The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety
Open accessAbstract
Dietary supplementation with fermentable carbohydrate protects against body weight gain. Fermentation by the resident gut microbiota produces short-chain fatty acids, which act at free fatty acid receptor 2 (FFAR2). Our aim was to test the hypothesis that FFAR2 is important in regulating the beneficial effects of fermentable carbohydrate on body weight and to understand the role of gut hormones PYY and GLP-1. Wild-type or Ffar2−/− mice were fed an inulin supplemented or control diet. Mice were metabolically characterized and gut hormone concentrations, enteroendocrine cell density measurements were carried out. Intestinal organoids and colonic cultures were utilized to substantiate the in vivo findings. We provide new mechanistic insight into how fermentable carbohydrate regulates metabolism. Using mice that lack FFAR2, we demonstrate that the fermentable carbohydrate inulin acts via this receptor to drive an 87% increase in the density of cells that produce the appetite-suppressing hormone peptide YY (PYY), reduce food intake, and prevent diet-induced obesity. Our results demonstrate that FFAR2 is predominantly involved in regulating the effects of fermentable carbohydrate on metabolism and does so, in part, by enhancing PYY cell density and release. This highlights the potential for targeting enteroendocrine cell differentiation to treat obesity.
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Background
Cited by
Gut microbiome and health: mechanistic insights
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The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity
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Metadata
- Authors
- Brooks, L., Viardot, A., Tsakmaki, A., Stolarczyk, E., Howard, J. K., Cani, P. D., Everard, A., Sleeth, M. L., Psichas, A., Anastasovskaj, J., Bell, J. D., Bell-Anderson, K., Mackay, C. R., Ghatei, M. A., Bloom, S. R., Frost, G., & Bewick, G. A.
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 6
- Issue
- 1
- Pages
- 48-60
- ISSN
- 2212-8778 (ISSN-L)
- OpenAlex
- W2547640677
- Cited by
- 258
- References
- 70
- FWCI
- 12.63
- Type
- journal article
- Language
- en
- Open access
- gold
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- Brooks, L., Viardot, A., Tsakmaki, A., Stolarczyk, E., Howard, J. K., Cani, P. D., Everard, A., Sleeth, M. L., Psichas, A., Anastasovskaj, J., Bell, J. D., Bell-Anderson, K., Mackay, C. R., Ghatei, M. A., Bloom, S. R., Frost, G., & Bewick, G. A. (2017). Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety. Molecular Metabolism. https://doi.org/10.1016/j.molmet.2016.10.011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
