implications

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Sepsis research: where have we gone wrong?

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