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Exposure of pregnant mice to carbon black by intratracheal instillation: Toxicogenomic effects in dams and offspring

Jackson, Petra, Hougaard, Karin S., Vogel, Ulla, Wu, Dongmei, Casavant, Lorraine, Williams, Andrew, Wade, Mike, Yauk, Carole L., Wallin, Håkan, Halappanavar, Sabina·2012·Mutation Research/Genetic Toxicology and Environmental Mutagenesis
DOI 10.1016/j.mrgentox.2011.09.018
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Fig. 2 Lung histology. Representative H-E and Trichrome-stained lung tissue sections from dams exposed to three different doses of CB Printex 90 (11, 54 and 268 𝛍 g/animal) 26-27 days post-exposure. (A-D) (20 × , bars 50 𝛍 m): H-E stained lung sections. Black arrows show particle deposition. (E-H) (10 × , bars 100 𝛍 m): trichrome stained lung sections showing uniform blue-stained fibrils of collagen. (I-J) (100 × , bars 10 𝛍 m): H-E stained lung sections showing inflammatory cells in CB treated samples. Solid line arrows show macrophages and dashed-line arrows indicate neutrophils.
Fig. 2 Lung histology. Representative H-E and Trichrome-stained lung tissue sections from dams exposed to three different doses of CB Printex 90 (11, 54 and 268 𝛍 g/animal) 26-27 days post-exposure. (A-D) (20 × , bars 50 𝛍 m): H-E stained lung sections. Black arrows show particle deposition. (E-H) (10 × , bars 100 𝛍 m): trichrome stained lung sections showing uniform blue-stained fibrils of collagen. (I-J) (100 × , bars 10 𝛍 m): H-E stained lung sections showing inflammatory cells in CB treated samples. Solid line arrows show macrophages and dashed-line arrows indicate neutrophils.CC-BY-NC-ND · From the PDF
Fig. 3 Tissue protein abundance. Evaluation of the abundance of several inflammatory proteins in lung tissues derived from dams exposed to three different doses of CB (11, 54 and 268 𝛍 g/animal) at the 26-27 day post-exposure time point. Numbers indicate fold changes over matched controls. Statistical significance was calculated using Student's t -test. * p -Value <0.1, ** p -value <0.01 and *** p -value< 0.001.
Fig. 3 Tissue protein abundance. Evaluation of the abundance of several inflammatory proteins in lung tissues derived from dams exposed to three different doses of CB (11, 54 and 268 𝛍 g/animal) at the 26-27 day post-exposure time point. Numbers indicate fold changes over matched controls. Statistical significance was calculated using Student's t -test. * p -Value <0.1, ** p -value <0.01 and *** p -value< 0.001.CC-BY-NC-ND · From the PDF
Fig. 4 Functional pathway analysis. Adversely affected pathways in dams ( ) male offspring ( ) and female offspring ( ). The Y -axis shows the Fisher's Exact Test p -values. The threshold line is set at 0.05.
Fig. 4 Functional pathway analysis. Adversely affected pathways in dams ( ) male offspring ( ) and female offspring ( ). The Y -axis shows the Fisher's Exact Test p -values. The threshold line is set at 0.05.CC-BY-NC-ND · From the PDF

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Metadata

Authors
Jackson, P., Hougaard, K. S., Vogel, U., Wu, D., Casavant, L., Williams, A., Wade, M., Yauk, C. L., Wallin, H., & Halappanavar, S.
Venue
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Publisher
Elsevier BV
Published
2012-06
Volume
745
Issue
1-2
Pages
73-83
ISSN
1383-5718
DOI
10.1016/j.mrgentox.2011.09.018
Cited by
96
References
2
Language
en
Licence
Funders
  • Health Canada's Internal A-Base
  • Roskilde University
  • Danish Agency for Science, Technology and Innovation

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