MicroRNAs in cancer: biomarkers, functions and therapy

Hallmarks of Cancer: The Next Generation

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

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MicroRNA expression profiles classify human cancers

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Circulating microRNAs as stable blood-based markers for cancer detection

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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

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The widespread regulation of microRNA biogenesis, function and decay

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miRBase: tools for microRNA genomics

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Treatment of HCV Infection by Targeting MicroRNA

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MiR-513c suppresses neuroblastoma cell migration, invasion, and proliferation through direct targeting glutaminase (GLS)

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Conservation of a microRNA cluster in parasitic nematodes and profiling of miRNAs in excretory-secretory products and microvesicles of Haemonchus contortus

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miR‐204‐5p suppresses hepatocellular cancer proliferation by regulating homeoprotein SIX 1 expression

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MiR-21-5p, miR-34a, and human telomerase RNA component as surrogate markers for cervical cancer progression

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Visualizing miR-155 To Monitor Breast Tumorigenesis and Response to Chemotherapeutic Drugs by a Self-Assembled Photoacoustic Nanoprobe

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MicroRNA-130b functions as an oncomiRNA in non-small cell lung cancer by targeting tissue inhibitor of metalloproteinase-2

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Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy

Chen, T., & Chen, J. (2019) · eLife · doi:10.7554/elife.50848 · Cited by 43

Potential miRNA biomarkers for the diagnosis and prognosis of esophageal cancer detected by a novel absolute quantitative RT-qPCR method

Lin, Z., Chen, Y., Lin, Y., Lin, H., Li, H., Su, X., Fang, Z., Wang, J., Wei, Q., Teng, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77119-6 · Cited by 41

MicroRNA profiling of low-grade glial and glioneuronal tumors shows an independent role for cluster 14q32.31 member miR-487b

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Epigenetic modulation of antitumor immunity and immunotherapy response in breast cancer: biological mechanisms and clinical implications

Yin, J., Gu, T., Chaudhry, N. Y., Davidson, N. E., & Huang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1325615 · Cited by 40

RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding

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MicroRNA regulation and analytical methods in cancer cell metabolism

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Recent advances in peptide nucleic acid for cancer bionanotechnology

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MicroRNA-135a regulates NHE9 to inhibit proliferation and migration of glioblastoma cells

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Argonaute 2 drives miR-145-5p-dependent gene expression program in breast cancer cells

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Identification of a three‐miRNA signature as a novel potential prognostic biomarker in patients with clear cell renal cell carcinoma

Luo, Y., Chen, L., Wang, G., Xiao, Y., Ju, L., & Wang, X. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28648 · Cited by 40

Electrochemical Nano-biosensors as Novel Approach for the Detection of Lung Cancer-related MicroRNAs

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Epstein-Barr virus circRNAome as host miRNA sponge regulates virus infection, cell cycle, and oncogenesis

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LINC02381 Promoted Cell Viability and Migration via Targeting miR-133b in Cervical Cancer Cells

Chen, X., Zhang, Z., Ma, Y., Su, H., Xie, P., & Ran, J. (2020) · Cancer Management and Research · doi:10.2147/cmar.s237285 · Cited by 40

IGF2-AS knockdown inhibits glycolysis and accelerates apoptosis of gastric cancer cells through targeting miR-195/CREB1 axis

Yan, B., Ren, Z., Sun, J., Ding, C., & Yang, D. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110600 · Cited by 40

Small molecule-based bioluminescence and chemiluminescence probes for sensing and imaging of reactive species

Zhan, Z., Dai, Y.-C., Li, Q., & Lv, Y. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116129 · Cited by 40

miR-340: A multifunctional role in human malignant diseases

Huang, Z., Xu, Y., Wan, M., Zeng, X., & Wu, J. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.51123 · Cited by 40

Evolution in Biosensors for Cancers Biomarkers Detection: A Review

Alharthi, S. D., Bijukumar, D. R., Prasad, S., Khan, A. M., & Mathew, M. T. (2021) · Journal of Bio- and Tribo-Corrosion · doi:10.1007/s40735-020-00463-7 · Cited by 40

MicroRNA expression profiling analysis in serum for nasopharyngeal carcinoma diagnosis

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The landscape of exosomal non-coding RNAs in breast cancer drug resistance, focusing on underlying molecular mechanisms

Rezaee, M., Mohammadi, F., Keshavarzmotamed, A., Yahyazadeh, S., Vakili, O., Milasi, Y. E., Veisi, V., Dehmordi, R. M., Asadi, S., Ghorbanhosseini, S. S., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1152672 · Cited by 39

Applications of electrochemical impedance spectroscopy in disease diagnosis—A review

Ribeiro, J. A., & Jorge, P. A. S. (2024) · Sensors and Actuators Reports · doi:10.1016/j.snr.2024.100205 · Cited by 45

High serum microRNA-122 level is independently associated with higher overall survival rate in hepatocellular carcinoma patients

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Identification of T Cell–Mediated Vascular Rejection After Kidney Transplantation by the Combined Measurement of 5 Specific MicroRNAs in Blood

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MiR‐382 inhibits cell growth and invasion by targeting NR2F2 in colorectal cancer

Zhou, B., Song, J., Han, T., Huang, M., Jiang, H., Qiao, H., Shi, J., & Wang, Y. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22466 · Cited by 39

Overcoming cisplatin resistance in osteosarcoma through the miR-199a-modulated inhibition of HIF-1α

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MicroRNA-136 inhibits colon cancer cell proliferation and invasion through targeting liver receptor homolog-1/Wnt signaling

Yuan, Q., Cao, G., Li, J., Zhang, Y., & Yang, W. (2017) · Gene · doi:10.1016/j.gene.2017.07.031 · Cited by 39

Collateral Damage Intended—Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy

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The miR‐139‐5p regulates proliferation of supratentorial paediatric low‐grade gliomas by targeting the PI3K/AKT/mTORC1 signalling

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Simple PDMS microdevice for biomedical applications

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MORC4 is a novel breast cancer oncogene regulated by miR‐193b‐3p

Yang, Z., Zhuang, Q., Hu, G., & Geng, S. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27751 · Cited by 39

Circulating epithelial-mesenchymal transition-associated miRNAs are promising biomarkers in ovarian cancer

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CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathways

Qin, L., Lin, J., & Xie, X. (2019) · Molecular Medicine · doi:10.1186/s10020-019-0094-1 · Cited by 39

Identification of Cell-Free Circulating MicroRNAs for the Detection of Early Breast Cancer and Molecular Subtyping

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LncRNA CYTOR affects the proliferation, cell cycle and apoptosis of hepatocellular carcinoma cells by regulating the miR-125b-5p/KIAA1522 axis

Hu, B., Yang, X., Yang, X., & Sang, X. (2020) · Aging · doi:10.18632/aging.202306 · Cited by 39

Small Non-Coding-RNA in Gynecological Malignancies

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Biliary Tract Cancers: Treatment Updates and Future Directions in the Era of Precision Medicine and Immuno-Oncology

Manne, A., Woods, E., Tsung, A., & Mittra, A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.768009 · Cited by 39

Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links?

Beck, R., Stýblo, M., & Sethupathy, P. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0845-8 · Cited by 39

Oncogenic long intervening noncoding RNA Linc00284 promotes c-Met expression by sponging miR-27a in colorectal cancer

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Preanalytic Methodological Considerations and Sample Quality Control of Circulating miRNAs

Chan, S.-F., He, C., Goh, K. K.-R., & Zou, R. (2023) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2023.03.005 · Cited by 38

microRNA-146a inhibits proliferation, migration and invasion of human cervical and colorectal cancer cells

Sathyanarayanan, A., Chandrasekaran, K. S., & Karunagaran, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.054 · Cited by 38

mRNA–miRNA bipartite network reconstruction to predict prognostic module biomarkers in colorectal cancer stage differentiation

MotieGhader, H., Kouhsar, M. P., Najafi, A., Sadeghı, B., & Masoudi‐Nejad, A. (2017) · Molecular BioSystems · doi:10.1039/c7mb00400a · Cited by 38

miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP

Choe, M. H., Yina, Y., Kim, J., Hwang, S.-G., Han, Y.-H., & Kim, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0698-3 · Cited by 38

Protocols for the Analysis of microRNA Expression, Biogenesis, and Function in Immune Cells

Zhang, N., Hu, G., Myers, T. G., & Williamson, P. R. (2019) · Current Protocols in Immunology · doi:10.1002/cpim.78 · Cited by 39

miR-145 sensitizes esophageal squamous cell carcinoma to cisplatin through directly inhibiting PI3K/AKT signaling pathway

Zheng, T., Li, D.-P., He, Z., & Zhao, S. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0943-6 · Cited by 38

piR‐39980 promotes cell proliferation, migration and invasion, and inhibits apoptosis via repression of SERPINB1 in human osteosarcoma

Das, B., Jain, N., & Mallick, B. (2019) · Biology of the Cell · doi:10.1111/boc.201900063 · Cited by 38

Expression scoring of a small‐nucleolar‐RNA signature identified by machine learning serves as a prognostic predictor for head and neck cancer

Xing, L., Zhang, X., Zhang, X., & Tong, D. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29462 · Cited by 38

Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells

Prabhu, K. S., Raza, A., Karedath, T., Raza, S. S., Fathima, H., Ahmed, E. I., Kuttikrishnan, S., Therachiyil, L., Kuliński, M., Dermime, S., et al. (2020) · Cancers · doi:10.3390/cancers12020351 · Cited by 38

Label-free graphene oxide–based SPR genosensor for the quantification of microRNA21

Mujica, M. L., Zhang, Y., Fethi Bedioui, A., Gutierrez, F. A., & Rivas, G. A. (2020) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-020-02593-w · Cited by 38

LncRNA MEG3 suppressed the progression of ovarian cancer via sponging miR-30e-3p and regulating LAMA4 expression

Liu, Y., Xu, Y., Ding, L., Yu, L., Zhang, B., & Wei, D. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01259-y · Cited by 38

circ‐AKT3 aggravates renal ischaemia‐reperfusion injury via regulating miR‐144‐5p /Wnt/β‐catenin pathway and oxidative stress

Xu, Y., Jiang, W., Zhong, L., Li, H., Bai, L., Chen, X., Lin, Y., & Zheng, D. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16072 · Cited by 38

Myeloid cell leukemia 1 (MCL-1): Structural characteristics and application in cancer therapy

Mittal, P., Singh, S., Sinha, R., Shrivastava, A., Singh, A. K., & Singh, I. K. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.07.166 · Cited by 39

Electrochemiluminescence detection of miRNA-21 based on dual signal amplification strategies: Duplex-specific nuclease -mediated target recycle and nicking endonuclease-driven 3D DNA nanomachine

Wang, M., Jing, W.-J., Wang, L., Jia, L., Ma, R.-N., Zhang, W., Shang, L., Li, X., Xue, Q., & Wang, H. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115116 · Cited by 38

miR-9 Enhances the Chemosensitivity of AML Cells to Daunorubicin by Targeting the EIF5A2/MCL-1 Axis

Liu, Y., Lei, P., Qiao, H., Sun, K., Lu, X., Bao, F., Yu, R., Lian, C., Li, Y., Chen, W., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.29775 · Cited by 38

Identification of microRNAs as potential biomarkers for lung adenocarcinoma using integrating genomics analysis

Peng, Z., Pan, L., Niu, Z., Li, W. X., Dang, X., Wan, L., Zhang, R., & Yang, S. (2017) · Oncotarget · doi:10.18632/oncotarget.19358 · Cited by 37

RNA expression signatures and posttranscriptional regulation in diabetic nephropathy

Rudnicki, M., Beckers, A., Neuwirt, H., & Vandesompele, J. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv079 · Cited by 37

miR-200b induces cell cycle arrest and represses cell growth in esophageal squamous cell carcinoma

Zhang, H., Alshareef, A., Wu, C., Jiao, J.-W., Sorensen, P. H. B., Lai, R. L., Xu, L., & Li, E. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw079 · Cited by 37

Therapeutic Targeting of Epithelial Plasticity Programs: Focus on the Epithelial-Mesenchymal Transition

Malek, R. A., Wang, H., Taparra, K., & Tran, P. T. (2017) · Cells Tissues Organs · doi:10.1159/000447238 · Cited by 40

The MicroRNA miR-210 Is Expressed by Cancer Cells but Also by the Tumor Microenvironment in Triple-Negative Breast Cancer

Bar, I., Merhi, A., Abdel‐Sater, F., Addi, A. B., Sollennita, S., Canon, J.-L. R., & Delrée, P. (2017) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155417702849 · Cited by 37

miR-27a induced by colon cancer cells in HLECs promotes lymphangiogenesis by targeting SMAD4

Xu, Q., Tong, J.-L., Zhang, C.-P., Xiao, Q., Lin, X., & Xiao, X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186718 · Cited by 37

A Comprehensive Analysis of Argonaute-CLIP Data Identifies Novel, Conserved and Species-Specific Targets of miR-21 in Human Liver and Hepatocellular Carcinoma

Koenig, A. B., Barajas, J. M., Guerrero, M. J., & Ghoshal, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030851 · Cited by 37

UHRF1 is regulated by miR‐124‐3p and promotes cell proliferation in intrahepatic cholangiocarcinoma

Zhu, M., Wei, C., Lin, J., Dong, S., Gao, D., Chen, J., Zhao, Y., & Liu, B. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28586 · Cited by 37

Development of a miRNA-seq based prognostic signature in lung adenocarcinoma

Siriwardhana, C., Khadka, V. S., Chen, J. J., & Deng, Y. (2019) · BMC Cancer · doi:10.1186/s12885-018-5206-8 · Cited by 38

Clinical Translatability of “Identified” Circulating miRNAs for Diagnosing Breast Cancer: Overview and Update

Grimaldi, A., & Incoronato, M. (2019) · Cancers · doi:10.3390/cancers11070901 · Cited by 37

Low serum exosomal miR-484 expression predicts unfavorable prognosis in ovarian cancer

Zhang, W., Su, X., Li, S., Liu, Z., Wang, Q., & Zeng, H. (2020) · Cancer Biomarkers · doi:10.3233/cbm-191123 · Cited by 37

Plasmonic nanobiosensors for detection of microRNA cancer biomarkers in clinical samples

Crawford, B. M., Wang, H., Stolarchuk, C., von Furstenberg, R. J., Strobbia, P., Zhang, D., Qin, X., Owzar, K., Garman, K. S., & Vo‐Dinh, T. (2020) · The Analyst · doi:10.1039/d0an00193g · Cited by 37

ST8SIA6-AS1 promotes hepatocellular carcinoma by absorbing miR-5195-3p to regulate HOXB6

Li, Y., & Jiang, A. (2020) · Cancer Biology & Therapy · doi:10.1080/15384047.2020.1743150 · Cited by 37

Paeonol suppresses the effect of ox-LDL on mice vascular endothelial cells by regulating miR-338-3p/TET2 axis in atherosclerosis

Yu, Y., Yan, R., Chen, X., Sun, T., & Yan, J. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03865-w · Cited by 37

Deregulated microRNAs Involved in Prostate Cancer Aggressiveness and Treatment Resistance Mechanisms

Gujrati, H., Ha, S., & Wang, B. (2023) · Cancers · doi:10.3390/cancers15123140 · Cited by 37

miR-663 sustains NSCLC by inhibiting mitochondrial outer membrane permeabilization (MOMP) through PUMA/BBC3 and BTG2

Fiori, M. E., Villanova, L., Barbini, C., Angelis, M. L. D., & Maria, R. D. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0080-x · Cited by 39

Diagnosis of Carcinogenic Pathologies through Breath Biomarkers: Present and Future Trends

Vassilenko, V., Moura, P. C., & Raposo, M. (2023) · Biomedicines · doi:10.3390/biomedicines11113029 · Cited by 36

MicroRNA-370 inhibits the progression of non-small cell lung cancer by downregulating oncogene TRAF4

Chen, T., Gao, F., FENG, S., YANG, T., & Chen, M. (2015) · Oncology Reports · doi:10.3892/or.2015.3978 · Cited by 36

Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation

Sun, M., Huang, F., Yu, D., Zhang, Y., Xu, H., Zhang, L., Li, L., Dong, L., Guo, L., & Wang, S. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.225 · Cited by 36

MicroRNA-driven deregulation of cytokine expression helps development of drug resistance in metastatic melanoma

Fattore, L., Sacconi, A., Mancini, R., & Ciliberto, G. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.05.003 · Cited by 36

Kinetics of Circulating MicroRNAs in Response to Cardiac Stress in Patients With Coronary Artery Disease

Jansen, F., Schäfer, L., Wang, H., Schmitz, T., Flender, A., Schueler, R., Hammerstingl, C., Nickenig, G., Sinning, J., & Werner, N. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005270 · Cited by 37

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

Mensah, M., Borzi, C., Verri, C., Suatoni, P., Conte, D., Pastorino, U., Fortunato, O., Sozzi, G., & Boeri, M. (2017) · Journal of Visualized Experiments · doi:10.3791/56326 · Cited by 36

miR-9 induces cell arrest and apoptosis of oral squamous cell carcinoma via CDK 4/6 pathway

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MicroRNA-211 Loss Promotes Metabolic Vulnerability and BRAF Inhibitor Sensitivity in Melanoma

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