Why have clinical trials in sepsis failed?

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,317

Early goal-directed therapy in the treatment of severe sepsis and septic shock

Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Bernard, G. R., Vincent, J., Laterre, P., LaRosa, S. P., Dhainaut, J.-F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441001 · Cited by 6,124

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

Levy, M. M., Fink, M. P., Marshall, J. C., Abraham, E. H., Angus, D. C., Cook, D., Cohen, J., Opal, S. M., Vincent, J., & Ramsay, G. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000050454.01978.3b · Cited by 5,976

Intensive versus Conventional Glucose Control in Critically Ill Patients

(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810625 · Cited by 5,119

Genomic responses in mouse models poorly mimic human inflammatory diseases

Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

Herridge, M. S., Tansey, C. M., Matte, A. L., TOMLINSON, G. A., Diaz-Granados, N., Cooper, A., Guest, C. B., Mazer, C. D., Mehta, S., Stewart, T. E., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011802 · Cited by 2,892

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448

Pathophysiology of Neonatal Sepsis

Wynn, J. L., & Wong, H. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00152-9 · Cited by 45

Immunomodulatory Nanoparticles Mitigate Macrophage Inflammation via Inhibition of PAMP Interactions and Lactate-Mediated Functional Reprogramming of NF-κB and p38 MAPK

Lasola, J. J., Cottingham, A. L., Scotland, B. L., Truong, N., Hong, C. C., Shapiro, P. S., & Pearson, R. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111841 · Cited by 40

LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent

Han, H. W., Hahn, S., Jeong, H. Y., Jee, J., Nam, M.-O., Kim, H. K., Lee, D. H., Lee, S., Choi, D. K., Yu, J. H., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33039-0 · Cited by 38

Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells

Jensen, I. J., Li, X., McGonagill, P. W., Shan, Q., Fosdick, M. G., Tremblay, M. M., Houtman, J. C. D., Xue, H., Griffith, T. S., Peng, W., et al. (2021) · eLife · doi:10.7554/elife.70989 · Cited by 38

Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management

Song, C., Xu, J., Gao, C., Zhang, W., Fang, X., & Shang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1026173 · Cited by 38

Early immune system alterations in patients with septic shock

Tang, H., Qin, S., Li, Z., Gao, W., Tang, M., & Dong, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1126874 · Cited by 39

Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis

Khan, N., Kumar, V., Li, P., RAPIDS Study Group, Schlapbach, L. J., Boyd, A., Coulthard, M. G., Woodruff, T. M., Schlapbach, L. J., Raman, S., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adg5768 · Cited by 39

Biomaterial-Driven Immunomodulation: Cell Biology-Based Strategies to Mitigate Severe Inflammation and Sepsis

Lasola, J. J., Kamdem, H., McDaniel, M. W., & Pearson, R. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01726 · Cited by 38

Immunological Endotyping of Chronic Critical Illness After Severe Sepsis

Fenner, B. P., Darden, D. B., Kelly, L. S., Rincon, J. C., Brakenridge, S. C., Larson, S. D., Moore, F. A., Efron, P. A., & Moldawer, L. L. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.616694 · Cited by 41

Sepsis with liver dysfunction and coagulopathy predicts an inflammatory pattern of macrophage activation

Anderko, R. R., Gómez, H., Canna, S., Shakoory, B., Angus, D. C., Yealy, D. M., Huang, D. T., Kellum, J. A., Carcillo, J. A., For the ProCESS Investigators, et al. (2022) · Intensive Care Medicine Experimental · doi:10.1186/s40635-022-00433-y · Cited by 37

Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia

Medina, L. M. P., Babačić, H., Dzidic, M., Parke, Å., García, M., Maleki, K. T., Unge, C., Lourda, M., Kvedaraite, E., Chen, P., et al. (2023) · Respiratory Research · doi:10.1186/s12931-023-02364-y · Cited by 41

The immunosuppressive face of sepsis early on intensive care unit—A large-scale microarray meta-analysis

Schaack, D., Siegler, B. H., Tamulyte, S., Weigand, M. A., & Uhle, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198555 · Cited by 35

PKCδ causes sepsis-induced cardiomyopathy by inducing mitochondrial dysfunction

Joseph, L. C., Reyes, M. V., Lakkadi, K. R., Gowen, B. H., Haskó, G., Drosatos, K., & Morrow, J. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00749.2019 · Cited by 38

Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors

Roberson, S. W., Nwosu, S., Collar, E. M., Kiehl, A. L., Harrison, F. E., Bastarache, J. A., Wilson, J. E., Mart, M. F., Sevransky, J., Ely, E. W., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.0380 · Cited by 38

Dual Pharmacological Inhibition of Angiopoietin-2 and VEGF-A in Murine Experimental Sepsis

Hauschildt, J., Schrimpf, C., Thamm, K., Retzlaff, J., Idowu, T. O., von Kaisenberg, C., Haller, H. G., & David, S. (2019) · Journal of Vascular Research · doi:10.1159/000503787 · Cited by 34

The association between the non-HDL-cholesterol to HDL-cholesterol ratio and 28-day mortality in sepsis patients: a cohort study

Chang, L., Chen, X., & Lian, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-07459-y · Cited by 36

The noncanonical inflammasome-induced pyroptosis and septic shock

Wu, J., Cai, J., Tang, Y., & Lü, B. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101844 · Cited by 37

MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome

Wu, X., Zhao, X., Li, F., Wang, Y., Ou, Y., Zhang, H., Wu, X., Wu, X., Wang, L., Li, M., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01217-y · Cited by 38

MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock

Vasques‐Nóvoa, F., Laundos, T. L., Cerqueira, R. J., Quina‐Rodrigues, C., Soares-dos-Reis, R., Baganha, F., Ribeiro, S., Mendonça, L., Gonçalves, F., Reguenga, C., et al. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003296 · Cited by 36

Red-flag sepsis and SOFA identifies different patient population at risk of sepsis-related deaths on the general ward

Kopczynska, M., Sharif, B., Cleaver, S., Spencer, N., Kurani, A., Lee, C., Davis, J., Durie, C., Joseph-Gubral, J., Sharma, A., et al. (2018) · Medicine · doi:10.1097/md.0000000000013238 · Cited by 36

Simvastatin Inhibits Endotoxin-Induced Apoptosis in Liver and Spleen Through Up-Regulation of Survivin/NF-κB/p65 Expression

Nežić, L., Amidžić, L., Škrbić, R., Gajanin, R., Nepovimová, E., Vališ, M., Kuča, K., & Jacevic, V. M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00054 · Cited by 36

Nanoplatforms for Sepsis Management: Rapid Detection/Warning, Pathogen Elimination and Restoring Immune Homeostasis

Luo, G., Zhang, J., Sun, Y., Wang, Y., Wang, H., Cheng, B., Shu, Q., & Fang, X. (2021) · Nano-Micro Letters · doi:10.1007/s40820-021-00598-3 · Cited by 36

Salidroside rescued mice from experimental sepsis through anti-inflammatory and anti-apoptosis effects

Liu, S., Yu, X., Hu, B., Zou, Y., Li, J., Bo, L., & Deng, X. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.01.021 · Cited by 36

Heat-shock protein-90 prolongs septic neutrophil survival by protecting c-Src kinase and caspase-8 from proteasomal degradation

Gupta, S., Lee, C., Wang, J., Parodo, J. C., Jia, S., Hu, J., & Marshall, J. C. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.4a0816-354r · Cited by 35

NK Cell–Derived IL-10 Supports Host Survival during Sepsis

Jensen, I. J., McGonagill, P. W., Butler, N. S., Harty, J. T., Griffith, T. S., & Badovinac, V. P. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001131 · Cited by 38

Endothelial Damage and the Microcirculation in Critical Illness

Cusack, R. A. F., Léone, M., Rodríguez, A. H., & Martín‐Loeches, I. (2022) · Biomedicines · doi:10.3390/biomedicines10123150 · Cited by 39

LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism

Fallarino, F., Pallotta, M. T., Matino, D., Gargaro, M., Orabona, C., Vacca, C., Mondanelli, G., Allegrucci, M., Boon, L., Romani, R., et al. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.09.017 · Cited by 34

Emerging drugs for the treatment of sepsis

Heming, N., Lamothe, L., Ambrosi, X., & Annane, D. (2006) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2016.1132700 · Cited by 17

Clinical trial design for unmet clinical needs: a spotlight on sepsis

Vincent, J., & Sakr, Y. L. (2019) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2019.1643235 · Cited by 34

Early ICU-mortality in sepsis – causes, influencing factors and variability in clinical judgement: a retrospective cohort study

Driessen, R., Heijnen, N. F. L., Hulsewe, R. P. M. G., Holtkamp, J. W. M., Winkens, B., van der Horst, I. C. C., van der Horst, I. C. C., Bergmans, D. C. J. J., & Schnabel, R. M. (2020) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2020.1821912 · Cited by 34

Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock

Azambuja, P., Valente, R. H., Brunoro, G. V. F., Nakaya, H. I., Araújo‐Pereira, M., Bozza, P. T., Bozza, F. A., & Trugilho, M. R. O. (2021) · Scientific Reports · doi:10.1038/s41598-021-94474-0 · Cited by 33

Pro-Resolving Molecules—New Approaches to Treat Sepsis?

Buechler, C., Pohl, R., & Aslanidis, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030476 · Cited by 34

Patient stratification using plasma cytokines and their regulators in sepsis: relationship to outcomes, treatment effect and leucocyte transcriptomic subphenotypes

Antcliffe, D. B., Mi, Y., Santhakumaran, S., Burnham, K. L., Prevost, A. T., Ward, J. K., Marshall, T. J., Bradley, C., Al-Beidh, F., Hutton, P., et al. (2024) · Thorax · doi:10.1136/thorax-2023-220538 · Cited by 33

Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock — rationale and design of a multicenter randomized controlled superiority trial

Roggeveen, L. F., Fleuren, L. M., Guo, T., Thoral, P. J., de Grooth, H., Swart, E. L., Klausch, T. L. T., van der Voort, P. H. J., Girbes, A. R. J., Bosman, R. J., et al. (2019) · Trials · doi:10.1186/s13063-019-3911-5 · Cited by 33

Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB

Yan, R., van Meurs, M., Popa, E. R., Jongman, R. M., Zwiers, P. J., Niemarkt, A. E., Kuiper, T., Kamps, J. A. A. M., Heeringa, P., Zijlstra, J. G., et al. (2017) · Journal of Innate Immunity · doi:10.1159/000477211 · Cited by 32

Future of sepsis therapies

van der Poll, T. (2016) · Critical Care · doi:10.1186/s13054-016-1274-9 · Cited by 32

The Multiple Organ Dysfunction Syndrome: Syndrome, Metaphor, and Unsolved Clinical Challenge

Marshall, J. C., & Deutschman, C. S. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005139 · Cited by 32

Global Collaboration in Acute Care Clinical Research: Opportunities, Challenges, and Needs

Marshall, J. C. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002211 · Cited by 32

Heterogeneity and phenotypic stratification in acute respiratory distress syndrome

Lawler, P. R., & Fan, E. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30287-x · Cited by 32

Comparison of host immune responses to LPS in human using an immune profiling panel, in vivo endotoxemia versus ex vivo stimulation

Tawfik, D. M., Lankelma, J. M., Vachot, L., Cerrato, E., Pachot, A., Wiersinga, W. J., & Textoris, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-66695-2 · Cited by 35

Immune-modulating therapy in acute pancreatitis: Fact or fiction

Akinosoglou, K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15200 · Cited by 34

Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions

Sharma, N., Chwastek, D., Dwivedi, D. J., Schlechte, J., Yu, I.-L., McDonald, B., Arora, J., Cani, E., Eng, M., Engelberts, D., et al. (2023) · Intensive Care Medicine Experimental · doi:10.1186/s40635-023-00533-3 · Cited by 36

Mouse Models of Sepsis

Kannan, S. K., Kim, C. Y., Heidarian, M., Berton, R. R., Jensen, I. J., Griffith, T. S., & Badovinac, V. P. (2024) · Current Protocols · doi:10.1002/cpz1.997 · Cited by 31

Plasma Proteome Signature of Sepsis: a Functionally Connected Protein Network

Pimienta, G., Heithoff, D. M., Campos, A. R., Tran, M., Esko, J. D., Mahan, M. J., Marth, J. D., & Smith, J. W. (2019) · PROTEOMICS · doi:10.1002/pmic.201800389 · Cited by 27

Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice

Joseph, B., Shimojo, G. L., Li, Z., Thompson-Bonilla, M. D. R., Shah, R., Kanashiro, A., Salgado, H. C., & Ulloa, L. (2019) · Scientific Reports · doi:10.1038/s41598-018-36298-z · Cited by 30

Disseminated intravascular coagulation

Chang, J. C. (2018) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0000000000000727 · Cited by 31

Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis

Press, A. T., Babic, P., Hoffmann, B., Müller, T., Foo, W., Hauswald, W., Benecke, J., Beretta, M., Cseresnyés, Z., Hoeppener, S., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114436 · Cited by 29

Dynamics of monocytic HLA-DR expression differs between bacterial etiologies during the course of bloodstream infection

Cajander, S., Rasmussen, G., Tina, E., Magnuson, A., Söderquist, B., Källman, J., & Strålin, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192883 · Cited by 30

Sepsis in the critically ill patient: current and emerging management strategies

Heming, N., Azabou, É., Cazaumayou, X., Moine, P., & Annane, D. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2021.1846522 · Cited by 32

Lessons Learned Comparing Immune System Alterations of Bacterial Sepsis and SARS-CoV-2 Sepsis

Dong, X., Wang, C., Liu, X., Gao, W., Bai, X., & Li, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.598404 · Cited by 27

Sepsis and the evolution of human increased sensitivity to lipopolysaccharide

Brinkworth, J. F., & Valizadegan, N. (2021) · Evolutionary Anthropology: Issues, News, and Reviews · doi:10.1002/evan.21887 · Cited by 28

Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTs

Shankar‐Hari, M., Santhakumaran, S., Prevost, A. T., Ward, J. K., Marshall, T. J., Bradley, C., Calfee, C. S., Delucchi, K., Sinha, P., Matthay, M. A., et al. (2021) · Efficacy and Mechanism Evaluation · doi:10.3310/eme08100 · Cited by 28

Distinct subsets of neutrophils crosstalk with cytokines and metabolites in patients with sepsis

Parthasarathy, U., Kuang, Y., Thakur, G., Hogan, J., Wyche, T. P., Norton, J. E., Killough, J. R., Sana, T. R., Beakes, C., Shyong, B., et al. (2023) · iScience · doi:10.1016/j.isci.2023.105948 · Cited by 31

Using heparan sulfate octadecasaccharide (18-mer) as a multi-target agent to protect against sepsis

Liao, Y.-E., Xu, Y., Arnold, K., Zhang, F., Li, J., Sellers, R. S., Yin, C., Pagadala, V., Inman, A. M., Linhardt, R. J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209528120 · Cited by 29

Dopaminergic Control of Inflammation and Glycemia in Sepsis and Diabetes

Feketeova, E., Li, Z., Joseph, B., Shah, R., Spolarics, Z., & Ulloa, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00943 · Cited by 28

Cellular Markers of Immunosuppression in Sepsis

Cérbulo‐Vázquez, A., Arriaga‐Pizano, L., & Ferat-Osorio, E. A. (2021) · Archives of Medical Research · doi:10.1016/j.arcmed.2021.10.001 · Cited by 39

Immunomodulatory drugs in sepsis: a systematic review and meta‐analysis

Robey, R. C., Logue, C., Caird, C. A., Hansel, J., Hellyer, T. P., Simpson, J. A., Dark, P. M., Mathioudakis, A. G., & Felton, T. (2024) · Anaesthesia · doi:10.1111/anae.16263 · Cited by 35

Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies

Zhang, X., Zhang, W., Zhang, H., & Liao, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1546474 · Cited by 30

Paramedic Recognition of Sepsis in the Prehospital Setting: A Prospective Observational Study

Green, R. S., Travers, A. H., Cain, E., Campbell, S., Jensen, J. L., Petrie, D. A., Erdogan, M., Patrick, G., & Patrick, W. D. (2016) · Emergency Medicine International · doi:10.1155/2016/6717261 · Cited by 28

Right dose, right now: using big data to optimize antibiotic dosing in the critically ill

Elbers, P., Girbes, A. R. J., Malbrain, M. L. N. G., & Bosman, R. J. (2015) · Anaesthesiology Intensive Therapy · doi:10.5603/ait.a2015.0061 · Cited by 28

Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis

Wang, X., Buechler, N. L., Long, D. L., Furdui, C. M., Yoza, B. K., McCall, C. E., & Vachharajani, V. (2018) · Inflammation · doi:10.1007/s10753-018-0881-9 · Cited by 28

Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses

Oshima, K., Han, X., Ouyang, Y., Masri, R. E., Yang, Y., Haeger, S. M., McMurtry, S. A., Lane, T. C., Davizon‐Castillo, P., Zhang, F., et al. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00175.2019 · Cited by 28

In Situ Neutralization and Detoxification of LPS to Attenuate Hyperinflammation

Li, X., Qu, S., Song, X., Wu, C., Shen, J., & Zhu, K. (2023) · Advanced Science · doi:10.1002/advs.202302950 · Cited by 27

The Search for Efficacious New Therapies in Sepsis Needs to Embrace Heterogeneity

Scicluna, B. P., & Baillie, J. K. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201811-2148ed · Cited by 28

Transglutaminase 2 as a Marker for Inflammation and Therapeutic Target in Sepsis

Su, T., Qin, X., & Furutani, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041897 · Cited by 27

Advances in the Development of Biomaterials for Endotoxin Adsorption in Sepsis

Yang, Q., Li, Y., Tuohuti, P., Qin, Z., Zhang, Z., Zhao, W., & Su, B. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.699418 · Cited by 27

Peripheral blood neutrophil-to-lymphocyte ratio is associated with mortality across the spectrum of cardiogenic shock severity

Jentzer, J. C., Szekely, Y., Burstein, B. J., Ballal, Y., Kim, E. Y., van Diepen, S., Tabi, M., Wiley, B. M., KASHANI, K. B., & Lawler, P. R. (2021) · Journal of Critical Care · doi:10.1016/j.jcrc.2021.12.005 · Cited by 29

Comparison of time series clustering methods for identifying novel subphenotypes of patients with infection

Bhavani, S. V., Xiong, L., Pius, A., Semler, M. W., Qian, E. T., Verhoef, P. A., Robichaux, C. J., Coopersmith, C. M., & Churpek, M. M. (2023) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocad063 · Cited by 30

Attrition of memory CD8 T cells during sepsis requires LFA-1

Serbanescu, M. A., Ramonell, K. M., Hadley, A., Margoles, L. M., Mittal, R., Lyons, J. D., Liang, Z., Coopersmith, C. M., Ford, M. L., & McConnell, K. W. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4a1215-563rr · Cited by 27

Long Noncoding RNA HOTAIRM1 Promotes Immunosuppression in Sepsis by Inducing T Cell Exhaustion

Chen, W., Liu, J., Ge, F., Chen, Z., Qu, M., Nan, K., Gu, J., Jiang, Y., Gao, S., Liao, Y., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100709 · Cited by 27

Ex vivo and in vitro Monocyte Responses Do Not Reflect in vivo Immune Responses and Tolerance

Jansen, A., Bruse, N., Waalders, N. J. B., Gerretsen, J., Rijbroek, D., Pickkers, P., & Kox, M. (2022) · Journal of Innate Immunity · doi:10.1159/000525572 · Cited by 28

Potential Antioxidant Multitherapy against Complications Occurring in Sepsis

Abelli, J., Méndez-Valdés, G., Gómez-Hevia, F., Bragato, M. C., Chichiarelli, S., Saso, L., & Rodrigo, R. (2022) · Biomedicines · doi:10.3390/biomedicines10123088 · Cited by 27

Improving clinical outcomes in sepsis and multiple organ dysfunction through precision medicine

Mehta, S., & Gill, S. E. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.11.74 · Cited by 26

Understanding immunopathology of severe dengue: lessons learnt from sepsis

Aguilar-Briseño, J. A., Moser, J., & Rodenhuis‐Zybert, I. A. (2020) · Current Opinion in Virology · doi:10.1016/j.coviro.2020.07.010 · Cited by 32

National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research

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