Cited by 240Fungal Biology and ApplicationsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

β-Glucans in promoting health: Prevention against mutation and cancer

Mantovani, Mário S., Bellini, Marilanda F., Angeli, José Pedro F., Oliveira, Rodrigo J., Silva, Ariane F., Ribeiro, Lúcia R.·2008·Mutation Research/Reviews in Mutation Research

Abstract

The polysaccharides beta-glucans occur as a principal component of the cellular walls. Some microorganisms, such as yeast and mushrooms, and also cereals such as oats and barley, are of economic interest because they contain large amounts of beta-glucans. These substances stimulate the immune system, modulating humoral and cellular immunity, and thereby have beneficial effect in fighting infections (bacterial, viral, fungal and parasitic). beta-Glucans also exhibit hypocholesterolemic and anticoagulant properties. Recently, they have been demonstrated to be anti-cytotoxic, antimutagenic and anti-tumorogenic, making them promising candidate as pharmacological promoters of health.

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Crossref · 10.1016/j.mrrev.2007.07.002

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  • Not only laminarans, but also other β-d-glucans from yeast, fungi, and cereals demonstrated anti-cytotoxic, anti-mutagenic, and anti-tumorigenic properties, making this class promising for health.

    “It is of special interest that not only laminarans, but also other β-d-glucans, isolated from yeast, fungi and cereals demonstrated anti-cytotoxic, anti-mutagenic, and anti-tumorigenic properties, making this class of polysaccharides a promising promoter of health [89].”

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Authors
Mantovani, M. S., Bellini, M. F., Angeli, J. P. F., Oliveira, R. J., Silva, A. F., & Ribeiro, L. R.
Affiliations
  • Universidade Estadual de Londrina (BR)
  • Instituto de Biociências, Letras e Ciências Exatas, câmpus de São José do Rio Preto (BR)
  • Universidade Estadual Paulista (Unesp) (BR)
Corresponding author
Mantovani, Mário S.
Venue
Mutation Research/Reviews in Mutation Research
Publisher
Elsevier BV
Published
2008-03
Volume
658
Issue
3
Pages
154-161
ISSN
1383-5742 (ISSN-L)
OpenAlex
W2080014425
Cited by
240
References
59
Citations by year
2026: 1 · 2025: 7 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 14 · 2019: 16 · 2018: 9 · 2017: 18 · 2016: 18 · 2015: 26 · 2014: 25 · 2013: 20 · 2012: 12
FWCI
0.94
Type
journal article
Language
en
Open access
closed
Locations
  • Mutation Research/Reviews in Mutation Research (publishedVersion)
  • PubMed (publishedVersion)
  • Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
  • UNESP Institutional Repository (São Paulo State University) (submittedVersion)
Funders
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords
β-glucan, polysaccharides, immunomodulation, antimutagenic activity, anticancer activity, cholesterol-lowering effect, anticoagulant activity, health promotion, yeast, mushrooms, oat, barley, infection resistance
MeSH terms
Animals, Anti-Infective Agents, Antineoplastic Agents, Health Promotion, Humans, Models, Biological, Mutation, Neoplasms, Antimutagenic Agents, Cytoprotection, beta-Glucans

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