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Cited by 1,132Multiple Sclerosis Research StudiesHealth Systems, Economic Evaluations, Quality of LifeCancer survivorship and care

A health-related quality of life measure for multiple sclerosis

Vickrey, B. G., Hays, R. D., Harooni, R., Myers, L. W., Ellison, G. W.·1995·Quality of Life Research
DOI 10.1007/bf02260859
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Abstract

The need for measures of health-related quality of life (HRQOL) for clinical effectiveness research and for quality of care research, particularly for chronic diseases, is increasingly recognized. We assessed a measure of HRQOL for people with multiple sclerosis, a chronic neurological condition. We used the RAND 36-Item Health Survey 1.0 (aka SF-36) as a generic core measure, to enable comparisons of HRQOL of patients with multiple sclerosis to those of other patient populations and to the general population. To enhance comparisons within groups of multiple sclerosis patients, these items were supplemented with 18 additional items in the areas of health distress (four items), sexual function (four items), satisfaction with sexual function (one item), overall quality of life (two items), cognitive function (four items), energy (one item), pain (one item), and social function (one item). The final measure, the Multiple Sclerosis Quality of Life (MSQOL)-54 Instrument, contains 52 items distributed into 12 scales, and two single items. Internal consistency reliability estimates for the 12 multi-item scales ranged from 0.75 to 0.96 in a sample of 179 patients with multiple sclerosis. Test-retest intraclass correlation coefficients ranged from 0.66 to 0.96. Exploratory factor analysis confirmed two underlying dimensions of physical health and mental health. Construct validity was supported by significant associates between MSQOL-54 scales and degree of multiple sclerosis symptom severity in the prior year, level of ambulation, employment limitations due to health, admission to hospital in the previous year, and depressive symptoms.

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Authors
Vickrey, B. G., Hays, R. D., Harooni, R., Myers, L. W., & Ellison, G. W.
Affiliations
  • University of California, Los Angeles (US)
  • RAND Corporation (US)
  • Tel Aviv University (IL)
ORCID
Venue
Quality of Life Research
Publisher
Springer Science and Business Media LLC
Published
1995-06
Volume
4
Issue
3
Pages
187-206
ISSN
  • 0962-9343 (ISSN-L)
  • 1573-2649
DOI
10.1007/bf02260859
OpenAlex
W1998609863
Cited by
1,132
References
51
Citations by year
2026: 45 · 2025: 60 · 2024: 66 · 2023: 61 · 2022: 57 · 2021: 72 · 2020: 56 · 2019: 47 · 2018: 34 · 2017: 53 · 2016: 50 · 2015: 51 · 2014: 34 · 2013: 46 · 2012: 35
FWCI
5.33
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Quality of Life Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1k08ns001669-01)
  • National Institute of Neurological Disorders and Stroke (K08 NS01669-02)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords
multiple sclerosis, health-related quality of life, MSQOL-54, SF-36, patient-reported outcome measures, sexual function, cognitive function, energy, pain, social function, depressive symptoms, symptom severity, chronic neurological disease
MeSH terms
Activities of Daily Living, Adult, Aged, Female, Humans, Libido, Male, Mental Processes, Middle Aged, Multiple Sclerosis, Quality of Life, Surveys and Questionnaires, Sexual Behavior, Social Adjustment, Stress, Psychological, Reproducibility of Results, Comorbidity

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