The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells
Open accessAbstract
The molecular mechanisms regulating secretion of the orexigenic-glucoregulatory hormone ghrelin remain unclear. Based on qPCR analysis of FACS-purified gastric ghrelin cells, highly expressed and enriched 7TM receptors were comprehensively identified and functionally characterized using in vitro, ex vivo and in vivo methods. Five Gαs-coupled receptors efficiently stimulated ghrelin secretion: as expected the β1-adrenergic, the GIP and the secretin receptors but surprisingly also the composite receptor for the sensory neuropeptide CGRP and the melanocortin 4 receptor. A number of Gαi/o-coupled receptors inhibited ghrelin secretion including somatostatin receptors SSTR1, SSTR2 and SSTR3 and unexpectedly the highly enriched lactate receptor, GPR81. Three other metabolite receptors known to be both Gαi/o- and Gαq/11-coupled all inhibited ghrelin secretion through a pertussis toxin-sensitive Gαi/o pathway: FFAR2 (short chain fatty acid receptor; GPR43), FFAR4 (long chain fatty acid receptor; GPR120) and CasR (calcium sensing receptor). In addition to the common Gα subunits three non-common Gαi/o subunits were highly enriched in ghrelin cells: GαoA, GαoB and Gαz. Inhibition of Gαi/o signaling via ghrelin cell-selective pertussis toxin expression markedly enhanced circulating ghrelin. These 7TM receptors and associated Gα subunits constitute a major part of the molecular machinery directly mediating neuronal and endocrine stimulation versus metabolite and somatostatin inhibition of ghrelin secretion including a series of novel receptor targets not previously identified on the ghrelin cell.
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Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
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“FFAR1 (GPR40, Ffar1) and FFAR4 (GPR120, Ffar4) recognizing long chain fatty acids (LCFAs), and GPR119 (Gpr119) sensing 2-acyl glycerols (Figure 2B) [52,53].”
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Exercise-induced suppression of acylated ghrelin in humans
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Cited by
Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.005 · Cited by 1,034
Self-citationFree Fatty Acid Receptors in Health and Disease
Kimura, I., Ichimura, A., Ohue-Kitano, R., & Igarashi, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00041.2018 · Cited by 1,018
Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium
Gribble, F. M., & Reimann, F. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105439 · Cited by 683
Function and mechanisms of enteroendocrine cells and gut hormones in metabolism
Gribble, F. M., & Reimann, F. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0168-8 · Cited by 670
Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578
Metadata
- Authors
- Engelstoft, M. S., Park, W.-M., Sakata, I., Kristensen, L. V., Husted, A. S., Osborne-Lawrence, S., Piper, P. K., Walker, A. K., Pedersen, M. H., Nøhr, M. K., Pan, J., Sinz, C. J., Carrington, P. E., Akiyama, T. E., Jones, R. M., Tang, C., Ahmed, K., Offermanns, S., Egerod, K. L., Zigman, J. M., & Schwartz, T. W.
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 2
- Issue
- 4
- Pages
- 376-392
- ISSN
- 2212-8778 (ISSN-L)
- OpenAlex
- W1992955585
- Cited by
- 323
- References
- 9
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- gold
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- Engelstoft, M. S., Park, W.-M., Sakata, I., Kristensen, L. V., Husted, A. S., Osborne-Lawrence, S., Piper, P. K., Walker, A. K., Pedersen, M. H., Nøhr, M. K., Pan, J., Sinz, C. J., Carrington, P. E., Akiyama, T. E., Jones, R. M., Tang, C., Ahmed, K., Offermanns, S., Egerod, K. L., . . . Schwartz, T. W. (2013). Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Molecular Metabolism. https://doi.org/10.1016/j.molmet.2013.08.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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