Cited by 2,049MicroRNA in disease regulationCancer-related molecular mechanisms researchCancer-related Molecular Pathways

The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.

MicroRNAs in cancer: biomarkers, functions and therapy

Open access

Hayes, Josie, Peruzzi, Pier Paolo, Lawler, Sean·2014·Trends in Molecular Medicine

DOI 10.1016/j.molmed.2014.06.005

Open this paper in CoChat — free account Open PDF

Abstract

The emergence of microRNAs has been one of the defining developments in cancer biology over the past decade, and the explosion of knowledge in this area has brought forward new diagnostic and therapeutic opportunities. The importance of microRNAs in cancer has been underlined by the identification of alterations in microRNA target binding sites and the microRNA processing machinery in tumor cells. Clinical trials utilizing microRNA profiling for patient prognosis and clinical response are now underway, and the first microRNA mimic entered the clinic for cancer therapy in 2013. In this article we review the potential applications of microRNAs for the clinical assessment of patient outcome in cancer, as well as in cancer monitoring and therapy.

Integrity signals

Registry

Crossref · 10.1016/j.molmed.2014.06.005

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

1 retracted

HMGA2 functions as a competing endogenous RNA to promote lung cancer progression
Kumar, M. S., Armenteros-Monterroso, E., East, P., Chakravorty, P., Matthews, N., Winslow, M. M., & Downward, J. (2013) · Nature · doi:10.1038/nature12785 · Cited by 255
Retracted
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
miRBase: tools for microRNA genomics
Griffiths‐Jones, S., Saini, H. K., van Dongen, S., & Enright, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm952 · Cited by 4,432
Treatment of HCV Infection by Targeting MicroRNA
Janssen, H. L. A., Reesink, H. W., Lawitz, E., Zeuzem, S., Rodriguez‐Torres, M., Patel, K., van der Meer, A. J., Patick, A. K., Chen, A. P., Zhou, Y., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209026 · Cited by 2,262

Flagged first, then by citations

Show all 79 references

Research works printed but not linked: 1

Choudhury, 2012, Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells, J. Clin. Invest., 122, 4059, 10.1172/JCI62925 · DOI

Sorted by citations

Items 701–800 of 1,000

Deep gene selection method to select genes from microarray datasets for cancer classification
Alanni, R., Hou, J., Azzawi, H., & Xiang, Y. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-3161-2 · Cited by 30
MicroRNA-Based Multitarget Approach for Alzheimer’s Disease: Discovery of the First-In-Class Dual Inhibitor of Acetylcholinesterase and MicroRNA-15b Biogenesis
Gabr, M. T., & Brogi, S. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00756 · Cited by 30
Recognition of Single‐Point Mutation Using a Biological Nanopore
Liu, P., & Kawano, R. (2020) · Small Methods · doi:10.1002/smtd.202000101 · Cited by 30
The Multifaceted Roles of MicroRNAs in Cystic Fibrosis
Palma, F. D. E. D., Raia, V., Kroemer, G., & Maiuri, M. C. (2020) · Diagnostics · doi:10.3390/diagnostics10121102 · Cited by 30
The APEX1/miRNA-27a-5p axis plays key roles in progression, metastasis and targeted chemotherapy of gastric cancer
He, H., Song, F., Gao, Q., Lu, Z., Yuan, Y., Li, X., Chen, L., Jia, C., Yang, R., Yang, J. P., et al. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120446 · Cited by 31
Liquid biopsies to distinguish malignant from benign pulmonary nodules
Tao, R., Cao, W., Zhu, F., Nie, J. J., Wang, H., Wang, L., Liu, P., Chen, H., Hong, B., & Zhao, D. (2021) · Thoracic Cancer · doi:10.1111/1759-7714.13982 · Cited by 30
The role of non-coding RNAs in chemotherapy for gastrointestinal cancers
Dashti, F., Mirazimi, S. M. A., Rabiei, N., Fathazam, R., Rabiei, N., Piroozmand, H., Vosough, M., Rahimian, N., Hamblin, M. R., & Mirzaei, H. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.10.004 · Cited by 30
Significant position of C-myc in colorectal cancer: a promising therapeutic target
Tan, L. H., Peng, D., & Cheng, Y. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-02910-y · Cited by 30
Molecular Insights into Epigenetics and Cannabinoid Receptors
Basavarajappa, B. S., & Subbanna, S. (2022) · Biomolecules · doi:10.3390/biom12111560 · Cited by 30
Ultra-sensitive detection of microRNA-21 based on duplex-specific nuclease-assisted target recycling and horseradish peroxidase cascading signal amplification
Peng, W., Zhao, Q., Piao, J., Zhao, M., Huang, Y., Zhang, B., Gao, W., Zhou, D., Shu, G., Gong, X., et al. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.02.143 · Cited by 30
MiR-3188 Inhibits Non-small Cell Lung Cancer Cell Proliferation Through FOXO1-Mediated mTOR-p-PI3K/AKT-c-JUN Signaling Pathway
Wang, C., Liu, E., Li, W. J., Cui, J., & Li, T. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01362 · Cited by 30
Current role of non-coding RNAs in the clinical setting
Vicentini, C., Galuppini, F., Corbo, V., & Fassan, M. (2019) · Non-coding RNA Research · doi:10.1016/j.ncrna.2019.09.001 · Cited by 30
Self-Priming Cyclic Amplification Accelerating CRISPR Sensor for Sensitive and Specific MicroRNA Analysis with No Background
Li, D., Yao, Y., Cheng, W., Hou, Z., Wang, Z., & Xiang, Y. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c04866 · Cited by 29
Updates on the role of epigenetics in familial mediterranean fever (FMF)
Chaaban, A., Salman, Z., Karam, L., Kobeissy, P. H., & Ibrahim, J.-N. (2024) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-024-03098-w · Cited by 31
Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancer
Li, T., Lu, H., Mukherjee, D., Lahiri, S. K., Shen, C., Yu, L., & Zhao, J. (2015) · Oncotarget · doi:10.18632/oncotarget.4077 · Cited by 29
Long-Term Cigarette Smoke Exposure and Changes in MiRNA Expression and Proteome in Non-Small-Cell Lung Cancer
Advani, J., Subbannayya, Y., Patel, K., Khan, A. A., Patil, A. H., Jain, A., Solanki, H. S., Radhakrishnan, A., Pinto, S. M., Sahasrabuddhe, N. A., et al. (2017) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2017.0045 · Cited by 29
RETRACTED: MicroRNA‐612 inhibits cervical cancer progression by targeting NOB1
Yang, J., Zhou, X., Yao, X., Zhang, Z., Cui, M., & Yang, L. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14985 · Cited by 29
Retracted
miR‑148a‑3p regulates alcoholic liver fibrosis through targeting ERBB3
Xiong, J., Ni, J., Chen, C., & Wang, K. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4655 · Cited by 29
RETRACTED ARTICLE: MicroRNA-143 targets MAPK3 to regulate the proliferation and bone metastasis of human breast cancer cells
Du, Y., Zhang, J., Meng, Y., Huang, M., Yan, W., & Wu, Z. (2020) · AMB Express · doi:10.1186/s13568-020-01072-w · Cited by 29
Retracted
Serum-Derived Exosomes-Mediated Circular RNA ARHGAP10 Modulates the Progression of Non-Small Cell Lung Cancer Through the miR-638/FAM83F Axis
Fang, K., Chen, X., Qiu, F., Xu, J., Xiong, H., & Zhanmin, Z. (2020) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2019.3534 · Cited by 29
How metformin affects various malignancies by means of microRNAs: a brief review
Alimoradi, N., Firouzabadi, N., & Fatehi, R. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01921-z · Cited by 29
miRNA‐31 increases radiosensitivity through targeting STK40 in colorectal cancer cells
Zhang, W., Zhu, Y., Zhou, Y., Wang, J., Jiang, P., & Xue, L. (2021) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.13602 · Cited by 29
Long intergenic non-protein coding RNA 1094 (LINC01094) promotes the progression of breast cancer (BC) by regulating the microRNA-340-5p (miR-340-5p)/E2F transcription factor 3 (E2F3) axis
Wu, X., Kong, C., & Wu, Y. (2021) · Bioengineered · doi:10.1080/21655979.2021.1993715 · Cited by 29
Identification of a miRNA-based non-invasive predictive biomarker of response to target therapy in BRAF-mutant melanoma
Ruggiero, C. F., Fattore, L., Terrenato, I., Sperati, F., Salvati, V., Madonna, G., Capone, M., Valenti, F., Martino, S. D., Mandoj, C., et al. (2022) · Theranostics · doi:10.7150/thno.77761 · Cited by 29
MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition
Hsiao, S., Weng, S.-M., Hsiao, J., Wu, Y.-Y., Wu, J., Tung, C.-H., Shen, W.-L., Sun, S.-F., Huang, W.-T., Lin, C.-Y., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02597-1 · Cited by 29
KRAS Hijacks the miRNA Regulatory Pathway in Cancer
Bortoletto, A. S., & Parchem, R. J. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0296 · Cited by 30
Extracellular vesicle‐encapsulated microRNA‐296‐3p from cancer‐associated fibroblasts promotes ovarian cancer development through regulation of the PTEN / AKT and SOCS6 / STAT3 pathways
Sun, L., Ke, M.-L., Yin, M., Zeng, Y., Ji, Y., Hu, Y., Fu, S., & Zhang, C. (2023) · Cancer Science · doi:10.1111/cas.16014 · Cited by 29
Epigenomics, Pharmacoepigenomics, and Personalized Medicine in Cervical Cancer
Kabekkodu, S. P., Chakrabarty, S., Ghosh, S., Brand, A. M., & Satyamoorthy, K. (2017) · Public Health Genomics · doi:10.1159/000475804 · Cited by 29
miR-31 Functions as an Oncomir Which Promotes Epithelial-Mesenchymal Transition via Regulating BAP1 in Cervical Cancer
Wang, N., Li, Y., & Zhou, J. (2017) · BioMed Research International · doi:10.1155/2017/6361420 · Cited by 29
MicroRNA-495 enhances chondrocyte apoptosis, senescence and promotes the progression of osteoarthritis by targeting AKT1.
Zhao, X., Wang, T., Cai, B., Wang, X., Feng, W. S., Han, Y., Li, D., Li, S., & Liu, J. (2019) · PubMed Central · Cited by 29
Bargain with the tooth fairy – The savings accounts for dental stem cells
Häfner, S. J. (2020) · Biomedical Journal · doi:10.1016/j.bj.2020.04.001 · Cited by 29
Liquid biopsy in urothelial carcinoma: Detection techniques and clinical applications
Wu, S., Li, R., Jiang, Y., Yu, J., Zheng, J., Li, Z., Li, M., Xin, K., Wang, Y., Xu, Z., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115027 · Cited by 30
Targeted delivery of anti-miRNA21 sensitizes PD-L1high tumor to immunotherapy by promoting immunogenic cell death
Kim, E. H., Choi, J., Jang, H., Kim, Y., Lee, J. W., Ryu, Y., Choi, J., Choi, Y., Chi, S.-G., Kwon, I. C., et al. (2024) · Theranostics · doi:10.7150/thno.97755 · Cited by 30
Prognostic Value of MicroRNA-182 in Cancers: A Meta-Analysis
Wang, F., Zhong, S., Zhang, H., Zhang, W., Zhang, H., Wu, X., & Chen, B. (2015) · Disease Markers · doi:10.1155/2015/482146 · Cited by 28
MicroRNA-203 As a Stemness Inhibitor of Glioblastoma Stem Cells
Deng, Y., Zhu, G., Luo, H., & Zhao, S. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.0118 · Cited by 28
T-ALL and thymocytes: a message of noncoding RNAs
Wallaert, A., Durinck, K., Taghon, T., Vlierberghe, P. V., & Speleman, F. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0432-0 · Cited by 29
Detection of 1,5-anhydroglucitol as a Biomarker for Diabetes Using an Organic Field-Effect Transistor-Based Biosensor
Furusawa, H., Ichimura, Y., Nagamine, K., Shiwaku, R., Matsui, H., & Tokito, S. (2018) · Technologies · doi:10.3390/technologies6030077 · Cited by 28
MicroRNA-19a regulates the proliferation, migration and invasion of human gastric cancer cells by targeting CUL5
Zhu, Y., Li, L., Hou, D., Ouyang, Y., Guo, X., Wang, Y., Li, J., & Gong, K. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.11.023 · Cited by 28
MicroRNA networks regulate the differentiation, expansion and suppression function of myeloid-derived suppressor cells in tumor microenvironment
Su, Y., Qiu, Y., Qiu, Z., & Qu, P. (2019) · Journal of Cancer · doi:10.7150/jca.35205 · Cited by 28
MiR-506 Targets UHRF1 to Inhibit Colorectal Cancer Proliferation and Invasion via the KISS1/PI3K/NF-κB Signaling Axis
Lin, Y., Chen, Z., Zheng, Y., Liu, Y., Gao, J., Lin, S., & Chen, S. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00266 · Cited by 28
KCNQ1OT1 promotes migration and inhibits apoptosis by modulating miR‐185‐5p/Rab14 axis in oral squamous cell carcinoma
Bao, Q., Liao, X., Li, R., & Nan, D. (2019) · Development Growth & Differentiation · doi:10.1111/dgd.12638 · Cited by 28
The impact of microRNAs on alterations of gene regulatory networks in allergic diseases
Baskara-Yhuellou, I., & Tost, J. (2020) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.11.006 · Cited by 29
Long non-coding RNA GAS5 regulates the growth and metastasis of human cervical cancer cells via induction of apoptosis and cell cycle arrest
Yan, Z., Luo, R., Li, X., Hua, L., Jun, Z., Peng, Y., Wang, L., Aili, T., Zhao, Y., Lin, M., et al. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108320 · Cited by 28
miR-125b-5p/STAT3 Pathway Regulated by mTORC1 Plays a Critical Role in Promoting Cell Proliferation and Tumor Growth
Zhang, C., Wan, X., Tang, S., Li, K., Wang, Y., Liu, Y., Sha, Q., Zha, X., & Liu, Y. (2019) · Journal of Cancer · doi:10.7150/jca.33696 · Cited by 28
MicroRNAs: emerging driver of cancer perineural invasion
Zhang, M., Xian, H.-C., Dai, L., Tang, Y., & Liang, X. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00630-4 · Cited by 28
A multiplexed ion-exchange membrane-based miRNA (MIX·miR) detection platform for rapid diagnosis of myocardial infarction
Ren, X., Ellis, B. W., Ronan, G., Blood, S. R., DeShetler, C. M., Senapati, S., March, K. L., Handberg, E. M., Anderson, D., Pepine, C. J., et al. (2021) · Lab on a Chip · doi:10.1039/d1lc00685a · Cited by 28
Smartphone-Based Device for Colorimetric Detection of MicroRNA Biomarkers Using Nanoparticle-Based Assay
Krishnan, T., Wang, H., & Vo‐Dinh, T. (2021) · Sensors · doi:10.3390/s21238044 · Cited by 28
The molecular mechanism of miR-96-5p in the pathogenesis and treatment of polycystic ovary syndrome
Liu, Y., Zhang, S., Chen, L., Huang, X., Wang, M., Ponikwicka‐Tyszko, D., Rahman, N. A., Wołczyński, S., Yao, B., & Li, X. (2022) · Translational research · doi:10.1016/j.trsl.2022.12.007 · Cited by 28
Thiol functionalised gold nanoparticles loaded with methotrexate for cancer treatment: From synthesis to in vitro studies on neuroblastoma cell lines
Salamone, T. A., Rutigliano, L., Pennacchi, B., Cerra, S., Matassa, R., Nottola, S. A., Sciubba, F., Battocchio, C., Marsotto, M., Giudice, A. D., et al. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.06.078 · Cited by 28
Mini crRNA-mediated CRISPR/Cas12a system (MCM-CRISPR/Cas12a) and its application in RNA detection
Chen, X., Huang, C., Zhang, J., Hu, Q., Wang, D., You, Q., Guo, Y., Chen, H., Xu, J., & Hu, M. (2023) · Talanta · doi:10.1016/j.talanta.2023.125350 · Cited by 28
Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes
Lin, L., Cai, Q., Zhang, X., Zhang, H., Yang, Z. H., Xu, C., & Li, Y. (2015) · Protein & Cell · doi:10.1007/s13238-015-0142-8 · Cited by 28
Regulation of oncogenic genes by MicroRNAs and pseudogenes in human lung cancer
Tutar, Y., Özgür, A., Tutar, E., Tutar, L., Pulliero, A., & Izzotti, A. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.08.043 · Cited by 28
Overexpression of miR-202 resensitizes imatinib resistant chronic myeloid leukemia cells through targetting Hexokinase 2
Deng, Y., Li, X., Feng, J., & Zhang, X. (2018) · Bioscience Reports · doi:10.1042/bsr20171383 · Cited by 28
miRCancerdb: a database for correlation analysis between microRNA and gene expression in cancer
Ahmed, M., Nguyen, H. Q., Lai, T. H., & Kim, D. R. (2018) · BMC Research Notes · doi:10.1186/s13104-018-3160-9 · Cited by 28
Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review)
Zhang, S., Pan, S., Liang, S., Han, Y., Chen, H.-B., & Li, J. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5188 · Cited by 28
A new method for improving the accuracy of miRNA detection with NaYF4:Yb,Er upconversion nanoparticles
Mao, L., Lu, Z., He, N., Zhang, L., Deng, Y., & Duan, D. (2016) · Science China Chemistry · doi:10.1007/s11426-016-0021-0 · Cited by 27
MiR-26a downregulates retinoblastoma in colorectal cancer
López–Urrutia, E., Coronel-Hernández, J., García-Castillo, V., Contreras-Romero, C., Martínez-Gutiérrez, A. D., Estrada-Galicia, D., Terrazas, L. I., López‐Camarillo, C., Maldonado-Martínez, H. A., Jacobo-Herrera, N. J., et al. (2017) · Tumor Biology · doi:10.1177/1010428317695945 · Cited by 27
microRNA‐146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis
Shao, L., Lihong, Q., Di, Y., Yu, B., Xiaolin, L., & Mi, J. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27422 · Cited by 27
MiR-4295 facilitates cell proliferation and metastasis in head and neck squamous cell carcinoma by targeting NPTX1
Lu, S., Zhou, C., Zou, B., Zhang, H., & Feng, M. (2019) · Genes and Immunity · doi:10.1038/s41435-019-0081-0 · Cited by 27
MiRNA expression patterns are associated with tumor mutational burden in lung adenocarcinoma
Lv, Y., Huang, Z., Lin, Y., Fang, Y., Chen, Z., Pan, L., Zhang, Y., & Xu, Z. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1629260 · Cited by 27
Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms
Bastami, M., Choupani, J., Saadatian, Z., Vahed, S. Z., Ouladsahebmadarek, E., Mansoori, Y., Daraei, A., Kafil, H. S., Yousefi, B., Mahdipour, M., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205088 · Cited by 27
Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma
Li, Q., Geng, S., Yuan, H., Li, Y., Zhang, S., Pu, L., Ge, J., Niu, X., Li, Y., & Jiang, H. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12741 · Cited by 27
Circulating microRNAs as biomarkers for diagnosis and prediction of preeclampsia: A systematic review and meta-analysis
Yin, Y., Liu, M., Yu, H., Zhang, J., & Zhou, R. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.08.016 · Cited by 28
The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy
Simionescu, N., Zonda, R., Petrovici, A. R., & Georgescu, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070988 · Cited by 28
The Potential Roles of Exosomal Non-Coding RNAs in Hepatocellular Carcinoma
Wang, W., Hao, L., Song, H., Chu, X., & Wang, R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.790916 · Cited by 27
Cancer-associated fibroblasts drive colorectal cancer cell progression through exosomal miR-20a-5p-mediated targeting of PTEN and stimulating interleukin-6 production
Shahpar, M. G., Pakravan, K., Razmara, E., Amooie, F., Mahmoudian, M., Heshmati, M., & Babashah, S. (2024) · BMC Cancer · doi:10.1186/s12885-024-12190-0 · Cited by 27
Expression of apoptosis-regulating miRNAs and target mRNAs in oral squamous cell carcinoma
Coutinho‐Camillo, C. M., Lourenço, S. V., Lima, L. D. A., Kowalski, L. P., & Soares, F. A. (2015) · Cancer Genetics · doi:10.1016/j.cancergen.2015.04.004 · Cited by 27
Angiomirs expression profiling in diffuse large B-Cell lymphoma
Borges, N. M., Elias, M. D. V., Alves, V. L. F., de Andrade, T. A., de Conti, M. L., de Macêdo, M. P., Begnami, M. D., Campos, A. H. J. F. M., Etto, L. Y., Bortoluzzo, A. B., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6624 · Cited by 27
Gga-miR-219b targeting BCL11B suppresses proliferation, migration and invasion of Marek’s disease tumor cell MSB1
Zhao, C., Li, X., Han, B., You, Z., Qu, L., Liu, C., Song, J., Lian, L., & Yang, N. (2017) · Scientific Reports · doi:10.1038/s41598-017-04434-w · Cited by 27
MicroRNA-1 inhibits ovarian cancer cell proliferation and migration through c-Met pathway
Qu, W., Chen, X., Wang, J., Lv, J., & Yan, D. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.07.008 · Cited by 27
Overview of DNA Self-Assembling: Progresses in Biomedical Applications
Jorge, A. F., & Eritja, R. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040268 · Cited by 27
Knockdown THOC2 suppresses the proliferation and invasion of melanoma
Zhou, X., Liu, X., Zhang, G., Zhang, Q., Chen, H., Wang, Y., Fang, F., & Sun, J. (2019) · Bioengineered · doi:10.1080/21655979.2019.1685727 · Cited by 27
Evaluating the Use of microRNA Blood Tests for Gastric Cancer Screening in a Stratified Population-Level Screening Program: An Early Model-Based Cost-Effectiveness Analysis
Kapoor, R., So, J. B. Y., Zhu, F., Too, H., Yeoh, K. G., & Yoong, J. (2020) · Value in Health · doi:10.1016/j.jval.2020.04.1829 · Cited by 27
MiRNA-301b-3p induces proliferation and inhibits apoptosis in AML cells by targeting FOXF2 and regulating Wnt/β-catenin axis
Lu, Y., Zhong, L., Luo, X. W., Liu, C., Dan, W., Chu, X., Wan, P., Zhang, Z., Wang, X., Liu, Z., et al. (2022) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2022.101805 · Cited by 26
Photocontrollable DNA Walker-Based Molecular Circuit for the Tunable Detection of MicroRNA-21 Using Metal–Organic Frameworks as Label-Free Fluorescence Tags
Dong, J. X., Zhang, S. M., Li, Y. L., Zhang, X., Fan, Y. J., Su, M., Wang, Z., Li, H., Shen, S. G., Gao, Z. F., et al. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c03913 · Cited by 26
Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics
Sahreen, S., Vijayarathna, S., Hemagirri, M., Adnan, M., Hassan, M. I., Patel, M. B., Gupta, R., Shanmugapriya, S., Chen, Y., Gopinath, S. C. B., et al. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.06.003 · Cited by 27
Insights into the genetic and epigenetic mechanisms governing X-chromosome-linked-miRNAs expression in cancer; a step-toward ncRNA precision
Hamdy, N. Μ., Zaki, M. B., Abdelmaksoud, N. M., Abdelhamid, R., Abd‐Elmawla, M. A., Rizk, N. I., Fathi, D., & Abulsoud, A. I. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138773 · Cited by 26
Reduced expression of THRβ in papillary thyroid carcinomas: relationship with BRAF mutation, aggressiveness and miR expression
Rosignolo, F., Maggisano, V., Sponziello, M., Celano, M., Gioia, C. R. T. D., D’Agostino, M., Giacomelli, L., Verrienti, A., Dima, M., Pecce, V., et al. (2015) · Journal of Endocrinological Investigation · doi:10.1007/s40618-015-0309-4 · Cited by 26
Discovering the miR-26a-5p Targetome in Prostate Cancer Cells
Rizzo, M., Berti, G., Russo, F., Fazio, S., Evangelista, M., D’Aurizio, R., Pellegrini, M., & Rainaldi, G. (2017) · Journal of Cancer · doi:10.7150/jca.18396 · Cited by 26
RETRACTED: Identification of miR-758-3p as Potential Modulator of CBX5 Expression in Gastric Cancer
Guo, J.-X., Zhang, Z., Pan, L., & Zhou, Y. (2018) · Technology in Cancer Research & Treatment · doi:10.1177/1533033818816061 · Cited by 26
Retracted
Downregulation of miR‐146a promotes cell migration in Helicobacter pylori–negative gastric cancer
Shomali, N., Shirafkan, N., Duijf, P. H. G., Ghasabi, M., Babaloo, Z., Yousefi, M., Mansoori, B., Asadi, M., Shanehbandi, D., Baghbani, E., et al. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28225 · Cited by 26
Circulating MicroRNAs as Potential Biomarkers for Lung Cancer
Müller, S., Janke, F., Dietz, S., & Sültmann, H. (2019) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-030-26439-0_16 · Cited by 26
Identification of suitable controls for miRNA quantification in T-cells and whole blood cells in sepsis
Hirschberger, S., Hübner, M., Strauß, G., Effinger, D., Bauer, M. W., Weis, S., Giamarellos‐Bourboulis, E. J., & Kreth, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-51782-w · Cited by 27
Integrated analyses identify miR‐34c‐3p/MAGI3 axis for the Warburg metabolism in hepatocellular carcinoma
Weng, Q., Chen, M., Yang, W., Li, J., Fan, K., Xu, M., Weng, W., Lv, X., Fang, S., Zheng, L., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902895r · Cited by 26
Identification of A Four-Microrna Panel in Serum As Promising Biomarker for Colorectal Carcinoma Detection
Huang, G., Wei, B., Chen, Z., Wang, J., Zhao, L., Peng, X., Liu, K., Lai, Y., & Ni, L. (2020) · Biomarkers in Medicine · doi:10.2217/bmm-2019-0605 · Cited by 26
Identification of MicroRNAs as Diagnostic Biomarkers for Breast Cancer Based on the Cancer Genome Atlas
Kim, J. (2021) · Diagnostics · doi:10.3390/diagnostics11010107 · Cited by 26
miR-145 inhibits mitochondrial function of ovarian cancer by targeting ARL5B
Zhao, S., Zhang, Y., Pei, M., Wu, L., & Li, J. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-020-00762-0 · Cited by 26
The role of miRNA, lncRNA and circRNA in the development of intervertebral disk degeneration (Review)
Jiang, J. F., Sun, Y., Xu, G., Wang, H., & Wang, L. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9987 · Cited by 27
Development of a microRNA Panel for Classification of Abnormal Mammograms for Breast Cancer
Zou, R., Loke, S. Y., Tan, V. K. M., Quek, S. T., Jagmohan, P., Tang, Y. C., Madhukumar, P., Tan, B. K. T., Yong, W. S., Sim, Y., et al. (2021) · Cancers · doi:10.3390/cancers13092130 · Cited by 26
Identification of a Two-MicroRNA Signature in Plasma as a Novel Biomarker for Very Early Diagnosis of Breast Cancer
Adam‐Artigues, A., Garrido‐Cano, I., Carbonell‐Asins, J. A., Lameirinhas, A., Simón, S., Ortega-Morillo, B., Martínez, M. T., Hernándo, C., Constâncio, V., Burgués, O., et al. (2021) · Cancers · doi:10.3390/cancers13112848 · Cited by 26
CircWHSC1 regulates malignancy and glycolysis by the miR-212-5p/AKT3 pathway in triple-negative breast cancer
Ding, L., & Xie, Z. (2021) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2021.104704 · Cited by 26
Nanoparticulate Strategies for The Delivery of miRNA Mimics and Inhibitors in Anticancer Therapy and its Potential Utility in Oral Submucous Fibrosis
Manikkath, J., Jishnu, P. V., Wich, P. R., Manikkath, A., & Radhakrishnan, R. A. (2022) · Nanomedicine · doi:10.2217/nnm-2021-0381 · Cited by 26
Roles of microRNAs in Regulating Apoptosis in the Pathogenesis of Endometriosis
Azam, I. N. A., Wahab, N. A., Mokhtar, M. H., Shafiee, M. N., & Mokhtar, N. M. (2022) · Life · doi:10.3390/life12091321 · Cited by 26
A non-invasive miRNA-based approach in early diagnosis and therapeutics of oral cancer
Dar, G. M., Agarwal, S., Kumar, A., Nimisha, Apurva, A., Sharma, A. K., Verma, R., Sattar, R. S. A., Ahmad, E., Ali, A., et al. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103850 · Cited by 26
Role of regulatory non-coding RNAs in traumatic brain injury
Li, S., Qiu, N., Ni, A., Hamblin, M. H., & Yin, K. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105643 · Cited by 26
Systematic evaluation of cancer risk associated with rs2292832 in miR-149 and rs895819 in miR-27a: a comprehensive and updated meta-analysis
Feng, Y., Duan, F., Song, C., Zhao, X., Dai, L., & Cui, S. (2016) · Oncotarget · doi:10.18632/oncotarget.8082 · Cited by 26
Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules with Huge Impact?
Fischer‐Posovszky, P., Roos, J., Kotnik, P., Battelino, T., Inzaghi, E., Nobili, V., Cianfarani, S., & Wabitsch, M. (2016) · Hormone Research in Paediatrics · doi:10.1159/000444677 · Cited by 27
MicroRNAs and Inflammation in Colorectal Cancer
Josse, C., & Bours, V. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-42059-2_3 · Cited by 26
Fluorescent miRNA analysis enhanced by mesopore effects of polydopamine nanoquenchers
Wang, Z., Zhang, J., Chen, F., & Cai, K. (2017) · The Analyst · doi:10.1039/c7an00528h · Cited by 27
Aberrant expression of microRNAs and the miR‐1/MET pathway in canine hepatocellular carcinoma
Lai, Y., Ushio, N., Rahman, M. M., Katanoda, Y., OGIHARA, K., Naya, Y., Moriyama, A., Iwanaga, T., Saitoh, Y., Sogawa, T., et al. (2018) · Veterinary and Comparative Oncology · doi:10.1111/vco.12379 · Cited by 27

Authors: Hayes, J., Peruzzi, P. P., & Lawler, S.
Affiliations: St James's University Hospital (GB)
The Ohio State University Wexner Medical Center (US)
Brigham and Women's Hospital (US)
Corresponding author: Lawler, Sean
ORCID: Hayes, Josie
Peruzzi, Pier Paolo
Lawler, Sean
Venue: Trends in Molecular Medicine
Publisher: Elsevier BV
Published: 2014-08
Volume: 20
Issue: 8
Pages: 460-469
ISSN: 1471-4914 (ISSN-L)
DOI: 10.1016/j.molmed.2014.06.005
OpenAlex: W1974254202
Cited by: 2,049
References: 79
Citations by year: 2026: 61 · 2025: 78 · 2024: 103 · 2023: 130 · 2022: 186 · 2021: 244 · 2020: 290 · 2019: 273 · 2018: 235 · 2017: 203 · 2016: 140 · 2015: 91 · 2014: 12
FWCI: 14.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: microRNA, cancer, biomarkers, microRNA processing, miRNA expression profiling, prognosis, cancer therapy, miRNA mimics, cancer monitoring
MeSH terms: Animals, Humans, Neoplasms, Prognosis, Biomarkers, Tumor, Genetic Therapy, Gene Expression Regulation, Neoplastic, MicroRNAs, Gene Regulatory Networks

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

MicroRNAs in cancer: biomarkers, functions and therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks