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Identification and functional analysis of specific MS risk miRNAs and their target genes

Luo, Deling, Wang, Jingguo, Zhang, Xuemei, Rang, Xinming, Xu, Chaohan, Fu, Jin·2020·Multiple Sclerosis and Related Disorders
DOI 10.1016/j.msard.2020.102044
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Abstract

Background It has been widely acknowledged that abnormal expression of microRNAs (miRNAs) may lead to the occurrence and development of MS through regulating target genes. Currently, only few studies have comprehensively evaluated the function and relationship between MS-related miRNAs and their target genes. Methods Differentially expressed miRNAs in MS patients' serum and plasma were selected by reviewing numerous literatures manually. Then, thousands of target genes were screened by several online databases, of which 899 MS-related genes were further identified. Gene ontology, protein-protein interaction and KEGG pathway analysis were used to determine high-risk pathways and MS risk genes. Transcriptomic datasets from GEO was analyzed to evaluate these risk genes. Results 28 MS-related miRNAs were extracted. MiR-30e, miR-93, miR-155 were identified as the most crucial miRNAs through targeting hub genes: PIK3CA, PIK3R1, PIK3R2 and MAPK8. Seven immune pathways were screened out according to KEGG pathway analysis. Six transcriptomic datasets were used to evaluate results, and PIK3CA was differentially expressed in MS patients compared with healthy donors. Conclusions According to our research, MS-related miRNAs and their target genes of MS were identified and comprehensively evaluated. This work may provide a new insight for discovering pathogenesis and possible biomarkers of MS in future studies.

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Metadata

Authors
Luo, D., Wang, J., Zhang, X., Rang, X., Xu, C., & Fu, J.
Venue
Multiple Sclerosis and Related Disorders
Publisher
Elsevier BV
Published
2020-06
Volume
41
Pages
102044
ISSN
2211-0348
DOI
10.1016/j.msard.2020.102044
Cited by
12
References
1
Language
en
Licence
Funders
  • Natural Science Foundation of Heilongjiang Province
  • National Natural Science Foundation of China

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