Osteoclasts: more than ‘bone eaters’

Osteoclast differentiation and activation

Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · see citing works

Metastasis to bone: causes, consequences and therapeutic opportunities

Mundy, G. R. (2002) · Nature reviews. Cancer · doi:10.1038/nrc867 · Cited by 2,787 · see citing works

Mechanisms of Bone Metastasis

Roodman, G. D. (2004) · New England Journal of Medicine · doi:10.1056/nejmra030831 · Cited by 2,752 · see citing works

The bone marrow niche for haematopoietic stem cells

Morrison, S. J., & Scadden, D. T. (2014) · Nature · doi:10.1038/nature12984 · Cited by 2,451 · see citing works

WNT signaling in bone homeostasis and disease: From human mutations to treatments

Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093 · see citing works

Romosozumab in Postmenopausal Women with Low Bone Mineral Density

McClung, M. R., Grauer, A., Boonen, S., Bolognese, M. A., Brown, J. P., Diez-Perez, A., Langdahl, B. L., Reginster, J.-Y., Zanchetta, J. R., Wasserman, S. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1305224 · Cited by 1,258 · see citing works

The Effects of Parathyroid Hormone and Alendronate Alone or in Combination in Postmenopausal Osteoporosis

Black, D. M., Greenspan, S. L., Ensrud, K. E., Palermo, L., McGowan, J., Lang, T., Garnero, P., Bouxsein, M., Bilezikian, J. P., & Rosen, C. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa031975 · Cited by 1,171 · see citing works

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

Tang, Y., Wu, X., Lei, W., Pang, L., Wan, C., Shi, Z., Zhao, L., Nagy, T. R., Peng, X., Hu, J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1979 · Cited by 1,165 · see citing works

Excess mortality following hip fracture: a systematic epidemiological review

Abrahamsen, B., van Staa, T., Ariely, R., Olson, M., & Cooper, C. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0920-3 · Cited by 1,079 · see citing works

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

Zhen, G., Wen, C., Jia, X., Li, Y., Crane, J. L., Mears, S. C., Askin, F. B., Frassica, F. J., Chang, W., Yao, J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3143 · Cited by 946 · see citing works

Bone and haematopoietic defects in mice lacking c-fos

Wang, Z., Ovitt, C. E., Grigoriadis, A. E., Möhle-Steinlein, U., Rüther, U., & Wagner, E. F. (1992) · Nature · doi:10.1038/360741a0 · Cited by 932 · see citing works

The Effects of Parathyroid Hormone, Alendronate, or Both in Men with Osteoporosis

Finkelstein, J. S., Hayes, A.-M., Hunzelman, J. L., Wyland, J. J., Lee, H., & Neer, R. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035725 · Cited by 827 · see citing works

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777 · see citing works

Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

Kollet, Ó., Dar, A., Shivtiel, S., Kalinkovich, A., Lapid, K., Sztainberg, Y., Tesio, M., Samstein, R. M., Goichberg, P., Spiegel, A., et al. (2006) · Nature Medicine · doi:10.1038/nm1417 · Cited by 774 · see citing works

Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study

Thomas, D. M., Henshaw, R. M., Skubitz, K. M., Chawla, S. P., Staddon, A. P., Blay, J., Roudier, M. P., Smith, J. W. G., Ye, Z., Sohn, W. Y., et al. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70010-3 · Cited by 714 · see citing works

Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit

Sims, N. A., & Martin, T. J. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2013.215 · Cited by 706 · see citing works

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

Lacey, D. L., Boyle, W. J., Simonet, W. S., Kostenuik, P. J., Dougall, W. C., Sullivan, J. K., Martín, J. S., & Dansey, R. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3705 · Cited by 692 · see citing works

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

Xian, L., Wu, X., Pang, L., Lou, M., Rosen, C. J., Qiu, T., Crane, J., Frassica, F., Zhang, L., Rodriguez, J. P., et al. (2012) · Nature Medicine · doi:10.1038/nm.2793 · Cited by 631 · see citing works

Skeletal disease in primary hyperparathyroidism

Silverberg, S. J., Shane, E. J., de la Cruz, L., Dempster, D. W., Feldman, F., Seldin, D. W., Jacobs, T. P., Siris, E. S., Cafferty, M. S., Parisien, M. V., et al. (1989) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650040302 · Cited by 621 · see citing works

Osteopetrosis: genetics, treatment and new insights into osteoclast function

Sobacchi, C., Schulz, A., Coxon, F. P., Villa, A., & Helfrich, M. H. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.137 · Cited by 580 · see citing works

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

Pederson, L., Ruan, M., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805133106 · Cited by 556 · see citing works

Biochemical and molecular mechanisms of action of bisphosphonates

Rogers, M. J., Crockett, J. C., Coxon, F. P., & Mönkkönen, J. (2010) · Bone · doi:10.1016/j.bone.2010.11.008 · Cited by 532 · see citing works

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Ishii, M., Egen, J. G., Klauschen, F., Meier-Schellersheim, M., Saeki, Y., Vacher, J., Proia, R. L., & Germain, R. N. (2009) · Nature · doi:10.1038/nature07713 · Cited by 515 · see citing works

Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial

Tsai, J. N., Uihlein, A. V., Lee, H., Kumbhani, R., Siwila-Sackman, E., McKay, E. A., Burnett‐Bowie, S. M., Neer, R. M., & Leder, B. Z. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60856-9 · Cited by 500 · see citing works

Suppression of bone formation by osteoclastic expression of semaphorin 4D

Negishi-Koga, T., Shinohara, M., Komatsu, N., Bito, H., Kodama, T., Friedel, R. H., & Takayanagi, H. (2011) · Nature Medicine · doi:10.1038/nm.2489 · Cited by 498 · see citing works

Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling

Guihard, P. J., Danger, Y., Royer, B. B.-L., David, E., Brion, R., Delécrin, J., Richards, C. D., Chevalier, S., Rédiní, F., Heymann, D., et al. (2012) · Stem Cells · doi:10.1002/stem.1040 · Cited by 477 · see citing works

Advances in the regulation of osteoclasts and osteoclast functions

Boyce, B. F. (2013) · Journal of Dental Research · doi:10.1177/0022034513500306 · Cited by 457 · see citing works

Denosumab Induces Tumor Reduction and Bone Formation in Patients with Giant-Cell Tumor of Bone

Branstetter, D. G., Nelson, S. D., Manivel, J. C., Blay, J., Chawla, S. P., Thomas, D. M., Jun, S., & Jacobs, I. A. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0578 · Cited by 426 · see citing works

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL

Sobacchi, C., Frattini, A., Guerrini, M. M., Abinun, M., Pangrazio, A., Susani, L., Bredius, R. G. M., Mancini, G. M. S., Cant, A. J., Bishop, N. J., et al. (2007) · Nature Genetics · doi:10.1038/ng2076 · Cited by 389 · see citing works

Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhPTH(1–34)] in postmenopausal osteoporosis

Cosman, F., Eriksen, E. F., Recknor, C. P., Miller, P. D., Guañabens, N., Kasperk, C. H., Papanastasiou, P., Readie, A., Rao, H., Gasser, J. A., et al. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.238 · Cited by 358 · see citing works

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

Aliprantis, A. O., Ueki, Y., Sulyanto, R. M., Park, A., Sigrist, K. S., Sharma, S. M., Ostrowski, M. C., Olsen, B. R., & Glimcher, L. H. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35711 · Cited by 346 · see citing works

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation

Lotinun, S., Kiviranta, R., Matsubara, T., Alzate, J. A. R., Neff, L., Lüth, A., Koskivirta, I., Kleuser, B., Vacher, J., VUORIO, E. I., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64840 · Cited by 328 · see citing works

Sphingosine 1‐phosphate as a regulator of osteoclast differentiation and osteoclast–osteoblast coupling

Ryu, J., Kim, H. J., Chang, E., Huang, H., Banno, Y., & Hong‐Hee, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601430 · Cited by 318 · see citing works

Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization

Morrison, S. J., Wright, D. E., & Weissman, I. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1908 · Cited by 314 · see citing works

Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation.

Wiktor-Jędrzejczak, W., Ahmed, A. A., Szczylik, C. A., & Skelly, R. R. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.156.5.1516 · Cited by 293 · see citing works

Decreased C-Src Expression Enhances Osteoblast Differentiation and Bone Formation

Marzia, M., Sims, N. A., Voit, S., Migliaccio, S., Taranta, A., Bernardini, S., Faraggiana, T., Yoneda, T., Mundy, G. R., Boyce, B. F., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.311 · Cited by 283 · see citing works

Denosumab treatment for fibrous dysplasia

Boyce, A. M., Chong, W. H., Yao, J., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1603 · Cited by 262 · see citing works

Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus

Kiechl, S. J., Wittmann, J., Giaccari, A., Knoflach, M., Willeit, P., Bözec, A., Moschen, A. R., Muscogiuri, G., Sorice, G. P., Kireva, T., et al. (2013) · Nature Medicine · doi:10.1038/nm.3084 · Cited by 259 · see citing works

Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

Ishii, M., Kikuta, J., Shimazu, Y., Meier‐Schellersheim, M., & Germain, R. N. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101474 · Cited by 254 · see citing works

Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation

Takeshita, S., Fumoto, T., Matsuoka, K., Park, K.-A., Aburatani, H., Kato, S., Ito, M., & Ikeda, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69493 · Cited by 249 · see citing works

Are Nonresorbing Osteoclasts Sources of Bone Anabolic Activity?

Karsdal, M. A., Martin, T. J., Bollerslev, J., Christiansen, C., & Henriksen, K. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070109 · Cited by 242 · see citing works

Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells

Li, H., Hong, S., Qian, J., Zheng, Y., Yang, J., & Yi, Q. (2010) · Blood · doi:10.1182/blood-2009-11-255026 · Cited by 240 · see citing works

Osteoclast Activity and Subtypes as a Function of Physiology and Pathology—Implications for Future Treatments of Osteoporosis

Henriksen, K., Bollerslev, J., Everts, V. E., & Karsdal, M. A. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0006 · Cited by 230 · see citing works

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

Kanaya, T., Hase, K., Takahashi, D., Fukuda, S., Hoshino, K., Sasaki, I., Hemmi, H., Knoop, K. A., Kumar, N., Sato, M., et al. (2012) · Nature Immunology · doi:10.1038/ni.2352 · Cited by 228 · see citing works

Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.

Grano, M., Galimi, F., Zambonin, G., Colucci, S. C., Cottone, E., Zallone, A. Z., & Comoglio, P. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7644 · Cited by 221 · see citing works

Autosomal Recessive Osteopetrosis: Variability of Findings at Diagnosis and During the Natural Course

Gerritsen, E. J. A., Vossen, J. M. J. J., van Loo, I. H. C., et al. (1994) · PEDIATRICS · doi:10.1542/peds.93.2.247 · Cited by 220 · see citing works

Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis

Korpal, M., Yan, J., Lü, X., Xu, S., Lerit, D. A., & Kang, Y. (2009) · Nature Medicine · doi:10.1038/nm.1943 · Cited by 217 · see citing works

Osteoclast-Derived Complement Component 3a Stimulates Osteoblast Differentiation

Matsuoka, K., Park, K.-A., Ito, M., Ikeda, K., & Takeshita, S. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2187 · Cited by 216 · see citing works

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

Mansour, A., Abou‐Ezzi, G., Sitnicka, E., Jacobsen, S. E. W., Wakkach, A., & Blin‐Wakkach, C. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20110994 · Cited by 216 · see citing works

Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: A case–control study

Tse, L. F., Wong, K. C., Kumta, S. M., et al. (2007) · Bone · doi:10.1016/j.bone.2007.08.038 · Cited by 201 · see citing works

CTLA-4 directly inhibits osteoclast formation

Axmann, R., Herman, S., Zaiss, M. M., Franz, S., Polzer, K., Zwerina, J., i, M. H., Smolen, J. S., & Schett, G. A. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.080713 · Cited by 200 · see citing works

Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

Walker, E. C., McGregor, N. E., Poulton, I. J., Pompolo, S., Allan, E. H., Quinn, J. M., Gillespie, M. T., Martin, T. J., & Sims, N. A. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080706 · Cited by 190 · see citing works

Identification of Multiple Osteoclast Precursor Populations in Murine Bone Marrow

Jacquin, C., Gran, D. E., Lee, S. K., Lorenzo, J. A., & Aguila, H. L. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051007 · Cited by 190 · see citing works

Transgenic Mice Overexpressing Tartrate-Resistant Acid Phosphatase Exhibit an Increased Rate of Bone Turnover

Angel, N. Z., Walsh, N. C., Forwood, M. R., Ostrowski, M. C., Cassady, A. I., & Hume, D. A. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.1.103 · Cited by 187 · see citing works

Myeloid-Derived Suppressor Cells Function as Novel Osteoclast Progenitors Enhancing Bone Loss in Breast Cancer

Sawant, A., Deshane, J. S., Jules, J., Lee, C. M., Harris, B. A., Feng, X., & Ponnazhagan, S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2202 · Cited by 182 · see citing works

Clinical, genetic, and cellular analysis of 49 osteopetrotic patients: implications for diagnosis and treatment

Fattore, A. D., Peruzzi, B., Rucci, N., Recchia, I., Cappariello, A., Longo, M., Fortunati, D., Ballanti, P., Iacobini, M., Luciani, M., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.036673 · Cited by 181 · see citing works

Increased IL-6-production by cells isolated from the fibrous bone dysplasia tissues in patients with McCune-Albright syndrome.

Yamamoto, T., Ozono, K., Kasayama, S., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118773 · Cited by 179 · see citing works

Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis

Irie, N., Takada, Y., Watanabe, Y., Matsuzaki, Y., Naruse, C., Asano, M., Iwakura, Y., Suda, T., & Matsuo, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807598200 · Cited by 175 · see citing works

T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway

Bözec, A., Zaiss, M. M., Kagwiria, R., Voll, R. E., Rauh, M., Chen, Z., Mueller-Schmucker, S. M., Kroczek, R. A., Heinzerling, L., Moser, M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007764 · Cited by 175 · see citing works

Bone cell interactions through Eph/ephrin: Bone modeling, remodeling and associated diseases

Matsuo, K., & Otaki, N. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.20888 · Cited by 167 · see citing works

Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function

Charles, J. F., Hsu, L., Niemi, E. C., Weiss, A., Aliprantis, A. O., & Nakamura, M. C. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60920 · Cited by 167 · see citing works

The Severe Chronic Neutropenia International Registry: 10-Year Follow-up Report

Dale, D. C., Bolyard, A. A., Schwinzer, B., Pracht, G., Bonilla, M. A., Boxer, L. A., Freedman, M. H., Donadieu, J., Kannourakis, G., Alter, B. P., et al. (2006) · Supportive Cancer Therapy · doi:10.3816/sct.2006.n.020 · Cited by 166 · see citing works

Odanacatib in the treatment of postmenopausal women with low bone mineral density: Five years of continued therapy in a phase 2 study

Langdahl, B. L., Binkley, N., Bone, H. G., Gilchrist, N. L., Resch, H., Rodriguez-Portales, J. A., Denker, A. E., Lombardi, A., Tilleghem, C. L. B. D., DaSilva, C. A., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1695 · Cited by 159 · see citing works

Examining the Metastatic Niche: Targeting the Microenvironment

Guise, T. A. (2010) · Seminars in Oncology · doi:10.1053/j.seminoncol.2010.10.007 · Cited by 149 · see citing works

Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of Bone

Balke, M., Campanacci, L., Gebert, C., Picci, P., Gibbons, M., Taylor, R. M., Hogendoorn, P. C. W., Kroep, J. R., Wass, J. A. H., & Athanasou, N. A. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-462 · Cited by 149 · see citing works

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

Miyamoto, K., Yoshida, S., Kawasumi, M., Hashimoto, K., Kimura, T., Sato, Y., Kobayashi, T., Miyauchi, Y., Hoshi, H., Iwasaki, R., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101890 · Cited by 149 · see citing works

Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo

Lymperi, S., Ersek, A., Ferraro, F., Dazzi, F., & Horwood, N. J. (2010) · Blood · doi:10.1182/blood-2010-05-282855 · Cited by 147 · see citing works

Bone density, strength, and formation in adult cathepsin K (−/−) mice

Pennypacker, B. L., Shea, M., Liu, Q., Masarachia, P. J., Säftig, P., Rodan, S. B., Rodan, G. A., & Kimmel, D. B. (2008) · Bone · doi:10.1016/j.bone.2008.08.130 · Cited by 146 · see citing works

Fibrous Dysplasia

Riddle, N. D., & Bui, M. M. (2012) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2012.0013-rs · Cited by 142 · see citing works

Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm

Vilardaga, J., Romero, G. G., Friedman, P. A., & Gardella, T. J. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0465-9 · Cited by 141 · see citing works

Update on clinical experience with AMD3100, an SDF-1/CXCL12–CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cells

Pusic, I., & DiPersio, J. F. (2010) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328338b7d5 · Cited by 141 · see citing works

Die normale Resorption des Knochengewebes und ihre Bedeutung für die Entstehungder typischen Knochenformen

Kölliker, A. (1873) · Cited by 140 · see citing works

Myeloid-derived suppressor cells expand during breast cancer progression and promote tumor-induced bone destruction

Danilin, S., Merkel, A. R., Johnson, J., Johnson, R. W., Edwards, J., & Sterling, J. A. R. (2012) · OncoImmunology · doi:10.4161/onci.21990 · Cited by 140 · see citing works

Osteoclast-Mediated Bone Resorption Is Stimulated During Short-Term Administration of Granulocyte Colony-Stimulating Factor But Is Not Responsible for Hematopoietic Progenitor Cell Mobilization

Takamatsu, Y., Simmons, P. J., Moore, R. J., et al. (1998) · Blood · doi:10.1182/blood.v92.9.3465 · Cited by 137 · see citing works

Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey

Cusick, T. E., Chen, C. M., Pennypacker, B. L., Pickarski, M., Kimmel, D. B., Scott, B. B., & Duong, L. T. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1477 · Cited by 134 · see citing works

BMP-6 and mesenchymal stem cell differentiation

Vukičević, S., & Grgurević, L. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.020 · Cited by 133 · see citing works

Patients with sclerosteosis and disease carriers: Human models of the effect of sclerostin on bone turnover

van Lierop, A. H., Hamdy, N. A. T., Hamersma, H. A., van Bezooijen, R. L., Power, J., Loveridge, N., & Papapoulos, S. E. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.474 · Cited by 133 · see citing works

Regulatory Mechanism of Osteoclastogenesis by RANKL and Wnt Signals

Takahashi, N. (2010) · Frontiers in bioscience · doi:10.2741/3673 · Cited by 131 · see citing works

Osteoclasts Control Osteoblast Chemotaxis via PDGF-BB/PDGF Receptor Beta Signaling

Sanchez-Fernandez, M. A., Gallois, A., Riedl, T., Jurdic, P., & Hoflack, B. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003537 · Cited by 128 · see citing works

Advances in osteoclast biology resulting from the study of osteopetrotic mutations

Segovia‐Silvestre, T., Neutzsky-Wulff, A. V., Sørensen, M. G., Christiansen, C., Bollerslev, J., Karsdal, M. A., & Henriksen, K. (2008) · Human Genetics · doi:10.1007/s00439-008-0583-8 · Cited by 127 · see citing works

Osteoclast-Mediated Bone Resorption Is Stimulated During Short-Term Administration of Granulocyte Colony-Stimulating Factor But Is Not Responsible for Hematopoietic Progenitor Cell Mobilization

Takamatsu, Y., Simmons, P. J., Moore, R. J., et al. (1998) · Blood · doi:10.1182/blood.v92.9.3465.421k35_3465_3473 · Cited by 124 · see citing works

Osteoclastogenesis in fibrous dysplasia of bone: in situ and in vitro analysis of IL-6 expression

Riminucci, M., Kuznetsov, S. A., Cherman, N., et al. (2003) · Bone · doi:10.1016/s8756-3282(03)00064-4 · Cited by 123 · see citing works

Mice Lacking Cathepsin K Maintain Bone Remodeling but Develop Bone Fragility Despite High Bone Mass

Li, C. Y., Jepsen, K. J., Majeska, R. J., Zhang, J., Ni, R., Gelb, B. D., & Schaffler, M. B. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060313 · Cited by 121 · see citing works

Osteoclasts in Multiple Myeloma Are Derived from Gr-1+CD11b+Myeloid-Derived Suppressor Cells

Zhuang, J., Zhang, J., Lwin, S. T., Edwards, J., Edwards, C. M., Mundy, G. R., & Yang, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048871 · Cited by 121 · see citing works

Cthrc1 Is a Positive Regulator of Osteoblastic Bone Formation

Kimura, H. J., Kwan, K. M., Zhang, Z., Deng, J. M., Darnay, B. G., Behringer, R. R., Nakamura, T., Crombrugghe, B. D., & Akiyama, H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003174 · Cited by 111 · see citing works

Cross-Presentation by Osteoclasts Induces FoxP3 in CD8+ T Cells

Kiesel, J. R., Buchwald, Z. S., & Aurora, R. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803897 · Cited by 109 · see citing works

Osteoclast heterogeneity:

Everts, V. E., de Vries, T. J., & Helfrich, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.05.004 · Cited by 108 · see citing works

Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia

Regard, J. B., Cherman, N., Palmer, D., Kuznetsov, S. A., Celi, F. S., Guettier, J., Chen, M., Bhattacharyya, N., Wess, J., Coughlin, S. R., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114656108 · Cited by 107 · see citing works

Genotype-Phenotype Relationship in Human ATP6i-Dependent Autosomal Recessive Osteopetrosis

Taranta, A., Migliaccio, S., Recchia, I., Caniglia, M., Luciani, M., Rossi, G., Dionisi‐Vici, C., Pinto, R. M., Francalanci, P., Boldrini, R., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63798-4 · Cited by 106 · see citing works

Osteoclast Deficiency Results in Disorganized Matrix, Reduced Mineralization, and Abnormal Osteoblast Behavior in Developing Bone

Dai, X.-M., Zong, X.-H., Akhter, M. P., & Stanley, E. R. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040514 · Cited by 105 · see citing works

Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH

Bedi, B., Li, J., Tawfeek, H. A. W., Baek, K., Adams, J., Vangara, S. S., Chang, M.-K., Kneissel, M., Weitzmann, M. N., & Pacifici, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120735109 · Cited by 100 · see citing works

Denosumab in patients with cancer—a surgical strike against the osteoclast

Brown, J. E., & Coleman, R. E. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.197 · Cited by 99 · see citing works

Disruption of PTH Receptor 1 in T Cells Protects against PTH-Induced Bone Loss

Tawfeek, H. A., Bedi, B., Li, J., Adams, J. W., Kobayashi, T., Weitzmann, M., Kronenberg, H. M., & Pacifici, R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012290 · Cited by 93 · see citing works

Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection

Jones, D. C., Glimcher, L. H., & Aliprantis, A. O. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46262 · Cited by 92 · see citing works

Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors

Ota, K., Quint, P. S., Weivoda, M. M., Ruan, M. M., Pederson, L. G., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2013) · Bone · doi:10.1016/j.bone.2013.07.023 · Cited by 92 · see citing works

Myeloid derived suppressor cells in physiological and pathological conditions: the good, the bad, and the ugly

Serafini, P. (2013) · Immunologic Research · doi:10.1007/s12026-013-8455-2 · Cited by 90 · see citing works

Mechanisms of osteoclast-dependent bone formation

Teti, A. M. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.183 · Cited by 89 · see citing works

Tartrate‐Resistant Acid Phosphatase Knockout Mice

Hayman, A. R., & Cox, T. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.10.1905 · Cited by 89 · see citing works

Are Osteoclasts Needed for the Bone Anabolic Response to Parathyroid Hormone?

Pierroz, D. D., Bonnet, N., Baldock, P. A. J., Ominsky, M. S., Stolina, M., Kostenuik, P. J., & Ferrari, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.101964 · Cited by 85 · see citing works

Osteoclast Activated FoxP3+ CD8+ T-Cells Suppress Bone Resorption in vitro

Buchwald, Z. S., Kiesel, J. R., DiPaolo, R. J., Pagadala, M. S., & Aurora, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038199 · Cited by 83 · see citing works

A New Heterozygous Mutation (R714C) of the Osteopetrosis Gene, Pleckstrin Homolog Domain Containing Family M (With Run Domain) Member 1 (PLEKHM1), Impairs Vesicular Acidification and Increases TRACP Secretion in Osteoclasts

Fattore, A. D., Fornari, R., Wesenbeeck, L. V., de Freitas, F., Timmermans, J., Peruzzi, B., Cappariello, A., Rucci, N., Spera, G., Helfrich, M., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.071107 · Cited by 82 · see citing works

Non‐resorbing osteoclasts induce migration and osteogenic differentiation of mesenchymal stem cells

Kreja, L., Brenner, R. E., Tautzenberger, A., Liedert, A., Friemert, B., Ehrnthaller, C., Huber-Lang, M. S., & Ignatius, A. A. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22406 · Cited by 79 · see citing works

Basic research and clinical applications of bisphosphonates in bone disease: what have we learned over the last 40 years?

Xu, X., Gou, W.-L., Wang, Y., Wang, Y., Guo, Q., Lu, Q., Lu, S., & Peng, J. C. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-303 · Cited by 79 · see citing works

Stimulation of Bone Formation in Cortical Bone of Mice Treated with a Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-binding Peptide That Possesses Osteoclastogenesis Inhibitory Activity

Furuya, Y., Inagaki, A., Khan, M., Mori, K., Penninger, J. M., Nakamura, M., Udagawa, N., Aoki, K., Ohya, K., Uchida, K., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426080 · Cited by 77 · see citing works

RANK-dependent autosomal recessive osteopetrosis: Characterization of five new cases with novel mutations

Pangrazio, A., Cassani, B., Guerrini, M. M., Crockett, J. C., Marrella, V., Zammataro, L. A., Strina, D., Schulz, A., Schlack, C., Kornak, U., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.559 · Cited by 75 · see citing works

Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast‐mediated stimulation of mineralization

Ota, K., Quint, P. S., Ruan, M. M., Pederson, L. G., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24537 · Cited by 71 · see citing works

Overexpression of the granulocyte colony-stimulating factor gene leads to osteoporosis in mice.

Takahashi, T., Wada, T., Mori, M., et al. (1996) · PubMed · Cited by 67 · see citing works

Rapid biochemical response to denosumab in fibrous dysplasia of bone: report of two cases

Ganda, K., & Seibel, M. J. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2585-1 · Cited by 66 · see citing works

RANKL-RANK interaction in immune regulatory systems

Akiyama, T. (2012) · World Journal of Orthopedics · doi:10.5312/wjo.v3.i9.142 · Cited by 63 · see citing works

RANKL/RANK – From bone physiology to breast cancer

Sigl, V., & Penninger, J. M. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.01.002 · Cited by 57 · see citing works

Inhibition of Cathepsin K Increases Modeling-Based Bone Formation, and Improves Cortical Dimension and Strength in Adult Ovariectomized Monkeys

Pennypacker, B. L., Chen, C. M., Zheng, H., Shih, M., Belfast, M., Samadfam, R., & Duong, L. T. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2211 · Cited by 54 · see citing works

Resorption Controls Bone Anabolism Driven by Parathyroid Hormone (PTH) Receptor Signaling in Osteocytes

Rhee, Y., Lee, E.-Y., Lezcano, V., Ronda, A. C., Condon, K. W., Allen, M. R., Plotkin, L. I., & Bellido, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.485938 · Cited by 53 · see citing works

Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice

Buchwald, Z. S., Kiesel, J. R., Yang, C., DiPaolo, R. J., Novack, D. V., & Aurora, R. (2013) · Bone · doi:10.1016/j.bone.2013.05.024 · Cited by 52 · see citing works

T cell suppression by osteoclasts in vitro

Grassi, F., Manferdini, C., Cattini, L., Piacentini, A., Gabusi, E., Facchini, A., & Lisignoli, G. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22411 · Cited by 52 · see citing works

Reduced osteoblastic population and defective mineralization in osteopetrotic (op/op) mice

Sakagami, N., Amizuka, N., Li, M., Takeuchi, K., Hoshino, M., Nakamura, M., Nozawa‐Inoue, K., Udagawa, N., & Maeda, T. (2005) · Micron · doi:10.1016/j.micron.2005.06.008 · Cited by 51 · see citing works

Hepatocyte Growth Factor Increases Osteopontin Expression in Human Osteoblasts through PI3K, Akt, c-Src, and AP-1 Signaling Pathway

Chen, H., Tsou, H., Chang, C.-H., & Tang, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038378 · Cited by 48 · see citing works

Egress and Mobilization of Hematopoietic Stem and Progenitor Cells: A Dynamic Multi-facet Process

Lapid, K., Glait‐Santar, C., Gur‐Cohen, S., Canaani, J., Kollet, Ó., & Lapidot, T. (2012) · doi:10.3824/stembook.1.91.1 · Cited by 47 · see citing works

Afamin secreted from nonresorbing osteoclasts acts as a chemokine for preosteoblasts via the Akt-signaling pathway

Kim, B., Lee, Y., Lee, S.-Y., Park, S., Dieplinger, H., Ryu, S. H., Yea, K., Choi, S., Lee, S. H., Koh, J., et al. (2012) · Bone · doi:10.1016/j.bone.2012.06.015 · Cited by 42 · see citing works

Serum cathepsin K as a marker of bone metabolism in postmenopausal women treated with alendronate

Muñoz‐Torres, M., Reyes‐García, R., Mezquita‐Raya, P., et al. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.09.011 · Cited by 41 · see citing works

The anabolic action of intermittent PTH in combination with cathepsin K Inhibitor or alendronate differs depending on the remodeling status in bone in ovariectomized mice

Yamane, H., Sakai, A., Mori, T., et al. (2008) · Bone · doi:10.1016/j.bone.2008.05.010 · Cited by 37 · see citing works

Clinical and Radiological Observations in a Case Series of 26 Patients with Fibrous Dysplasia

Thomsen, M. D., & Rejnmark, L. (2014) · Calcified Tissue International · doi:10.1007/s00223-013-9829-0 · Cited by 37 · see citing works

A pivotal role of bone remodeling in granulocyte colony stimulating factor induced hematopoietic stem/progenitor cells mobilization

Li, S., Zhai, Q.-L., Zou, D., et al. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24246 · Cited by 37 · see citing works

Fibrous Dysplasia in a 120,000+ Year Old Neandertal from Krapina, Croatia

Monge, J., Kricun, M. E., Radovčić, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064539 · Cited by 35 · see citing works

Osteoprotegerin Abrogated Cortical Porosity and Bone Marrow Fibrosis in a Mouse Model of Constitutive Activation of the PTH/PTHrP Receptor

Ohishi, M., Chiusaroli, R., Ominsky, M. S., Asuncion, F., Thomas, C., Khatri, R., Kostenuik, P. J., & Schipani, E. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081026 · Cited by 34 · see citing works

The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells

Kook, S., Cho, J., Lee, S. B., & Lee, B.-C. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64060 · Cited by 31 · see citing works

Zoledronic Acid to Prevent and Treat Cancer Metastasis: New Prospects for An Old Drug

Young, R., & Coleman, R. E. (2013) · Future Oncology · doi:10.2217/fon.13.28 · Cited by 25 · see citing works

Osteoporosis in Children With Severe Congenital Neutropenia: Bone Mineral Density and Treatment With Bisphosphonates

Borzutzky, A., Reyes, M. L., Figueroa, V., et al. (2006) · Journal of Pediatric Hematology/Oncology · doi:10.1097/01.mph.0000210409.48877.c3 · Cited by 22 · see citing works

Altered Hematopoietic Stem Cell and Osteoclast Precursor Frequency in Cathepsin K Null Mice

Jacome-Galarza, C. E., Soung, D. Y., Adapala, N. S., Pickarski, M., Sanjay, A., Duong, L. T., Lorenzo, J., & Drissi, H. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24801 · Cited by 18 · see citing works

The development and characterization of an ELISA specifically detecting the active form of cathepsin K

Sun, S., Karsdal, M. A., Bay‐Jensen, A., Sørensen, M. G., Zheng, Q., Dziegiel, M. H., Maksymowych, W. P., & Henriksen, K. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.04.012 · Cited by 12 · see citing works

Osteoclasts are not crucial for hematopoietic stem cell maintenance in adult mice

Flores, C., Moscatelli, I., Thudium, C. S., Gudmann, N. S., Thomsen, J. S., Brüel, A., Karsdal, M. A., Henriksen, K., & Richter, J. (2013) · Haematologica · doi:10.3324/haematol.2013.089466 · Cited by 12 · see citing works

The National Osteoporosis Guideline Group's new guidelines: what is new?

Bukhari, M. A. S. (2009) · Lara D. Veeken · doi:10.1093/rheumatology/ken454 · Cited by 11 · see citing works

PDGF BB purified from osteoclasts acts as osteoblastogenesis inhibitory factor (OBIF).

Kubota, K., Sakikawa, C., Katsumata, M., Nakamura, T., & Wakabayashi, K. (2002) · PubMed Central · Cited by 9 · see citing works

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

Italiani, P., & Boraschi, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00514 · Cited by 2,067 · see citing works

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works

Gut microbiota induce IGF-1 and promote bone formation and growth

Yan, J., Herzog, J. W., Tsang, K., Brennan, C. A., Bower, M. A., Garrett, W. S., Sartor, B. R., Aliprantis, A. O., & Charles, J. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607235113 · Cited by 750 · see citing works

Aptamer-functionalized exosomes from bone marrow stromal cells target bone to promote bone regeneration

Luo, Z.-W., Li, F.-X.-Z., Liu, Y.-W., Rao, S.-S., Yin, H., Huang, J., Chen, C.-Y., Hu, Y., Zhang, Y., Tan, Y.-J., et al. (2019) · Nanoscale · doi:10.1039/c9nr02791b · Cited by 281 · see citing works

Re-thinking the bone remodeling cycle mechanism and the origin of bone loss

Delaisse, J.-M., Andersen, T. L., Kristensen, H. B., Jensen, P. R., Andreasen, C. M., & Søe, K. (2020) · Bone · doi:10.1016/j.bone.2020.115628 · Cited by 152 · see citing works

Osteoimmunology: The correlation between osteoclasts and the Th17/Treg balance in osteoporosis

Huang, F., Wong, P., Li, J., Lv, Z., Xu, L., Zhu, G., He, M., & Luo, Y. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17399 · Cited by 91 · see citing works

High-Dose TGF-β1 Impairs Mesenchymal Stem Cell–Mediated Bone Regeneration via Bmp2 Inhibition

Xu, J., Liu, J., Gan, Y., Dai, K., Zhao, J., Huang, M., Huang, Y., Zhuang, Y., & Zhang, X. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3871 · Cited by 68 · see citing works

Deletion of <i>Wnt5a</i> in osteoclasts results in bone loss through decreased bone formation

Roberts, J. L., Liu, G., Paglia, D. N., Kinter, C. W., Fernandes, L. M., Lorenzo, J., Hansen, M. F., Arif, A., & Drissi, H. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14293 · Cited by 32 · see citing works

Frequent administration of abaloparatide shows greater gains in bone anabolic window and bone mineral density in mice: A comparison with teriparatide

Makino, A., Hasegawa, T., Takagi, H., Takahashi, Y., Hase, N., & Amizuka, N. (2021) · Bone · doi:10.1016/j.bone.2020.115651 · Cited by 22 · see citing works

Reduction of protein phosphatase 2A Cα promotes in vivo bone formation and adipocyte differentiation

Yoshida, K., Teramachi, J., Uchibe, K., Ikegame, M., Qiu, L., Yang, D., & Okamura, H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.11.005 · Cited by 7 · see citing works

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Genentech taps Affimed’s antibodies

Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

KOMPLIKASI REGIONAL ANESTESI PADA PEDIATRIK

Sari, D. (2023) · Jurnal Komplikasi Anestesi · doi:10.22146/jka.v5i1.7322

Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia