Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion.

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Osteoclast-derived activity in the coupling of bone formation to resorption

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Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

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Osteotropic Agents Regulate the Expression of Osteoclast Differentiation Factor and Osteoprotegerin in Osteoblastic Stromal Cells

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Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors

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Use of Type I Collagen Green Fluorescent Protein Transgenes to Identify Subpopulations of Cells at Different Stages of the Osteoblast Lineage

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Activated parathyroid hormone/parathyroid hormone–related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone

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Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-β in bone remodeling in females but not in males

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Role of the CCAAT Enhancer Binding Proteins (C/EBPs) in Adipocyte Differentiation

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Interleukin‐6 modulates production of T lymphocyte–derived cytokines in antigen‐induced arthritis and drives inflammation‐induced osteoclastogenesis

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Bone homeostasis in growth hormone receptor–null mice is restored by IGF-I but independent of Stat5

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CCAAT/Enhancer-binding Proteins (C/EBP) β and δ Activate Osteocalcin Gene Transcription and Synergize with Runx2 at the C/EBP Element to Regulate Bone-specific Expression

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Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by Interleukin-6-Type Cytokines Promotes Osteoblast Differentiation

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Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

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Null Leukemia Inhibitory Factor Receptor (LIFR) Mutations in Stüve-Wiedemann/Schwartz-Jampel Type 2 Syndrome

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Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survivals

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Interleukin‐11 Receptor Signaling Is Required for Normal Bone Remodeling

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Parathyroid Hormone Bone Anabolic Action Requires Cbfa1/Runx2-Dependent Signaling

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Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin‐11

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Interleukin-11 as a Stimulatory Factor for Bone Formation Prevents Bone Loss with Advancing Age in Mice

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Cardiotrophin-1, a Muscle-Derived Cytokine, Is Required for the Survival of Subpopulations of Developing Motoneurons

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Osteoblasts display receptors for and responses to leukemia‐inhibitory factor

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The effect of leukemia inhibitory factor on bone in vivo

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The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me/me mutant mice

Aoki, K., DiDomenico, E., Sims, N. A., Mukhopadhyay, K., Neff, L., Houghton, A., Amling, M., Levy, J. B., Horne, W. C., & Baron, R. (1999) · Bone · doi:10.1016/s8756-3282(99)00174-x · Cited by 109 · see citing works

STIMULATION OF OSTEOCLAST DIFFERENTIATION IN VITRO BY MOUSE ONCOSTATIN M, LEUKAEMIA INHIBITORY FACTOR, CARDIOTROPHIN-1 AND INTERLEUKIN 6: SYNERGY WITH DEXAMETHASONE

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Functional Cooperation between CCAAT/Enhancer-Binding Proteins and the Vitamin D Receptor in Regulation of 25-Hydroxyvitamin D 3 24-Hydroxylase

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Oncostatin-M: a new bone active cytokine that activates osteoblasts and inhibits bone resorption.

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CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Regulates Osteoblast Differentiation

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Osteoclastic Potential of Human CFU-GM: Biphasic Effect of GM-CSF

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Differentiation potential of a mouse bone marrow stromal cell line

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Perinatal testosterone surge is required for normal adult bone size but not for normal bone remodeling

Sims, N. A., Brennan, K., Spaliviero, J. A., Handelsman, D. J., & Seibel, M. J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00311.2005 · Cited by 74 · see citing works

Human and Murine Osteocalcin Gene Expression: Conserved Tissue Restricted Expression and Divergent Responses to 1,25-Dihydroxyvitamin D3 in Vivo

Sims, N. A., White, C., Sunn, K. L., Thomas, G. P., Drummond, M. L., Morrison, N. A., Eisman, J. A., & Gardiner, E. M. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.11.0008 · Cited by 68 · see citing works

Craniosynostosis-Associated Gene Nell-1 Is Regulated by Runx2

Truong, T. V., Zhang, X., Pathmanathan, D., Soo, C. B., & Ting, K. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061012 · Cited by 67 · see citing works

gp130-Mediated Signaling Is Necessary for Normal Osteoblastic Function in Vivo and in Vitro

Shin, H., Pajevic, P. D., Sims, N. A., Kobayashi, T., Miao, D., Karaplis, A. C., Baron, R., Bringhurst, R., & Kronenberg, H. M. (2003) · Endocrinology · doi:10.1210/en.2003-0839 · Cited by 66 · see citing works

Bone Morphogenetic Protein 2 Activates Smad6 Gene Transcription through Bone-specific Transcription Factor Runx2

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The generation of highly enriched osteoclast-lineage cell populations

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An Immunoluminometric Assay for Cardiotrophin-1: A Newly Identified Cytokine Is Present in Normal Human Plasma and Is Increased in Heart Failure

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Expression of leukemia inhibitory factor (LIF)/interleukin-6 family cytokines and receptors during in vitro osteogenesis: differential regulation by dexamethasone and LIF

Liu, F., Aubin, J. E., & Malaval, L. (2002) · Bone · doi:10.1016/s8756-3282(02)00806-2 · Cited by 47 · see citing works

Skeletal hormones and the C/EBP and Runx transcription factors: interactions that integrate and redefine gene expression

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CCAAT/enhancer-binding protein δ activates the Runx2-mediated transcription of mouse osteocalcin II promoter

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Osteoclast differentiation by RANKL and OPG signaling pathways

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Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit

Sims, N. A., & Martin, T. J. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2013.215 · Cited by 706 · see citing works

Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts

Han, Y., You, X., Xing, W., Zhang, Z., & Zou, W. (2018) · Bone Research · doi:10.1038/s41413-018-0019-6 · Cited by 582 · see citing works

Osteoimmunology: The conceptual framework unifying the immune and skeletal systems

Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T., & Takayanagi, H. (2017) · Physiological Reviews · doi:10.1152/physrev.00036.2016 · Cited by 534 · see citing works

Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption

Sims, N. A., & Gooi, J. H. (2008) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.07.016 · Cited by 513 · see citing works

Bone remodelling at a glance

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Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works

Bone grafts and their substitutes

Fillingham, Y. A., & Jacobs, J. J. (2016) · The Bone & Joint Journal · doi:10.1302/0301-620x.98b.36350 · Cited by 424 · see citing works

Osteoclasts: more than ‘bone eaters’

Charles, J. F., & Aliprantis, A. O. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.06.001 · Cited by 391 · see citing works

Regulation of Osteoblast Differentiation by Cytokine Networks

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The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo

Whyte, L. S., Ryberg, E., Sims, N. A., Ridge, S. A., Mackie, K., Greasley, P. J., Ross, R. A., & Rogers, M. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902743106 · Cited by 331 · see citing works

Cytokine responses against periodontal infection: protective and destructive roles

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Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

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Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms

Sims, N. A., & Martin, T. J. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034425 · Cited by 286 · see citing works

Local communication on and within bone controls bone remodeling

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The role of cytokines in inflammatory bone loss

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Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned

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Regulation of Bone Remodeling by Parathyroid HormonePreprint

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Osteoclast Activity and Subtypes as a Function of Physiology and Pathology—Implications for Future Treatments of Osteoporosis

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Osteoclast-Derived Complement Component 3a Stimulates Osteoblast Differentiation

Matsuoka, K., Park, K.-A., Ito, M., Ikeda, K., & Takeshita, S. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2187 · Cited by 216 · see citing works

A Review of Osteocyte Function and the Emerging Importance of Sclerostin

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Biomimetic whitlockite inorganic nanoparticles-mediated in situ remodeling and rapid bone regeneration

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Breast cancer bone metastases: pathogenesis and therapeutic targets

Brook, N., Brook, E., Dharmarajan, A., Dass, C. R., & Chan, A. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.01.003 · Cited by 186 · see citing works

Osteoclast-secreted SLIT3 coordinates bone resorption and formation

Kim, B.-J., Lee, Y.-S., Lee, S.-Y., Baek, W.-Y., Choi, Y. J., Moon, S. A., Lee, S. H., Kim, J.-E., Chang, E.-J., Kim, E.-Y., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci91086 · Cited by 174 · see citing works

Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

Sims, N. A., & Martin, T. J. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00041 · Cited by 184 · see citing works

Bone cell interactions through Eph/ephrin: Bone modeling, remodeling and associated diseases

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Interplay between Inflammation and Pathological Bone Resorption: Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives

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HIF-1α Regulates Bone Homeostasis and Angiogenesis, Participating in the Occurrence of Bone Metabolic Diseases

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Inflammation and Bone Metabolism in Rheumatoid Arthritis: Molecular Mechanisms of Joint Destruction and Pharmacological Treatments

Maeda, K., Yoshida, K., Nishizawa, T., Otani, K., Yamashita, Y., Okabe, H., Hadano, Y., Kayama, T., Kurosaka, D., & Saito, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052871 · Cited by 152 · see citing works

Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases

Takegahara, N., Kim, H., & Choi, Y. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01157-7 · Cited by 147 · see citing works

Impact of Inflammation on the Osteoblast in Rheumatic Diseases

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Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption

Sims, N. A. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.08.003 · Cited by 125 · see citing works

Advances in osteoclast biology resulting from the study of osteopetrotic mutations

Segovia‐Silvestre, T., Neutzsky-Wulff, A. V., Sørensen, M. G., Christiansen, C., Bollerslev, J., Karsdal, M. A., & Henriksen, K. (2008) · Human Genetics · doi:10.1007/s00439-008-0583-8 · Cited by 127 · see citing works

Intercellular Cross-Talk Among Bone Cells: New Factors and Pathways

Sims, N. A., & Walsh, N. C. (2012) · Current Osteoporosis Reports · doi:10.1007/s11914-012-0096-1 · Cited by 126 · see citing works

GP130 cytokines and bone remodelling in health and disease.

Sims, N., & Walsh, N. (2010) · BMB Reports · doi:10.5483/bmbrep.2010.43.8.513 · Cited by 133 · see citing works

Regulation of cortical and trabecular bone mass by communication between osteoblasts, osteocytes and osteoclasts

Sims, N. A., & Vrahnas, C. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.015 · Cited by 123 · see citing works

Muscle–Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies

Maurel, D., Jähn, K., & Lara-Castillo, N. (2017) · Biomedicines · doi:10.3390/biomedicines5040062 · Cited by 111 · see citing works

Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes

Gooi, J. H., Pompolo, S., Karsdal, M. A., Kulkarni, N. H., Kalajzic, I., McAhren, S. H. M., Han, B., Onyia, J. E., Ho, P. W. M., Gillespie, M. T., et al. (2010) · Bone · doi:10.1016/j.bone.2010.02.018 · Cited by 117 · see citing works

The interrelationship between bone and fat: from cellular see-saw to endocrine reciprocity

Gijsen, H. S., Crowther, N. J., Hough, F. S., & Ferris, W. F. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1211-2 · Cited by 113 · see citing works

Coupling factors involved in preserving bone balance

Kim, B.-J., & Koh, J.-M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2981-y · Cited by 111 · see citing works

New Insights Into Osteoclast Biology

McDonald, M. M., Kim, A. S., Mulholland, B. S., & Rauner, M. (2021) · JBMR Plus · doi:10.1002/jbm4.10539 · Cited by 116 · see citing works

Coupling factors and exosomal packaging micro RNA s involved in the regulation of bone remodelling

Zhu, S., Yao, F., Qiu, H., Zhang, G., Xu, H., & Xu, J. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12353 · Cited by 107 · see citing works

The Primary Function of gp130 Signaling in Osteoblasts Is To Maintain Bone Formation and Strength, Rather Than Promote Osteoclast Formation

Johnson, R. W., Brennan, H. J., Vrahnas, C., Poulton, I. J., McGregor, N. E., Standal, T., Walker, E. C., Koh, T.-T., Nguyen, H., Walsh, N. C., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2159 · Cited by 105 · see citing works

The origins and roles of osteoclasts in bone development, homeostasis and repair

Yahara, Y., Nguyen, T., Ishikawa, K., Kamei, K., & Alman, B. A. (2022) · Development · doi:10.1242/dev.199908 · Cited by 107 · see citing works

IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis

McGregor, N. E., Murat, M., Elango, J., Poulton, I. J., Walker, E. C., Crimeen‐Irwin, B., Ho, P. W. M., Gooi, J. H., Martin, T. J., & Sims, N. A. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008074 · Cited by 101 · see citing works

Influences of the IL-6 cytokine family on bone structure and function

Sims, N. A. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155655 · Cited by 100 · see citing works

A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro

Murakami, K., Kobayashi, Y., Uehara, S., Suzuki, T., Koide, M., Yamashita, T., Nakamura, M., Takahashi, N., Kato, H., Udagawa, N., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181126 · Cited by 97 · see citing works

The critical interplay between bone resorbing and bone forming cells

Lerner, U. H., Kindstedt, E., & Lundberg, P. (2019) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13051 · Cited by 99 · see citing works

The origins and formation of bone-resorbing osteoclasts

Elson, A., Anuj, A., Barnea-Zohar, M., & Reuven, N. (2022) · Bone · doi:10.1016/j.bone.2022.116538 · Cited by 95 · see citing works

Zinc Finger Protein 467 Is a Novel Regulator of Osteoblast and Adipocyte Commitment

Quach, J., Walker, E. C., Allan, E. H., Solano, M., Yokoyama, A., Kato, S., Sims, N. A., Gillespie, M. T., & Martin, T. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.178251 · Cited by 93 · see citing works

The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology

Sims, N. A. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0445-6 · Cited by 94 · see citing works

Bone cell communication factors and Semaphorins

Negishi-Koga, T., & Takayanagi, H. (2012) · BoneKEy Reports · doi:10.1038/bonekey.2012.183 · Cited by 90 · see citing works

Semaphorins in bone development, homeostasis, and disease

Kang, S., & Kumanogoh, A. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.09.008 · Cited by 87 · see citing works

Recent Advances in Osteoclast Biological Behavior

Sun, Y., Li, J., Xie, X., Gu, F., Sui, Z., Zhang, K., & Yu, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.788680 · Cited by 81 · see citing works

Current perspectives on the multiple roles of osteoclasts: Mechanisms of osteoclast–osteoblast communication and potential clinical implications

Daponte, V., Henke, K., & Drissi, H. (2024) · eLife · doi:10.7554/elife.95083 · Cited by 84 · see citing works

Cortical bone development, maintenance and porosity: genetic alterations in humans and mice influencing chondrocytes, osteoclasts, osteoblasts and osteocytes

Isojima, T., & Sims, N. A. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03884-w · Cited by 78 · see citing works

Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms

Jilka, R. L., O’Brien, C. A., Bartell, S. M., Weinstein, R. S., & Manolagas, S. C. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.145 · Cited by 78 · see citing works

Treatment of post-menopausal osteoporosis: beyond bisphosphonates

Ishtiaq, S., Fogelman, I., & Hampson, G. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0152-z · Cited by 76 · see citing works

Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts

Koide, M., Kobayashi, Y., Yamashita, T., Uehara, S., Nakamura, M., Hiraoka, B. Y., Ozaki, Y., Iimura, T., Yasuda, H., Takahashi, N., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3175 · Cited by 76 · see citing works

Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization

Poulton, I. J., McGregor, N. E., Pompolo, S., Walker, E. C., & Sims, N. A. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1485 · Cited by 73 · see citing works

JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration

Damerau, A., Gaber, T., Ohrndorf, S., & Hoff, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239004 · Cited by 71 · see citing works

Nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway

He, Y., Li, Z., Ding, X., Xu, B., Wang, J., Li, Y., Chen, F., Meng, F., Song, W., & Zhang, Y. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.033 · Cited by 71 · see citing works

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Vrahnas, C., Blank, M., Dite, T. A., Tatarczuch, L., Ansari, N., Crimeen-Irwin, B., Nguyen, H., Forwood, M. R., Hu, Y., Ikegame, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11373-9 · Cited by 70 · see citing works

Ciliary Neurotrophic Factor Inhibits Bone Formation and Plays a Sex-Specific Role in Bone Growth and Remodeling

McGregor, N. E., Poulton, I. J., Walker, E. C., Pompolo, S., Quinn, J. M. W., Martin, T. J., & Sims, N. A. (2010) · Calcified Tissue International · doi:10.1007/s00223-010-9337-4 · Cited by 70 · see citing works

The Chemokine Cxcl1 Is a Novel Target Gene of Parathyroid Hormone (PTH)/PTH-Related Protein in Committed Osteoblasts

Onan, D., Allan, E. H., Quinn, J. M. W., Gooi, J. H., Pompolo, S., Sims, N. A., Gillespie, M. T., & Martin, T. J. (2009) · Endocrinology · doi:10.1210/en.2008-1597 · Cited by 67 · see citing works

Novel insights into the coupling of osteoclasts and resorption to bone formation

Durdan, M., Azaria, R. D., & Weivoda, M. M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.10.008 · Cited by 65 · see citing works

Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice

Essex, A. L., Pin, F., Huot, J. R., Bonewald, L. F., Plotkin, L. I., & Bonetto, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00809 · Cited by 63 · see citing works

Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone.

Johnson, R. W., McGregor, N. E., Brennan, H. J., Crimeen‐Irwin, B., Poulton, I. J., Martin, T., & Sims, N. (2015) · Bone · doi:10.1016/j.bone.2015.08.005 · Cited by 56 · see citing works

An integrated multi-omics analysis reveals osteokines involved in global regulation

Liang, W., Wei, T., Hu, L., Chen, M., Tong, L., Zhou, W., Duan, X., Zhao, X., Zhou, W., Jiang, Q., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.03.006 · Cited by 67 · see citing works

Preclinical Rodent Models for Human Bone Disease, Including a Focus on Cortical Bone

Koh, N. Y. Y., Miszkiewicz, J. J., Fac, M. L., Wee, N. K. Y., & Sims, N. A. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae004 · Cited by 60 · see citing works

Implications of Osteoblast-Osteoclast Interactions in the Management of Osteoporosis by Antiresorptive Agents Denosumab and Odanacatib

Sims, N. A., & Ng, K. W. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0196-1 · Cited by 61 · see citing works

Myokines (muscle-derived cytokines and chemokines) including ciliary neurotrophic factor (CNTF) inhibit osteoblast differentiation

Johnson, R. W., White, J. D., Walker, E. C., Martin, T. J., & Sims, N. A. (2014) · Bone · doi:10.1016/j.bone.2014.03.053 · Cited by 59 · see citing works

Leukemia inhibitory factor: A paracrine mediator of bone metabolism

Sims, N. A., & Johnson, R. W. (2012) · Growth Factors · doi:10.3109/08977194.2012.656760 · Cited by 59 · see citing works

Osteogenesis and angiogenesis promoting bioactive ceramics

Rajendran, A. K., Anthraper, M. S. J., Hwang, N. S.-Y., & Jayakumar, R. (2024) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2024.100801 · Cited by 60 · see citing works

Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo

Walker, E. C., Poulton, I. J., McGregor, N. E., Ho, P. W. M., Allan, E. H., Quach, J., Martin, T. J., & Sims, N. A. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1506 · Cited by 58 · see citing works

Germline deletion of AMP‐activated protein kinase β subunits reduces bone mass without altering osteoclast differentiation or function

Quinn, J. M. W., Tam, S., Sims, N. A., Saleh, H., McGregor, N. E., Poulton, I. J., Scott, J. W., Gillespie, M. T., Kemp, B. E., & van Denderen, B. J. W. (2009) · The FASEB Journal · doi:10.1096/fj.09-137158 · Cited by 58 · see citing works

Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders

Sims, N. A. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.014 · Cited by 57 · see citing works

Absence of Cardiotrophin 1 Is Associated With Decreased Age-Dependent Arterial Stiffness and Increased Longevity in Mice

López‐Andrés, N., Calvier, L., Labat, C., Fay, R., Dı́ez, J., Bénétos, A., Zannad, F. M., Lacolley, P. J., & Rossignol, P. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.201699 · Cited by 51 · see citing works

Regulatory mechanisms of sclerostin expression during bone remodeling

Koide, M., & Kobayashi, Y. (2018) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-018-0971-7 · Cited by 46 · see citing works

Triple Culture of Primary Human Osteoblasts, Osteoclasts and Osteocytes as an In Vitro Bone Model

Bernhardt, A., Skottke, J., von Witzleben, M., & Gelinsky, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147316 · Cited by 45 · see citing works

gp130 signaling in bone cell biology: Multiple roles revealed by analysis of genetically altered mice

Sims, N. A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.08.025 · Cited by 43 · see citing works

GP130 Cytokines in Breast Cancer and Bone

Omokehinde, T., & Johnson, R. W. (2020) · Cancers · doi:10.3390/cancers12020326 · Cited by 42 · see citing works

The cytokine interleukin-11 crucially links bone formation, remodeling and resorption

Kespohl, B., Schumertl, T., Bertrand, J., Lokau, J., & Garbers, C. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.04.002 · Cited by 42 · see citing works

Severe developmental bone phenotype in ClC-7 deficient mice

Neutzsky-Wulff, A. V., Sims, N. A., Supanchart, C., Kornak, U., Felsenberg, D., Poulton, I. J., Martin, T. J., Karsdal, M. A., & Henriksen, K. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.06.018 · Cited by 39 · see citing works

Stüve-Wiedemann syndrome: LIFR and associated cytokines in clinical course and etiology

Mikelonis, D., Jorcyk, C. L., Tawara, K., & Oxford, J. T. (2014) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-9-34 · Cited by 41 · see citing works

Vaginally Administered PEGylated LIF Antagonist Blocked Embryo Implantation and Eliminated Non-Target Effects on Bone in Mice

Menkhorst, E. M., Zhang, J., Sims, N. A., Morgan, P. O., Soo, P., Poulton, I. J., Metcalf, D., Alexandrou, E., Gresle, M. M., Salamonsen, L. A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019665 · Cited by 40 · see citing works

Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

Cho, D.-C., Brennan, H. J., Johnson, R. W., Poulton, I. J., Gooi, J., Tonkin, B., McGregor, N. E., Walker, E. C., Handelsman, D., Martin, T., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00920-x · Cited by 36 · see citing works

Osteoclasts: Other functions

Park‐Min, K., & Lorenzo, J. A. (2022) · Bone · doi:10.1016/j.bone.2022.116576 · Cited by 38 · see citing works

gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation

Standal, T., Johnson, R. W., McGregor, N. E., Poulton, I. J., Ho, P. W. M., Martin, T. J., & Sims, N. A. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0424 · Cited by 36 · see citing works

What Is Breast in the Bone?

Shemanko, C. S., Cong, Y., & Forsyth, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101764 · Cited by 36 · see citing works

Potential role of odanacatib in the treatment of osteoporosis

Ng, K. W. (2012) · Clinical Interventions in Aging · doi:10.2147/cia.s26729 · Cited by 35 · see citing works

The role of aryl hydrocarbon receptor in bone remodeling

Yu, H., Jiang, L., Wan, B., Zhang, W., Yao, L., Che, T., Gan, C., Su, N., He, J., Huang, J., et al. (2017) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2017.12.005 · Cited by 33 · see citing works

Talking among Ourselves: Paracrine Control of Bone Formation within the Osteoblast Lineage

Tonna, S. J., & Sims, N. A. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9738-2 · Cited by 33 · see citing works

The sclerostin story: From human genetics to the development of novel anabolic treatment for osteoporosis

Yavropoulou, M. P., Xygonakis, C., Lolou, M., Karadimou, F., & Yovos, J. G. (2014) · HORMONES · doi:10.14310/horm.2002.1552 · Cited by 35 · see citing works

Chondrocytic EphrinB2 promotes cartilage destruction by osteoclasts in endochondral ossification

Tonna, S. J., Poulton, I. J., Taykar, F., Ho, P. W. M., Tonkin, B. A., Crimeen‐Irwin, B., Tatarczuch, L., McGregor, N. E., Mackie, E. J., Martin, T. J., et al. (2016) · Development · doi:10.1242/dev.125625 · Cited by 33 · see citing works

Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

Walker, E. C., Truong, K., McGregor, N. E., Poulton, I. J., Isojima, T., Gooi, J. H., Martin, T. J., & Sims, N. A. (2020) · eLife · doi:10.7554/elife.56666 · Cited by 30 · see citing works

RARγ is a negative regulator of osteoclastogenesis

Green, A. C., Poulton, I. J., Vrahnas, C., Hausler, K. D., Walkley, C. R., Wu, J. Y., Martin, T. J., Gillespie, M. T., Chandraratna, R. A. S., Quinn, J. M. W., et al. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.03.005 · Cited by 30 · see citing works

Sclerostin expression in trabecular bone is downregulated by osteoclasts

Koide, M., Yamashita, T., Murakami, K., Uehara, S., Nakamura, K., Nakamura, M., Matsushita, M., Ara, T., Yasuda, H., Penninger, J. M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70817-1 · Cited by 29 · see citing works

Fibrodysplasia Ossificans Progressiva-related Activated Activin-like Kinase Signaling Enhances Osteoclast Formation during Heterotopic Ossification in Muscle Tissues

Yano, M., Kawao, N., Okumoto, K., Tamura, Y., Okada, K., & Kaji, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.526038 · Cited by 27 · see citing works

HIF‐1α regulates osteoclast activation and mediates osteogenesis during mandibular bone repair via CT‐1

Tian, Y., Shao, Q., Tang, Y., Li, X., Qi, X., Jiang, R., Liang, Y., & Kang, F. (2020) · Oral Diseases · doi:10.1111/odi.13745 · Cited by 27 · see citing works

Cardiotrophin-1 signaling essential for normal mouse bone resorption and formation

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Cardiotrophin-1 regulates osteoclast and osteoblast function in a manner distinct from other gp130 cytokines

Sims, N. A., Walker, E. C., Quinn, J. M. W., Allen, E. A., Saleh, H., & Martin, T. J. (2006) · Bone · doi:10.1016/j.bone.2006.01.121

Cthrc1 Is a Positive Regulator of Osteoblastic Bone Formation

Kimura, H. J., Kwan, K. M., Zhang, Z., Deng, J. M., Darnay, B. G., Behringer, R. R., Nakamura, T., Crombrugghe, B. D., & Akiyama, H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003174 · Cited by 111 · see citing works

Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation

Takeshita, S., Fumoto, T., Matsuoka, K., Park, K.-A., Aburatani, H., Kato, S., Ito, M., & Ikeda, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69493 · Cited by 249 · see citing works

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

Keller, J., Catala-Lehnen, P., Huebner, A. K., Jeschke, A., Heckt, T., Lueth, A., Krause, M., Koehne, T., Albers, J., Schulze, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6215 · Cited by 211 · see citing works