β-Glucans in promoting health: Prevention against mutation and cancer
Abstract
The polysaccharides beta-glucans occur as a principal component of the cellular walls. Some microorganisms, such as yeast and mushrooms, and also cereals such as oats and barley, are of economic interest because they contain large amounts of beta-glucans. These substances stimulate the immune system, modulating humoral and cellular immunity, and thereby have beneficial effect in fighting infections (bacterial, viral, fungal and parasitic). beta-Glucans also exhibit hypocholesterolemic and anticoagulant properties. Recently, they have been demonstrated to be anti-cytotoxic, antimutagenic and anti-tumorogenic, making them promising candidate as pharmacological promoters of health.
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Not only laminarans, but also other β-d-glucans from yeast, fungi, and cereals demonstrated anti-cytotoxic, anti-mutagenic, and anti-tumorigenic properties, making this class promising for health.
“It is of special interest that not only laminarans, but also other β-d-glucans, isolated from yeast, fungi and cereals demonstrated anti-cytotoxic, anti-mutagenic, and anti-tumorigenic properties, making this class of polysaccharides a promising promoter of health [89].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [89]
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- Authors
- Mantovani, M. S., Bellini, M. F., Angeli, J. P. F., Oliveira, R. J., Silva, A. F., & Ribeiro, L. R.
- Affiliations
- Universidade Estadual de Londrina (BR)
- Instituto de Biociências, Letras e Ciências Exatas, câmpus de São José do Rio Preto (BR)
- Universidade Estadual Paulista (Unesp) (BR)
- Corresponding author
- Mantovani, Mário S.
- ORCID
- Venue
- Mutation Research/Reviews in Mutation Research
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 658
- Issue
- 3
- Pages
- 154-161
- ISSN
- 1383-5742 (ISSN-L)
- OpenAlex
- W2080014425
- Cited by
- 240
- References
- 59
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 14 · 2019: 16 · 2018: 9 · 2017: 18 · 2016: 18 · 2015: 26 · 2014: 25 · 2013: 20 · 2012: 12
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mutation Research/Reviews in Mutation Research (publishedVersion)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- β-glucan, polysaccharides, immunomodulation, antimutagenic activity, anticancer activity, cholesterol-lowering effect, anticoagulant activity, health promotion, yeast, mushrooms, oat, barley, infection resistance
- MeSH terms
- Animals, Anti-Infective Agents, Antineoplastic Agents, Health Promotion, Humans, Models, Biological, Mutation, Neoplasms, Antimutagenic Agents, Cytoprotection, beta-Glucans
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