The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.
Macrophages: The Road Less Traveled, Changing Anticancer Therapy
Open accessAbstract
Macrophages are present in all vertebrate tissues and have emerged as multifarious cells with complex roles in development, tissue homeostasis and disease. Macrophages are a major constituent of the tumor microenvironment, where they either promote or inhibit tumorigenesis and metastasis, depending on their state. Successful preclinical strategies to target macrophages for anti-cancer therapy are now being evaluated in the clinic and provide proof-of-concept that this strategy may enhance current therapies; however, clinical success has been limited. This review discusses the promise of targeting macrophages for anti-cancer therapy, yet highlights how much is unknown regarding their ontogeny, regulation and tissue specific diversity. Further work might identify subsets of macrophages within different tissues, which could reveal novel therapeutic opportunities for anti-cancer therapy.
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Cites
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Cited by
Tumor-associated macrophages: an accomplice in solid tumor progression
Chen, Y., Song, Y., Du, W., Gong, L., Chang, H., & Zou, Z. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0568-z · Cited by 1,096
Targeting tumor-associated macrophages in cancer
Pathria, P., Louis, T. L., & Varner, J. A. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.02.003 · Cited by 933
Macrophage diversity in cancer revisited in the era of single-cell omics
Ma, R.-Y., Black, A., & Qian, B.-Z. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.04.008 · Cited by 698
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review
Oura, K., Morishita, A., Tani, J., & Masaki, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115801 · Cited by 426
Harnessing tumor‐associated macrophages as aids for cancer immunotherapy
Li, X., Liu, R., Su, X., Pan, Y., Han, X., Shao, C., & Shi, Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1102-3 · Cited by 364
Metadata
- Authors
- Guerriero, J. L.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 24
- Issue
- 5
- Pages
- 472-489
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2797203065
- Cited by
- 293
- References
- 164
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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