Cited by 2,049MicroRNA in disease regulationCancer-related molecular mechanisms researchCancer-related Molecular Pathways

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MicroRNAs in cancer: biomarkers, functions and therapy

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Hayes, Josie, Peruzzi, Pier Paolo, Lawler, Sean·2014·Trends in Molecular Medicine

DOI 10.1016/j.molmed.2014.06.005

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Abstract

The emergence of microRNAs has been one of the defining developments in cancer biology over the past decade, and the explosion of knowledge in this area has brought forward new diagnostic and therapeutic opportunities. The importance of microRNAs in cancer has been underlined by the identification of alterations in microRNA target binding sites and the microRNA processing machinery in tumor cells. Clinical trials utilizing microRNA profiling for patient prognosis and clinical response are now underway, and the first microRNA mimic entered the clinic for cancer therapy in 2013. In this article we review the potential applications of microRNAs for the clinical assessment of patient outcome in cancer, as well as in cancer monitoring and therapy.

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Authors: Hayes, J., Peruzzi, P. P., & Lawler, S.
Affiliations: St James's University Hospital (GB)
The Ohio State University Wexner Medical Center (US)
Brigham and Women's Hospital (US)
Corresponding author: Lawler, Sean
ORCID: Hayes, Josie
Peruzzi, Pier Paolo
Lawler, Sean
Venue: Trends in Molecular Medicine
Publisher: Elsevier BV
Published: 2014-08
Volume: 20
Issue: 8
Pages: 460-469
ISSN: 1471-4914 (ISSN-L)
DOI: 10.1016/j.molmed.2014.06.005
OpenAlex: W1974254202
Cited by: 2,049
References: 79
Citations by year: 2026: 61 · 2025: 78 · 2024: 103 · 2023: 130 · 2022: 186 · 2021: 244 · 2020: 290 · 2019: 273 · 2018: 235 · 2017: 203 · 2016: 140 · 2015: 91 · 2014: 12
FWCI: 14.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: microRNA, cancer, biomarkers, microRNA processing, miRNA expression profiling, prognosis, cancer therapy, miRNA mimics, cancer monitoring
MeSH terms: Animals, Humans, Neoplasms, Prognosis, Biomarkers, Tumor, Genetic Therapy, Gene Expression Regulation, Neoplastic, MicroRNAs, Gene Regulatory Networks

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